Click here to switch to the map view.

The map label for this gene is groEL [H]

Identifier: 38234584

GI number: 38234584

Start: 2073868

End: 2075508

Strand: Reverse

Name: groEL [H]

Synonym: DIP2020

Alternate gene names: 38234584

Gene position: 2075508-2073868 (Counterclockwise)

Preceding gene: 38234585

Following gene: 38234583

Centisome position: 83.4

GC content: 55.76

Gene sequence:

>1641_bases
ATGGCAAAGATCATTGCCTTTGATGAGGAAGCACGTCGTGGCCTTGAAAAGGGTTTGAACACTCTGGCAGATGCCGTAAA
GGTAACGTTGGGTCCTAAGGGTCGTAACGTTGTTTTGGAGAAGAGCTGGGGCGCTCCCACCATTACTAACGACGGTGTCT
CGATTGCTCGCGAGATTGAGCTCGAGGATCCGTATGAGAAGATCGGCGCTGAGCTGGTTAAGGAAGTCGCTAAGAAGACT
GACGACGTAGCTGGCGACGGCACCACTACTGCGACCGTTTTGGCACAGGCACTTGTTCGCGAGGGCCTGCGTAACGTTGC
TGCTGGTTCTAACCCAATGGGCATTAAGCGCGGTATTGAGCTGGCTACCGCTAAGGTTACTGAAGCACTGCTGGCTTCTG
CTAAAGAGGTTGAGACTGAGGAGCAGATCGCTGCTACTGCTGGTATTTCTGCTGCCGATCCAGCTATTGGTGAGCAGATC
GCTAAGGCGATGTACGCAGTCGGCGGTGGCAAGCTGAACAAAGAATCCGTGATTACGGTTGAAGAGTCCAACACCTTCGG
TGTGGATCTCGAGGTTACTGAGGGTATGCGCTTTGATAAGGGCTACATCTCCGGTTACTTCGCAACCGACATGGAGCGCC
TTGAGGCTGTTCTGGAAGACCCATACATTTTGTTGGTTTCCGGCAAGATCTCTAACATCAAGGAACTTCTCCCATTGCTG
GAGAAGGTTATGCAGACCGGCAAGCCACTGCTCATCATCGCTGAAGATGTTGAGGGCGAGGCTTTGTCCACCTTGGTTGT
GAACAAGATCCGCGGCACCTTCAAATCTGTTGCTGTTAAGGCACCAGGTTTCGGTGACCGTCGTAAGGCTCAGCTGCAGG
ATATGGCTATCCTGACCGGCAGCCAGGTTATCTCCGAAGAGGTCGGTCTCTCCCTTGAGACTGCTGATCTGCCATTGCTG
GGTCGCGCACGCAAGGTTGTTGTGACCAAGGATGACACCACCATCGTTGAGGGTGCTGGCGATTCCGCTCAGATCGACGG
TCGCGTGAACCAGATCCGCACCGAGATCGAGAACTCTGACTCCGAGTACGACCGCGAGAAGCTGCAGGAGCGCCTAGCTA
AGTTGTCTGGCGGCGTTGCAGTTATCAAAGTCGGTGCGGCTACCGAAGTCGAGCTGACCGAGCGCAAGCACCGTATTGAG
GATGCTGTGCGTAACGCAAAGGCTGCTGTGGAAGAGGGCATCGTTGCCGGTGGTGGCGTAGCACTTCTCCAGGCCGCACA
CGTGTTGGCTAACGACCTTGACCTGACTGGCGACGAAGCCACCGGTGTCAAGATCGTCCGCGAGGCACTTTCTGCACCAC
TGAAGCAGATCGCTCTCAACGCAGGCCTTGAGGCTGGCGTTGTGGCAGACAAGGTTTCCCACCTGCCAGCAGGCGAGGGC
CTAAACGCTGCTACCGGCGAGTACGTCGACCTGATGGCTGCGGGCATTAACGATCCAGTGAAGGTTACCCGCTCTGCTCT
GCAGAACGCCGCCTCCATTGCAGCGCTGTTCCTGACCACTGAGGCTGTTGTTGCTGATAAACCAGAGCCAGCAGCTCCAG
CTATGCCAGGTGCTGACGAGATGGGCGGCATGGGCTTCTAA

Upstream 100 bases:

>100_bases
TGCCGTCGCGGGCGCCTGCTGGGTTGTTTAAGGCGTGAGTGTCGTCCTGCGAAAGTTCTCAAGAGTTTTACGCCTCTATA
TATAAGGAGCACAAAGTTTC

Downstream 100 bases:

>100_bases
TTTTCGGCCCAATACCTTTCAAAAGCCCCCCCGAAAATGGGGGCTTTTGCTATTTAAAGAGGAGGTATTGACGCTATATC
GGCCGGTGTGCTAGGTGCGT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2 [H]

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MAKIIAFDEEARRGLEKGLNTLADAVKVTLGPKGRNVVLEKSWGAPTITNDGVSIAREIELEDPYEKIGAELVKEVAKKT
DDVAGDGTTTATVLAQALVREGLRNVAAGSNPMGIKRGIELATAKVTEALLASAKEVETEEQIAATAGISAADPAIGEQI
AKAMYAVGGGKLNKESVITVEESNTFGVDLEVTEGMRFDKGYISGYFATDMERLEAVLEDPYILLVSGKISNIKELLPLL
EKVMQTGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAQLQDMAILTGSQVISEEVGLSLETADLPLL
GRARKVVVTKDDTTIVEGAGDSAQIDGRVNQIRTEIENSDSEYDREKLQERLAKLSGGVAVIKVGAATEVELTERKHRIE
DAVRNAKAAVEEGIVAGGGVALLQAAHVLANDLDLTGDEATGVKIVREALSAPLKQIALNAGLEAGVVADKVSHLPAGEG
LNAATGEYVDLMAAGINDPVKVTRSALQNAASIAALFLTTEAVVADKPEPAAPAMPGADEMGGMGF

Sequences:

>Translated_546_residues
MAKIIAFDEEARRGLEKGLNTLADAVKVTLGPKGRNVVLEKSWGAPTITNDGVSIAREIELEDPYEKIGAELVKEVAKKT
DDVAGDGTTTATVLAQALVREGLRNVAAGSNPMGIKRGIELATAKVTEALLASAKEVETEEQIAATAGISAADPAIGEQI
AKAMYAVGGGKLNKESVITVEESNTFGVDLEVTEGMRFDKGYISGYFATDMERLEAVLEDPYILLVSGKISNIKELLPLL
EKVMQTGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAQLQDMAILTGSQVISEEVGLSLETADLPLL
GRARKVVVTKDDTTIVEGAGDSAQIDGRVNQIRTEIENSDSEYDREKLQERLAKLSGGVAVIKVGAATEVELTERKHRIE
DAVRNAKAAVEEGIVAGGGVALLQAAHVLANDLDLTGDEATGVKIVREALSAPLKQIALNAGLEAGVVADKVSHLPAGEG
LNAATGEYVDLMAAGINDPVKVTRSALQNAASIAALFLTTEAVVADKPEPAAPAMPGADEMGGMGF
>Mature_545_residues
AKIIAFDEEARRGLEKGLNTLADAVKVTLGPKGRNVVLEKSWGAPTITNDGVSIAREIELEDPYEKIGAELVKEVAKKTD
DVAGDGTTTATVLAQALVREGLRNVAAGSNPMGIKRGIELATAKVTEALLASAKEVETEEQIAATAGISAADPAIGEQIA
KAMYAVGGGKLNKESVITVEESNTFGVDLEVTEGMRFDKGYISGYFATDMERLEAVLEDPYILLVSGKISNIKELLPLLE
KVMQTGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAQLQDMAILTGSQVISEEVGLSLETADLPLLG
RARKVVVTKDDTTIVEGAGDSAQIDGRVNQIRTEIENSDSEYDREKLQERLAKLSGGVAVIKVGAATEVELTERKHRIED
AVRNAKAAVEEGIVAGGGVALLQAAHVLANDLDLTGDEATGVKIVREALSAPLKQIALNAGLEAGVVADKVSHLPAGEGL
NAATGEYVDLMAAGINDPVKVTRSALQNAASIAALFLTTEAVVADKPEPAAPAMPGADEMGGMGF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=530, Percent_Identity=46.7924528301887, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI31542947, Length=530, Percent_Identity=46.7924528301887, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI5453603, Length=122, Percent_Identity=37.7049180327869, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=58.7901701323251, Blast_Score=571, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI17555558, Length=534, Percent_Identity=46.2546816479401, Blast_Score=448, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=48.3412322274881, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI25144674, Length=131, Percent_Identity=34.3511450381679, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=529, Percent_Identity=49.1493383742911, Blast_Score=469, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6322524, Length=190, Percent_Identity=30.5263157894737, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320058, Length=184, Percent_Identity=27.7173913043478, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24641193, Length=530, Percent_Identity=47.1698113207547, Blast_Score=457, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24641191, Length=530, Percent_Identity=47.1698113207547, Blast_Score=457, Evalue=1e-129,
Organism=Drosophila melanogaster, GI45550936, Length=530, Percent_Identity=45.6603773584906, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI45550132, Length=530, Percent_Identity=45.6603773584906, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI45550935, Length=530, Percent_Identity=45.6603773584906, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI17864606, Length=528, Percent_Identity=38.6363636363636, Blast_Score=359, Evalue=2e-99,
Organism=Drosophila melanogaster, GI24584129, Length=542, Percent_Identity=33.9483394833948, Blast_Score=268, Evalue=7e-72,
Organism=Drosophila melanogaster, GI19921262, Length=542, Percent_Identity=33.9483394833948, Blast_Score=268, Evalue=7e-72,
Organism=Drosophila melanogaster, GI28571140, Length=124, Percent_Identity=34.6774193548387, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI18858175, Length=118, Percent_Identity=36.4406779661017, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57206; Mature: 57075

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIIAFDEEARRGLEKGLNTLADAVKVTLGPKGRNVVLEKSWGAPTITNDGVSIAREIE
CCEEEECCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCCEEEEEC
LEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGSNPMGIKRGIE
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCHH
LATAKVTEALLASAKEVETEEQIAATAGISAADPAIGEQIAKAMYAVGGGKLNKESVITV
HHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEE
EESNTFGVDLEVTEGMRFDKGYISGYFATDMERLEAVLEDPYILLVSGKISNIKELLPLL
ECCCCEEEEEEECCCCEECCCHHCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHH
EKVMQTGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAQLQDMAILTG
HHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHH
SQVISEEVGLSLETADLPLLGRARKVVVTKDDTTIVEGAGDSAQIDGRVNQIRTEIENSD
HHHHHHHHCCEEECCCCCCCCCCCEEEEECCCCEEEECCCCCCEECCHHHHHHHHHCCCC
SEYDREKLQERLAKLSGGVAVIKVGAATEVELTERKHRIEDAVRNAKAAVEEGIVAGGGV
CHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ALLQAAHVLANDLDLTGDEATGVKIVREALSAPLKQIALNAGLEAGVVADKVSHLPAGEG
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCC
LNAATGEYVDLMAAGINDPVKVTRSALQNAASIAALFLTTEAVVADKPEPAAPAMPGADE
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
MGGMGF
CCCCCC
>Mature Secondary Structure 
AKIIAFDEEARRGLEKGLNTLADAVKVTLGPKGRNVVLEKSWGAPTITNDGVSIAREIE
CEEEECCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCCEEEEEC
LEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGSNPMGIKRGIE
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCHH
LATAKVTEALLASAKEVETEEQIAATAGISAADPAIGEQIAKAMYAVGGGKLNKESVITV
HHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEE
EESNTFGVDLEVTEGMRFDKGYISGYFATDMERLEAVLEDPYILLVSGKISNIKELLPLL
ECCCCEEEEEEECCCCEECCCHHCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHH
EKVMQTGKPLLIIAEDVEGEALSTLVVNKIRGTFKSVAVKAPGFGDRRKAQLQDMAILTG
HHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHH
SQVISEEVGLSLETADLPLLGRARKVVVTKDDTTIVEGAGDSAQIDGRVNQIRTEIENSD
HHHHHHHHCCEEECCCCCCCCCCCEEEEECCCCEEEECCCCCCEECCHHHHHHHHHCCCC
SEYDREKLQERLAKLSGGVAVIKVGAATEVELTERKHRIEDAVRNAKAAVEEGIVAGGGV
CHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ALLQAAHVLANDLDLTGDEATGVKIVREALSAPLKQIALNAGLEAGVVADKVSHLPAGEG
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCC
LNAATGEYVDLMAAGINDPVKVTRSALQNAASIAALFLTTEAVVADKPEPAAPAMPGADE
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
MGGMGF
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA