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The map label for this gene is lysS [H]

Identifier: 38234551

GI number: 38234551

Start: 2035873

End: 2037435

Strand: Reverse

Name: lysS [H]

Synonym: DIP1987

Alternate gene names: 38234551

Gene position: 2037435-2035873 (Counterclockwise)

Preceding gene: 38234553

Following gene: 38234548

Centisome position: 81.87

GC content: 59.37

Gene sequence:

>1563_bases
GTGAGTAACGCTAAAAACACCCAAGACGTACCTGAGCAGCTCCGCATTCGTCGCGAGAAGCGCCAGAAGCTTATCGACGC
CGGCGTGGAGCCGTATCCAGTCATCGTTGACCGCACCCACTCGATCACCGAGCTGCGCGAGAAGTTTGCAGCTGTGCCAG
AGGGTGAAAAGGGCGACAAGCCAGGCGTTACCTACCTCGAACCAGGCGAGGATTCCGGCGTAGAGGTTGCCATCACCGGC
CGCGCCCTGTTTATCCGCAACACCGGCAAGCTGTGCTTCGCTGCTCTCCAAGAGGGCAACGGCGAGTACATGCAGGCTAT
GTTGTCCTTGGCTGAGGTTGGCGAGGAATCCTTGGCATCGTGGAAGGCCGATGTTGACCTAGGCGACATCGTTTCCATCC
GCGGTACCGTCGTCGCTTCCAAGCGTGGCGAGCTTTCTGTGATGGTGAACTCGTGGCACATGGCGTCGAAATCGCTACGC
CCACTGCCTGTGGCCTTCGCTGATATGAGCGAGGACATGCGTATCCGCCACCGTTACACCGACTTGATTATGCGTGAACA
GGCTCGTACCAACGCTATGACTCGTATTAAGGTCATGCGCGCGCTACGCCATTACCTTGAAGGCCAGGACTTCATGGAAG
TTGAAACCCCCATGCTGCAAACCCTGCACGGCGGCGCAGCGGCACGTCCGTTTGTTACGCACTCCAACGCCCTTGATATC
GACCTCTACCTGCGTATCGCGCCAGAACTTTACCTCAAGCGCTGCGTGGTTGGTGGTATCGAGCGTGTATTCGAGGTTAA
CCGCAACTTCCGCAACGAGGGCGTGGACTCCTCGCACTCCCCAGAGTTCGCCATGCTGGAAACCTACCAAGCGTGGGGCA
CCTACGATGACGGCGCGAAGATGATCCAAGAGCTCATCCAGTCCGTCGCAATGGAAGTCTTTGGCTCCACCACCGTCACG
CTTGTCGACGGCACCGAGTACGACCTCGGCGGCGAATGGAAGACCATCGAGATGTACCCATCACTCAACGAGGCGTTGAC
ACGCAAGTTCCCAGGCCAGCCAGAGGTCACCATCGACTCCACCGTGGATGAACTCAAAGCAATCGCCGCTGTTATCGGTT
TGGACGTTCCAGCCAAGGGCGGTTGGGGCCACGGCAAGCTGGTCGAAGAGATCTGGGAGCACCTGTGCGAAGACCAGCTC
TACGGCCCAATCTTCGTTCGTGACTTCCCAGTGGAAACCTCGCCGCTGACTCGCCAGCACCGCTCCAAGCCAGGTGTTAC
CGAAAAGTGGGACCTCTACGTGCGCGGTTTCGAACTAGCAACCGGCTACTCCGAGCTTGTCGACCCCGTCATCCAGCGCG
AGCGCTTCGAGGACCAAGCTCGTCTTGCCGCCGGTGGCGACGATGAGGCCATGGTCTTGGACGAGGACTTCCTCGCAGCT
ATGGAGCAGGGCATGCCACCAACGGCAGGCTGCGGCATGGGCATTGACCGCCTCCTGATGGCCCTGACCGGCCTTGGCAT
CCGCGAGACAGTACTGTTCCCAATCGTGAAGCCGGAGCGCTAA

Upstream 100 bases:

>100_bases
GGGTGGACAGGCTATGAATCTTCGGTGCCTTGGGGTGGAACTGCTAACAACGTAATGGGCTATTGGTGGGTGGACAGGAA
GTGCACTACCCTGATGTAGC

Downstream 100 bases:

>100_bases
AAAGCTCTAAAGGGCGGTTCTCCTTGAGTTAAAGGAGAACCGCCCTTTAACTATGTTTTTAGAAAGCTACAACACTGACT
CTTCCGGGGTTTTAGAGTGC

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MSNAKNTQDVPEQLRIRREKRQKLIDAGVEPYPVIVDRTHSITELREKFAAVPEGEKGDKPGVTYLEPGEDSGVEVAITG
RALFIRNTGKLCFAALQEGNGEYMQAMLSLAEVGEESLASWKADVDLGDIVSIRGTVVASKRGELSVMVNSWHMASKSLR
PLPVAFADMSEDMRIRHRYTDLIMREQARTNAMTRIKVMRALRHYLEGQDFMEVETPMLQTLHGGAAARPFVTHSNALDI
DLYLRIAPELYLKRCVVGGIERVFEVNRNFRNEGVDSSHSPEFAMLETYQAWGTYDDGAKMIQELIQSVAMEVFGSTTVT
LVDGTEYDLGGEWKTIEMYPSLNEALTRKFPGQPEVTIDSTVDELKAIAAVIGLDVPAKGGWGHGKLVEEIWEHLCEDQL
YGPIFVRDFPVETSPLTRQHRSKPGVTEKWDLYVRGFELATGYSELVDPVIQRERFEDQARLAAGGDDEAMVLDEDFLAA
MEQGMPPTAGCGMGIDRLLMALTGLGIRETVLFPIVKPER

Sequences:

>Translated_520_residues
MSNAKNTQDVPEQLRIRREKRQKLIDAGVEPYPVIVDRTHSITELREKFAAVPEGEKGDKPGVTYLEPGEDSGVEVAITG
RALFIRNTGKLCFAALQEGNGEYMQAMLSLAEVGEESLASWKADVDLGDIVSIRGTVVASKRGELSVMVNSWHMASKSLR
PLPVAFADMSEDMRIRHRYTDLIMREQARTNAMTRIKVMRALRHYLEGQDFMEVETPMLQTLHGGAAARPFVTHSNALDI
DLYLRIAPELYLKRCVVGGIERVFEVNRNFRNEGVDSSHSPEFAMLETYQAWGTYDDGAKMIQELIQSVAMEVFGSTTVT
LVDGTEYDLGGEWKTIEMYPSLNEALTRKFPGQPEVTIDSTVDELKAIAAVIGLDVPAKGGWGHGKLVEEIWEHLCEDQL
YGPIFVRDFPVETSPLTRQHRSKPGVTEKWDLYVRGFELATGYSELVDPVIQRERFEDQARLAAGGDDEAMVLDEDFLAA
MEQGMPPTAGCGMGIDRLLMALTGLGIRETVLFPIVKPER
>Mature_519_residues
SNAKNTQDVPEQLRIRREKRQKLIDAGVEPYPVIVDRTHSITELREKFAAVPEGEKGDKPGVTYLEPGEDSGVEVAITGR
ALFIRNTGKLCFAALQEGNGEYMQAMLSLAEVGEESLASWKADVDLGDIVSIRGTVVASKRGELSVMVNSWHMASKSLRP
LPVAFADMSEDMRIRHRYTDLIMREQARTNAMTRIKVMRALRHYLEGQDFMEVETPMLQTLHGGAAARPFVTHSNALDID
LYLRIAPELYLKRCVVGGIERVFEVNRNFRNEGVDSSHSPEFAMLETYQAWGTYDDGAKMIQELIQSVAMEVFGSTTVTL
VDGTEYDLGGEWKTIEMYPSLNEALTRKFPGQPEVTIDSTVDELKAIAAVIGLDVPAKGGWGHGKLVEEIWEHLCEDQLY
GPIFVRDFPVETSPLTRQHRSKPGVTEKWDLYVRGFELATGYSELVDPVIQRERFEDQARLAAGGDDEAMVLDEDFLAAM
EQGMPPTAGCGMGIDRLLMALTGLGIRETVLFPIVKPER

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI5031815, Length=524, Percent_Identity=36.8320610687023, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI194272210, Length=524, Percent_Identity=36.8320610687023, Blast_Score=316, Evalue=3e-86,
Organism=Escherichia coli, GI1790571, Length=522, Percent_Identity=40.8045977011494, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI1789256, Length=515, Percent_Identity=40.5825242718447, Blast_Score=377, Evalue=1e-106,
Organism=Escherichia coli, GI87082379, Length=337, Percent_Identity=26.4094955489614, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788173, Length=175, Percent_Identity=25.7142857142857, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17535927, Length=504, Percent_Identity=35.9126984126984, Blast_Score=306, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI17535925, Length=504, Percent_Identity=35.9126984126984, Blast_Score=305, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI71994340, Length=504, Percent_Identity=35.9126984126984, Blast_Score=305, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI32566633, Length=227, Percent_Identity=25.5506607929515, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320242, Length=527, Percent_Identity=36.8121442125237, Blast_Score=310, Evalue=5e-85,
Organism=Saccharomyces cerevisiae, GI6324256, Length=509, Percent_Identity=27.8978388998035, Blast_Score=161, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24640849, Length=529, Percent_Identity=37.4291115311909, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24640851, Length=523, Percent_Identity=37.8585086042065, Blast_Score=319, Evalue=3e-87,
Organism=Drosophila melanogaster, GI24584738, Length=303, Percent_Identity=26.4026402640264, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 58005; Mature: 57874

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNAKNTQDVPEQLRIRREKRQKLIDAGVEPYPVIVDRTHSITELREKFAAVPEGEKGDK
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCC
PGVTYLEPGEDSGVEVAITGRALFIRNTGKLCFAALQEGNGEYMQAMLSLAEVGEESLAS
CCCEEECCCCCCCEEEEEECCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHH
WKADVDLGDIVSIRGTVVASKRGELSVMVNSWHMASKSLRPLPVAFADMSEDMRIRHRYT
HCCCCCCCCEEEECEEEEECCCCCEEEEEECHHHHCCCCCCCCEEHHCCCHHHHHHHHHH
DLIMREQARTNAMTRIKVMRALRHYLEGQDFMEVETPMLQTLHGGAAARPFVTHSNALDI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCEEECCCCEEE
DLYLRIAPELYLKRCVVGGIERVFEVNRNFRNEGVDSSHSPEFAMLETYQAWGTYDDGAK
EEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCHHHH
MIQELIQSVAMEVFGSTTVTLVDGTEYDLGGEWKTIEMYPSLNEALTRKFPGQPEVTIDS
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEECCCHHHHHHHCCCCCCCEEEHH
TVDELKAIAAVIGLDVPAKGGWGHGKLVEEIWEHLCEDQLYGPIFVRDFPVETSPLTRQH
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHH
RSKPGVTEKWDLYVRGFELATGYSELVDPVIQRERFEDQARLAAGGDDEAMVLDEDFLAA
CCCCCCCCCEEEEEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHH
MEQGMPPTAGCGMGIDRLLMALTGLGIRETVLFPIVKPER
HHHCCCCCCCCCCCHHHHHHHHHCCCHHHHEEEECCCCCC
>Mature Secondary Structure 
SNAKNTQDVPEQLRIRREKRQKLIDAGVEPYPVIVDRTHSITELREKFAAVPEGEKGDK
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCC
PGVTYLEPGEDSGVEVAITGRALFIRNTGKLCFAALQEGNGEYMQAMLSLAEVGEESLAS
CCCEEECCCCCCCEEEEEECCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHH
WKADVDLGDIVSIRGTVVASKRGELSVMVNSWHMASKSLRPLPVAFADMSEDMRIRHRYT
HCCCCCCCCEEEECEEEEECCCCCEEEEEECHHHHCCCCCCCCEEHHCCCHHHHHHHHHH
DLIMREQARTNAMTRIKVMRALRHYLEGQDFMEVETPMLQTLHGGAAARPFVTHSNALDI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCEEECCCCEEE
DLYLRIAPELYLKRCVVGGIERVFEVNRNFRNEGVDSSHSPEFAMLETYQAWGTYDDGAK
EEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCHHHH
MIQELIQSVAMEVFGSTTVTLVDGTEYDLGGEWKTIEMYPSLNEALTRKFPGQPEVTIDS
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEECCCHHHHHHHCCCCCCCEEEHH
TVDELKAIAAVIGLDVPAKGGWGHGKLVEEIWEHLCEDQLYGPIFVRDFPVETSPLTRQH
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHH
RSKPGVTEKWDLYVRGFELATGYSELVDPVIQRERFEDQARLAAGGDDEAMVLDEDFLAA
CCCCCCCCCEEEEEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHH
MEQGMPPTAGCGMGIDRLLMALTGLGIRETVLFPIVKPER
HHHCCCCCCCCCCCHHHHHHHHHCCCHHHHEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA