Click here to switch to the map view.

The map label for this gene is cls [H]

Identifier: 38234605

GI number: 38234605

Start: 2094420

End: 2095853

Strand: Direct

Name: cls [H]

Synonym: DIP2048

Alternate gene names: 38234605

Gene position: 2094420-2095853 (Clockwise)

Preceding gene: 38234604

Following gene: 38234608

Centisome position: 84.16

GC content: 58.23

Gene sequence:

>1434_bases
TTGATAGATTGGCAAACAGCTGGCCTGATCATCGACTACGCCATCAAAATCGTAGCCATCGGATTCGTCCCCGAAGGCCG
TCGTCCCTCCAGCTCCACCGCATGGCTCCTCGCCATTTTGCTGCTCCCCTTTGTAGGCCTACCCCTCTTCTTGCTGATGG
GCAGCCCCTACATCAACCGCCGCCGTCACGACGTCCAACGCCGCGCCTTCCAAATGATCAGGGAACGCCAATCCCACGTA
CCCGACTACCCGCCAGACACCGTCCAAAGCCCTGAGCTGACCTCCATGATCCGCATGAACCGTCGGCTCACCGCCATGAC
GGCCACCACCGGATCAGTAAAACTACACTCCGATTACGAAGAAACCATCCAAGCGATGGCCGATGCCGTAGACCAAGCCC
GCGATTACGTCCACGTACAGATCTACATCGTTGCTTGGGACGACACCACCGACGTATTCTTCCGAGCACTTGAACGCGCA
GTCCAACGAGGCGTAGAAGTCCGCCTCCTCTTCGACCAAGTAGGCAGCTGGAAATACCCAGGCTACCGCCGCCTCGGCAA
ACGCCTCACCGCCATCGGAGTGGACTTCCACCTCATGCTGCCCCTGCAGCCCTTCCGCTGGCGCTTCCGCCGACCCGACC
TGCGCAATCACCGCAAGCTACTCATTATCGACGGCCAACGCGGCTTCCTCGGCTCCCAAAACATGATTGCCCCCCACTAC
ACCCCACGCAATCGCGCCAAAGGCCGTCACTGGGTTGACGTGATGGTCGAGCTCGAAGGCCCCATCGTGGCCTCCATGAA
CACCGTCTTTGTTGTCGACTGGTCCCAAGAAAGCCACATCGTCCCAGAATTCGAAGTACCCCCAGCCGACCACGGCGACG
TTATGCAAATCGTCCCCTCCGGCCCAGGTTTTAGCACCGAACCAAACCTCCGGCTGTTCAACGAGATGATCCACCACGCC
AAAAACCAGCTGATCATGTGCAGCCCTTACTTCATTCCCGACGAATCCATGCTCGAAGCAGTCACCTCCGCCTGCTACCG
CGGAGTACGCGTAGAACTCCTCGTCAGCGAACAAGCCGACCAATTTGTTGTTGATCACGCTCAGTCCAGCTATTATCAGA
CGCTTCTCGAAGCCGGCGTACACATCTACCGCTACCACGCCCCCGCCGTGCTCCACAGCAAGTTCCTCATCGCAGACCCC
CACGGCGTGGCCGTCTCCGTGATGGGTTCCTCCAACATGGACATGCGCAGCTTCGGCCTCAACTACGAAGTCTCCCTCAT
GACACTCCAAGGCCAACTCACCCACCTGCTTTACGAGCTAGCCGAAACCTACAAAGAAAACTCCACCGAACTCACCCTCG
AAGAATGGAACCAGCGCGGAATCGTCCGCCGCTACGTAGACAACATCATGAAACTGACCTCAGCGCTGCAATAA

Upstream 100 bases:

>100_bases
ACTTCCAGCTCTCCAACATGACCCCCACCGGCGGATTCATCGACGTTGAAGAGCGCAAAGGCAAGGGGGCTTCCGATCAC
GCCCCAGTGGTGGTGGACTA

Downstream 100 bases:

>100_bases
TCGCTGGCTAGACAAAGAAATCGGTCCGGTGAGGGTTCGGACGTCGCACAAGATACCAGGGTCCCTAGCTTTGTCCGTAC
AAAACCAAGGACCTACCGTG

Product: putative cardiolipin synthase

Products: NA

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MIDWQTAGLIIDYAIKIVAIGFVPEGRRPSSSTAWLLAILLLPFVGLPLFLLMGSPYINRRRHDVQRRAFQMIRERQSHV
PDYPPDTVQSPELTSMIRMNRRLTAMTATTGSVKLHSDYEETIQAMADAVDQARDYVHVQIYIVAWDDTTDVFFRALERA
VQRGVEVRLLFDQVGSWKYPGYRRLGKRLTAIGVDFHLMLPLQPFRWRFRRPDLRNHRKLLIIDGQRGFLGSQNMIAPHY
TPRNRAKGRHWVDVMVELEGPIVASMNTVFVVDWSQESHIVPEFEVPPADHGDVMQIVPSGPGFSTEPNLRLFNEMIHHA
KNQLIMCSPYFIPDESMLEAVTSACYRGVRVELLVSEQADQFVVDHAQSSYYQTLLEAGVHIYRYHAPAVLHSKFLIADP
HGVAVSVMGSSNMDMRSFGLNYEVSLMTLQGQLTHLLYELAETYKENSTELTLEEWNQRGIVRRYVDNIMKLTSALQ

Sequences:

>Translated_477_residues
MIDWQTAGLIIDYAIKIVAIGFVPEGRRPSSSTAWLLAILLLPFVGLPLFLLMGSPYINRRRHDVQRRAFQMIRERQSHV
PDYPPDTVQSPELTSMIRMNRRLTAMTATTGSVKLHSDYEETIQAMADAVDQARDYVHVQIYIVAWDDTTDVFFRALERA
VQRGVEVRLLFDQVGSWKYPGYRRLGKRLTAIGVDFHLMLPLQPFRWRFRRPDLRNHRKLLIIDGQRGFLGSQNMIAPHY
TPRNRAKGRHWVDVMVELEGPIVASMNTVFVVDWSQESHIVPEFEVPPADHGDVMQIVPSGPGFSTEPNLRLFNEMIHHA
KNQLIMCSPYFIPDESMLEAVTSACYRGVRVELLVSEQADQFVVDHAQSSYYQTLLEAGVHIYRYHAPAVLHSKFLIADP
HGVAVSVMGSSNMDMRSFGLNYEVSLMTLQGQLTHLLYELAETYKENSTELTLEEWNQRGIVRRYVDNIMKLTSALQ
>Mature_477_residues
MIDWQTAGLIIDYAIKIVAIGFVPEGRRPSSSTAWLLAILLLPFVGLPLFLLMGSPYINRRRHDVQRRAFQMIRERQSHV
PDYPPDTVQSPELTSMIRMNRRLTAMTATTGSVKLHSDYEETIQAMADAVDQARDYVHVQIYIVAWDDTTDVFFRALERA
VQRGVEVRLLFDQVGSWKYPGYRRLGKRLTAIGVDFHLMLPLQPFRWRFRRPDLRNHRKLLIIDGQRGFLGSQNMIAPHY
TPRNRAKGRHWVDVMVELEGPIVASMNTVFVVDWSQESHIVPEFEVPPADHGDVMQIVPSGPGFSTEPNLRLFNEMIHHA
KNQLIMCSPYFIPDESMLEAVTSACYRGVRVELLVSEQADQFVVDHAQSSYYQTLLEAGVHIYRYHAPAVLHSKFLIADP
HGVAVSVMGSSNMDMRSFGLNYEVSLMTLQGQLTHLLYELAETYKENSTELTLEEWNQRGIVRRYVDNIMKLTSALQ

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787502, Length=469, Percent_Identity=27.9317697228145, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1787007, Length=330, Percent_Identity=27.5757575757576, Blast_Score=96, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.-

Molecular weight: Translated: 54701; Mature: 54701

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDWQTAGLIIDYAIKIVAIGFVPEGRRPSSSTAWLLAILLLPFVGLPLFLLMGSPYINR
CCCCCHHHHHHHEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
RRHDVQRRAFQMIRERQSHVPDYPPDTVQSPELTSMIRMNRRLTAMTATTGSVKLHSDYE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCEEECCCHH
ETIQAMADAVDQARDYVHVQIYIVAWDDTTDVFFRALERAVQRGVEVRLLFDQVGSWKYP
HHHHHHHHHHHHHCCEEEEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
GYRRLGKRLTAIGVDFHLMLPLQPFRWRFRRPDLRNHRKLLIIDGQRGFLGSQNMIAPHY
CHHHHHCHHHHEECCEEEEECCCHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCC
TPRNRAKGRHWVDVMVELEGPIVASMNTVFVVDWSQESHIVPEFEVPPADHGDVMQIVPS
CCCCCCCCCEEEEEEEEECCCEEEECCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEC
GPGFSTEPNLRLFNEMIHHAKNQLIMCSPYFIPDESMLEAVTSACYRGVRVELLVSEQAD
CCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCH
QFVVDHAQSSYYQTLLEAGVHIYRYHAPAVLHSKFLIADPHGVAVSVMGSSNMDMRSFGL
HHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHCEEEEECCCCEEEEEECCCCCCHHHCCC
NYEVSLMTLQGQLTHLLYELAETYKENSTELTLEEWNQRGIVRRYVDNIMKLTSALQ
CEEEEEEEEHHHHHHHHHHHHHHHHCCCCEEEHHHHCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIDWQTAGLIIDYAIKIVAIGFVPEGRRPSSSTAWLLAILLLPFVGLPLFLLMGSPYINR
CCCCCHHHHHHHEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
RRHDVQRRAFQMIRERQSHVPDYPPDTVQSPELTSMIRMNRRLTAMTATTGSVKLHSDYE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCEEECCCHH
ETIQAMADAVDQARDYVHVQIYIVAWDDTTDVFFRALERAVQRGVEVRLLFDQVGSWKYP
HHHHHHHHHHHHHCCEEEEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
GYRRLGKRLTAIGVDFHLMLPLQPFRWRFRRPDLRNHRKLLIIDGQRGFLGSQNMIAPHY
CHHHHHCHHHHEECCEEEEECCCHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCC
TPRNRAKGRHWVDVMVELEGPIVASMNTVFVVDWSQESHIVPEFEVPPADHGDVMQIVPS
CCCCCCCCCEEEEEEEEECCCEEEECCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEC
GPGFSTEPNLRLFNEMIHHAKNQLIMCSPYFIPDESMLEAVTSACYRGVRVELLVSEQAD
CCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCH
QFVVDHAQSSYYQTLLEAGVHIYRYHAPAVLHSKFLIADPHGVAVSVMGSSNMDMRSFGL
HHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHCEEEEECCCCEEEEEECCCCCCHHHCCC
NYEVSLMTLQGQLTHLLYELAETYKENSTELTLEEWNQRGIVRRYVDNIMKLTSALQ
CEEEEEEEEHHHHHHHHHHHHHHHHCCCCEEEHHHHCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA