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The map label for this gene is fba [H]

Identifier: 38234643

GI number: 38234643

Start: 2144833

End: 2145867

Strand: Reverse

Name: fba [H]

Synonym: DIP2094

Alternate gene names: 38234643

Gene position: 2145867-2144833 (Counterclockwise)

Preceding gene: 38234644

Following gene: 38234639

Centisome position: 86.23

GC content: 56.43

Gene sequence:

>1035_bases
ATGCCTATCGCAACACCAGAGGTCTACAACGAGATGCTTGACCGCGCTAAGGCAGGCGGATTCGCCTACCCAGCCATCAA
CTGCACCTCCTCTGAAACCATCAACGCAGCATTGCGTGGATTTGCTGAGGCGGAGTCCGACGGCATCATCCAGTTCTCTA
CAGGTGGCGCAGAATTTGGCTCCGGTCTATCCGTTAAGAACAAGGTTGCAGGCGCTTGCGCACTGGCAGCCTTCGCTCAT
GAGGCAGCAAAGCACTACGGCATCAACGTCGCATTGCACACCGACCACTGCCAGAAGGAAGTTCTTGACGAGTACGTTCG
CCCACTCATCGCCATCTCCCAAGAGCGCGTAGACCGCGGCGAGCAGCCACTATTCCAGTCCCACATGTGGGATGGTTCCG
CAATTCCAATCGACGAGAACCTCGTCATTGCGCAGGAGCTGCTGGAGAAGGCACGCAAGGCCCACATCATTCTTGAAGCT
GAGATCGGTGTTGTTGGCGGCGAAGAAGACGGTGTTGAAGCCAAGGCTGGCGCTAACCTCTACACCTCTCCAGAGGACTT
TGAAAAGACCATCGACGCTCTCGGCACCGGTGAAAAGGGCCGCTACCTGCTCGCCGCTACCTTCGGCAACGTTCACGGTG
TGTACAAGCCAGGTAACGTCAAGCTGCGCCCAGAGGTTCTCCTTGAGGGCCAGAAGGTTGCTCGCGAGAAGTTGGGTCTG
GATGACTCCGCACTCCCATTCGACTTCGTCTTCCACGGTGGCTCCGGCTCCGAGAAGGAAAAGATCGAAGAGGCACTCGG
CTACGGCGTTATCAAGATGAACGTTGACACCGACACCCAGTACGCATTCACCCGCCCAGTCGTCACCCACATGTTCACCA
ACTACGACGGTGTACTCAAGATCGACGGCGAAGTAGGAAACAAGAAGGTCTACGACCCACGCTCCTACATGAAGAAGGCT
GAGCAGGCTATGGCTGACCGTATCATCGAGGCCTGCCAGGATCTGCACTCTGTTGGAACCACTTTGAGCAAGTAA

Upstream 100 bases:

>100_bases
TTTGTCTCCGAAAAAATTTGGGATATGGGAAGCATTCTCGTGCTAACGCTGGCATACTTGGTGTCGAGCAAATAAATACA
ACCCACTGGAGGATTACTTC

Downstream 100 bases:

>100_bases
TTCCAGCTAATAAAGGATAAGGGCCCTGCGGGGCCCTTATTTTTATGTGCTATCTCAAATCGCTTGACGCTGTATCGTGT
GTTGGGATTTTGTGCTTTCT

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MPIATPEVYNEMLDRAKAGGFAYPAINCTSSETINAALRGFAEAESDGIIQFSTGGAEFGSGLSVKNKVAGACALAAFAH
EAAKHYGINVALHTDHCQKEVLDEYVRPLIAISQERVDRGEQPLFQSHMWDGSAIPIDENLVIAQELLEKARKAHIILEA
EIGVVGGEEDGVEAKAGANLYTSPEDFEKTIDALGTGEKGRYLLAATFGNVHGVYKPGNVKLRPEVLLEGQKVAREKLGL
DDSALPFDFVFHGGSGSEKEKIEEALGYGVIKMNVDTDTQYAFTRPVVTHMFTNYDGVLKIDGEVGNKKVYDPRSYMKKA
EQAMADRIIEACQDLHSVGTTLSK

Sequences:

>Translated_344_residues
MPIATPEVYNEMLDRAKAGGFAYPAINCTSSETINAALRGFAEAESDGIIQFSTGGAEFGSGLSVKNKVAGACALAAFAH
EAAKHYGINVALHTDHCQKEVLDEYVRPLIAISQERVDRGEQPLFQSHMWDGSAIPIDENLVIAQELLEKARKAHIILEA
EIGVVGGEEDGVEAKAGANLYTSPEDFEKTIDALGTGEKGRYLLAATFGNVHGVYKPGNVKLRPEVLLEGQKVAREKLGL
DDSALPFDFVFHGGSGSEKEKIEEALGYGVIKMNVDTDTQYAFTRPVVTHMFTNYDGVLKIDGEVGNKKVYDPRSYMKKA
EQAMADRIIEACQDLHSVGTTLSK
>Mature_343_residues
PIATPEVYNEMLDRAKAGGFAYPAINCTSSETINAALRGFAEAESDGIIQFSTGGAEFGSGLSVKNKVAGACALAAFAHE
AAKHYGINVALHTDHCQKEVLDEYVRPLIAISQERVDRGEQPLFQSHMWDGSAIPIDENLVIAQELLEKARKAHIILEAE
IGVVGGEEDGVEAKAGANLYTSPEDFEKTIDALGTGEKGRYLLAATFGNVHGVYKPGNVKLRPEVLLEGQKVAREKLGLD
DSALPFDFVFHGGSGSEKEKIEEALGYGVIKMNVDTDTQYAFTRPVVTHMFTNYDGVLKIDGEVGNKKVYDPRSYMKKAE
QAMADRIIEACQDLHSVGTTLSK

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789293, Length=344, Percent_Identity=39.5348837209302, Blast_Score=238, Evalue=3e-64,
Organism=Escherichia coli, GI87082041, Length=325, Percent_Identity=25.8461538461538, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1789526, Length=324, Percent_Identity=25.9259259259259, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788072, Length=261, Percent_Identity=26.4367816091954, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322790, Length=350, Percent_Identity=36.8571428571429, Blast_Score=196, Evalue=3e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006411
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 37256; Mature: 37125

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIATPEVYNEMLDRAKAGGFAYPAINCTSSETINAALRGFAEAESDGIIQFSTGGAEFG
CCCCCHHHHHHHHHHHHCCCEECCEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCC
SGLSVKNKVAGACALAAFAHEAAKHYGINVALHTDHCQKEVLDEYVRPLIAISQERVDRG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
EQPLFQSHMWDGSAIPIDENLVIAQELLEKARKAHIILEAEIGVVGGEEDGVEAKAGANL
CCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCEEEEEEEEEEECCCCCCCCCCCCCCC
YTSPEDFEKTIDALGTGEKGRYLLAATFGNVHGVYKPGNVKLRPEVLLEGQKVAREKLGL
CCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEECCCCEEECHHHHHCCHHHHHHHCCC
DDSALPFDFVFHGGSGSEKEKIEEALGYGVIKMNVDTDTQYAFTRPVVTHMFTNYDGVLK
CCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCEEE
IDGEVGNKKVYDPRSYMKKAEQAMADRIIEACQDLHSVGTTLSK
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PIATPEVYNEMLDRAKAGGFAYPAINCTSSETINAALRGFAEAESDGIIQFSTGGAEFG
CCCCHHHHHHHHHHHHCCCEECCEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCC
SGLSVKNKVAGACALAAFAHEAAKHYGINVALHTDHCQKEVLDEYVRPLIAISQERVDRG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCC
EQPLFQSHMWDGSAIPIDENLVIAQELLEKARKAHIILEAEIGVVGGEEDGVEAKAGANL
CCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCEEEEEEEEEEECCCCCCCCCCCCCCC
YTSPEDFEKTIDALGTGEKGRYLLAATFGNVHGVYKPGNVKLRPEVLLEGQKVAREKLGL
CCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEECCCCEEECHHHHHCCHHHHHHHCCC
DDSALPFDFVFHGGSGSEKEKIEEALGYGVIKMNVDTDTQYAFTRPVVTHMFTNYDGVLK
CCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCEEE
IDGEVGNKKVYDPRSYMKKAEQAMADRIIEACQDLHSVGTTLSK
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2615658; 12948626 [H]