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The map label for this gene is poxB [H]

Identifier: 38234517

GI number: 38234517

Start: 2002457

End: 2004193

Strand: Reverse

Name: poxB [H]

Synonym: DIP1952

Alternate gene names: 38234517

Gene position: 2004193-2002457 (Counterclockwise)

Preceding gene: 38234519

Following gene: 38234512

Centisome position: 80.53

GC content: 55.9

Gene sequence:

>1737_bases
ATGGCAAAAAATTTTGCGGAACAAATCGTAGAAAGCTTGGAAAACCAAGGAGTAAAGCGCATCTATGGTTTGGTCGGAGA
TAGCCTCAACCCGATCGTGGATGCAGTACGCACCTCCAACATCGAATGGATCCACGTCCGCAATGAGGAAACAGCAGCCT
TCGCAGCAGAAGCAGAAAGCCTGCTCACCGGCGAACTAGCTGTCTGTGCAGCCTCCTGCGGCCCTGGAAATACCCACCTC
GTCCAAGGGCTTTACGACGCCAACCGAAACGGCGCCAAAGTACTCGCCATCGCCAGCCACATTCCCTCACGCCAAATCGG
CTCACATTTCTTCCAAGAAACCCACCCAGAAGCCCTCTTTGCTGAGTGCTCCGGCTACTGCGAAATGGCTAACTCTGCAC
TCCAGGGTGAGGTCATCTTGCACCACGCCATCCAGTCGACCATGGCTGGCAAAGGCGTATCCGTGCTGGTCCTTCCAGGC
GATGTGACCATGCAAGACGTGGAGGACGACACCTTCACCGGTTCGCGGATCTCCAACGCACGTCCCATCATGTACCCAGA
CCCAGCTGAGGCCGCTGACCTTGTCAAAGCCATCAACGAGGCCAAAACCGTCACTTTGTTCTGCGGTGCCGGCGTGCGCT
ACGCCCGAAAAGAAGTCCTCGAACTCGCAGAAAAGATCAAGGCACCCATCGGCCACGCGCTCGGCGGAAAAATGTACATC
CAGTACGACAACCCTTTCGACGTGGGCATGTCCGGCCTGCTCGGCTACGGAGCCTGCCACGACGCTTCCAACGACGCCGA
CCTGCTGATCCTCCTCGGCACCGACTTCCCCTACAACGACTTCTTGCCACGCAAGAACGTTGCACAGATCGACATCGACG
GCTCCCACATCGGCCGCCGCACCCGCATCAGCCACCCTGTGGTTGGCGACGTTGCCGCAACAATTTCGAACATCTTGCCG
CACATCGAGGAAAAGACTGACCGTTCCTTCCTCGACCGCATGCTGAAAAAGCATCACCGCAAGCTTAACGACGTGATCGA
GGCCTACACCTCAGGCGTGGAGAAGCACACCCCTATCCACCCAGAATTTGTGGCCAACATTATCGACGAAATCGCCGCCG
ACGATGCCGTATTCACCATCGATACCGGCATGTGCAACGTTTGGGGTGCTCGCTACATCACCCCTAATGGCAAGCGTGAA
ATGATCGGCTCGTTCCGCCACGGCACCATGGCGAATGCGCTGCCACAGGCTATCGGCGCATCTGCTGCTAACCCAAGACG
TCAGGTTGTCACCTTCTCTGGCGATGGTGGACTCGGCATGCTCATGGGCGAGCTGCTCACTGTTAAGCTGCACAACCTTC
CTATTAAGACTGTTGTGTTTAACAACTCCTCGCTGGGCATGGTCAAGCTGGAAATGCTGGTTCAGGGCATGCCAGAGCAC
GAAACTGATCATGAGCATGTGGACTTTGATGCCATTGCTGCTGCAGTGGGTATCGAGCACATTAAGATTACGGACCCAGC
TAAGGCACGTCAGCAGCTTCAGGCAGCATTTGATTATGACGGTCCTGTGCTGATCGACATCATCACTGACCCTAACGCTT
TGTCGATCCCACCGAACATCACGATGGATATGCTGATGGGCTTCTCTCGTGCAGCTACGCGCACTGTTTTCGGTGGCGGC
GTGGGCCACATGGTAGATATGGCGAAGTCCAATCTGCGTAACATTCCAAAGCCATAG

Upstream 100 bases:

>100_bases
GTCACAACTCCCGCGACGGTGTGGGATTGGAGTCGATAGGTGGCGGCGCCGCGGAAATCGGGCGAATGATAGATGTATCA
ACTTAAGAAAGGTGTCGAGT

Downstream 100 bases:

>100_bases
TTCTGGTTGGTGCTGTTGATACAGCAAACCGGTTCTTCTGGTTTTAGAGTGCATTGAGGCTCTGTTGCAAAGATTGGCGG
CAGTCAGAGGTAGGCTGTCG

Product: pyruvate dehydrogenase

Products: NA

Alternate protein names: Pyruvate oxidase; POX [H]

Number of amino acids: Translated: 578; Mature: 577

Protein sequence:

>578_residues
MAKNFAEQIVESLENQGVKRIYGLVGDSLNPIVDAVRTSNIEWIHVRNEETAAFAAEAESLLTGELAVCAASCGPGNTHL
VQGLYDANRNGAKVLAIASHIPSRQIGSHFFQETHPEALFAECSGYCEMANSALQGEVILHHAIQSTMAGKGVSVLVLPG
DVTMQDVEDDTFTGSRISNARPIMYPDPAEAADLVKAINEAKTVTLFCGAGVRYARKEVLELAEKIKAPIGHALGGKMYI
QYDNPFDVGMSGLLGYGACHDASNDADLLILLGTDFPYNDFLPRKNVAQIDIDGSHIGRRTRISHPVVGDVAATISNILP
HIEEKTDRSFLDRMLKKHHRKLNDVIEAYTSGVEKHTPIHPEFVANIIDEIAADDAVFTIDTGMCNVWGARYITPNGKRE
MIGSFRHGTMANALPQAIGASAANPRRQVVTFSGDGGLGMLMGELLTVKLHNLPIKTVVFNNSSLGMVKLEMLVQGMPEH
ETDHEHVDFDAIAAAVGIEHIKITDPAKARQQLQAAFDYDGPVLIDIITDPNALSIPPNITMDMLMGFSRAATRTVFGGG
VGHMVDMAKSNLRNIPKP

Sequences:

>Translated_578_residues
MAKNFAEQIVESLENQGVKRIYGLVGDSLNPIVDAVRTSNIEWIHVRNEETAAFAAEAESLLTGELAVCAASCGPGNTHL
VQGLYDANRNGAKVLAIASHIPSRQIGSHFFQETHPEALFAECSGYCEMANSALQGEVILHHAIQSTMAGKGVSVLVLPG
DVTMQDVEDDTFTGSRISNARPIMYPDPAEAADLVKAINEAKTVTLFCGAGVRYARKEVLELAEKIKAPIGHALGGKMYI
QYDNPFDVGMSGLLGYGACHDASNDADLLILLGTDFPYNDFLPRKNVAQIDIDGSHIGRRTRISHPVVGDVAATISNILP
HIEEKTDRSFLDRMLKKHHRKLNDVIEAYTSGVEKHTPIHPEFVANIIDEIAADDAVFTIDTGMCNVWGARYITPNGKRE
MIGSFRHGTMANALPQAIGASAANPRRQVVTFSGDGGLGMLMGELLTVKLHNLPIKTVVFNNSSLGMVKLEMLVQGMPEH
ETDHEHVDFDAIAAAVGIEHIKITDPAKARQQLQAAFDYDGPVLIDIITDPNALSIPPNITMDMLMGFSRAATRTVFGGG
VGHMVDMAKSNLRNIPKP
>Mature_577_residues
AKNFAEQIVESLENQGVKRIYGLVGDSLNPIVDAVRTSNIEWIHVRNEETAAFAAEAESLLTGELAVCAASCGPGNTHLV
QGLYDANRNGAKVLAIASHIPSRQIGSHFFQETHPEALFAECSGYCEMANSALQGEVILHHAIQSTMAGKGVSVLVLPGD
VTMQDVEDDTFTGSRISNARPIMYPDPAEAADLVKAINEAKTVTLFCGAGVRYARKEVLELAEKIKAPIGHALGGKMYIQ
YDNPFDVGMSGLLGYGACHDASNDADLLILLGTDFPYNDFLPRKNVAQIDIDGSHIGRRTRISHPVVGDVAATISNILPH
IEEKTDRSFLDRMLKKHHRKLNDVIEAYTSGVEKHTPIHPEFVANIIDEIAADDAVFTIDTGMCNVWGARYITPNGKREM
IGSFRHGTMANALPQAIGASAANPRRQVVTFSGDGGLGMLMGELLTVKLHNLPIKTVVFNNSSLGMVKLEMLVQGMPEHE
TDHEHVDFDAIAAAVGIEHIKITDPAKARQQLQAAFDYDGPVLIDIITDPNALSIPPNITMDMLMGFSRAATRTVFGGGV
GHMVDMAKSNLRNIPKP

Specific function: Unknown

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=562, Percent_Identity=24.0213523131673, Blast_Score=117, Evalue=4e-26,
Organism=Escherichia coli, GI1787096, Length=573, Percent_Identity=45.8987783595113, Blast_Score=499, Evalue=1e-142,
Organism=Escherichia coli, GI1790104, Length=537, Percent_Identity=28.8640595903166, Blast_Score=201, Evalue=9e-53,
Organism=Escherichia coli, GI87081685, Length=569, Percent_Identity=24.780316344464, Blast_Score=146, Evalue=4e-36,
Organism=Escherichia coli, GI1786717, Length=552, Percent_Identity=23.9130434782609, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1788716, Length=551, Percent_Identity=22.8675136116152, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17531299, Length=478, Percent_Identity=25.7322175732218, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17531301, Length=478, Percent_Identity=25.7322175732218, Blast_Score=115, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6323755, Length=567, Percent_Identity=24.8677248677249, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6320816, Length=559, Percent_Identity=21.1091234347048, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19922626, Length=487, Percent_Identity=23.4086242299795, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =1.2.5.1 [H]

Molecular weight: Translated: 62498; Mature: 62367

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKNFAEQIVESLENQGVKRIYGLVGDSLNPIVDAVRTSNIEWIHVRNEETAAFAAEAES
CCCHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHH
LLTGELAVCAASCGPGNTHLVQGLYDANRNGAKVLAIASHIPSRQIGSHFFQETHPEALF
HHHCCHHEEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHCCCHHHH
AECSGYCEMANSALQGEVILHHAIQSTMAGKGVSVLVLPGDVTMQDVEDDTFTGSRISNA
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCCCEEECCCCCCCCCCCCCCC
RPIMYPDPAEAADLVKAINEAKTVTLFCGAGVRYARKEVLELAEKIKAPIGHALGGKMYI
CCCCCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
QYDNPFDVGMSGLLGYGACHDASNDADLLILLGTDFPYNDFLPRKNVAQIDIDGSHIGRR
EECCCHHHCCHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCHHCCCC
TRISHPVVGDVAATISNILPHIEEKTDRSFLDRMLKKHHRKLNDVIEAYTSGVEKHTPIH
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PEFVANIIDEIAADDAVFTIDTGMCNVWGARYITPNGKREMIGSFRHGTMANALPQAIGA
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEECCCCHHHHHHHHCCCHHHHHHHHHHCC
SAANPRRQVVTFSGDGGLGMLMGELLTVKLHNLPIKTVVFNNSSLGMVKLEMLVQGMPEH
CCCCCCEEEEEEECCCCHHHHHHHHHHEEECCCCEEEEEECCCCCCCEEHHHHHCCCCCC
ETDHEHVDFDAIAAAVGIEHIKITDPAKARQQLQAAFDYDGPVLIDIITDPNALSIPPNI
CCCCCCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCEECCCCC
TMDMLMGFSRAATRTVFGGGVGHMVDMAKSNLRNIPKP
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AKNFAEQIVESLENQGVKRIYGLVGDSLNPIVDAVRTSNIEWIHVRNEETAAFAAEAES
CCHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHH
LLTGELAVCAASCGPGNTHLVQGLYDANRNGAKVLAIASHIPSRQIGSHFFQETHPEALF
HHHCCHHEEEECCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHCCCHHHH
AECSGYCEMANSALQGEVILHHAIQSTMAGKGVSVLVLPGDVTMQDVEDDTFTGSRISNA
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCCCEEECCCCCCCCCCCCCCC
RPIMYPDPAEAADLVKAINEAKTVTLFCGAGVRYARKEVLELAEKIKAPIGHALGGKMYI
CCCCCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
QYDNPFDVGMSGLLGYGACHDASNDADLLILLGTDFPYNDFLPRKNVAQIDIDGSHIGRR
EECCCHHHCCHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCHHCCCC
TRISHPVVGDVAATISNILPHIEEKTDRSFLDRMLKKHHRKLNDVIEAYTSGVEKHTPIH
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PEFVANIIDEIAADDAVFTIDTGMCNVWGARYITPNGKREMIGSFRHGTMANALPQAIGA
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEECCCCHHHHHHHHCCCHHHHHHHHHHCC
SAANPRRQVVTFSGDGGLGMLMGELLTVKLHNLPIKTVVFNNSSLGMVKLEMLVQGMPEH
CCCCCCEEEEEEECCCCHHHHHHHHHHEEECCCCEEEEEECCCCCCCEEHHHHHCCCCCC
ETDHEHVDFDAIAAAVGIEHIKITDPAKARQQLQAAFDYDGPVLIDIITDPNALSIPPNI
CCCCCCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCEECCCCC
TMDMLMGFSRAATRTVFGGGVGHMVDMAKSNLRNIPKP
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3016647; 8905232; 9278503; 2663858; 3902830; 8022274 [H]