Click here to switch to the map view.

The map label for this gene is adhA [H]

Identifier: 38234663

GI number: 38234663

Start: 2163769

End: 2164809

Strand: Reverse

Name: adhA [H]

Synonym: DIP2114

Alternate gene names: 38234663

Gene position: 2164809-2163769 (Counterclockwise)

Preceding gene: 38234664

Following gene: 38234661

Centisome position: 86.99

GC content: 57.73

Gene sequence:

>1041_bases
ATGTCTGCTACTGAATTCCCCTCTGCCTTTACCGCCGCTGTTGTGGACAAGTTTGGCTCCGAGCTCAACATCCACGACGT
TGACCTTCCAGAGCCAGGCCAACACCAAGCACTGGTCAAGGTGCTCACCTCCGGCATCTGCCACACTGACCTCCACGCCG
CCGAAGGCGACTGGCCAGTCAAGCCAAAGCCACCATTCGTCCCAGGCCACGAGGGCGTAGGCGAAGTGGTCAAACTTGGC
CCAGGTGAGCATAGCGTTGCGCTGGGTGACATGGTCGGTAACGTCTGGCTGTGGTCAGCTTGTGGCGAGTGTGAATACTG
CCGCACCGGCTGGGAGACTATGTGTGAGAAAGCCGAGTACGGTGGATACACCGTCGATGGCTCTTTCGGTCAGTATATGC
TGGTAGATACTCGCTACTGTGCCCGCATCCCAGACGGCTGTGACCTGCTGGAAGTCGCCCCAATTTTGTGCGCTGGCGTG
ACCGTGTACAAAGGACTCAAGGTTACCGAAACCCGCCCAGGCCAGTTCGTGGTCATCTCTGGCGTGGGCGGTCTGGGCCA
TATCGCCGTCCAGTACGCCGTGGCTATGGGCATGCGCGTTATCGCCGTGGATATTGCGGACGACAAGCTCGAACTGGCTA
AAAAGCATGGCGCTGAGTTTGTGGTCAATGCTCGTGAAGAAGACCCAACTGAGGCAATTGTGAAGTACACCAAGGGTGGC
GCACACGGCGTGCTGGTCACCGCGGTGCACCCTCAGGCCTTCGGTCAGGCAATTGGCATGGCTCGTAAGAACGGAACCAT
TGTGTTCAATGGTCTTCCTCCAGGAGAGTTCCCAGCACCGATTTTCGACATCGTGTTCAAGGGCCTGACCATCCGCGGCT
CCCTCGTGGGAACGCGCCAAGACCTCGAAGAGGCTTTGGACTTCTACGCTCGCGGCATGATCAAGCCAACGGTTACTGAA
TGCAAGCTTGACGACGTCAACTCGGTCTTTGCTGATATGAAGCAAGGCAAGATCGACGGCCGCATGGCTATCCGCTACTA
G

Upstream 100 bases:

>100_bases
CAAACTTATAACTTCATACGGTTCAGCCCCCGCATTTCGCGGGGTTTTGCCATTTCTGCCACCTATTGAAAATAGGTACC
ATTAGAAAGGATTGTGACCG

Downstream 100 bases:

>100_bases
TTTCACCGGTACCTCGATGAGCCTCCTGCGCTAGCCGCTGTAGGAGGCGCTTATCGGTGAAGTACGACTCGTGGCCGCCC
GCGACACCCCAGCGCTCAAA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MSATEFPSAFTAAVVDKFGSELNIHDVDLPEPGQHQALVKVLTSGICHTDLHAAEGDWPVKPKPPFVPGHEGVGEVVKLG
PGEHSVALGDMVGNVWLWSACGECEYCRTGWETMCEKAEYGGYTVDGSFGQYMLVDTRYCARIPDGCDLLEVAPILCAGV
TVYKGLKVTETRPGQFVVISGVGGLGHIAVQYAVAMGMRVIAVDIADDKLELAKKHGAEFVVNAREEDPTEAIVKYTKGG
AHGVLVTAVHPQAFGQAIGMARKNGTIVFNGLPPGEFPAPIFDIVFKGLTIRGSLVGTRQDLEEALDFYARGMIKPTVTE
CKLDDVNSVFADMKQGKIDGRMAIRY

Sequences:

>Translated_346_residues
MSATEFPSAFTAAVVDKFGSELNIHDVDLPEPGQHQALVKVLTSGICHTDLHAAEGDWPVKPKPPFVPGHEGVGEVVKLG
PGEHSVALGDMVGNVWLWSACGECEYCRTGWETMCEKAEYGGYTVDGSFGQYMLVDTRYCARIPDGCDLLEVAPILCAGV
TVYKGLKVTETRPGQFVVISGVGGLGHIAVQYAVAMGMRVIAVDIADDKLELAKKHGAEFVVNAREEDPTEAIVKYTKGG
AHGVLVTAVHPQAFGQAIGMARKNGTIVFNGLPPGEFPAPIFDIVFKGLTIRGSLVGTRQDLEEALDFYARGMIKPTVTE
CKLDDVNSVFADMKQGKIDGRMAIRY
>Mature_345_residues
SATEFPSAFTAAVVDKFGSELNIHDVDLPEPGQHQALVKVLTSGICHTDLHAAEGDWPVKPKPPFVPGHEGVGEVVKLGP
GEHSVALGDMVGNVWLWSACGECEYCRTGWETMCEKAEYGGYTVDGSFGQYMLVDTRYCARIPDGCDLLEVAPILCAGVT
VYKGLKVTETRPGQFVVISGVGGLGHIAVQYAVAMGMRVIAVDIADDKLELAKKHGAEFVVNAREEDPTEAIVKYTKGGA
HGVLVTAVHPQAFGQAIGMARKNGTIVFNGLPPGEFPAPIFDIVFKGLTIRGSLVGTRQDLEEALDFYARGMIKPTVTEC
KLDDVNSVFADMKQGKIDGRMAIRY

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=332, Percent_Identity=28.9156626506024, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI34577061, Length=332, Percent_Identity=29.8192771084337, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI262073058, Length=331, Percent_Identity=26.8882175226586, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI71743840, Length=331, Percent_Identity=26.8882175226586, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI71565152, Length=367, Percent_Identity=25.8855585831063, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI4501929, Length=331, Percent_Identity=28.3987915407855, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI71565154, Length=254, Percent_Identity=27.9527559055118, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI4501939, Length=358, Percent_Identity=25.1396648044693, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=25.2032520325203, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI156627571, Length=284, Percent_Identity=27.112676056338, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI22538446, Length=292, Percent_Identity=26.3698630136986, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI22538444, Length=292, Percent_Identity=26.3698630136986, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI87081918, Length=312, Percent_Identity=43.2692307692308, Blast_Score=234, Evalue=7e-63,
Organism=Escherichia coli, GI1786518, Length=329, Percent_Identity=33.1306990881459, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1790045, Length=325, Percent_Identity=30.1538461538462, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI87082401, Length=333, Percent_Identity=27.6276276276276, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1788073, Length=262, Percent_Identity=28.6259541984733, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI87082125, Length=234, Percent_Identity=32.9059829059829, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI226510992, Length=297, Percent_Identity=29.96632996633, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790718, Length=293, Percent_Identity=27.3037542662116, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787863, Length=308, Percent_Identity=27.5974025974026, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1786552, Length=371, Percent_Identity=29.9191374663073, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1788407, Length=266, Percent_Identity=28.9473684210526, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1788075, Length=313, Percent_Identity=28.1150159744409, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790485, Length=305, Percent_Identity=27.8688524590164, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786825, Length=349, Percent_Identity=24.0687679083095, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562584, Length=349, Percent_Identity=38.9684813753582, Blast_Score=243, Evalue=8e-65,
Organism=Caenorhabditis elegans, GI17562582, Length=347, Percent_Identity=40.6340057636888, Blast_Score=229, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI71988145, Length=348, Percent_Identity=36.2068965517241, Blast_Score=220, Evalue=9e-58,
Organism=Caenorhabditis elegans, GI17562876, Length=284, Percent_Identity=28.169014084507, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25146526, Length=366, Percent_Identity=26.5027322404372, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562878, Length=225, Percent_Identity=27.5555555555556, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=368, Percent_Identity=26.3586956521739, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=341, Percent_Identity=26.6862170087977, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=348, Percent_Identity=43.9655172413793, Blast_Score=277, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6323961, Length=343, Percent_Identity=43.4402332361516, Blast_Score=275, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6323729, Length=346, Percent_Identity=43.0635838150289, Blast_Score=273, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6324486, Length=327, Percent_Identity=44.6483180428135, Blast_Score=270, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6319949, Length=331, Percent_Identity=28.7009063444109, Blast_Score=102, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6323980, Length=334, Percent_Identity=28.4431137724551, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6319520, Length=357, Percent_Identity=23.249299719888, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=26.1455525606469, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322619, Length=334, Percent_Identity=25.748502994012, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319955, Length=334, Percent_Identity=25.748502994012, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737895, Length=260, Percent_Identity=27.6923076923077, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17137530, Length=283, Percent_Identity=25.0883392226148, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17737897, Length=221, Percent_Identity=25.7918552036199, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37145; Mature: 37014

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATEFPSAFTAAVVDKFGSELNIHDVDLPEPGQHQALVKVLTSGICHTDLHAAEGDWPV
CCCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
KPKPPFVPGHEGVGEVVKLGPGEHSVALGDMVGNVWLWSACGECEYCRTGWETMCEKAEY
CCCCCCCCCCCCCCHHEEECCCCCCEEHHHHHCCEEEEECCCCCHHHHCCHHHHHHHHHC
GGYTVDGSFGQYMLVDTRYCARIPDGCDLLEVAPILCAGVTVYKGLKVTETRPGQFVVIS
CCEEEECCCCCEEEEECHHHHCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCEEEEE
GVGGLGHIAVQYAVAMGMRVIAVDIADDKLELAKKHGAEFVVNAREEDPTEAIVKYTKGG
CCCCHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCC
AHGVLVTAVHPQAFGQAIGMARKNGTIVFNGLPPGEFPAPIFDIVFKGLTIRGSLVGTRQ
CCEEEEEEECHHHHHHHHHCEECCCEEEECCCCCCCCCCHHHHHHHCCCEEEEEECCCHH
DLEEALDFYARGMIKPTVTECKLDDVNSVFADMKQGKIDGRMAIRY
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECC
>Mature Secondary Structure 
SATEFPSAFTAAVVDKFGSELNIHDVDLPEPGQHQALVKVLTSGICHTDLHAAEGDWPV
CCCCCCHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
KPKPPFVPGHEGVGEVVKLGPGEHSVALGDMVGNVWLWSACGECEYCRTGWETMCEKAEY
CCCCCCCCCCCCCCHHEEECCCCCCEEHHHHHCCEEEEECCCCCHHHHCCHHHHHHHHHC
GGYTVDGSFGQYMLVDTRYCARIPDGCDLLEVAPILCAGVTVYKGLKVTETRPGQFVVIS
CCEEEECCCCCEEEEECHHHHCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCEEEEE
GVGGLGHIAVQYAVAMGMRVIAVDIADDKLELAKKHGAEFVVNAREEDPTEAIVKYTKGG
CCCCHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCC
AHGVLVTAVHPQAFGQAIGMARKNGTIVFNGLPPGEFPAPIFDIVFKGLTIRGSLVGTRQ
CCEEEEEEECHHHHHHHHHCEECCCEEEECCCCCCCCCCHHHHHHHCCCEEEEEECCCHH
DLEEALDFYARGMIKPTVTECKLDDVNSVFADMKQGKIDGRMAIRY
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9659380; 11481432 [H]