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The map label for this gene is argE [C]

Identifier: 38234595

GI number: 38234595

Start: 2087440

End: 2088801

Strand: Direct

Name: argE [C]

Synonym: DIP2037

Alternate gene names: 38234595

Gene position: 2087440-2088801 (Clockwise)

Preceding gene: 38234594

Following gene: 38234596

Centisome position: 83.88

GC content: 60.35

Gene sequence:

>1362_bases
ATGACAAAAACAGCTATCCAGACCGTCCGACCACTCGTAGAAAAACAACGCGAGCGCATCTTCAAAGACCTCAGCGAAAT
TACCTCCTACAACTCAGTGCACTCCACCCCAGAATGCGCCGAAGACCACGCCGCAGCCTGCGCCTGGATCGTCAACGCAC
TGAAAGAAGCCGACCTCAACGTCACCGAATACCTCTATGACGGCGGCGCAACCACAGTCATCGGCACCAAAGAACCAGAA
GACGGCGCACCCACCGTCCTCCTCTACTGCCACTATGACGTAGTCCCCGCCGGCGACCCAACCGCATGGGAAAGCGACCC
CTTCACCCTCACCGAACGCAACGGACGCTGGTACGCCCGCGGCGCAGCCGACTGCAAAGGCAACATCGCCATGCACCTCG
CCGCGCTCCGCGCAGTCAAAGAAGCTGGCGGCACCAAACTCGGCATCAAATTCCTCGTCGAAGGCTCCGAAGAACAAGGC
GGCGCAGAACTCTCCGACCTCATCAAAAAACACCCAGAACTCTTCGACACCGACGTCATCCTCATCGCCGACTCCGGCAA
CCAAGCCGTCGGAATCCCCACAATGACCACCACCCTCCGCGGCGGCGCACGCATCACCGTCACCCTCCGAACCCTCGAAT
CCGGCGTACACTCCGGCGCATTCGGCGGCGCAGCACCAGACGCAACCGCAGCACTCATCCGACTCCTCGACACCCTCAAA
GACGAACACGGCCGCACCACCATCGACGGCGTCGACTGCACCGCCCACTGGGAAGGCGGCACCTACGACCGCGAAGCCTT
CAAAAAAGACGCAACCATGCTTGAAGGCACCACCATCATGGGCACCGAAAACGACAACCCAGCCGACATGGTCTGGGCAC
GCCCAGCAATCTCCATCATCGGATTCACCTCCACCCCAGTCGACCACGCCATCAACGCTGTGCCACCAGTAGCATCTGCA
CGCCTCAACCTGCGTGTTCCACCAAAAATGGACGCCAACGAAGTAGCAAACGCACTCGTCGAACACCTCAAAAACCACGT
CCCATGGGGCGCACACATCGACGTCACCTACGACGACGCCAACCAACCCTTCTCCGCCAAACTCGACGGCCCCGCCATGC
AACTATTCAACAGCTGCCTCGCCGGCGCATACGGCCAAGACGACACCGTCAAAATCGGCTCCGGCGGATCCATCCCACTG
TGCTCCGAACTCCTCGAAGTAGTCCCACGCGCAGAACTCGCCCTCTTCGGCGTAGAAGACCCACAAGCCACCATCCACTC
CCCCAACGAATCCGTTGACCCCAACGAAATCCGCGACATCGCCGTCGCAGAAGCAGCCTTCCTGCTCAGCTACAGCAAGT
AG

Upstream 100 bases:

>100_bases
GCAGCGTAGTTTAGCCAATCCCCGCTGGTGAACGTCGATAAGCGAAACTTCACAGCACCCAACAATTACAACACCTAGGC
CACAACGTATGCTGGATAAC

Downstream 100 bases:

>100_bases
CGCGCGGGGCTCGTGTTTTGGCGCCTGGTGTCTAGTGCTTGGTGCCTAGCACCCTGGCGTGAGCAATTTTTGTACCCTAA
GCCCGCATTTCCGCAGGACG

Product: hypothetical protein

Products: Acetate; Ornithine [C]

Alternate protein names: Peptidase; M20/M25/M40 Family Peptidase; Peptidase Family; ArgE/DapE/Acy1 Family Protein; Succinyl-Diaminopimelate Desuccinylase; Beta-Ala-His Dipeptidase; Peptidase Dimerization Domain Protein; M20 Family Peptidase; Deacylase; Zinc Metallopeptidase; N-Acyl-L-Amino Acid Amidohydrolase; Succinyl-Diaminopimelate Desuccinylase Protein; Peptidase Dimerisation Domain Protein; Peptidase Dimerisation Domain-Containing Protein; Peptidase Or Deacetlylase Family Protein; Acetylornithine Deacetylase ArgE; Low Quality Protein; Metallopeptidase; Thiol Dipeptidase; ArgE/DapE/Acy1 Family Peptidase; Peptidase Dimerisation

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MTKTAIQTVRPLVEKQRERIFKDLSEITSYNSVHSTPECAEDHAAACAWIVNALKEADLNVTEYLYDGGATTVIGTKEPE
DGAPTVLLYCHYDVVPAGDPTAWESDPFTLTERNGRWYARGAADCKGNIAMHLAALRAVKEAGGTKLGIKFLVEGSEEQG
GAELSDLIKKHPELFDTDVILIADSGNQAVGIPTMTTTLRGGARITVTLRTLESGVHSGAFGGAAPDATAALIRLLDTLK
DEHGRTTIDGVDCTAHWEGGTYDREAFKKDATMLEGTTIMGTENDNPADMVWARPAISIIGFTSTPVDHAINAVPPVASA
RLNLRVPPKMDANEVANALVEHLKNHVPWGAHIDVTYDDANQPFSAKLDGPAMQLFNSCLAGAYGQDDTVKIGSGGSIPL
CSELLEVVPRAELALFGVEDPQATIHSPNESVDPNEIRDIAVAEAAFLLSYSK

Sequences:

>Translated_453_residues
MTKTAIQTVRPLVEKQRERIFKDLSEITSYNSVHSTPECAEDHAAACAWIVNALKEADLNVTEYLYDGGATTVIGTKEPE
DGAPTVLLYCHYDVVPAGDPTAWESDPFTLTERNGRWYARGAADCKGNIAMHLAALRAVKEAGGTKLGIKFLVEGSEEQG
GAELSDLIKKHPELFDTDVILIADSGNQAVGIPTMTTTLRGGARITVTLRTLESGVHSGAFGGAAPDATAALIRLLDTLK
DEHGRTTIDGVDCTAHWEGGTYDREAFKKDATMLEGTTIMGTENDNPADMVWARPAISIIGFTSTPVDHAINAVPPVASA
RLNLRVPPKMDANEVANALVEHLKNHVPWGAHIDVTYDDANQPFSAKLDGPAMQLFNSCLAGAYGQDDTVKIGSGGSIPL
CSELLEVVPRAELALFGVEDPQATIHSPNESVDPNEIRDIAVAEAAFLLSYSK
>Mature_452_residues
TKTAIQTVRPLVEKQRERIFKDLSEITSYNSVHSTPECAEDHAAACAWIVNALKEADLNVTEYLYDGGATTVIGTKEPED
GAPTVLLYCHYDVVPAGDPTAWESDPFTLTERNGRWYARGAADCKGNIAMHLAALRAVKEAGGTKLGIKFLVEGSEEQGG
AELSDLIKKHPELFDTDVILIADSGNQAVGIPTMTTTLRGGARITVTLRTLESGVHSGAFGGAAPDATAALIRLLDTLKD
EHGRTTIDGVDCTAHWEGGTYDREAFKKDATMLEGTTIMGTENDNPADMVWARPAISIIGFTSTPVDHAINAVPPVASAR
LNLRVPPKMDANEVANALVEHLKNHVPWGAHIDVTYDDANQPFSAKLDGPAMQLFNSCLAGAYGQDDTVKIGSGGSIPLC
SELLEVVPRAELALFGVEDPQATIHSPNESVDPNEIRDIAVAEAAFLLSYSK

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI271398239, Length=479, Percent_Identity=25.2609603340292, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI21071039, Length=385, Percent_Identity=26.4935064935065, Blast_Score=112, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17563146, Length=443, Percent_Identity=27.0880361173815, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI193211059, Length=474, Percent_Identity=24.8945147679325, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321159, Length=394, Percent_Identity=27.1573604060914, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6319758, Length=356, Percent_Identity=24.7191011235955, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24585880, Length=464, Percent_Identity=25.6465517241379, Blast_Score=124, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.5.1.16 [C]

Molecular weight: Translated: 48460; Mature: 48329

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTAIQTVRPLVEKQRERIFKDLSEITSYNSVHSTPECAEDHAAACAWIVNALKEADLN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
VTEYLYDGGATTVIGTKEPEDGAPTVLLYCHYDVVPAGDPTAWESDPFTLTERNGRWYAR
HHHHEECCCCEEEEECCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCEEEEECCCEEEEC
GAADCKGNIAMHLAALRAVKEAGGTKLGIKFLVEGSEEQGGAELSDLIKKHPELFDTDVI
CCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCEE
LIADSGNQAVGIPTMTTTLRGGARITVTLRTLESGVHSGAFGGAAPDATAALIRLLDTLK
EEECCCCCEECCCCHHHEECCCCEEEEEEEHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
DEHGRTTIDGVDCTAHWEGGTYDREAFKKDATMLEGTTIMGTENDNPADMVWARPAISII
HHCCCCEECCCEEEEECCCCCCCHHHHHHCCCEECCEEEEECCCCCCHHEEEECCCEEEE
GFTSTPVDHAINAVPPVASARLNLRVPPKMDANEVANALVEHLKNHVPWGAHIDVTYDDA
ECCCCCHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCC
NQPFSAKLDGPAMQLFNSCLAGAYGQDDTVKIGSGGSIPLCSELLEVVPRAELALFGVED
CCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEEECCC
PQATIHSPNESVDPNEIRDIAVAEAAFLLSYSK
CCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TKTAIQTVRPLVEKQRERIFKDLSEITSYNSVHSTPECAEDHAAACAWIVNALKEADLN
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
VTEYLYDGGATTVIGTKEPEDGAPTVLLYCHYDVVPAGDPTAWESDPFTLTERNGRWYAR
HHHHEECCCCEEEEECCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCEEEEECCCEEEEC
GAADCKGNIAMHLAALRAVKEAGGTKLGIKFLVEGSEEQGGAELSDLIKKHPELFDTDVI
CCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCEE
LIADSGNQAVGIPTMTTTLRGGARITVTLRTLESGVHSGAFGGAAPDATAALIRLLDTLK
EEECCCCCEECCCCHHHEECCCCEEEEEEEHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
DEHGRTTIDGVDCTAHWEGGTYDREAFKKDATMLEGTTIMGTENDNPADMVWARPAISII
HHCCCCEECCCEEEEECCCCCCCHHHHHHCCCEECCEEEEECCCCCCHHEEEECCCEEEE
GFTSTPVDHAINAVPPVASARLNLRVPPKMDANEVANALVEHLKNHVPWGAHIDVTYDDA
ECCCCCHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCC
NQPFSAKLDGPAMQLFNSCLAGAYGQDDTVKIGSGGSIPLCSELLEVVPRAELALFGVED
CCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEEECCC
PQATIHSPNESVDPNEIRDIAVAEAAFLLSYSK
CCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Glutathione. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N2-Acetyl-L-ornithine; H2O [C]

Specific reaction: N2-Acetyl-L-ornithine + H2O --> Acetate + Ornithine [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA