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The map label for this gene is mprA [H]

Identifier: 38234503

GI number: 38234503

Start: 1991068

End: 1991778

Strand: Reverse

Name: mprA [H]

Synonym: DIP1936

Alternate gene names: 38234503

Gene position: 1991778-1991068 (Counterclockwise)

Preceding gene: 38234512

Following gene: 38234502

Centisome position: 80.03

GC content: 47.26

Gene sequence:

>711_bases
ATGGAAACCATGAATGAATATGCAACTCGGGTTCTGGTGGTCGATGATGAGCCAAACATCGTCGAGCTGTTAAAAGTAAG
CCTGAAATTCCAAGGCTTTGAGGTAGAAACCGCCCAATCAGGGATTGAAGCTTTAGAAAAGGCCCGTTCTTTTCAACCCG
ATGCTTTTATCTTGGACGTGATGATGCCGGGCATGGATGGTTATGAATTGCTGCCCAAGTTGCGTGCTGACGGCTTTGAG
GGACCAGTGCTCTACCTGACGGCAAAAGATGCGGTAGAACATCGAATTCATGGTCTTACTATTGGTGCGGATGATTATGT
GACTAAACCATTCTCGCTTGAAGAGGTAATTACCCGCCTGCGTGTGATTCTGCGTCGAGGACTGCGTCATGATGACGTGG
ATGATTCTGCGACCTTGGTTTATGCCGATTTGACCTTGAATGATGATACTCACGAGGTCACTAAAGCTGGGCAGGTTGTC
GAGCTATCGCCAACGGAATTTAACCTACTGCGCTATTTAATGCTCAATGCAGAAGTGGTGCTGTCGAAGTCGAAGATTTT
GAACAATGTTTGGCATTACGACTTCGGCGGCGATGGCAACGTTGTGGAATCTTATATTTCCTATTTGCGTCGCAAAGTTG
ATACTCAAGAACCAGCGTTGATTCAAACGGTTCGTGGTGTCGGCTACGTGCTACGTAAACCTCGGTCGTAG

Upstream 100 bases:

>100_bases
AGGTGTGCAGCAGAAACTAGCCAGTTCAATCAGTTGTACTGAGAGCCAATAACGATTCACATAATAAAAAGTTCAAAATG
CTGAGGTAGGCAGGGTAAAA

Downstream 100 bases:

>100_bases
AAGCAAGGATTCGTCGATAGGAAATCTAGACAAGCATGAACAATCCTTACGCCAGAGCGGTTGTTTCGGAACCAATAGAT
GAAACGCAATGTTCATCTGT

Product: putative two component system response regulator protein

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
METMNEYATRVLVVDDEPNIVELLKVSLKFQGFEVETAQSGIEALEKARSFQPDAFILDVMMPGMDGYELLPKLRADGFE
GPVLYLTAKDAVEHRIHGLTIGADDYVTKPFSLEEVITRLRVILRRGLRHDDVDDSATLVYADLTLNDDTHEVTKAGQVV
ELSPTEFNLLRYLMLNAEVVLSKSKILNNVWHYDFGGDGNVVESYISYLRRKVDTQEPALIQTVRGVGYVLRKPRS

Sequences:

>Translated_236_residues
METMNEYATRVLVVDDEPNIVELLKVSLKFQGFEVETAQSGIEALEKARSFQPDAFILDVMMPGMDGYELLPKLRADGFE
GPVLYLTAKDAVEHRIHGLTIGADDYVTKPFSLEEVITRLRVILRRGLRHDDVDDSATLVYADLTLNDDTHEVTKAGQVV
ELSPTEFNLLRYLMLNAEVVLSKSKILNNVWHYDFGGDGNVVESYISYLRRKVDTQEPALIQTVRGVGYVLRKPRS
>Mature_236_residues
METMNEYATRVLVVDDEPNIVELLKVSLKFQGFEVETAQSGIEALEKARSFQPDAFILDVMMPGMDGYELLPKLRADGFE
GPVLYLTAKDAVEHRIHGLTIGADDYVTKPFSLEEVITRLRVILRRGLRHDDVDDSATLVYADLTLNDDTHEVTKAGQVV
ELSPTEFNLLRYLMLNAEVVLSKSKILNNVWHYDFGGDGNVVESYISYLRRKVDTQEPALIQTVRGVGYVLRKPRS

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=38.0530973451327, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=38.7387387387387, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=34.2105263157895, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=34.3891402714932, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=37.0535714285714, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=33.7837837837838, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=34.061135371179, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=32.7510917030568, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1786911, Length=227, Percent_Identity=36.1233480176211, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=30.6666666666667, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=34.9344978165939, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1788550, Length=179, Percent_Identity=30.7262569832402, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=29.4372294372294, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=26.431718061674, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=28.6343612334802, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI1790299, Length=120, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790437, Length=128, Percent_Identity=35.15625, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788191, Length=126, Percent_Identity=37.3015873015873, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788713, Length=141, Percent_Identity=34.0425531914894, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI145693157, Length=104, Percent_Identity=36.5384615384615, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=33.6633663366337, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26650; Mature: 26650

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METMNEYATRVLVVDDEPNIVELLKVSLKFQGFEVETAQSGIEALEKARSFQPDAFILDV
CCCHHHHCCEEEEECCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHCCCCCEEEEEE
MMPGMDGYELLPKLRADGFEGPVLYLTAKDAVEHRIHGLTIGADDYVTKPFSLEEVITRL
CCCCCCCHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHH
RVILRRGLRHDDVDDSATLVYADLTLNDDTHEVTKAGQVVELSPTEFNLLRYLMLNAEVV
HHHHHHCCCCCCCCCCCEEEEEEEEECCCHHHHHHCCCEEEECCCHHHHHHHHHHHHHHH
LSKSKILNNVWHYDFGGDGNVVESYISYLRRKVDTQEPALIQTVRGVGYVLRKPRS
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
METMNEYATRVLVVDDEPNIVELLKVSLKFQGFEVETAQSGIEALEKARSFQPDAFILDV
CCCHHHHCCEEEEECCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHCCCCCEEEEEE
MMPGMDGYELLPKLRADGFEGPVLYLTAKDAVEHRIHGLTIGADDYVTKPFSLEEVITRL
CCCCCCCHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHH
RVILRRGLRHDDVDDSATLVYADLTLNDDTHEVTKAGQVVELSPTEFNLLRYLMLNAEVV
HHHHHHCCCCCCCCCCCEEEEEEEEECCCHHHHHHCCCEEEECCCHHHHHHHHHHHHHHH
LSKSKILNNVWHYDFGGDGNVVESYISYLRRKVDTQEPALIQTVRGVGYVLRKPRS
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA