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The map label for this gene is hppA

Identifier: 159184648

GI number: 159184648

Start: 1167264

End: 1169402

Strand: Direct

Name: hppA

Synonym: Atu1174

Alternate gene names: 159184648

Gene position: 1167264-1169402 (Clockwise)

Preceding gene: 15888510

Following gene: 159184650

Centisome position: 41.08

GC content: 61.34

Gene sequence:

>2139_bases
ATGACCGTAATACCCATAGTAATTTTATGCGGTGTCCTGTCCGTGGTTTACGCGGTATGGACCACCAAGAGTGTTCTCGA
TGCCGATCAGGGCAACGAGCGTATGCGTGAAATAGCAGGTTATATCCGTGAAGGCGCACAGGCTTATCTCACCCGTCAAT
ATCTCACCATCGCCATCGTCGGACTGATCGTCGCCGTTCTCGCCTGGTATCTGCTGTCGGCCATCGCGGCCATCGGTTTC
GTTATCGGTGCGGTATTGTCCGGCGTCGCCGGTTTCGTCGGCATGCATGTTTCCGTGCGTGCCAATCTGCGCACCGCGCA
GGCAGCATCTCACAGCCTTGGTGCCGGTCTCGATATCGCCTTCAAGTCGGGCGCCATTACCGGCATGCTGGTTGCCGGCC
TCGCGCTGCTTGGCGTTTCAATCTATTATTTTGTTCTGACGTCCGTCCTTGGCCATCCGCCCGGATCACGCGCCGTTATC
GACGCGTTGGTGTCGCTCGGTTTCGGCGCTTCGCTGATCTCCATCTTCGCCCGTCTCGGCGGCGGTATCTTCACCAAGGG
TGCGGATGTCGGCGGCGATCTCGTCGGCAAGGTGGAGGCGGGCATTCCCGAGGATGATCCGCGCAACCCCGCAACCATTG
CCGACAATGTCGGCGATAACGTCGGTGACTGCGCCGGCATGGCGGCTGACCTGTTCGAAACCTATGCCGTCTCCGTGGTC
GCGACCATGGTTCTCGCCGCGATCTTCTTTGCGGGAACGCCGATTCTGGAAAGCGCCATGGTCTATCCGCTGGCGATCTG
CGGCGCCTGCATCCTGACCTCGATTGCCGGTACCTTCTTCGTGAAGCTCGGCACCAACAATTCCATCATGGGCGCGCTCT
ACAAGGGGCTCATCGCCACTGGCGTGTTCTCAGTCGCCGGCCTTGCCGTGGCAACCTATGCCACGGTCGGCTGGGGAACG
ATCGGCACGGTGGCCGGCATGGAGATCACCGGCACCAACCTCTTCTTCTGCGGATTGGTTGGCCTCGTCGTGACGGCGCT
GATCGTCGTCATCACCGAATATTATACCGGCACCAACAAGCGGCCGGTCAATTCCATCGCCCAAGCATCGGTTACCGGCC
ACGGCACCAACGTCATTCAGGGCCTTGCGGTCTCGCTGGAATCGACCGCGCTGCCGGCCATCGTCATCGTCGGCGGTATC
ATCGGCACCTACCAGCTCGGCGGCCTGTTCGGCACCGGCATCGCCGTTACCGCCATGCTCGGGCTGGCGGGCATGATCGT
CGCGCTCGACGCCTTCGGCCCGGTCACGGACAATGCCGGCGGCATCGCCGAAATGGCGGGTCTCGATCCTGATGTGCGCA
AGGCGACCGACGCGCTGGATGCCGTTGGCAACACCACCAAGGCGGTGACCAAGGGTTACGCCATCGGTTCGGCCGGTCTC
GGCGCATTGGTGCTGTTTGCGGCCTATGCCAACGACCTGTCCTATTTCGCCGCCAATGGCGATACCTATCCTTACTTCAA
GGATATCGGAGAAATCTCCTTCAGCCTCGCCAATCCTTACGTGGTTGCCGGTCTGCTGTTCGGCGGTCTCATCCCCTACC
TCTTCGGCGGCATCGCCATGACGGCGGTGGGTAAGGCGGCAAGCGCCATCGTTGAGGAAGTCCGCCGCCAGTTCCGCGAA
AAGCCCGGCATCATGGCCGGCACGGAAAAGCCTGACTACGGCAGGGCCGTGGACCTGCTGACCAAGGCGGCAATCAGGGA
AATGGTCATCCCGTCGCTTCTGCCGGTTCTCGCGCCGCTCGTGGTTTATTTCGGCGTGCTGCTGATCTCGGGCTCAAAGG
CGTCCGCCTTTGCCGCGCTGGGTGCATCCTTGCTGGGTGTCATCATCAACGGGCTGTTCGTGGCAATTTCCATGACGTCG
GGTGGTGGCGCCTGGGACAACGCCAAGAAGAGCTTCGAAGATGGCTTCATCGACAAGGACGGGGTACGCCACGTCAAAGG
TTCCGAGGCGCACAAGGCATCGGTAACGGGCGACACGGTCGGCGATCCCTACAAGGATACCGCGGGTCCAGCCGTCAACC
CGGCCATCAAGATCACCAATATCGTGGCGCTGCTGCTGCTGGCAGTTCTTGCCCACTGA

Upstream 100 bases:

>100_bases
CCAAGACAGGACCCGGCGTGCGTTTCATCGCCTGGTCCTTGCACATGGTTCGCCACGCCGGGGAGGGAGTGAGACCCGGC
CTTTTGGGAGGTAAGTGCGC

Downstream 100 bases:

>100_bases
AGGCTACGGTTCCGACAAATGAAAAGGCCCGGGGAGCGATCCCCGGGCCTTCGAACTTTCCGTTCCTGCTGCGGTCAGGG
GGCGTTGTTGCCGCCCTGGC

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound proton-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; H(+)-PPase

Number of amino acids: Translated: 712; Mature: 711

Protein sequence:

>712_residues
MTVIPIVILCGVLSVVYAVWTTKSVLDADQGNERMREIAGYIREGAQAYLTRQYLTIAIVGLIVAVLAWYLLSAIAAIGF
VIGAVLSGVAGFVGMHVSVRANLRTAQAASHSLGAGLDIAFKSGAITGMLVAGLALLGVSIYYFVLTSVLGHPPGSRAVI
DALVSLGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVSVV
ATMVLAAIFFAGTPILESAMVYPLAICGACILTSIAGTFFVKLGTNNSIMGALYKGLIATGVFSVAGLAVATYATVGWGT
IGTVAGMEITGTNLFFCGLVGLVVTALIVVITEYYTGTNKRPVNSIAQASVTGHGTNVIQGLAVSLESTALPAIVIVGGI
IGTYQLGGLFGTGIAVTAMLGLAGMIVALDAFGPVTDNAGGIAEMAGLDPDVRKATDALDAVGNTTKAVTKGYAIGSAGL
GALVLFAAYANDLSYFAANGDTYPYFKDIGEISFSLANPYVVAGLLFGGLIPYLFGGIAMTAVGKAASAIVEEVRRQFRE
KPGIMAGTEKPDYGRAVDLLTKAAIREMVIPSLLPVLAPLVVYFGVLLISGSKASAFAALGASLLGVIINGLFVAISMTS
GGGAWDNAKKSFEDGFIDKDGVRHVKGSEAHKASVTGDTVGDPYKDTAGPAVNPAIKITNIVALLLLAVLAH

Sequences:

>Translated_712_residues
MTVIPIVILCGVLSVVYAVWTTKSVLDADQGNERMREIAGYIREGAQAYLTRQYLTIAIVGLIVAVLAWYLLSAIAAIGF
VIGAVLSGVAGFVGMHVSVRANLRTAQAASHSLGAGLDIAFKSGAITGMLVAGLALLGVSIYYFVLTSVLGHPPGSRAVI
DALVSLGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVSVV
ATMVLAAIFFAGTPILESAMVYPLAICGACILTSIAGTFFVKLGTNNSIMGALYKGLIATGVFSVAGLAVATYATVGWGT
IGTVAGMEITGTNLFFCGLVGLVVTALIVVITEYYTGTNKRPVNSIAQASVTGHGTNVIQGLAVSLESTALPAIVIVGGI
IGTYQLGGLFGTGIAVTAMLGLAGMIVALDAFGPVTDNAGGIAEMAGLDPDVRKATDALDAVGNTTKAVTKGYAIGSAGL
GALVLFAAYANDLSYFAANGDTYPYFKDIGEISFSLANPYVVAGLLFGGLIPYLFGGIAMTAVGKAASAIVEEVRRQFRE
KPGIMAGTEKPDYGRAVDLLTKAAIREMVIPSLLPVLAPLVVYFGVLLISGSKASAFAALGASLLGVIINGLFVAISMTS
GGGAWDNAKKSFEDGFIDKDGVRHVKGSEAHKASVTGDTVGDPYKDTAGPAVNPAIKITNIVALLLLAVLAH
>Mature_711_residues
TVIPIVILCGVLSVVYAVWTTKSVLDADQGNERMREIAGYIREGAQAYLTRQYLTIAIVGLIVAVLAWYLLSAIAAIGFV
IGAVLSGVAGFVGMHVSVRANLRTAQAASHSLGAGLDIAFKSGAITGMLVAGLALLGVSIYYFVLTSVLGHPPGSRAVID
ALVSLGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVSVVA
TMVLAAIFFAGTPILESAMVYPLAICGACILTSIAGTFFVKLGTNNSIMGALYKGLIATGVFSVAGLAVATYATVGWGTI
GTVAGMEITGTNLFFCGLVGLVVTALIVVITEYYTGTNKRPVNSIAQASVTGHGTNVIQGLAVSLESTALPAIVIVGGII
GTYQLGGLFGTGIAVTAMLGLAGMIVALDAFGPVTDNAGGIAEMAGLDPDVRKATDALDAVGNTTKAVTKGYAIGSAGLG
ALVLFAAYANDLSYFAANGDTYPYFKDIGEISFSLANPYVVAGLLFGGLIPYLFGGIAMTAVGKAASAIVEEVRRQFREK
PGIMAGTEKPDYGRAVDLLTKAAIREMVIPSLLPVLAPLVVYFGVLLISGSKASAFAALGASLLGVIINGLFVAISMTSG
GGAWDNAKKSFEDGFIDKDGVRHVKGSEAHKASVTGDTVGDPYKDTAGPAVNPAIKITNIVALLLLAVLAH

Specific function: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Acidocalcisome membrane; Multi-pass membrane protein

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPPA_AGRT5 (Q8UG67)

Other databases:

- EMBL:   AE007869
- EMBL:   AF417520
- EMBL:   AF417521
- EMBL:   AJ251784
- PIR:   AD2721
- PIR:   H97502
- RefSeq:   NP_354192.2
- STRING:   Q8UG67
- GeneID:   1133212
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1174
- eggNOG:   COG3808
- HOGENOM:   HBG593668
- OMA:   AYLARQY
- ProtClustDB:   PRK00733
- BioCyc:   ATUM176299-1:ATU1174-MONOMER
- HAMAP:   MF_01129
- InterPro:   IPR004131
- PIRSF:   PIRSF001265
- TIGRFAMs:   TIGR01104

Pfam domain/function: PF03030 H_PPase

EC number: =3.6.1.1

Molecular weight: Translated: 72505; Mature: 72374

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe16ac64)-; HASH(0xe55b394)-; HASH(0xe3745d4)-; HASH(0xe55b43c)-; HASH(0xb356418)-; HASH(0xe54b438)-; HASH(0xe2efd88)-; HASH(0xd3ca9c4)-; HASH(0xe409168)-; HASH(0xb67ac70)-; HASH(0xb93d174)-; HASH(0xb5b20a8)-; HASH(0xdec1f38)-; HASH(0xd538cb4)-; HASH(0xc0eb70c)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVIPIVILCGVLSVVYAVWTTKSVLDADQGNERMREIAGYIREGAQAYLTRQYLTIAIV
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLIVAVLAWYLLSAIAAIGFVIGAVLSGVAGFVGMHVSVRANLRTAQAASHSLGAGLDIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHCCCCCEEE
FKSGAITGMLVAGLALLGVSIYYFVLTSVLGHPPGSRAVIDALVSLGFGASLISIFARLG
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHC
GGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVSVV
CCEEECCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ATMVLAAIFFAGTPILESAMVYPLAICGACILTSIAGTFFVKLGTNNSIMGALYKGLIAT
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHH
GVFSVAGLAVATYATVGWGTIGTVAGMEITGTNLFFCGLVGLVVTALIVVITEYYTGTNK
HHHHHHHHHHHHHHHHCCCHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RPVNSIAQASVTGHGTNVIQGLAVSLESTALPAIVIVGGIIGTYQLGGLFGTGIAVTAML
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
GLAGMIVALDAFGPVTDNAGGIAEMAGLDPDVRKATDALDAVGNTTKAVTKGYAIGSAGL
HHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHH
GALVLFAAYANDLSYFAANGDTYPYFKDIGEISFSLANPYVVAGLLFGGLIPYLFGGIAM
HHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
TAVGKAASAIVEEVRRQFREKPGIMAGTEKPDYGRAVDLLTKAAIREMVIPSLLPVLAPL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVYFGVLLISGSKASAFAALGASLLGVIINGLFVAISMTSGGGAWDNAKKSFEDGFIDKD
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHCCCCCCC
GVRHVKGSEAHKASVTGDTVGDPYKDTAGPAVNPAIKITNIVALLLLAVLAH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
TVIPIVILCGVLSVVYAVWTTKSVLDADQGNERMREIAGYIREGAQAYLTRQYLTIAIV
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLIVAVLAWYLLSAIAAIGFVIGAVLSGVAGFVGMHVSVRANLRTAQAASHSLGAGLDIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHCCCCCEEE
FKSGAITGMLVAGLALLGVSIYYFVLTSVLGHPPGSRAVIDALVSLGFGASLISIFARLG
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHC
GGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVSVV
CCEEECCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ATMVLAAIFFAGTPILESAMVYPLAICGACILTSIAGTFFVKLGTNNSIMGALYKGLIAT
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHH
GVFSVAGLAVATYATVGWGTIGTVAGMEITGTNLFFCGLVGLVVTALIVVITEYYTGTNK
HHHHHHHHHHHHHHHHCCCHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RPVNSIAQASVTGHGTNVIQGLAVSLESTALPAIVIVGGIIGTYQLGGLFGTGIAVTAML
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
GLAGMIVALDAFGPVTDNAGGIAEMAGLDPDVRKATDALDAVGNTTKAVTKGYAIGSAGL
HHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHH
GALVLFAAYANDLSYFAANGDTYPYFKDIGEISFSLANPYVVAGLLFGGLIPYLFGGIAM
HHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
TAVGKAASAIVEEVRRQFREKPGIMAGTEKPDYGRAVDLLTKAAIREMVIPSLLPVLAPL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVYFGVLLISGSKASAFAALGASLLGVIINGLFVAISMTSGGGAWDNAKKSFEDGFIDKD
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHCCCCCCC
GVRHVKGSEAHKASVTGDTVGDPYKDTAGPAVNPAIKITNIVALLLLAVLAH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194; 12783865