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The map label for this gene is cah [H]

Identifier: 15889755

GI number: 15889755

Start: 2457274

End: 2457915

Strand: Direct

Name: cah [H]

Synonym: Atu2488

Alternate gene names: 15889755

Gene position: 2457274-2457915 (Clockwise)

Preceding gene: 159185237

Following gene: 159185241

Centisome position: 86.48

GC content: 58.26

Gene sequence:

>642_bases
ATGAAAGATTTTCCGGAAACACTTCTCAACGGCTACAAGAACTTCATGAGCGGCCGCTATGTCGATGAGCGCGAAAGATA
CCGCGTTCTCGCCGATACCGGACAGAAACCGCAGACCCTGTTCATTGCCTGTTGTGACTCCCGTTCGGCGCCGGAAACCA
TTTTCGACTGCGGACCGGGAGAACTTTTCGTTGTTCGCAACGTCGCCAACATGGTGCCGCCATTCGAGCCGGACGGACAG
TATCACGCCACGTCGGCCGCCATCGAATATGCCGTGCAGGTTCTCAAGGTGAAGGATATCGTCGTCATGGGCCACGGCCG
CTGCGGCGGCATTCAGGCGGCGCTTGACCCCAATCTCGAGCCGCTGTCACCAGGCGATTTCATCGGCAAATGGATGAACA
TGGTCAAATCGGCGGCCGAACAAATCCAGAGTAACGACGTCATGACCGCCTCCGAACGCCAGACGGCGCTGGAACGCGTC
TCCATCCGCAACTCCATCGCCAACCTACGTGGTTTCCCCTTCGTCAAGGCACAGGAGACCGCCGGCAAGGTCAAGCTGCA
CGGCGCATGGTTCGATATCTCGACCGGTGAATTGTGGGTGATGGACAGCAAAACGGGCGACTTTCGCCGCCCGGATCTGT
GA

Upstream 100 bases:

>100_bases
TTCGCGGTTCGAAGAAAAGCGAAAATGCTCTAAAGGATTGGTCTTCAACGCGCCGAGTTCCTCTCTTGATCTCGGTCCAA
CCACAACGGTACTGCGATAG

Downstream 100 bases:

>100_bases
AAACAGGTTTCTGATTGAAAGAGCGAGACGGCCTTATTGGCCGTCGATCGCCTTGCCGATGAAGGCGATGGCCTGTTGAT
AGACGCTTGCCGCGTTCCAA

Product: carbonate dehydratase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MKDFPETLLNGYKNFMSGRYVDERERYRVLADTGQKPQTLFIACCDSRSAPETIFDCGPGELFVVRNVANMVPPFEPDGQ
YHATSAAIEYAVQVLKVKDIVVMGHGRCGGIQAALDPNLEPLSPGDFIGKWMNMVKSAAEQIQSNDVMTASERQTALERV
SIRNSIANLRGFPFVKAQETAGKVKLHGAWFDISTGELWVMDSKTGDFRRPDL

Sequences:

>Translated_213_residues
MKDFPETLLNGYKNFMSGRYVDERERYRVLADTGQKPQTLFIACCDSRSAPETIFDCGPGELFVVRNVANMVPPFEPDGQ
YHATSAAIEYAVQVLKVKDIVVMGHGRCGGIQAALDPNLEPLSPGDFIGKWMNMVKSAAEQIQSNDVMTASERQTALERV
SIRNSIANLRGFPFVKAQETAGKVKLHGAWFDISTGELWVMDSKTGDFRRPDL
>Mature_213_residues
MKDFPETLLNGYKNFMSGRYVDERERYRVLADTGQKPQTLFIACCDSRSAPETIFDCGPGELFVVRNVANMVPPFEPDGQ
YHATSAAIEYAVQVLKVKDIVVMGHGRCGGIQAALDPNLEPLSPGDFIGKWMNMVKSAAEQIQSNDVMTASERQTALERV
SIRNSIANLRGFPFVKAQETAGKVKLHGAWFDISTGELWVMDSKTGDFRRPDL

Specific function: Reversible Hydration Of Carbon Dioxide. Carbon Dioxide Formed In The Bicarbonate-Dependent Decomposition Of Cyanate By Cyanase (Cyns) Diffuses Out Of The Cell Faster Than It Would Be Hydrated To Bicarbonate, So The Apparent Function Of This Enzyme Is To C

COG id: COG0288

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-class carbonic anhydrase family [H]

Homologues:

Organism=Escherichia coli, GI1786534, Length=203, Percent_Identity=33.0049261083744, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786318, Length=172, Percent_Identity=32.5581395348837, Blast_Score=78, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI115532990, Length=239, Percent_Identity=25.1046025104602, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI25147564, Length=207, Percent_Identity=25.6038647342995, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324292, Length=176, Percent_Identity=26.1363636363636, Blast_Score=75, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001765
- InterPro:   IPR015892 [H]

Pfam domain/function: PF00484 Pro_CA [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 23667; Mature: 23667

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00705 PROK_CO2_ANHYDRASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDFPETLLNGYKNFMSGRYVDERERYRVLADTGQKPQTLFIACCDSRSAPETIFDCGPG
CCCHHHHHHHHHHHHHCCCCCCCHHHEEEEECCCCCCCEEEEEEECCCCCCCCEEECCCC
ELFVVRNVANMVPPFEPDGQYHATSAAIEYAVQVLKVKDIVVMGHGRCGGIQAALDPNLE
CEEEEECHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCEECCCCCCCC
PLSPGDFIGKWMNMVKSAAEQIQSNDVMTASERQTALERVSIRNSIANLRGFPFVKAQET
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCC
AGKVKLHGAWFDISTGELWVMDSKTGDFRRPDL
CCEEEEEEEEEEECCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MKDFPETLLNGYKNFMSGRYVDERERYRVLADTGQKPQTLFIACCDSRSAPETIFDCGPG
CCCHHHHHHHHHHHHHCCCCCCCHHHEEEEECCCCCCCEEEEEEECCCCCCCCEEECCCC
ELFVVRNVANMVPPFEPDGQYHATSAAIEYAVQVLKVKDIVVMGHGRCGGIQAALDPNLE
CEEEEECHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCEECCCCCCCC
PLSPGDFIGKWMNMVKSAAEQIQSNDVMTASERQTALERVSIRNSIANLRGFPFVKAQET
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCC
AGKVKLHGAWFDISTGELWVMDSKTGDFRRPDL
CCEEEEEEEEEEECCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]