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The map label for this gene is folE [H]

Identifier: 38234565

GI number: 38234565

Start: 2048427

End: 2048999

Strand: Reverse

Name: folE [H]

Synonym: DIP2001

Alternate gene names: 38234565

Gene position: 2048999-2048427 (Counterclockwise)

Preceding gene: 38234566

Following gene: 38234564

Centisome position: 82.33

GC content: 58.46

Gene sequence:

>573_bases
ATGACCGCACAATTTGATCAACAACGCGCCGAAGCCGCAGTCCGAGAACTCCTCATCGCCGTCGGTGAAGATCCCGACCG
CGAAGGACTGCAAGAAACCCCAGCGCGCGTAGCCAAGGCCTACGCCGAAATGTTCGCAGGCCTGCACACCGACCCCACCG
AGGTCCTCGCTAAAACCTTCAGCGAGGACCATCGGGAAGTGGTCCTAGTCCGCGACATCCCGATCTACTCCACCTGCGAA
CACCACCTAGTGCCCTTCTTCGGCAAAGCACACATCGGCTACATCCCAGGTGAATCCGGAAAAGTCACCGGCCTATCCAA
ACTCGCACGACTCGTTGACCTCTACGCCAAACGCCCCCAAGTCCAAGAACGCCTAACCACCCAAGTGGCAGACGCACTGG
TAGACAAGCTACAAGCCCAAGCAGTCATCGTGGTCATCGAATGCGAACATCTCTGCATGGCCATGCGCGGAATCCGCAAA
CCAGGAGCCGTGACCACCACGTCTGCAGTTCGCGGCGGATTTAAAACCAACGCAGCCTCCCGCGCAGAAGTACTCAGCCT
CATCCGCAGCTAA

Upstream 100 bases:

>100_bases
GAATCCGGACGCCACCGCGCACCCGCCGACAGTGAGCGCCCCTCGTCTGATCCCACCCAAGTGATCAAACGAGTCGAAGA
AACTGACGAGTAACACACCC

Downstream 100 bases:

>100_bases
CAATGACCTTCATCTACGACAGCGACTGCGGATTCTGCCAATGGTCCGCACAGCACCTCGCCCGCATCAACCCAGCCTTG
ACCATCACACCAAGCCACCC

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 190; Mature: 189

Protein sequence:

>190_residues
MTAQFDQQRAEAAVRELLIAVGEDPDREGLQETPARVAKAYAEMFAGLHTDPTEVLAKTFSEDHREVVLVRDIPIYSTCE
HHLVPFFGKAHIGYIPGESGKVTGLSKLARLVDLYAKRPQVQERLTTQVADALVDKLQAQAVIVVIECEHLCMAMRGIRK
PGAVTTTSAVRGGFKTNAASRAEVLSLIRS

Sequences:

>Translated_190_residues
MTAQFDQQRAEAAVRELLIAVGEDPDREGLQETPARVAKAYAEMFAGLHTDPTEVLAKTFSEDHREVVLVRDIPIYSTCE
HHLVPFFGKAHIGYIPGESGKVTGLSKLARLVDLYAKRPQVQERLTTQVADALVDKLQAQAVIVVIECEHLCMAMRGIRK
PGAVTTTSAVRGGFKTNAASRAEVLSLIRS
>Mature_189_residues
TAQFDQQRAEAAVRELLIAVGEDPDREGLQETPARVAKAYAEMFAGLHTDPTEVLAKTFSEDHREVVLVRDIPIYSTCEH
HLVPFFGKAHIGYIPGESGKVTGLSKLARLVDLYAKRPQVQERLTTQVADALVDKLQAQAVIVVIECEHLCMAMRGIRKP
GAVTTTSAVRGGFKTNAASRAEVLSLIRS

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=180, Percent_Identity=48.3333333333333, Blast_Score=171, Evalue=3e-43,
Organism=Homo sapiens, GI4503949, Length=180, Percent_Identity=48.3333333333333, Blast_Score=171, Evalue=3e-43,
Organism=Homo sapiens, GI66932970, Length=148, Percent_Identity=46.6216216216216, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI66932972, Length=138, Percent_Identity=49.2753623188406, Blast_Score=131, Evalue=3e-31,
Organism=Escherichia coli, GI1788476, Length=178, Percent_Identity=43.2584269662921, Blast_Score=119, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17560486, Length=178, Percent_Identity=50.561797752809, Blast_Score=179, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6321706, Length=183, Percent_Identity=53.551912568306, Blast_Score=188, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24656782, Length=179, Percent_Identity=47.4860335195531, Blast_Score=161, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24656796, Length=179, Percent_Identity=47.4860335195531, Blast_Score=160, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24656791, Length=179, Percent_Identity=47.4860335195531, Blast_Score=159, Evalue=7e-40,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 20795; Mature: 20664

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQFDQQRAEAAVRELLIAVGEDPDREGLQETPARVAKAYAEMFAGLHTDPTEVLAKTF
CCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
SEDHREVVLVRDIPIYSTCEHHLVPFFGKAHIGYIPGESGKVTGLSKLARLVDLYAKRPQ
CCCCCEEEEEECCCCHHCHHHHCCCHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCHH
VQERLTTQVADALVDKLQAQAVIVVIECEHLCMAMRGIRKPGAVTTTSAVRGGFKTNAAS
HHHHHHHHHHHHHHHHHHHCEEEEEEEHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCHHH
RAEVLSLIRS
HHHHHHHHHC
>Mature Secondary Structure 
TAQFDQQRAEAAVRELLIAVGEDPDREGLQETPARVAKAYAEMFAGLHTDPTEVLAKTF
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
SEDHREVVLVRDIPIYSTCEHHLVPFFGKAHIGYIPGESGKVTGLSKLARLVDLYAKRPQ
CCCCCEEEEEECCCCHHCHHHHCCCHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCHH
VQERLTTQVADALVDKLQAQAVIVVIECEHLCMAMRGIRKPGAVTTTSAVRGGFKTNAAS
HHHHHHHHHHHHHHHHHHHCEEEEEEEHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCHHH
RAEVLSLIRS
HHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA