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The map label for this gene is ptrB [H]

Identifier: 38234493

GI number: 38234493

Start: 1978935

End: 1981064

Strand: Reverse

Name: ptrB [H]

Synonym: DIP1926

Alternate gene names: 38234493

Gene position: 1981064-1978935 (Counterclockwise)

Preceding gene: 38234494

Following gene: 38234492

Centisome position: 79.6

GC content: 53.76

Gene sequence:

>2130_bases
ATGCGTGAATCTCACAATGTCCTACCTCCGGTAGCTCCAGTCCGTCCTATTACTCGTACCCACCACGGGATTGATTTCGT
GGATAACTACGAGTGGTTGCGGGATAAAGAAAATCCGGAAACGATCCAGTATCTTGAGGCAGAGAATGCTTTTGTTGAGC
AGCAGACTGCGCACCTTTCGCAGTTAAAGGACAACATTTATCACGAGATTAAATCGCGGGTGAAGGAAACAGATATGTCT
GTTCCGCAGCGCGCTGGTGATTTTTGGTACTACGGTCGATCCGTGGAAGGGAAGAGCTACGGCTATTCTTGCCGTATTCC
TGTGAGCGAAGGCGCGGATGCGTGGGTGCCTCCGACGATTCCTGAAAGGGAGCCGGTTGCTGGGGAGCAGATTATTCTTG
ACGCCAATGAGCTGGCCGAGGGCCATGAGTTTTTTGCTTTAGGTGCTTCGACGGTGACCACATCGGGCCGTTACCTTGCG
TATTCGGTTGATACGGAAGGCGATGAGCGCTTTACGCTGCGGGTTAAGGATTTGGCAACGGGTGAGCATCTTGCTGATGA
GATTCCCGATGTGTTCTATGGCGCTACCTGGGCTGGTGAGGAGTACCTGTTCTATCAGCGTGTTGATGCTGCGTGGCGTC
CAGATTCGGTGTGGCGACATAAGATTGGTACCGATCCGGCAACGGATGTGCAGGTGTTCCATGAAGCCGATGAGCGCTTT
AATACTGGCGTGGGTGCTACGCGCTCCGAGCGTTTTTTGATGATCGAGTCGGCGTCGAAGATTACGTCGGAAATTTGGGT
ACTTGATCTAGATAATCCGACCGGCGATTTCCGTTGTGTGCTGCCACGGCAAGCGGGGGTGGAATACGACATTGACCATG
CTGTTGTTGCTGGTCGCGATACATGGATTGTGACTCACAATGCCGCTGGTCCGAATTTTGAGGTGGGCTGGACTCCGGTC
ACCGATGAGGAGATTTCTCTCGATTCTCTTGAGGTTTTGGTGCCGCACCGTGATGAGGTTCGTATCGAGGGCGTGGACAC
GTACCGTGATCACATTGTGTTGGCGTACCGCTCGGGTGCGATCGGTCGCGCAGCTGTGATGCAGCTTAATGCCGATGGTT
TTGGCACGTTTGAAGAGATTACTTTCGACGAAGAGCTCTACACGATTGGTGTGGGCGGCCACCCTGAGTGGGATACCCCT
GTGGTGCGCATGGTGTATGTGTCGTTTACGCAGCCGAGCCAAGTGTTTGATTATTGGATTGCTGATGGGCGTCGTACTTT
GCTCAAGCAGCAGGAGGTCGTCGGCGGCTATAATGCGGATGATTACACTGCGTCGCGGCTGTGGGTTGAGGCTCACGACG
GTGTGCGTATTCCCGTGTCGTTGATCCATCGCTCTGATCTTGACCTCAGCAAGCCGAACCCTACTTTGTTGTACGGCTAT
GGCTCTTATGAGTCCTCGATCGACCCTGGTTTTTCTATTGCGCGGTTGTCTTTGATGGACCGTGGCATGGTGTTCGCTAT
CGCCCATGTGCGCGGTGGTGGTGAGATGGGTCGTGGCTGGTACGACACGGGCAAGACTGTGACGAAGAAGAACACGTTTA
CGGACTTCATTGCGGTCGCCGATCATCTGATTGAGCATGGGGTGACTACCTCTGAAATGTTGGTGGCGGAAGGCGGATCT
GCCGGCGGCATGCTCATGGGTGCGGTGGCGAATATGGCAGGGGATCGTTTCAAAGCGATTGAGGCTGTGGTGCCTTTCGT
GGATCCGTTGACATCAATGCTGATGCCGGAGTTGCCGTTGACGGTAACTGAATGGGACGAGTGGGGTGACCCGCTGCATG
ACGTCGATGTGTATAACTACATGGCCTCTTATGCGCCTTATGAAAATATTGAGGCCAAGGCGTATCCCAATATCTTGGCG
GTGACCTCGCTTAATGACACTCGCGTGCTTTATGTTGAGCCGGCTAAGTGGATTGCCCAGTTGCGTGCGACGGCAACGGG
TGGACAGTTCTTGCTGAAGACGGAGATGTCTGCTGGTCACGGCGGTGTTTCAGGCCGTTATGAAAAGTGGAAGCAAACCG
CGTTTGAATACGCTTGGCTGTGCCATCAAGCAACCGGAAAGGAATCCTAG

Upstream 100 bases:

>100_bases
CCTTTCATTCGGAGTGTAACTTTCCTTGTAATGTAGGCGATCTCTCAGGCAATAGCAAGGTTTCGGGCTACGTTTTTCGC
TATCGGCTACGATCGTCACC

Downstream 100 bases:

>100_bases
GATGAGTATTTTAGATACCGAGGTCACGCTGATCAACGGCGAGAAAGCCTCAATGGATCAGTGGGCTGGTCATTGCCTGT
TGATTGTGAATACGGCATCA

Product: putative prolyl oligopeptidase

Products: NA

Alternate protein names: Oligopeptidase B; Protease II [H]

Number of amino acids: Translated: 709; Mature: 709

Protein sequence:

>709_residues
MRESHNVLPPVAPVRPITRTHHGIDFVDNYEWLRDKENPETIQYLEAENAFVEQQTAHLSQLKDNIYHEIKSRVKETDMS
VPQRAGDFWYYGRSVEGKSYGYSCRIPVSEGADAWVPPTIPEREPVAGEQIILDANELAEGHEFFALGASTVTTSGRYLA
YSVDTEGDERFTLRVKDLATGEHLADEIPDVFYGATWAGEEYLFYQRVDAAWRPDSVWRHKIGTDPATDVQVFHEADERF
NTGVGATRSERFLMIESASKITSEIWVLDLDNPTGDFRCVLPRQAGVEYDIDHAVVAGRDTWIVTHNAAGPNFEVGWTPV
TDEEISLDSLEVLVPHRDEVRIEGVDTYRDHIVLAYRSGAIGRAAVMQLNADGFGTFEEITFDEELYTIGVGGHPEWDTP
VVRMVYVSFTQPSQVFDYWIADGRRTLLKQQEVVGGYNADDYTASRLWVEAHDGVRIPVSLIHRSDLDLSKPNPTLLYGY
GSYESSIDPGFSIARLSLMDRGMVFAIAHVRGGGEMGRGWYDTGKTVTKKNTFTDFIAVADHLIEHGVTTSEMLVAEGGS
AGGMLMGAVANMAGDRFKAIEAVVPFVDPLTSMLMPELPLTVTEWDEWGDPLHDVDVYNYMASYAPYENIEAKAYPNILA
VTSLNDTRVLYVEPAKWIAQLRATATGGQFLLKTEMSAGHGGVSGRYEKWKQTAFEYAWLCHQATGKES

Sequences:

>Translated_709_residues
MRESHNVLPPVAPVRPITRTHHGIDFVDNYEWLRDKENPETIQYLEAENAFVEQQTAHLSQLKDNIYHEIKSRVKETDMS
VPQRAGDFWYYGRSVEGKSYGYSCRIPVSEGADAWVPPTIPEREPVAGEQIILDANELAEGHEFFALGASTVTTSGRYLA
YSVDTEGDERFTLRVKDLATGEHLADEIPDVFYGATWAGEEYLFYQRVDAAWRPDSVWRHKIGTDPATDVQVFHEADERF
NTGVGATRSERFLMIESASKITSEIWVLDLDNPTGDFRCVLPRQAGVEYDIDHAVVAGRDTWIVTHNAAGPNFEVGWTPV
TDEEISLDSLEVLVPHRDEVRIEGVDTYRDHIVLAYRSGAIGRAAVMQLNADGFGTFEEITFDEELYTIGVGGHPEWDTP
VVRMVYVSFTQPSQVFDYWIADGRRTLLKQQEVVGGYNADDYTASRLWVEAHDGVRIPVSLIHRSDLDLSKPNPTLLYGY
GSYESSIDPGFSIARLSLMDRGMVFAIAHVRGGGEMGRGWYDTGKTVTKKNTFTDFIAVADHLIEHGVTTSEMLVAEGGS
AGGMLMGAVANMAGDRFKAIEAVVPFVDPLTSMLMPELPLTVTEWDEWGDPLHDVDVYNYMASYAPYENIEAKAYPNILA
VTSLNDTRVLYVEPAKWIAQLRATATGGQFLLKTEMSAGHGGVSGRYEKWKQTAFEYAWLCHQATGKES
>Mature_709_residues
MRESHNVLPPVAPVRPITRTHHGIDFVDNYEWLRDKENPETIQYLEAENAFVEQQTAHLSQLKDNIYHEIKSRVKETDMS
VPQRAGDFWYYGRSVEGKSYGYSCRIPVSEGADAWVPPTIPEREPVAGEQIILDANELAEGHEFFALGASTVTTSGRYLA
YSVDTEGDERFTLRVKDLATGEHLADEIPDVFYGATWAGEEYLFYQRVDAAWRPDSVWRHKIGTDPATDVQVFHEADERF
NTGVGATRSERFLMIESASKITSEIWVLDLDNPTGDFRCVLPRQAGVEYDIDHAVVAGRDTWIVTHNAAGPNFEVGWTPV
TDEEISLDSLEVLVPHRDEVRIEGVDTYRDHIVLAYRSGAIGRAAVMQLNADGFGTFEEITFDEELYTIGVGGHPEWDTP
VVRMVYVSFTQPSQVFDYWIADGRRTLLKQQEVVGGYNADDYTASRLWVEAHDGVRIPVSLIHRSDLDLSKPNPTLLYGY
GSYESSIDPGFSIARLSLMDRGMVFAIAHVRGGGEMGRGWYDTGKTVTKKNTFTDFIAVADHLIEHGVTTSEMLVAEGGS
AGGMLMGAVANMAGDRFKAIEAVVPFVDPLTSMLMPELPLTVTEWDEWGDPLHDVDVYNYMASYAPYENIEAKAYPNILA
VTSLNDTRVLYVEPAKWIAQLRATATGGQFLLKTEMSAGHGGVSGRYEKWKQTAFEYAWLCHQATGKES

Specific function: Cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues [H]

COG id: COG1770

COG function: function code E; Protease II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=702, Percent_Identity=25.2136752136752, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI284172420, Length=526, Percent_Identity=26.2357414448669, Blast_Score=160, Evalue=4e-39,
Organism=Homo sapiens, GI284172413, Length=526, Percent_Identity=26.2357414448669, Blast_Score=160, Evalue=4e-39,
Organism=Homo sapiens, GI70778815, Length=526, Percent_Identity=26.2357414448669, Blast_Score=160, Evalue=4e-39,
Organism=Homo sapiens, GI284172438, Length=526, Percent_Identity=26.2357414448669, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI284172431, Length=526, Percent_Identity=26.2357414448669, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI108860686, Length=204, Percent_Identity=35.2941176470588, Blast_Score=126, Evalue=7e-29,
Organism=Homo sapiens, GI108860692, Length=281, Percent_Identity=30.9608540925267, Blast_Score=124, Evalue=3e-28,
Organism=Escherichia coli, GI1788150, Length=706, Percent_Identity=36.685552407932, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24583414, Length=704, Percent_Identity=24.5738636363636, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI221510989, Length=704, Percent_Identity=23.7215909090909, Blast_Score=155, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.83 [H]

Molecular weight: Translated: 79251; Mature: 79251

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRESHNVLPPVAPVRPITRTHHGIDFVDNYEWLRDKENPETIQYLEAENAFVEQQTAHLS
CCCCCCCCCCCCCCCCCHHCCCCCCCCCCCHHHCCCCCCCCEEEEECCCHHHHHHHHHHH
QLKDNIYHEIKSRVKETDMSVPQRAGDFWYYGRSVEGKSYGYSCRIPVSEGADAWVPPTI
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCEECCCCCCEEEEEECCCCCCCCCCCCC
PEREPVAGEQIILDANELAEGHEFFALGASTVTTSGRYLAYSVDTEGDERFTLRVKDLAT
CCCCCCCCCEEEEEHHHHCCCCEEEEECCCEEECCCCEEEEEECCCCCCEEEEEEECCCC
GEHLADEIPDVFYGATWAGEEYLFYQRVDAAWRPDSVWRHKIGTDPATDVQVFHEADERF
CHHHHHHCCHHHCCCEECCCCEEEEEECCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHH
NTGVGATRSERFLMIESASKITSEIWVLDLDNPTGDFRCVLPRQAGVEYDIDHAVVAGRD
CCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCEEEECCC
TWIVTHNAAGPNFEVGWTPVTDEEISLDSLEVLVPHRDEVRIEGVDTYRDHIVLAYRSGA
EEEEEECCCCCCEECCCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCEEEEEEECCC
IGRAAVMQLNADGFGTFEEITFDEELYTIGVGGHPEWDTPVVRMVYVSFTQPSQVFDYWI
CCEEEEEEECCCCCCCHHHEEECCEEEEEECCCCCCCCCCEEEEEEEEECCCHHHHHHHH
ADGRRTLLKQQEVVGGYNADDYTASRLWVEAHDGVRIPVSLIHRSDLDLSKPNPTLLYGY
HCCHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCEECCCEEEECCCCCCCCCCCEEEEEE
GSYESSIDPGFSIARLSLMDRGMVFAIAHVRGGGEMGRGWYDTGKTVTKKNTFTDFIAVA
CCCCCCCCCCCCEEEHHHHCCCEEEEEEEECCCCCCCCCEECCCCEEECCCCHHHHHHHH
DHLIEHGVTTSEMLVAEGGSAGGMLMGAVANMAGDRFKAIEAVVPFVDPLTSMLMPELPL
HHHHHCCCCCHHEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
TVTEWDEWGDPLHDVDVYNYMASYAPYENIEAKAYPNILAVTSLNDTRVLYVEPAKWIAQ
EEECCHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEECCHHHHHH
LRATATGGQFLLKTEMSAGHGGVSGRYEKWKQTAFEYAWLCHQATGKES
HHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRESHNVLPPVAPVRPITRTHHGIDFVDNYEWLRDKENPETIQYLEAENAFVEQQTAHLS
CCCCCCCCCCCCCCCCCHHCCCCCCCCCCCHHHCCCCCCCCEEEEECCCHHHHHHHHHHH
QLKDNIYHEIKSRVKETDMSVPQRAGDFWYYGRSVEGKSYGYSCRIPVSEGADAWVPPTI
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCEECCCCCCEEEEEECCCCCCCCCCCCC
PEREPVAGEQIILDANELAEGHEFFALGASTVTTSGRYLAYSVDTEGDERFTLRVKDLAT
CCCCCCCCCEEEEEHHHHCCCCEEEEECCCEEECCCCEEEEEECCCCCCEEEEEEECCCC
GEHLADEIPDVFYGATWAGEEYLFYQRVDAAWRPDSVWRHKIGTDPATDVQVFHEADERF
CHHHHHHCCHHHCCCEECCCCEEEEEECCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHH
NTGVGATRSERFLMIESASKITSEIWVLDLDNPTGDFRCVLPRQAGVEYDIDHAVVAGRD
CCCCCCCCCCCEEEEECCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCCCCCEEEECCC
TWIVTHNAAGPNFEVGWTPVTDEEISLDSLEVLVPHRDEVRIEGVDTYRDHIVLAYRSGA
EEEEEECCCCCCEECCCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCEEEEEEECCC
IGRAAVMQLNADGFGTFEEITFDEELYTIGVGGHPEWDTPVVRMVYVSFTQPSQVFDYWI
CCEEEEEEECCCCCCCHHHEEECCEEEEEECCCCCCCCCCEEEEEEEEECCCHHHHHHHH
ADGRRTLLKQQEVVGGYNADDYTASRLWVEAHDGVRIPVSLIHRSDLDLSKPNPTLLYGY
HCCHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCEECCCEEEECCCCCCCCCCCEEEEEE
GSYESSIDPGFSIARLSLMDRGMVFAIAHVRGGGEMGRGWYDTGKTVTKKNTFTDFIAVA
CCCCCCCCCCCCEEEHHHHCCCEEEEEEEECCCCCCCCCEECCCCEEECCCCHHHHHHHH
DHLIEHGVTTSEMLVAEGGSAGGMLMGAVANMAGDRFKAIEAVVPFVDPLTSMLMPELPL
HHHHHCCCCCHHEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
TVTEWDEWGDPLHDVDVYNYMASYAPYENIEAKAYPNILAVTSLNDTRVLYVEPAKWIAQ
EEECCHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEECCHHHHHH
LRATATGGQFLLKTEMSAGHGGVSGRYEKWKQTAFEYAWLCHQATGKES
HHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7629037 [H]