Click here to switch to the map view.

The map label for this gene is pyrE [H]

Identifier: 38234646

GI number: 38234646

Start: 2147786

End: 2148319

Strand: Reverse

Name: pyrE [H]

Synonym: DIP2097

Alternate gene names: 38234646

Gene position: 2148319-2147786 (Counterclockwise)

Preceding gene: 38234647

Following gene: 38234645

Centisome position: 86.33

GC content: 57.3

Gene sequence:

>534_bases
ATGTCCAAAAAGGCCGAACTTGCAGAGCTGGTCAAGGAACTCGCCGTTGTTCACGGCAAGGTTACGTTGTCGTCTGGAAA
GGAAGCGGATTACTACGTTGACCTGCGTCGTGCTACCTTGCACGCCCGCGCTTCTCGCCTGATTGGTGAGCTGCTGCGTG
AGCTGACTGCCGACTGGGACTATGTGGCCGTGGGTGGTTTGACCTTGGGTGCCGATCCGGTGGCTACCTCCGTTATGCAT
GCTGATGGCCGCGAAATCCATGCGTTTGTGGTGCGTAAAGAGGCTAAGAAGCACGGCATGCAGCGTCGTATAGAGGGCCC
CGATGTAGTGGGTAAGAAAGTGTTAGTGGTGGAAGACACCACCACGACTGGCAACTCTCCGCTGACTGCTGTCAAGGCGC
TGCGTGAGGCGGGTGCTGAGGTTGTGGGCGTAGCAACCGTTGTGGATCGTGCTACTGGCGCTGCCGATGTGATCGCTGCG
GAGGGCTTAGAGTACCGCTACATTTTGGGCTTGGAGGACTTGGGTCTTGCTTAA

Upstream 100 bases:

>100_bases
TTTGACGACCTTTCAGCGGAGCTAGGGCGTAACCCTTTAGAATGAGAGACTGCACATAAGTGCTGGGATATTTCATTGGA
ATCTTAAGGAGCCTCCGCGC

Downstream 100 bases:

>100_bases
CCCTGAGCAGGTTGCTGGCCCTACGGAGTGGGGCGAAGGCCGCCACGGGGTAGGGCCGTGGGCTGAGGAGCACCCCCATG
AGGAGGCAATTGATCCTCGG

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MSKKAELAELVKELAVVHGKVTLSSGKEADYYVDLRRATLHARASRLIGELLRELTADWDYVAVGGLTLGADPVATSVMH
ADGREIHAFVVRKEAKKHGMQRRIEGPDVVGKKVLVVEDTTTTGNSPLTAVKALREAGAEVVGVATVVDRATGAADVIAA
EGLEYRYILGLEDLGLA

Sequences:

>Translated_177_residues
MSKKAELAELVKELAVVHGKVTLSSGKEADYYVDLRRATLHARASRLIGELLRELTADWDYVAVGGLTLGADPVATSVMH
ADGREIHAFVVRKEAKKHGMQRRIEGPDVVGKKVLVVEDTTTTGNSPLTAVKALREAGAEVVGVATVVDRATGAADVIAA
EGLEYRYILGLEDLGLA
>Mature_176_residues
SKKAELAELVKELAVVHGKVTLSSGKEADYYVDLRRATLHARASRLIGELLRELTADWDYVAVGGLTLGADPVATSVMHA
DGREIHAFVVRKEAKKHGMQRRIEGPDVVGKKVLVVEDTTTTGNSPLTAVKALREAGAEVVGVATVVDRATGAADVIAAE
GLEYRYILGLEDLGLA

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=177, Percent_Identity=28.8135593220339, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17508631, Length=160, Percent_Identity=32.5, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17554964, Length=172, Percent_Identity=28.4883720930233, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 18859; Mature: 18728

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKAELAELVKELAVVHGKVTLSSGKEADYYVDLRRATLHARASRLIGELLRELTADWD
CCCHHHHHHHHHHHHHHHCEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCC
YVAVGGLTLGADPVATSVMHADGREIHAFVVRKEAKKHGMQRRIEGPDVVGKKVLVVEDT
EEEECCEEECCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECC
TTTGNSPLTAVKALREAGAEVVGVATVVDRATGAADVIAAEGLEYRYILGLEDLGLA
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHCCCCEEEEECCHHCCCC
>Mature Secondary Structure 
SKKAELAELVKELAVVHGKVTLSSGKEADYYVDLRRATLHARASRLIGELLRELTADWD
CCHHHHHHHHHHHHHHHCEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCC
YVAVGGLTLGADPVATSVMHADGREIHAFVVRKEAKKHGMQRRIEGPDVVGKKVLVVEDT
EEEECCEEECCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECC
TTTGNSPLTAVKALREAGAEVVGVATVVDRATGAADVIAAEGLEYRYILGLEDLGLA
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHCCCCEEEEECCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA