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The map label for this gene is ydgK [H]

Identifier: 38234711

GI number: 38234711

Start: 2241389

End: 2242600

Strand: Direct

Name: ydgK [H]

Synonym: DIP2168

Alternate gene names: 38234711

Gene position: 2241389-2242600 (Clockwise)

Preceding gene: 38234710

Following gene: 38234716

Centisome position: 90.06

GC content: 58.75

Gene sequence:

>1212_bases
ATGTCCCCAAGTCCTGCTTCCCCGACACGTCAGCTCATACCACCAGCATTGCTGGGCACCTTGGCGCTTGTTAACGCCAC
TGAACCGCTCAGCATCAACATGTACCTATCGGGGTTGCCCGTGTTGCGTCACGAGTTTGGTATCAGCCAATTCGACGCAC
AGTTGACCATCACGTTCTTCCTTATCGGAATGACCGTGGGCCAGCTGTTCAGTGGGCCGATTACCGACGCCCGCGGTCGG
CGCGGGCTATTTTTCATCGGCACGATTGTGCTTACGATAGCAACCTTGTTAAGCGCCCTCGCACCCCACGCATGGGTGCT
CTACCTCTCCCGCGCAGCCATGGGCTGGGCCGCCGGCACCGCAGTTGTTTCTGCACGCGCGATTGCCGCCGATAAGGCTT
CTGGCCCAGAACTAGCCAAGGTGTTCTCCATCCTCATGGTCCTAGGCAGCATCGCTCCCGTGGTTGGCCCCATCCTCGGC
GGTCTGATCGTCCACTCCGCCGGTTGGCGTGCTGTTTTCTGGTTCCTCACCGTGGTCTATGCGTTTACAGCTGTTATTGC
AGCACGCACTATCCCAGAAACTCTGCCTGTGGAACGTCGCACCCACGGTGGTATCCGCGCCATGCTTGCCGCGATCCGCA
CCTTGTTAAGCAATCGCGTCTACGTAGGCTCCACAGTGGCATTCGTTTTTGCCTTTGCCACCATGTTCACCTTCGTGTCT
GCTTCACCCTTTATCCTGCAGGAACACTTCGGATTCTCGCCGCTGCACTACGCACTCATCTTTGCCATGAACACCTCGGG
TCTAGCCACCATGGCAATCATCAACGCCCGAGTAGTTCATCGCTTTGGGGCACCTCGCCTTGCAGCAACAGGAGTGACCA
TCATGGCTTTGGCAGTTGCTTGGCTGGCGATCGCCGCAACATTTAGCCTCGGCACCGTGGCATTCTTGGCTGGAATTTTC
ACCATGACTGCTTCCATGGGCATGATCTTTGCCAACACCTCAGCACTGGCCATGTCCCACGCCGGCCCCGTGGGTGGCGC
TGCCTCCGCATTCTTGGGATCCGGCCAGTTCTTCATCGCAGGGCTGTACGCCCCCATGTTCGGCGTGGTCCAATCATGGG
GAATCGCACCCCCGCTCGCAGCCGCCACCATGATGTCGGTTACCGCGGTGATCACCGTCGTGGGCTTAGCACAAGCTCTG
CGCTCTTCCTAG

Upstream 100 bases:

>100_bases
GGCTACGAGTTGGGTGTCGGCCTTGGTGTGTGGGACATTCACTCCCCGCGTGTGCTCGCCCAGCTGGTCTAGTTGATAAT
AGTTGGGTACGTTCACTGAC

Downstream 100 bases:

>100_bases
AAGCTCGACGAACCACCAGCGCCGCTAAACCCAGAGCTAAACGAGGTGTTAGTACGCGAGGAGCTCGCACTGGCAGCCTC
TTGGGCTGCAATGTTGTCGG

Product: integral membrane transport protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MSPSPASPTRQLIPPALLGTLALVNATEPLSINMYLSGLPVLRHEFGISQFDAQLTITFFLIGMTVGQLFSGPITDARGR
RGLFFIGTIVLTIATLLSALAPHAWVLYLSRAAMGWAAGTAVVSARAIAADKASGPELAKVFSILMVLGSIAPVVGPILG
GLIVHSAGWRAVFWFLTVVYAFTAVIAARTIPETLPVERRTHGGIRAMLAAIRTLLSNRVYVGSTVAFVFAFATMFTFVS
ASPFILQEHFGFSPLHYALIFAMNTSGLATMAIINARVVHRFGAPRLAATGVTIMALAVAWLAIAATFSLGTVAFLAGIF
TMTASMGMIFANTSALAMSHAGPVGGAASAFLGSGQFFIAGLYAPMFGVVQSWGIAPPLAAATMMSVTAVITVVGLAQAL
RSS

Sequences:

>Translated_403_residues
MSPSPASPTRQLIPPALLGTLALVNATEPLSINMYLSGLPVLRHEFGISQFDAQLTITFFLIGMTVGQLFSGPITDARGR
RGLFFIGTIVLTIATLLSALAPHAWVLYLSRAAMGWAAGTAVVSARAIAADKASGPELAKVFSILMVLGSIAPVVGPILG
GLIVHSAGWRAVFWFLTVVYAFTAVIAARTIPETLPVERRTHGGIRAMLAAIRTLLSNRVYVGSTVAFVFAFATMFTFVS
ASPFILQEHFGFSPLHYALIFAMNTSGLATMAIINARVVHRFGAPRLAATGVTIMALAVAWLAIAATFSLGTVAFLAGIF
TMTASMGMIFANTSALAMSHAGPVGGAASAFLGSGQFFIAGLYAPMFGVVQSWGIAPPLAAATMMSVTAVITVVGLAQAL
RSS
>Mature_402_residues
SPSPASPTRQLIPPALLGTLALVNATEPLSINMYLSGLPVLRHEFGISQFDAQLTITFFLIGMTVGQLFSGPITDARGRR
GLFFIGTIVLTIATLLSALAPHAWVLYLSRAAMGWAAGTAVVSARAIAADKASGPELAKVFSILMVLGSIAPVVGPILGG
LIVHSAGWRAVFWFLTVVYAFTAVIAARTIPETLPVERRTHGGIRAMLAAIRTLLSNRVYVGSTVAFVFAFATMFTFVSA
SPFILQEHFGFSPLHYALIFAMNTSGLATMAIINARVVHRFGAPRLAATGVTIMALAVAWLAIAATFSLGTVAFLAGIFT
MTASMGMIFANTSALAMSHAGPVGGAASAFLGSGQFFIAGLYAPMFGVVQSWGIAPPLAAATMMSVTAVITVVGLAQALR
SS

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=349, Percent_Identity=32.0916905444126, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1790146, Length=236, Percent_Identity=29.2372881355932, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082312, Length=229, Percent_Identity=26.6375545851528, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI48994889, Length=227, Percent_Identity=23.7885462555066, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319657, Length=169, Percent_Identity=26.0355029585799, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42013; Mature: 41882

Theoretical pI: Translated: 11.68; Mature: 11.68

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPSPASPTRQLIPPALLGTLALVNATEPLSINMYLSGLPVLRHEFGISQFDAQLTITFF
CCCCCCCCCHHHCCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHCCHHHHHHHHHHHH
LIGMTVGQLFSGPITDARGRRGLFFIGTIVLTIATLLSALAPHAWVLYLSRAAMGWAAGT
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
AVVSARAIAADKASGPELAKVFSILMVLGSIAPVVGPILGGLIVHSAGWRAVFWFLTVVY
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
AFTAVIAARTIPETLPVERRTHGGIRAMLAAIRTLLSNRVYVGSTVAFVFAFATMFTFVS
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHC
ASPFILQEHFGFSPLHYALIFAMNTSGLATMAIINARVVHRFGAPRLAATGVTIMALAVA
CCCHHHHHHCCCCHHHHHHHHEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
WLAIAATFSLGTVAFLAGIFTMTASMGMIFANTSALAMSHAGPVGGAASAFLGSGQFFIA
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCHHHHHHCCCCCCCHHHHHHCCCCHHHH
GLYAPMFGVVQSWGIAPPLAAATMMSVTAVITVVGLAQALRSS
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SPSPASPTRQLIPPALLGTLALVNATEPLSINMYLSGLPVLRHEFGISQFDAQLTITFF
CCCCCCCCHHHCCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHCCHHHHHHHHHHHH
LIGMTVGQLFSGPITDARGRRGLFFIGTIVLTIATLLSALAPHAWVLYLSRAAMGWAAGT
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
AVVSARAIAADKASGPELAKVFSILMVLGSIAPVVGPILGGLIVHSAGWRAVFWFLTVVY
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
AFTAVIAARTIPETLPVERRTHGGIRAMLAAIRTLLSNRVYVGSTVAFVFAFATMFTFVS
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHC
ASPFILQEHFGFSPLHYALIFAMNTSGLATMAIINARVVHRFGAPRLAATGVTIMALAVA
CCCHHHHHHCCCCHHHHHHHHEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
WLAIAATFSLGTVAFLAGIFTMTASMGMIFANTSALAMSHAGPVGGAASAFLGSGQFFIA
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCHHHHHHCCCCCCCHHHHHHCCCCHHHH
GLYAPMFGVVQSWGIAPPLAAATMMSVTAVITVVGLAQALRSS
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]