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The map label for this gene is folP1 [H]

Identifier: 38234563

GI number: 38234563

Start: 2047150

End: 2047986

Strand: Reverse

Name: folP1 [H]

Synonym: DIP1999

Alternate gene names: 38234563

Gene position: 2047986-2047150 (Counterclockwise)

Preceding gene: 38234564

Following gene: 38234562

Centisome position: 82.29

GC content: 62.84

Gene sequence:

>837_bases
GTGAGCGCGAAAGACCTCATCATTCCCGAGCGAACAGCCGTCATGGGCATTGTGAACGTCACCGAAGACTCATTTTCCGA
CGGTGGCCGCTGGCTCGACATTGATGCCGCAATCGACCACGCCCGCGACCTCGTCGCAGCAGGCGCAGACATCATCGACG
TCGGCGGCGAATCCACCCGCCCAGGTGCCACCCGCGTCGACCCCGACGTGGAACGCAGCCGCGTGATCCCCGTCATCCGG
GCGCTATCCGAAGAAGGCATCGCCACCTCCATCGACACCATGCGCGCCAGTGTTGCCGCCGCAGCAGCCAACGCCGGCGT
AAAACTCATCAACGATGTTTCCGGTGGGCTCGCCGACCGCGCCATGTACTCCGTCATGGCCGACACCCAACTACCGGTCT
GCCTCATGCACTGGAAGACCGTTCGCTTCGGGGACGCAGCAGGAAGCGCCGACCACGGCGGCGACGTTGTAGCAGACGTA
CACCAGACCCTAGATAAGCTGGTCACCTCTGCACTCAACGCCGGTGTCAAAGAAGACAACATCACCATCGACCCAGGTCT
CGGCTTTGCCAAAACACAAGAAGATAACTGGGCACTCTTACGCGCCCTACCGGAATTTATCGCAGGCCCATACCCCGTGC
TCGTAGGAGCATCACGCAAACGCTTCCTGATGGCAGTCCGCGCCTCCCGAGGCCTGCAATCAGGGCCAGTCGACGCCGAC
CCCGCCACCGCAGCGGTGACAGCGATCGCCGCACACATGGGAGCATGGTGCGTGCGCGTCCACGAAGTAGCAGTTTCCCG
AGACGCGGTCGACGTTGCGGCCCTGTGGAATGCGTGA

Upstream 100 bases:

>100_bases
TGGTGAGTTCACCCAACTCGCCAGGCCGATTTTTACCAACGCGTAGTATGAGCACCACAACCACCCAAATACAACAGGCA
AGTGATAAAAGGAGCAGGGC

Downstream 100 bases:

>100_bases
TTGTTATGGCTGATCGTATCGAACTTAAAGGCTTGCACTGCTTTGGCTACCACGGGGTTTTCGAACACGAAAAACGCGAA
GGCCAAGACTTCATTATCGA

Product: putative dihydropteroate synthase

Products: NA

Alternate protein names: DHPS 1; Dihydropteroate pyrophosphorylase 1 [H]

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MSAKDLIIPERTAVMGIVNVTEDSFSDGGRWLDIDAAIDHARDLVAAGADIIDVGGESTRPGATRVDPDVERSRVIPVIR
ALSEEGIATSIDTMRASVAAAAANAGVKLINDVSGGLADRAMYSVMADTQLPVCLMHWKTVRFGDAAGSADHGGDVVADV
HQTLDKLVTSALNAGVKEDNITIDPGLGFAKTQEDNWALLRALPEFIAGPYPVLVGASRKRFLMAVRASRGLQSGPVDAD
PATAAVTAIAAHMGAWCVRVHEVAVSRDAVDVAALWNA

Sequences:

>Translated_278_residues
MSAKDLIIPERTAVMGIVNVTEDSFSDGGRWLDIDAAIDHARDLVAAGADIIDVGGESTRPGATRVDPDVERSRVIPVIR
ALSEEGIATSIDTMRASVAAAAANAGVKLINDVSGGLADRAMYSVMADTQLPVCLMHWKTVRFGDAAGSADHGGDVVADV
HQTLDKLVTSALNAGVKEDNITIDPGLGFAKTQEDNWALLRALPEFIAGPYPVLVGASRKRFLMAVRASRGLQSGPVDAD
PATAAVTAIAAHMGAWCVRVHEVAVSRDAVDVAALWNA
>Mature_277_residues
SAKDLIIPERTAVMGIVNVTEDSFSDGGRWLDIDAAIDHARDLVAAGADIIDVGGESTRPGATRVDPDVERSRVIPVIRA
LSEEGIATSIDTMRASVAAAAANAGVKLINDVSGGLADRAMYSVMADTQLPVCLMHWKTVRFGDAAGSADHGGDVVADVH
QTLDKLVTSALNAGVKEDNITIDPGLGFAKTQEDNWALLRALPEFIAGPYPVLVGASRKRFLMAVRASRGLQSGPVDADP
ATAAVTAIAAHMGAWCVRVHEVAVSRDAVDVAALWNA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=264, Percent_Identity=39.0151515151515, Blast_Score=164, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6324073, Length=324, Percent_Identity=32.7160493827161, Blast_Score=134, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 29072; Mature: 28941

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKDLIIPERTAVMGIVNVTEDSFSDGGRWLDIDAAIDHARDLVAAGADIIDVGGESTR
CCCCCCCCCCHHHEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCEEECCCCCCC
PGATRVDPDVERSRVIPVIRALSEEGIATSIDTMRASVAAAAANAGVKLINDVSGGLADR
CCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHEEHHHCCCHHHH
AMYSVMADTQLPVCLMHWKTVRFGDAAGSADHGGDVVADVHQTLDKLVTSALNAGVKEDN
HHHHHHHCCCCCEEEEEHEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
ITIDPGLGFAKTQEDNWALLRALPEFIAGPYPVLVGASRKRFLMAVRASRGLQSGPVDAD
EEECCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCCCCCC
PATAAVTAIAAHMGAWCVRVHEVAVSRDAVDVAALWNA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEECCC
>Mature Secondary Structure 
SAKDLIIPERTAVMGIVNVTEDSFSDGGRWLDIDAAIDHARDLVAAGADIIDVGGESTR
CCCCCCCCCHHHEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCEEECCCCCCC
PGATRVDPDVERSRVIPVIRALSEEGIATSIDTMRASVAAAAANAGVKLINDVSGGLADR
CCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHEEHHHCCCHHHH
AMYSVMADTQLPVCLMHWKTVRFGDAAGSADHGGDVVADVHQTLDKLVTSALNAGVKEDN
HHHHHHHCCCCCEEEEEHEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
ITIDPGLGFAKTQEDNWALLRALPEFIAGPYPVLVGASRKRFLMAVRASRGLQSGPVDAD
EEECCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCCCCCC
PATAAVTAIAAHMGAWCVRVHEVAVSRDAVDVAALWNA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]