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The map label for this gene is rkpK [H]

Identifier: 38234690

GI number: 38234690

Start: 2207481

End: 2208686

Strand: Reverse

Name: rkpK [H]

Synonym: DIP2141

Alternate gene names: 38234690

Gene position: 2208686-2207481 (Counterclockwise)

Preceding gene: 38234691

Following gene: 38234689

Centisome position: 88.75

GC content: 59.95

Gene sequence:

>1206_bases
ATGCGGATTGGGGTTTTCGGTGCGGGTTACCTAGGTATTACGCATGCTGCGTGTATGTCGCACCTTGGCCACGAGGTGGT
GGCTGTTGATACTGACGCTGCGCGGGTGGCGGAGTTGTTGGCAGGCCGGTTGCCTATTTCCGAGCCTGGTCTGGCGGATC
TTCTAGCGGCGAATTCGGTTGAGTGGACGGATGATCCGCAGCGTGCGCGCGATTGCGACCTCTATTTTGTGTGCGTGGGA
ACACCGAGCACCGATGGTCCCTCTGCCCAGGCAAGACTGGATGTGAGTGCCGTGGTTGCGGCGGTGGGGACTATTGCTAC
GCTTGCGCCCCACCCGGTGGTGGTGGGCAAGTCGACGGTGCCGGTGGGGACGTCGATACGCTTGTTGCAGCAATTCCCAC
AGATTCGCTTGCTGTGGAATCCTGAGTTTTTGCGCGAAGGTCACGCGGTGGCGGATACGCTGCACCCTGATCGCATTGTG
ATCGGTGGTGCGGATCCGCAGCCGCTTTTGCGTGTTTATGAGGGGATTAACGCCCCCGTGATCACCACTGATCTGGCTAC
GGCGGAGTTGGCAAAGTCGGCGGCTAATGCGTTTTTGGCTACCAAGCTCAGTTTTATTAATGGGCTGTCGGAACTGGCTA
GTGCCACCGGTGCGGATATTGGCACCATTACTCGGGCCATGGGGCTTGATCCCCGAATCGGCTCCCAGTATTTGTCCGCA
GGCTTGGGCTATGGCGGCGGTTGTTTGCCTAAGGACGTCCGTGGGCTTGCGGCCAGCGCTCGCGATTATCAGGCATCGCA
TTTTGCTGAGCTGTTGAGCATTATCGACGCCACCAATCTGCGGCAGCGCGAGCGCACCTGTGAACTCGTGGCCAACCTGT
GCACCCCAGGCGCGCGGATCGATGTATGGGGTGCCACGTTTAAAGAAGGTTCCGATGATGTGCGCGACTCCCCAGGGTTA
GCTGTGGCCCATGCGTTGAAAACTGCGGGTTTTCGTGTGCGCGTGGTGGATCCCCTCGTGGGGCATTGGCCGCCTGAACT
GCAAGAACCTGAGGCAATTGTGGTGGCAACGGCGTGGTCGGAGTTTAGTCGCGTTGTCCCTGAACCCCGCCTTGCGCATG
GATGTGGCGGTGTGGTGGTGGACGCGCGAGGTGTTTTGAACCGCTCGGCGTGGGTGGCCGCGGGGTGGACGTACAGGAAT
CTCTAA

Upstream 100 bases:

>100_bases
CGGCGCAGGCTCCTTATGGTTCAAATGTGCTGGGCTCGAAGTATCAGGGTCAGCGCGGACCTACTCCGTCGAAGGCGTAT
CTCAACTTCCGGTAGTCCTC

Downstream 100 bases:

>100_bases
CGTCTGCGGTTTAAGGTAGCACCCATGATGGTGAAGTTCGCACAATTCCTGCTGGTGGTTGCGTCGTTAACGTATGCGTC
GTTTGTGTGGGAGATCGCGT

Product: putative UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MRIGVFGAGYLGITHAACMSHLGHEVVAVDTDAARVAELLAGRLPISEPGLADLLAANSVEWTDDPQRARDCDLYFVCVG
TPSTDGPSAQARLDVSAVVAAVGTIATLAPHPVVVGKSTVPVGTSIRLLQQFPQIRLLWNPEFLREGHAVADTLHPDRIV
IGGADPQPLLRVYEGINAPVITTDLATAELAKSAANAFLATKLSFINGLSELASATGADIGTITRAMGLDPRIGSQYLSA
GLGYGGGCLPKDVRGLAASARDYQASHFAELLSIIDATNLRQRERTCELVANLCTPGARIDVWGATFKEGSDDVRDSPGL
AVAHALKTAGFRVRVVDPLVGHWPPELQEPEAIVVATAWSEFSRVVPEPRLAHGCGGVVVDARGVLNRSAWVAAGWTYRN
L

Sequences:

>Translated_401_residues
MRIGVFGAGYLGITHAACMSHLGHEVVAVDTDAARVAELLAGRLPISEPGLADLLAANSVEWTDDPQRARDCDLYFVCVG
TPSTDGPSAQARLDVSAVVAAVGTIATLAPHPVVVGKSTVPVGTSIRLLQQFPQIRLLWNPEFLREGHAVADTLHPDRIV
IGGADPQPLLRVYEGINAPVITTDLATAELAKSAANAFLATKLSFINGLSELASATGADIGTITRAMGLDPRIGSQYLSA
GLGYGGGCLPKDVRGLAASARDYQASHFAELLSIIDATNLRQRERTCELVANLCTPGARIDVWGATFKEGSDDVRDSPGL
AVAHALKTAGFRVRVVDPLVGHWPPELQEPEAIVVATAWSEFSRVVPEPRLAHGCGGVVVDARGVLNRSAWVAAGWTYRN
L
>Mature_401_residues
MRIGVFGAGYLGITHAACMSHLGHEVVAVDTDAARVAELLAGRLPISEPGLADLLAANSVEWTDDPQRARDCDLYFVCVG
TPSTDGPSAQARLDVSAVVAAVGTIATLAPHPVVVGKSTVPVGTSIRLLQQFPQIRLLWNPEFLREGHAVADTLHPDRIV
IGGADPQPLLRVYEGINAPVITTDLATAELAKSAANAFLATKLSFINGLSELASATGADIGTITRAMGLDPRIGSQYLSA
GLGYGGGCLPKDVRGLAASARDYQASHFAELLSIIDATNLRQRERTCELVANLCTPGARIDVWGATFKEGSDDVRDSPGL
AVAHALKTAGFRVRVVDPLVGHWPPELQEPEAIVVATAWSEFSRVVPEPRLAHGCGGVVVDARGVLNRSAWVAAGWTYRN
L

Specific function: Unknown

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=366, Percent_Identity=32.5136612021858, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI296040443, Length=353, Percent_Identity=29.1784702549575, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI296040438, Length=249, Percent_Identity=35.3413654618474, Blast_Score=137, Evalue=2e-32,
Organism=Escherichia coli, GI1788340, Length=354, Percent_Identity=31.9209039548023, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI48994968, Length=378, Percent_Identity=24.3386243386243, Blast_Score=85, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17560350, Length=368, Percent_Identity=34.5108695652174, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI17136908, Length=381, Percent_Identity=33.5958005249344, Blast_Score=184, Evalue=8e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 42281; Mature: 42281

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGVFGAGYLGITHAACMSHLGHEVVAVDTDAARVAELLAGRLPISEPGLADLLAANSV
CEEEEEECCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHCCCC
EWTDDPQRARDCDLYFVCVGTPSTDGPSAQARLDVSAVVAAVGTIATLAPHPVVVGKSTV
CCCCCCCHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCC
PVGTSIRLLQQFPQIRLLWNPEFLREGHAVADTLHPDRIVIGGADPQPLLRVYEGINAPV
CCCHHHHHHHHCCCEEEEECHHHHHCCCHHHHCCCCCEEEECCCCCHHHHHHHCCCCCCE
ITTDLATAELAKSAANAFLATKLSFINGLSELASATGADIGTITRAMGLDPRIGSQYLSA
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHH
GLGYGGGCLPKDVRGLAASARDYQASHFAELLSIIDATNLRQRERTCELVANLCTPGARI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCEE
DVWGATFKEGSDDVRDSPGLAVAHALKTAGFRVRVVDPLVGHWPPELQEPEAIVVATAWS
EECCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEECHHHCCCCCCCCCCCEEEEEECHH
EFSRVVPEPRLAHGCGGVVVDARGVLNRSAWVAAGWTYRNL
HHHHHCCCCCHHCCCCCEEEECCHHHCCCCEEEECCEECCC
>Mature Secondary Structure
MRIGVFGAGYLGITHAACMSHLGHEVVAVDTDAARVAELLAGRLPISEPGLADLLAANSV
CEEEEEECCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHCCCC
EWTDDPQRARDCDLYFVCVGTPSTDGPSAQARLDVSAVVAAVGTIATLAPHPVVVGKSTV
CCCCCCCHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCC
PVGTSIRLLQQFPQIRLLWNPEFLREGHAVADTLHPDRIVIGGADPQPLLRVYEGINAPV
CCCHHHHHHHHCCCEEEEECHHHHHCCCHHHHCCCCCEEEECCCCCHHHHHHHCCCCCCE
ITTDLATAELAKSAANAFLATKLSFINGLSELASATGADIGTITRAMGLDPRIGSQYLSA
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHH
GLGYGGGCLPKDVRGLAASARDYQASHFAELLSIIDATNLRQRERTCELVANLCTPGARI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCEE
DVWGATFKEGSDDVRDSPGLAVAHALKTAGFRVRVVDPLVGHWPPELQEPEAIVVATAWS
EECCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEECHHHCCCCCCCCCCCEEEEEECHH
EFSRVVPEPRLAHGCGGVVVDARGVLNRSAWVAAGWTYRNL
HHHHHCCCCCHHCCCCCEEEECCHHHCCCCEEEECCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]