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The map label for this gene is purM [H]

Identifier: 38234486

GI number: 38234486

Start: 1970918

End: 1971982

Strand: Reverse

Name: purM [H]

Synonym: DIP1919

Alternate gene names: 38234486

Gene position: 1971982-1970918 (Counterclockwise)

Preceding gene: 38234487

Following gene: 38234483

Centisome position: 79.24

GC content: 59.62

Gene sequence:

>1065_bases
ATGACGGAAAAGAACGACAACGTTTCCTACGCTGCCGCAGGCGTGGATATTGAGGCCGGCGACAAAGCAGTCGAGCTTTT
CGCCCCATTAGCAAAGAAAGCAACCCGCCCTGAGGTTCGTGGCGGCCTCGGCGGATTCGCCGGACTGTTCGCACTCGGCA
AGTACCGTAAGCCGCTGCTCGCAGCAGGTTCCGACGGCGTGGGCACCAAGCTGGCTATCGCCCAAGCTATGGACAAGCAC
GACACCATCGGTATTGACTTGGTGGCAATGTGCGTGGATGACCTCGTTGTCTGTGGCGCGGAACCACTGTTCCTCCAGGA
CTACATCGCAATCGGCAAAGTTGTGCCAGAGCACGTGGCACAAATCGTGTCCGGCATCGCCGAGGGCTGCATTCAGGCTG
GTTGCGCATTGCTCGGTGGCGAAACCGCAGAGCACCCAGGTGTGATGGAGCCTGAGCATTATGACGTCTCCGCAACCGCC
GTGGGCGTTGTTGAAGCCGATGAGGTTCTCGGCCCAGACCGCGTGCGCAACGGCGATGTTGTCATCGCTATGGCATCGTC
TGGTCTGCACTCCAACGGCTACTCCTTGGCTCGCCACGTATTGCTGGACAAGGCTGGTCTGCCTCTCGACGGCCACATGG
AAGAATTCGACCGCACCTTGGGTGAGGAGCTGCTCGAGCCAACCAAGATCTACACCAAGGACTGCTTGGCGCTTGCCGAC
GAATGCGAAGTGCACACCTTCTGCCACGTCACCGGTGGCGGCCTAGCCGGCAACTTGGCTCGTGTGATCCCAGAAGGCCT
TACCGCAGAGCTTTCTCGTGCCACCTGGACTCCTGGCCAGATCTTCCGCACGATCGAAACCATTGGACAGGTTCCTCAGG
TTGAGATGGAAAAGACCTTCAACATGGGTGTTGGCATGGTCGCTGTTGTTGCTCCAAAGGACCGCGACCGCGCGTTGGCC
ATCTTGACTGCCCGTCACATCGACGCATGGGAGCTAGGCACCGTGCGCGCAACCGAAGGCGAGGAGCCTTCTGTCATCCT
GACCGGCAACCACCCAGGCTACTAA

Upstream 100 bases:

>100_bases
TTTCTGCGATGAAACGCAGCTCGTGCGCAAGCCTCGACTAACGGCGAATCACCACCTATACCTACACCCCAAACCAACAT
AAGGATTACAGGTCCCCCAC

Downstream 100 bases:

>100_bases
GCCGAAAATCGCTGTAAAAACAGGGAGGCTGGCGCGGCTACATCGGTAGCTGGGTCAGCCTCTTTTTCTGAAGCAACAAG
TAACCCCCTGAGTAGCACTC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MTEKNDNVSYAAAGVDIEAGDKAVELFAPLAKKATRPEVRGGLGGFAGLFALGKYRKPLLAAGSDGVGTKLAIAQAMDKH
DTIGIDLVAMCVDDLVVCGAEPLFLQDYIAIGKVVPEHVAQIVSGIAEGCIQAGCALLGGETAEHPGVMEPEHYDVSATA
VGVVEADEVLGPDRVRNGDVVIAMASSGLHSNGYSLARHVLLDKAGLPLDGHMEEFDRTLGEELLEPTKIYTKDCLALAD
ECEVHTFCHVTGGGLAGNLARVIPEGLTAELSRATWTPGQIFRTIETIGQVPQVEMEKTFNMGVGMVAVVAPKDRDRALA
ILTARHIDAWELGTVRATEGEEPSVILTGNHPGY

Sequences:

>Translated_354_residues
MTEKNDNVSYAAAGVDIEAGDKAVELFAPLAKKATRPEVRGGLGGFAGLFALGKYRKPLLAAGSDGVGTKLAIAQAMDKH
DTIGIDLVAMCVDDLVVCGAEPLFLQDYIAIGKVVPEHVAQIVSGIAEGCIQAGCALLGGETAEHPGVMEPEHYDVSATA
VGVVEADEVLGPDRVRNGDVVIAMASSGLHSNGYSLARHVLLDKAGLPLDGHMEEFDRTLGEELLEPTKIYTKDCLALAD
ECEVHTFCHVTGGGLAGNLARVIPEGLTAELSRATWTPGQIFRTIETIGQVPQVEMEKTFNMGVGMVAVVAPKDRDRALA
ILTARHIDAWELGTVRATEGEEPSVILTGNHPGY
>Mature_353_residues
TEKNDNVSYAAAGVDIEAGDKAVELFAPLAKKATRPEVRGGLGGFAGLFALGKYRKPLLAAGSDGVGTKLAIAQAMDKHD
TIGIDLVAMCVDDLVVCGAEPLFLQDYIAIGKVVPEHVAQIVSGIAEGCIQAGCALLGGETAEHPGVMEPEHYDVSATAV
GVVEADEVLGPDRVRNGDVVIAMASSGLHSNGYSLARHVLLDKAGLPLDGHMEEFDRTLGEELLEPTKIYTKDCLALADE
CEVHTFCHVTGGGLAGNLARVIPEGLTAELSRATWTPGQIFRTIETIGQVPQVEMEKTFNMGVGMVAVVAPKDRDRALAI
LTARHIDAWELGTVRATEGEEPSVILTGNHPGY

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=348, Percent_Identity=44.8275862068966, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI209869995, Length=348, Percent_Identity=44.8275862068966, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI209869993, Length=348, Percent_Identity=44.8275862068966, Blast_Score=280, Evalue=2e-75,
Organism=Escherichia coli, GI1788845, Length=351, Percent_Identity=48.4330484330484, Blast_Score=323, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI17567511, Length=342, Percent_Identity=35.672514619883, Blast_Score=204, Evalue=7e-53,
Organism=Saccharomyces cerevisiae, GI6321203, Length=347, Percent_Identity=42.0749279538905, Blast_Score=265, Evalue=7e-72,
Organism=Drosophila melanogaster, GI24582400, Length=269, Percent_Identity=39.7769516728625, Blast_Score=194, Evalue=6e-50,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37273; Mature: 37142

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKNDNVSYAAAGVDIEAGDKAVELFAPLAKKATRPEVRGGLGGFAGLFALGKYRKPLL
CCCCCCCCEEEEECCEECCCCHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHCCCCE
AAGSDGVGTKLAIAQAMDKHDTIGIDLVAMCVDDLVVCGAEPLFLQDYIAIGKVVPEHVA
ECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
QIVSGIAEGCIQAGCALLGGETAEHPGVMEPEHYDVSATAVGVVEADEVLGPDRVRNGDV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEEHHHHCCCCCCCCCCE
VIAMASSGLHSNGYSLARHVLLDKAGLPLDGHMEEFDRTLGEELLEPTKIYTKDCLALAD
EEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
ECEVHTFCHVTGGGLAGNLARVIPEGLTAELSRATWTPGQIFRTIETIGQVPQVEMEKTF
CCCEEEEEEEECCCHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHH
NMGVGMVAVVAPKDRDRALAILTARHIDAWELGTVRATEGEEPSVILTGNHPGY
CCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCEEEECCCCCCCEEEECCCCCC
>Mature Secondary Structure 
TEKNDNVSYAAAGVDIEAGDKAVELFAPLAKKATRPEVRGGLGGFAGLFALGKYRKPLL
CCCCCCCEEEEECCEECCCCHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHCCCCE
AAGSDGVGTKLAIAQAMDKHDTIGIDLVAMCVDDLVVCGAEPLFLQDYIAIGKVVPEHVA
ECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
QIVSGIAEGCIQAGCALLGGETAEHPGVMEPEHYDVSATAVGVVEADEVLGPDRVRNGDV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEEHHHHCCCCCCCCCCE
VIAMASSGLHSNGYSLARHVLLDKAGLPLDGHMEEFDRTLGEELLEPTKIYTKDCLALAD
EEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
ECEVHTFCHVTGGGLAGNLARVIPEGLTAELSRATWTPGQIFRTIETIGQVPQVEMEKTF
CCCEEEEEEEECCCHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHH
NMGVGMVAVVAPKDRDRALAILTARHIDAWELGTVRATEGEEPSVILTGNHPGY
CCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCEEEECCCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA