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The map label for this gene is murB

Identifier: 39998158

GI number: 39998158

Start: 3372764

End: 3373630

Strand: Reverse

Name: murB

Synonym: GSU3067

Alternate gene names: 39998158

Gene position: 3373630-3372764 (Counterclockwise)

Preceding gene: 39998159

Following gene: 39998157

Centisome position: 88.45

GC content: 64.82

Gene sequence:

>867_bases
GTGCGGGGGGAGATCCTCCGGGACGAGCCCATGGCGCGCCATACGTCGCTGAGGGTGGGCGGTCCGGCGGACTTCTTCGT
CACCCCGGCCGATCCCGACGACATGCGAGCGCTCCTGGCGATTCTGGCCGAAACCGGCACTCCCTGGCTGGCTGTGGGGG
GAGGCTACAATCTCCTGATCCGCGACGGAGGCTTTCGGGGCGTTGTTATTTCGTCGGCGCGCATGACTAGCCTGGAGCGG
CTCGAAGGAAACCGGGCCGTGGTGGGGGCCGGGGTGGCCAACGGCAGGCTGACGGCCTTTCTCCGGAACGAAGGCCTTGC
CGGCCTGGAGTTTCTTTGCGGGATTCCCGGAACCGTTGGCGGTGCCCTTGCCATGAATGCCGGAGCCCACGGCGGTGCCA
TTCTCGACCGGGTCGAAGAGATCCTGACCATTGGCACTGCAGGCTTCGAATGCAAGGGGCGCGAATTGCTCGATTACGGC
TACCGGTACCTCAAGCTGCAACCGGGAGAGATCATCATCGGGGCTACGTTCGTGCTCGATTCCGACGATCCCCGACGGAT
CAGTGAGCGGATCGACGGGTGCCGGGCCCACCGGACCGCCAGCCAGCAGGTCGGCTTCCCCAATGCCGGGTCCTTCTTCA
AGAACCCGCCCGGTCAGGCGGCCTGGCGACTGATCGAAGATGCGGGGCTCAGGGGAGCTCGGGTGGGGGGAGCCCAGGTG
TCCGAGGTCCACACCAACTTTCTGGTGAACCGGGGTGGTGCCACGGCCGCCGATTTTCTGGCCCTGGCAGCGCGCATCAA
GGATGCGGTGAAGCTCAAAAGCGGCACGGCTCTTGAAGAAGAAGTCAAAATTTTCGGCGATGAGTAA

Upstream 100 bases:

>100_bases
AGGCGAGGCGTTCCTCGCGAAGCTGGAAGAAGCCCGGCAGGCCTAGCGGGCACGGGACGGTTCTTTGAACGATCGGTTGG
CGGCACGGCTTGAGGCGGAA

Downstream 100 bases:

>100_bases
GGGGCTGTAGTGTCCCGCGCGGAGCGGCAATGACGAGGGATGAGCTGAAAACCACGAAGATAGGCGTACTTATGGGAGGA
CTCTCGGCTGAGCGCGAAGT

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MRGEILRDEPMARHTSLRVGGPADFFVTPADPDDMRALLAILAETGTPWLAVGGGYNLLIRDGGFRGVVISSARMTSLER
LEGNRAVVGAGVANGRLTAFLRNEGLAGLEFLCGIPGTVGGALAMNAGAHGGAILDRVEEILTIGTAGFECKGRELLDYG
YRYLKLQPGEIIIGATFVLDSDDPRRISERIDGCRAHRTASQQVGFPNAGSFFKNPPGQAAWRLIEDAGLRGARVGGAQV
SEVHTNFLVNRGGATAADFLALAARIKDAVKLKSGTALEEEVKIFGDE

Sequences:

>Translated_288_residues
MRGEILRDEPMARHTSLRVGGPADFFVTPADPDDMRALLAILAETGTPWLAVGGGYNLLIRDGGFRGVVISSARMTSLER
LEGNRAVVGAGVANGRLTAFLRNEGLAGLEFLCGIPGTVGGALAMNAGAHGGAILDRVEEILTIGTAGFECKGRELLDYG
YRYLKLQPGEIIIGATFVLDSDDPRRISERIDGCRAHRTASQQVGFPNAGSFFKNPPGQAAWRLIEDAGLRGARVGGAQV
SEVHTNFLVNRGGATAADFLALAARIKDAVKLKSGTALEEEVKIFGDE
>Mature_288_residues
MRGEILRDEPMARHTSLRVGGPADFFVTPADPDDMRALLAILAETGTPWLAVGGGYNLLIRDGGFRGVVISSARMTSLER
LEGNRAVVGAGVANGRLTAFLRNEGLAGLEFLCGIPGTVGGALAMNAGAHGGAILDRVEEILTIGTAGFECKGRELLDYG
YRYLKLQPGEIIIGATFVLDSDDPRRISERIDGCRAHRTASQQVGFPNAGSFFKNPPGQAAWRLIEDAGLRGARVGGAQV
SEVHTNFLVNRGGATAADFLALAARIKDAVKLKSGTALEEEVKIFGDE

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_GEOSL (P61435)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_954109.1
- ProteinModelPortal:   P61435
- SMR:   P61435
- GeneID:   2686326
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU3067
- NMPDR:   fig|243231.1.peg.3047
- TIGR:   GSU3067
- HOGENOM:   HBG686573
- OMA:   ILIVPKH
- ProtClustDB:   PRK13905
- BioCyc:   GSUL243231:GSU_3067-MONOMER
- BRENDA:   1.1.1.158
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 30477; Mature: 30477

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 162-162 ACT_SITE 211-211 ACT_SITE 281-281

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGEILRDEPMARHTSLRVGGPADFFVTPADPDDMRALLAILAETGTPWLAVGGGYNLLI
CCCCCCCCCCCHHHCEEEECCCCCEEEECCCHHHHHHHHHHHHHCCCCEEEECCCEEEEE
RDGGFRGVVISSARMTSLERLEGNRAVVGAGVANGRLTAFLRNEGLAGLEFLCGIPGTVG
ECCCCCEEEEECHHHHHHHHHCCCEEEEECCCCCCEEEEEEECCCCCHHHHHHCCCCCCC
GALAMNAGAHGGAILDRVEEILTIGTAGFECKGRELLDYGYRYLKLQPGEIIIGATFVLD
CCEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCEEEEEECCCCEEEEEEEEEC
SDDPRRISERIDGCRAHRTASQQVGFPNAGSFFKNPPGQAAWRLIEDAGLRGARVGGAQV
CCCHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEECCCCHH
SEVHTNFLVNRGGATAADFLALAARIKDAVKLKSGTALEEEVKIFGDE
HHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEECCC
>Mature Secondary Structure
MRGEILRDEPMARHTSLRVGGPADFFVTPADPDDMRALLAILAETGTPWLAVGGGYNLLI
CCCCCCCCCCCHHHCEEEECCCCCEEEECCCHHHHHHHHHHHHHCCCCEEEECCCEEEEE
RDGGFRGVVISSARMTSLERLEGNRAVVGAGVANGRLTAFLRNEGLAGLEFLCGIPGTVG
ECCCCCEEEEECHHHHHHHHHCCCEEEEECCCCCCEEEEEEECCCCCHHHHHHCCCCCCC
GALAMNAGAHGGAILDRVEEILTIGTAGFECKGRELLDYGYRYLKLQPGEIIIGATFVLD
CCEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCEEEEEECCCCEEEEEEEEEC
SDDPRRISERIDGCRAHRTASQQVGFPNAGSFFKNPPGQAAWRLIEDAGLRGARVGGAQV
CCCHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEECCCCHH
SEVHTNFLVNRGGATAADFLALAARIKDAVKLKSGTALEEEVKIFGDE
HHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA