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The map label for this gene is hemH

Identifier: 38234494

GI number: 38234494

Start: 1981355

End: 1982248

Strand: Reverse

Name: hemH

Synonym: DIP1927

Alternate gene names: 38234494

Gene position: 1982248-1981355 (Counterclockwise)

Preceding gene: 38234495

Following gene: 38234493

Centisome position: 79.65

GC content: 54.81

Gene sequence:

>894_bases
ATGCGTCCTGAACTCTCCCAGTACACTCATGTCTCCGCTGGCAAGGTGCGTGAGATTTATGAGGTCGACGATGAACGCCT
CCTGATGGTTGTTTCTGATCGTATCTCTGCTTATGACCATATTTTGGAACCAGAGATTCCAGACAAGGGTCGCGTGCTCA
CTGCTATGAGCATGTACTTCTTCCACAACATCGATTTCCCGAACCACCTCGCAGGGCCTATCGACGACCCCGCAATCCCA
GAAGAGGTGCTCGGCCGTGCCATGGTGTGCAAGAAGCTCAAGATGTTGCCATTCGAGTGCGTTGCTCGTGGTTACCTCAC
TGGTTCCGGCTTGAAGGAATACCAGGAAACCGGCACCGTTTGTGGTGTGGAGCTACCCGAGGGCTTGGTGGAGGCTTCTA
AGCTCCCTGAGCCGATCTTCACCCCTGCTACGAAGGCAGAGCTTGGCGATCATGACGAGAACGTCTCTTTCGATGTTGTC
GTGGAAAAGCTGGGCGAGGCGCGTGCGAACGAGCTTCGCGACGCCACCTTGCGTATCTACTCCGAGGCTGCAGCGTTGGC
GGAAGAGCGCGGCATCATCTTGGCGGACACCAAGTTCGAGTTCGGTTTGGACGAGGATGGCAGGTTGGTGCTTGCCGACG
AAGTCCTTACCCCTGACTCTTCTCGTTATTGGCCAGCTGATGGCTACGAAGAGGGCAAGGTACAGCCAAGCTTTGATAAG
CAGTACGTTCGTAACTGGTTGACCGGACCAAAATCTGGTTGGTCTACTGACGACGTCACCCCGCCGCCATCACTGCCAGG
TTCTGTTGTAGAAGCTACTCGTGAACGCTACGTGGAAGCATTCGAGCGCATTACCGGCAAAAAATTCTGTGAGTGGATCG
GGTGCTGTGTGTAA

Upstream 100 bases:

>100_bases
GGTGACATTCTCTAACAACAGTTTTTAAGTACAAGTCATATCGCATCTGTGGGTGTTGCGATATGACTTGTTCTTGTTTC
AAGGTCTAGACTGCTTGATT

Downstream 100 bases:

>100_bases
AGGCGTTGGCCTCTCCTATGTGTTTTAGGTATTGAAAATACTCCCCCGATAAACTATCGGGGGAGTATTTTCAATAATTT
TACTTTTTGAATTTCTCAAC

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MRPELSQYTHVSAGKVREIYEVDDERLLMVVSDRISAYDHILEPEIPDKGRVLTAMSMYFFHNIDFPNHLAGPIDDPAIP
EEVLGRAMVCKKLKMLPFECVARGYLTGSGLKEYQETGTVCGVELPEGLVEASKLPEPIFTPATKAELGDHDENVSFDVV
VEKLGEARANELRDATLRIYSEAAALAEERGIILADTKFEFGLDEDGRLVLADEVLTPDSSRYWPADGYEEGKVQPSFDK
QYVRNWLTGPKSGWSTDDVTPPPSLPGSVVEATRERYVEAFERITGKKFCEWIGCCV

Sequences:

>Translated_297_residues
MRPELSQYTHVSAGKVREIYEVDDERLLMVVSDRISAYDHILEPEIPDKGRVLTAMSMYFFHNIDFPNHLAGPIDDPAIP
EEVLGRAMVCKKLKMLPFECVARGYLTGSGLKEYQETGTVCGVELPEGLVEASKLPEPIFTPATKAELGDHDENVSFDVV
VEKLGEARANELRDATLRIYSEAAALAEERGIILADTKFEFGLDEDGRLVLADEVLTPDSSRYWPADGYEEGKVQPSFDK
QYVRNWLTGPKSGWSTDDVTPPPSLPGSVVEATRERYVEAFERITGKKFCEWIGCCV
>Mature_297_residues
MRPELSQYTHVSAGKVREIYEVDDERLLMVVSDRISAYDHILEPEIPDKGRVLTAMSMYFFHNIDFPNHLAGPIDDPAIP
EEVLGRAMVCKKLKMLPFECVARGYLTGSGLKEYQETGTVCGVELPEGLVEASKLPEPIFTPATKAELGDHDENVSFDVV
VEKLGEARANELRDATLRIYSEAAALAEERGIILADTKFEFGLDEDGRLVLADEVLTPDSSRYWPADGYEEGKVQPSFDK
QYVRNWLTGPKSGWSTDDVTPPPSLPGSVVEATRERYVEAFERITGKKFCEWIGCCV

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=296, Percent_Identity=44.2567567567568, Blast_Score=251, Evalue=1e-67,
Organism=Drosophila melanogaster, GI18860083, Length=242, Percent_Identity=26.4462809917355, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24583917, Length=218, Percent_Identity=25.2293577981651, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_CORDI (Q6NFG4)

Other databases:

- EMBL:   BX248359
- RefSeq:   NP_940261.1
- HSSP:   P27616
- ProteinModelPortal:   Q6NFG4
- SMR:   Q6NFG4
- GeneID:   2648976
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1927
- NMPDR:   fig|257309.1.peg.1852
- HOGENOM:   HBG555040
- OMA:   LTLMDEV
- PhylomeDB:   Q6NFG4
- ProtClustDB:   PRK13961
- BioCyc:   CDIP257309:DIP1927-MONOMER
- BRENDA:   6.3.2.6
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 33170; Mature: 33170

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPELSQYTHVSAGKVREIYEVDDERLLMVVSDRISAYDHILEPEIPDKGRVLTAMSMYF
CCCCCCHHHCCCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
FHNIDFPNHLAGPIDDPAIPEEVLGRAMVCKKLKMLPFECVARGYLTGSGLKEYQETGTV
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHCCCE
CGVELPEGLVEASKLPEPIFTPATKAELGDHDENVSFDVVVEKLGEARANELRDATLRIY
EECCCCHHHHHHHHCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SEAAALAEERGIILADTKFEFGLDEDGRLVLADEVLTPDSSRYWPADGYEEGKVQPSFDK
HHHHHHHHHCCEEEEECCEECCCCCCCCEEEECCEECCCCCCCCCCCCCCCCCCCCCHHH
QYVRNWLTGPKSGWSTDDVTPPPSLPGSVVEATRERYVEAFERITGKKFCEWIGCCV
HHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRPELSQYTHVSAGKVREIYEVDDERLLMVVSDRISAYDHILEPEIPDKGRVLTAMSMYF
CCCCCCHHHCCCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
FHNIDFPNHLAGPIDDPAIPEEVLGRAMVCKKLKMLPFECVARGYLTGSGLKEYQETGTV
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHCCCE
CGVELPEGLVEASKLPEPIFTPATKAELGDHDENVSFDVVVEKLGEARANELRDATLRIY
EECCCCHHHHHHHHCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SEAAALAEERGIILADTKFEFGLDEDGRLVLADEVLTPDSSRYWPADGYEEGKVQPSFDK
HHHHHHHHHCCEEEEECCEECCCCCCCCEEEECCEECCCCCCCCCCCCCCCCCCCCCHHH
QYVRNWLTGPKSGWSTDDVTPPPSLPGSVVEATRERYVEAFERITGKKFCEWIGCCV
HHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910