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The map label for this gene is folK [H]

Identifier: 38234561

GI number: 38234561

Start: 2046290

End: 2046769

Strand: Reverse

Name: folK [H]

Synonym: DIP1997

Alternate gene names: 38234561

Gene position: 2046769-2046290 (Counterclockwise)

Preceding gene: 38234562

Following gene: 38234560

Centisome position: 82.24

GC content: 59.79

Gene sequence:

>480_bases
ATGCGCGCAGTGCTTTCTATTGGTTCGAATATGGATGACCGCTATGCCTTGCTGCGAACGGTTGTCGAAGAATTCGCAGG
GCAGATCGTGGCAGCATCCTCGATCTACTCCACGCCCCCGTGGGGAGTAGAGGACCAATACGAGTTCCTCAACGCGGTCG
TCATTGTGGACGTCGATAGTTCACCCCTTGAGCTGCTAAGACGTGGCCAGCGCCTAGAAGAAGCCGCGTGTCGACGTCGC
CTGCGGCACTGGGGTCCGCGCACCCTAGACGTCGATGTCGTGACCATCTACAACGACGACGGCACGCAGATGCGATCCAC
CGACCCCGAGCTGACCCTGCCGCACCCCTACGCCCACGAGCGAGCTTTTGTGCTTGTGCCTTGGGCAGAAGCAGACCCCG
AAGCTGAATTGCTAGGCCAGAAAGTAGCTCAGCGCGCCGCAGCACTGGGCGAAACATTTCCGGTGGTGGGAAGCCTATGA

Upstream 100 bases:

>100_bases
AGCCATTGAGGTCACCGTGCATAAGCCACAGGCACCGATTCCTCTAGAATTTACCGATGTAGCAGTAGTTGCCCGTAGGT
CAAGGAGGTAACCGGCGAAT

Downstream 100 bases:

>100_bases
AATCCACCAACTGGGTAGCACTGATCGCCCTCGGCGTGTTCGTCGCCGCAGCCTCATTACTTCTCGTCGCACGATTCTAT
GGCTCAATGAGTTCAGTGCC

Product: putative 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MRAVLSIGSNMDDRYALLRTVVEEFAGQIVAASSIYSTPPWGVEDQYEFLNAVVIVDVDSSPLELLRRGQRLEEAACRRR
LRHWGPRTLDVDVVTIYNDDGTQMRSTDPELTLPHPYAHERAFVLVPWAEADPEAELLGQKVAQRAAALGETFPVVGSL

Sequences:

>Translated_159_residues
MRAVLSIGSNMDDRYALLRTVVEEFAGQIVAASSIYSTPPWGVEDQYEFLNAVVIVDVDSSPLELLRRGQRLEEAACRRR
LRHWGPRTLDVDVVTIYNDDGTQMRSTDPELTLPHPYAHERAFVLVPWAEADPEAELLGQKVAQRAAALGETFPVVGSL
>Mature_159_residues
MRAVLSIGSNMDDRYALLRTVVEEFAGQIVAASSIYSTPPWGVEDQYEFLNAVVIVDVDSSPLELLRRGQRLEEAACRRR
LRHWGPRTLDVDVVTIYNDDGTQMRSTDPELTLPHPYAHERAFVLVPWAEADPEAELLGQKVAQRAAALGETFPVVGSL

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=154, Percent_Identity=36.3636363636364, Blast_Score=82, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324073, Length=135, Percent_Identity=34.8148148148148, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 17720; Mature: 17720

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVLSIGSNMDDRYALLRTVVEEFAGQIVAASSIYSTPPWGVEDQYEFLNAVVIVDVDS
CCCEEECCCCCCHHHHHHHHHHHHHHCCEEEHHHCCCCCCCCCCHHHHHHCEEEEEECCC
SPLELLRRGQRLEEAACRRRLRHWGPRTLDVDVVTIYNDDGTQMRSTDPELTLPHPYAHE
CHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCEECCCCCCEECCCCCCCC
RAFVLVPWAEADPEAELLGQKVAQRAAALGETFPVVGSL
CEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRAVLSIGSNMDDRYALLRTVVEEFAGQIVAASSIYSTPPWGVEDQYEFLNAVVIVDVDS
CCCEEECCCCCCHHHHHHHHHHHHHHCCEEEHHHCCCCCCCCCCHHHHHHCEEEEEECCC
SPLELLRRGQRLEEAACRRRLRHWGPRTLDVDVVTIYNDDGTQMRSTDPELTLPHPYAHE
CHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCEECCCCCCEECCCCCCCC
RAFVLVPWAEADPEAELLGQKVAQRAAALGETFPVVGSL
CEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]