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The map label for this gene is clpB

Identifier: 38234653

GI number: 38234653

Start: 2151849

End: 2154398

Strand: Reverse

Name: clpB

Synonym: DIP2104

Alternate gene names: 38234653

Gene position: 2154398-2151849 (Counterclockwise)

Preceding gene: 38234654

Following gene: 38234652

Centisome position: 86.57

GC content: 56.43

Gene sequence:

>2550_bases
ATGGCTGGTTTTAACCCCACAACGAAAACTCAAGAGGCATTGCAAGAGGCGCTGCAGAAGGCGTCGGCCGCAGGTAATCC
GGATATCCGTCCGGAGCACCTCCTTGCTGCGATTTTAGGCCAAGAAGATGGCATTGCTATTCCGGTATTGCGCGCTACGG
GCGTGGACCCCGATGTGGTTCGCCGTGAAGCAGAAGCATTGGTGGCCAAGCTGCCAAAGGCTGAAGGTGCCAACTTGGCA
AACCCGAACTTTAACCGTGATGCGTTAAGCGTTTTAAACAACGCCCAGGAGTTGGCGGGTGAGTTAGGCGACGAGTACGT
TTCTACCGAGGTGCTGCTGGCTGCGGTGGCCCGTGGGACTAACGATGCTGCCGAGTTGCTGACCAAGCGCGGTGCTACTT
ACGACGTCATCAAGGGTGTTTTCCCTTCGGTACGCGGTAATAAGAAGGTGACTACGGAGTCTCCAGAGGATCAGTTCCAA
GCATTAGAGAAGTACTCCACTGACCTGACTGCGCGGGCGCGGGAAGGCAAAATTGATCCGGTTATTGGCCGTGATCAGGA
GATTAGGCGTGTGGTTCAGGTGCTTTCTCGCCGCACTAAGAACAATCCTGTTCTTATTGGTGAGCCTGGTGTGGGCAAGA
CGGCCATCGTCGAAGGTCTTGCGCGCCGCATTGTGGCAGGGGATGTGCCGGAGTCGCTGAAGGGTAAAACTCTGATTAGC
TTGGATCTTGGTTCCATGGTGGCTGGTGCTAAGTACCGTGGTGAATTTGAGGAGCGTTTGAAGGCGGTTCTCGACGAAAT
CAAGTCTGCTGAGGGCGAGATCATCACCTTTATCGACGAGCTGCACACCATTGTGGGCGCTGGTGCTACCGGCGATTCCG
CTATGGATGCAGGCAATATGATTAAGCCGCTGTTGGCTCGTGGCGAGCTGCGTTTGGTGGGTGCTACCACCTTGGATGAG
TACCGCAAATACATTGAGAAGGATGCTGCGCTGGAGCGTCGTTTTCAGCAGGTCTTTGTCGGTGAGCCTTCGGTAGAAGA
TGCCGTGGGTATTTTGCGTGGCTTGAAGGAGCGCTACGAGGTGCACCATGGTGTACGGATCCAGGATTCGGCGTTGGTGG
CTGCTGCTACGCTGTCGGATCGCTATATCACCAGCAGGTTCTTGCCGGATAAGGCTATTGACTTGGTGGATGAGGCTGCA
TCGCGGTTACGCATGGAGATCGATTCTTCGCCGCAGGAGATCGATGAGCTGGAACGTATTGTGCGTCGCCTTGAGATTGA
GGAAGTAGCGCTGTCGAAGGAAACGGACGCTGCGTCGAAGGATCGCTTGATCAAGTTGCGTCAGGAGCTTGCCGACGAGC
GCGAGAAGCTCGGTGAGCTTGTGGCACGGTGGAACAACGAGAAGGGCGCGATTAATAAGGTTCGCGAAGCCAAGGAAGAG
CTGGAGCGGCTGCGCTCGGAGTCGGAAATCGCGGAACGCGACGGCGACTACGGCAAGGTAGCTGAGCTGCGCTATGGCCG
GATCCCTGAGCTGGAAAAGCAGGTCGCTGAGGCCGAGGAACACACCGTGGAAACCACCATGCTGAGCGAGGAGGTTACTC
CAGACACCATTGCTGAGGTGGTGTCGGCGTGGACTGGTATTCCTGCCGGCAAGATGTTGCAGGGTGAGACGGAGAAGCTG
CTCAACATGGAGGCTGAGCTAGGCAAACGTGTGGTTGGCCAGTCGGAGGCTGTGGTTGCGGTGTCTGATGCGGTGCGTCG
TGCCCGTGCCGGCGTGGCGGATCCGAACCGTCCGACAGGTTCCTTCCTCTTCCTGGGCCCTACGGGCGTGGGTAAGACGG
AGCTAGCCAAGGCCCTTGCGGAGTTCATGTTTGACGATGATCGTGCGATGGTACGCATTGATATGTCGGAGTATGGCGAG
AAGCATGCGGTCGCTCGTTTGGTCGGTGCCCCTCCAGGATATGTGGGTTACGACCAAGGCGGTCAGCTCACAGAGGCTGT
TCGACGTCGCCCGTACACCGTCGTTCTTTTCGACGAGGTGGAAAAGGCACACCCAGATGTGTTTGACATCCTGCTGCAGG
TCCTCGACGAGGGCCGGTTAACAGATGGCCAAGGCCGCACAGTGGACTTCCGTAATACAGTACTGATCCTGACGTCTAAC
CTAGGTGCCGGTGGCACAAAAGACGAGATGATGGATGCTGTAAAGCGGGCGTTTAAGCCAGAGTTTGTGAACCGCCTTGA
TGATGTGGTGATCTTTGATCCGCTGAGCCAAGAGCAGCTCACACACATTGTGGAGATTCAGATTGCGCAGCTGGCACAGC
GTCTTGCCGCTCGTCGTTTGACGTTGGCAGTGTCGGATTCTGCGAAGTTGTGGCTTGCGGAGCGCGGTTATGAGCCGGCT
TACGGTGCTCGTCCGTTGCGTCGATTGATCCAGCAGGCTATTGGCGATCAGTTGGCTAAGAAGCTGTTGTCTGGTGAGGT
TCGCGATGGTAGCGAGGTTCATGTGGATGCGGATTTGGACAATGATGGGTTGGTTATTAGCGCCTCGTAG

Upstream 100 bases:

>100_bases
TGGTGTGTGGAAACTTTTTTGAAGTTGAGTGGAACAAACTCAACTTTGTGTTCGTTGTGTTTAGTGACTGATAAAAGTCC
ACGGAAGGAAATGATGAACG

Downstream 100 bases:

>100_bases
TAACTGACGTTTGTAGCGATACATGCTGTAAGTACATGGTGACTAGTCGGCTGGAGGAACAACCTCCAGCCGACCTATGT
TTTTCTGAGGCACTTTAGTT

Product: putative ATP-dependent protease regulatory subunit, ClpB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 849; Mature: 848

Protein sequence:

>849_residues
MAGFNPTTKTQEALQEALQKASAAGNPDIRPEHLLAAILGQEDGIAIPVLRATGVDPDVVRREAEALVAKLPKAEGANLA
NPNFNRDALSVLNNAQELAGELGDEYVSTEVLLAAVARGTNDAAELLTKRGATYDVIKGVFPSVRGNKKVTTESPEDQFQ
ALEKYSTDLTARAREGKIDPVIGRDQEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLARRIVAGDVPESLKGKTLIS
LDLGSMVAGAKYRGEFEERLKAVLDEIKSAEGEIITFIDELHTIVGAGATGDSAMDAGNMIKPLLARGELRLVGATTLDE
YRKYIEKDAALERRFQQVFVGEPSVEDAVGILRGLKERYEVHHGVRIQDSALVAAATLSDRYITSRFLPDKAIDLVDEAA
SRLRMEIDSSPQEIDELERIVRRLEIEEVALSKETDAASKDRLIKLRQELADEREKLGELVARWNNEKGAINKVREAKEE
LERLRSESEIAERDGDYGKVAELRYGRIPELEKQVAEAEEHTVETTMLSEEVTPDTIAEVVSAWTGIPAGKMLQGETEKL
LNMEAELGKRVVGQSEAVVAVSDAVRRARAGVADPNRPTGSFLFLGPTGVGKTELAKALAEFMFDDDRAMVRIDMSEYGE
KHAVARLVGAPPGYVGYDQGGQLTEAVRRRPYTVVLFDEVEKAHPDVFDILLQVLDEGRLTDGQGRTVDFRNTVLILTSN
LGAGGTKDEMMDAVKRAFKPEFVNRLDDVVIFDPLSQEQLTHIVEIQIAQLAQRLAARRLTLAVSDSAKLWLAERGYEPA
YGARPLRRLIQQAIGDQLAKKLLSGEVRDGSEVHVDADLDNDGLVISAS

Sequences:

>Translated_849_residues
MAGFNPTTKTQEALQEALQKASAAGNPDIRPEHLLAAILGQEDGIAIPVLRATGVDPDVVRREAEALVAKLPKAEGANLA
NPNFNRDALSVLNNAQELAGELGDEYVSTEVLLAAVARGTNDAAELLTKRGATYDVIKGVFPSVRGNKKVTTESPEDQFQ
ALEKYSTDLTARAREGKIDPVIGRDQEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLARRIVAGDVPESLKGKTLIS
LDLGSMVAGAKYRGEFEERLKAVLDEIKSAEGEIITFIDELHTIVGAGATGDSAMDAGNMIKPLLARGELRLVGATTLDE
YRKYIEKDAALERRFQQVFVGEPSVEDAVGILRGLKERYEVHHGVRIQDSALVAAATLSDRYITSRFLPDKAIDLVDEAA
SRLRMEIDSSPQEIDELERIVRRLEIEEVALSKETDAASKDRLIKLRQELADEREKLGELVARWNNEKGAINKVREAKEE
LERLRSESEIAERDGDYGKVAELRYGRIPELEKQVAEAEEHTVETTMLSEEVTPDTIAEVVSAWTGIPAGKMLQGETEKL
LNMEAELGKRVVGQSEAVVAVSDAVRRARAGVADPNRPTGSFLFLGPTGVGKTELAKALAEFMFDDDRAMVRIDMSEYGE
KHAVARLVGAPPGYVGYDQGGQLTEAVRRRPYTVVLFDEVEKAHPDVFDILLQVLDEGRLTDGQGRTVDFRNTVLILTSN
LGAGGTKDEMMDAVKRAFKPEFVNRLDDVVIFDPLSQEQLTHIVEIQIAQLAQRLAARRLTLAVSDSAKLWLAERGYEPA
YGARPLRRLIQQAIGDQLAKKLLSGEVRDGSEVHVDADLDNDGLVISAS
>Mature_848_residues
AGFNPTTKTQEALQEALQKASAAGNPDIRPEHLLAAILGQEDGIAIPVLRATGVDPDVVRREAEALVAKLPKAEGANLAN
PNFNRDALSVLNNAQELAGELGDEYVSTEVLLAAVARGTNDAAELLTKRGATYDVIKGVFPSVRGNKKVTTESPEDQFQA
LEKYSTDLTARAREGKIDPVIGRDQEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLARRIVAGDVPESLKGKTLISL
DLGSMVAGAKYRGEFEERLKAVLDEIKSAEGEIITFIDELHTIVGAGATGDSAMDAGNMIKPLLARGELRLVGATTLDEY
RKYIEKDAALERRFQQVFVGEPSVEDAVGILRGLKERYEVHHGVRIQDSALVAAATLSDRYITSRFLPDKAIDLVDEAAS
RLRMEIDSSPQEIDELERIVRRLEIEEVALSKETDAASKDRLIKLRQELADEREKLGELVARWNNEKGAINKVREAKEEL
ERLRSESEIAERDGDYGKVAELRYGRIPELEKQVAEAEEHTVETTMLSEEVTPDTIAEVVSAWTGIPAGKMLQGETEKLL
NMEAELGKRVVGQSEAVVAVSDAVRRARAGVADPNRPTGSFLFLGPTGVGKTELAKALAEFMFDDDRAMVRIDMSEYGEK
HAVARLVGAPPGYVGYDQGGQLTEAVRRRPYTVVLFDEVEKAHPDVFDILLQVLDEGRLTDGQGRTVDFRNTVLILTSNL
GAGGTKDEMMDAVKRAFKPEFVNRLDDVVIFDPLSQEQLTHIVEIQIAQLAQRLAARRLTLAVSDSAKLWLAERGYEPAY
GARPLRRLIQQAIGDQLAKKLLSGEVRDGSEVHVDADLDNDGLVISAS

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family

Homologues:

Organism=Homo sapiens, GI13540606, Length=298, Percent_Identity=34.8993288590604, Blast_Score=197, Evalue=5e-50,
Organism=Escherichia coli, GI1788943, Length=847, Percent_Identity=56.6706021251476, Blast_Score=942, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=410, Percent_Identity=42.4390243902439, Blast_Score=294, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6320464, Length=693, Percent_Identity=55.8441558441558, Blast_Score=785, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=848, Percent_Identity=43.1603773584906, Blast_Score=672, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): CLPB_CORDI (Q6NF05)

Other databases:

- EMBL:   BX248360
- RefSeq:   NP_940420.1
- ProteinModelPortal:   Q6NF05
- GeneID:   2649571
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP2104
- NMPDR:   fig|257309.1.peg.2011
- HOGENOM:   HBG413133
- OMA:   GDQLAKK
- PhylomeDB:   Q6NF05
- ProtClustDB:   CLSK633964
- BioCyc:   CDIP257309:DIP2104-MONOMER
- GO:   GO:0005737
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- Gene3D:   G3DSA:1.10.1780.10
- PRINTS:   PR00300
- SMART:   SM00382
- TIGRFAMs:   TIGR03346

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small

EC number: NA

Molecular weight: Translated: 92903; Mature: 92772

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00870 CLPAB_1; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGFNPTTKTQEALQEALQKASAAGNPDIRPEHLLAAILGQEDGIAIPVLRATGVDPDVV
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCHHHH
RREAEALVAKLPKAEGANLANPNFNRDALSVLNNAQELAGELGDEYVSTEVLLAAVARGT
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NDAAELLTKRGATYDVIKGVFPSVRGNKKVTTESPEDQFQALEKYSTDLTARAREGKIDP
CHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCC
VIGRDQEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLARRIVAGDVPESLKGKTLIS
CCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCHHCCCEEEE
LDLGSMVAGAKYRGEFEERLKAVLDEIKSAEGEIITFIDELHTIVGAGATGDSAMDAGNM
EEHHHHHHCCHHCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCCCHHHCCCHH
IKPLLARGELRLVGATTLDEYRKYIEKDAALERRFQQVFVGEPSVEDAVGILRGLKERYE
HHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VHHGVRIQDSALVAAATLSDRYITSRFLPDKAIDLVDEAASRLRMEIDSSPQEIDELERI
HHCCCEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
VRRLEIEEVALSKETDAASKDRLIKLRQELADEREKLGELVARWNNEKGAINKVREAKEE
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LERLRSESEIAERDGDYGKVAELRYGRIPELEKQVAEAEEHTVETTMLSEEVTPDTIAEV
HHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
VSAWTGIPAGKMLQGETEKLLNMEAELGKRVVGQSEAVVAVSDAVRRARAGVADPNRPTG
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCCCCCCC
SFLFLGPTGVGKTELAKALAEFMFDDDRAMVRIDMSEYGEKHAVARLVGAPPGYVGYDQG
CEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHCCCHHHHHHHHCCCCCCCCCCCC
GQLTEAVRRRPYTVVLFDEVEKAHPDVFDILLQVLDEGRLTDGQGRTVDFRNTVLILTSN
CHHHHHHHHCCCEEEEECCHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEEEC
LGAGGTKDEMMDAVKRAFKPEFVNRLDDVVIFDPLSQEQLTHIVEIQIAQLAQRLAARRL
CCCCCCHHHHHHHHHHHCCHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
TLAVSDSAKLWLAERGYEPAYGARPLRRLIQQAIGDQLAKKLLSGEVRDGSEVHVDADLD
EEEECCCCEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCC
NDGLVISAS
CCCEEEECC
>Mature Secondary Structure 
AGFNPTTKTQEALQEALQKASAAGNPDIRPEHLLAAILGQEDGIAIPVLRATGVDPDVV
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCHHHH
RREAEALVAKLPKAEGANLANPNFNRDALSVLNNAQELAGELGDEYVSTEVLLAAVARGT
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NDAAELLTKRGATYDVIKGVFPSVRGNKKVTTESPEDQFQALEKYSTDLTARAREGKIDP
CHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCC
VIGRDQEIRRVVQVLSRRTKNNPVLIGEPGVGKTAIVEGLARRIVAGDVPESLKGKTLIS
CCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCHHCCCEEEE
LDLGSMVAGAKYRGEFEERLKAVLDEIKSAEGEIITFIDELHTIVGAGATGDSAMDAGNM
EEHHHHHHCCHHCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCCCHHHCCCHH
IKPLLARGELRLVGATTLDEYRKYIEKDAALERRFQQVFVGEPSVEDAVGILRGLKERYE
HHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VHHGVRIQDSALVAAATLSDRYITSRFLPDKAIDLVDEAASRLRMEIDSSPQEIDELERI
HHCCCEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
VRRLEIEEVALSKETDAASKDRLIKLRQELADEREKLGELVARWNNEKGAINKVREAKEE
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LERLRSESEIAERDGDYGKVAELRYGRIPELEKQVAEAEEHTVETTMLSEEVTPDTIAEV
HHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
VSAWTGIPAGKMLQGETEKLLNMEAELGKRVVGQSEAVVAVSDAVRRARAGVADPNRPTG
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCCCCCCC
SFLFLGPTGVGKTELAKALAEFMFDDDRAMVRIDMSEYGEKHAVARLVGAPPGYVGYDQG
CEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHCCCHHHHHHHHCCCCCCCCCCCC
GQLTEAVRRRPYTVVLFDEVEKAHPDVFDILLQVLDEGRLTDGQGRTVDFRNTVLILTSN
CHHHHHHHHCCCEEEEECCHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEEEC
LGAGGTKDEMMDAVKRAFKPEFVNRLDDVVIFDPLSQEQLTHIVEIQIAQLAQRLAARRL
CCCCCCHHHHHHHHHHHCCHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
TLAVSDSAKLWLAERGYEPAYGARPLRRLIQQAIGDQLAKKLLSGEVRDGSEVHVDADLD
EEEECCCCEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCC
NDGLVISAS
CCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910