Click here to switch to the map view.

The map label for this gene is fur [H]

Identifier: 15887705

GI number: 15887705

Start: 348239

End: 348667

Strand: Direct

Name: fur [H]

Synonym: Atu0354

Alternate gene names: 15887705

Gene position: 348239-348667 (Clockwise)

Preceding gene: 15887704

Following gene: 15887706

Centisome position: 12.26

GC content: 56.18

Gene sequence:

>429_bases
GTGATAGACCTTTCGAAAACGCTGGAGGAGCTTTGTGCCGAACGCGGCATGCGGATGACGGACCAGCGCCGTGTGATTGC
CCGCGTCCTTCAGGAATCAGCCGATCATCCCGATGTCGAGGAACTCTATCGCCGTTCTTCCGCCGTGGATCCGCGCATCT
CTATTTCAACGGTCTACAGAACGGTGAAGCTGTTCGAGGACGCTGGCATCATCGAACGTCACGATTTTCGCGATGGCCGC
TCGCGTTATGAGACCGTGCCTGAAGAACACCACGATCACCTGATCGATCTGAAGAACAGCGTGGTCATCGAATTCCATTC
GCCCGAGATCGAGGCGCTTCAGGAAAAGATCGCCCGCGAGCACGGCTTCAAGCTCGTCGATCATCGACTGGAACTTTATG
GCGTGCCGTTGAAACCCGAAGAACGCTGA

Upstream 100 bases:

>100_bases
GGCGCTTGTCATGCGCCGCGATCTTCGCTAGTTCCCTGCGACAGGCATTTTTTGGCGAAAGCTGCGAAATTCAACCGGAA
TACTCAAAAGGCCAGAAGAC

Downstream 100 bases:

>100_bases
GACGCCGGTGAACAAGCGGGCGTTCCCATCATGATGTGGCTTCGGACAGCCTATATCGCGATCGTTCTTCTGATCGTGAC
GCTCATATTGCTGCCGTTGC

Product: ferric uptake regulator

Products: NA

Alternate protein names: Ferric uptake regulator [H]

Number of amino acids: Translated: 142; Mature: 142

Protein sequence:

>142_residues
MIDLSKTLEELCAERGMRMTDQRRVIARVLQESADHPDVEELYRRSSAVDPRISISTVYRTVKLFEDAGIIERHDFRDGR
SRYETVPEEHHDHLIDLKNSVVIEFHSPEIEALQEKIAREHGFKLVDHRLELYGVPLKPEER

Sequences:

>Translated_142_residues
MIDLSKTLEELCAERGMRMTDQRRVIARVLQESADHPDVEELYRRSSAVDPRISISTVYRTVKLFEDAGIIERHDFRDGR
SRYETVPEEHHDHLIDLKNSVVIEFHSPEIEALQEKIAREHGFKLVDHRLELYGVPLKPEER
>Mature_142_residues
MIDLSKTLEELCAERGMRMTDQRRVIARVLQESADHPDVEELYRRSSAVDPRISISTVYRTVKLFEDAGIIERHDFRDGR
SRYETVPEEHHDHLIDLKNSVVIEFHSPEIEALQEKIAREHGFKLVDHRLELYGVPLKPEER

Specific function: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes [H]

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family [H]

Homologues:

Organism=Escherichia coli, GI1786899, Length=120, Percent_Identity=45, Blast_Score=102, Evalue=9e-24,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002481
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01475 FUR [H]

EC number: NA

Molecular weight: Translated: 16687; Mature: 16687

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDLSKTLEELCAERGMRMTDQRRVIARVLQESADHPDVEELYRRSSAVDPRISISTVYR
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHH
TVKLFEDAGIIERHDFRDGRSRYETVPEEHHDHLIDLKNSVVIEFHSPEIEALQEKIARE
HHHHHHCCCCCCCCCCCCHHHHHHCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHH
HGFKLVDHRLELYGVPLKPEER
HCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIDLSKTLEELCAERGMRMTDQRRVIARVLQESADHPDVEELYRRSSAVDPRISISTVYR
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHH
TVKLFEDAGIIERHDFRDGRSRYETVPEEHHDHLIDLKNSVVIEFHSPEIEALQEKIARE
HHHHHHCCCCCCCCCCCCHHHHHHCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHH
HGFKLVDHRLELYGVPLKPEER
HCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9835040 [H]