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The map label for this gene is dus [H]

Identifier: 38234473

GI number: 38234473

Start: 1958274

End: 1959425

Strand: Direct

Name: dus [H]

Synonym: DIP1903

Alternate gene names: 38234473

Gene position: 1958274-1959425 (Clockwise)

Preceding gene: 38234471

Following gene: 38234474

Centisome position: 78.69

GC content: 60.94

Gene sequence:

>1152_bases
GTGCAGGTGACTTTGACGATCGGCTCCCTAGCACTCGACTCCGTAGTAGCGCTTGCCCCCATGGCAGGCGTAACCAACAT
TGCGTTTCGTACTCTCTGTAGAGAACAAGAACTCGAACGCACCGGAACCGTATCGGGGCTCTACATCTGCGAGATGATTA
CCGCACGCGCCCTCGTGGAGCGCAACGAGAAAACACTCCACATGACCACCTTTGGTCCGCAAGAAGATATTCGCTCCCTG
CAGCTGTACACCGTTGACCCCGAGTACACCTACAAAGCGGCCAAGATGATCGCAGAGAACAACATGGCCGATCACATCGA
CATGAACTTCGGCTGCCCCGTGCCCAAAGTAACCAAACGTGGTGGTGGCTCCGCACTCCCATACAAACGTCGACTATTTG
GCAACATCGTCGCAGCCGCCGTCAAAGGCGTTGAAGGAACAGACATCCCCATCACCGTAAAATTCCGCATGGGCATTGAC
GACGACCACCTCACCTACCTCGACGCCGGCCGCATCGCCGCCGAAGAAGGTGCCGCAGCCGTAACCCTGCACGCTCGCAC
CGCAGCAGAGCGTTACTCTGGCGACGCCCACTGGGACGCTATCGGCACCCTCAAAGAGCACATGCGTGACTCCGGGATCC
CCGTCCTCGGCAATGGCGACATCTTCAAAGCCGAAGACGCCAAAGCCATGCTCGACGCCTCCGGCTGCGACGGCGTTGTC
GTCGGACGCGGCTGCCTCGGCCGACCTTGGCTATTCGCAGGAATCTCCGCAGCCCTGCGCGGCGAAGAACTCCCGCCAGA
ACCCACGCTGGGCGAAGTCACCCGCATTATCTACCGCCACGCAGAACTCTTGGCAGAACACGACGGTGAAAAGAAAGCCA
GCCGCGATATGCGCAAGCACATGGGCTGGTACATGCGCGGCTTCCCCGTAGGCGGTGAATTCCGCGGCGCCCTCGCAAGG
ATCAACTCGCTTGCTGAACTCCGCGAGGTGCTTGCCCCCTTCGCAGACTCCAATGCCCTAGCAGCCGACTCCGATAGCGC
ACGCGGACGCCAAGGCTCACCCGCTAAAGTTGCACTCCCCGACGGCTGGCTCGCCGACCCCGACGACGCCACGGTGCCCG
AAGGCGCTGAGATCATGCACTCCGGCGGATAA

Upstream 100 bases:

>100_bases
ACTACGCAGTTCAAACAGACAATTTCGCCCTATCGCCCCACATCGCACGTGTGCAGCCTCATGCCACGTTTGTGTCACTC
ATAGCCAAGGGGGAACAATA

Downstream 100 bases:

>100_bases
CACCTATATAGTTGCTGTATGCGCACAACGTATCGAGAGCATCTAGACGCATTTGCACAAGATCTGATCACCATGTGCGA
CACCGTCGCCGCCGTGGTAG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MQVTLTIGSLALDSVVALAPMAGVTNIAFRTLCREQELERTGTVSGLYICEMITARALVERNEKTLHMTTFGPQEDIRSL
QLYTVDPEYTYKAAKMIAENNMADHIDMNFGCPVPKVTKRGGGSALPYKRRLFGNIVAAAVKGVEGTDIPITVKFRMGID
DDHLTYLDAGRIAAEEGAAAVTLHARTAAERYSGDAHWDAIGTLKEHMRDSGIPVLGNGDIFKAEDAKAMLDASGCDGVV
VGRGCLGRPWLFAGISAALRGEELPPEPTLGEVTRIIYRHAELLAEHDGEKKASRDMRKHMGWYMRGFPVGGEFRGALAR
INSLAELREVLAPFADSNALAADSDSARGRQGSPAKVALPDGWLADPDDATVPEGAEIMHSGG

Sequences:

>Translated_383_residues
MQVTLTIGSLALDSVVALAPMAGVTNIAFRTLCREQELERTGTVSGLYICEMITARALVERNEKTLHMTTFGPQEDIRSL
QLYTVDPEYTYKAAKMIAENNMADHIDMNFGCPVPKVTKRGGGSALPYKRRLFGNIVAAAVKGVEGTDIPITVKFRMGID
DDHLTYLDAGRIAAEEGAAAVTLHARTAAERYSGDAHWDAIGTLKEHMRDSGIPVLGNGDIFKAEDAKAMLDASGCDGVV
VGRGCLGRPWLFAGISAALRGEELPPEPTLGEVTRIIYRHAELLAEHDGEKKASRDMRKHMGWYMRGFPVGGEFRGALAR
INSLAELREVLAPFADSNALAADSDSARGRQGSPAKVALPDGWLADPDDATVPEGAEIMHSGG
>Mature_383_residues
MQVTLTIGSLALDSVVALAPMAGVTNIAFRTLCREQELERTGTVSGLYICEMITARALVERNEKTLHMTTFGPQEDIRSL
QLYTVDPEYTYKAAKMIAENNMADHIDMNFGCPVPKVTKRGGGSALPYKRRLFGNIVAAAVKGVEGTDIPITVKFRMGID
DDHLTYLDAGRIAAEEGAAAVTLHARTAAERYSGDAHWDAIGTLKEHMRDSGIPVLGNGDIFKAEDAKAMLDASGCDGVV
VGRGCLGRPWLFAGISAALRGEELPPEPTLGEVTRIIYRHAELLAEHDGEKKASRDMRKHMGWYMRGFPVGGEFRGALAR
INSLAELREVLAPFADSNALAADSDSARGRQGSPAKVALPDGWLADPDDATVPEGAEIMHSGG

Specific function: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs [H]

COG id: COG0042

COG function: function code J; tRNA-dihydrouridine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dus family [H]

Homologues:

Organism=Homo sapiens, GI239788483, Length=307, Percent_Identity=29.6416938110749, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI239788462, Length=253, Percent_Identity=31.6205533596838, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI31742496, Length=240, Percent_Identity=31.6666666666667, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI40807366, Length=356, Percent_Identity=25.2808988764045, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1789660, Length=336, Percent_Identity=33.9285714285714, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1788462, Length=274, Percent_Identity=26.2773722627737, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17543114, Length=255, Percent_Identity=31.7647058823529, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI25144369, Length=234, Percent_Identity=27.7777777777778, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17507177, Length=244, Percent_Identity=28.2786885245902, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323437, Length=246, Percent_Identity=29.2682926829268, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323560, Length=319, Percent_Identity=26.0188087774295, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323433, Length=232, Percent_Identity=28.0172413793103, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24585320, Length=278, Percent_Identity=31.294964028777, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24580595, Length=308, Percent_Identity=25.974025974026, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19920448, Length=308, Percent_Identity=25.974025974026, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19921524, Length=244, Percent_Identity=27.4590163934426, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004652
- InterPro:   IPR001269
- InterPro:   IPR018517 [H]

Pfam domain/function: PF01207 Dus [H]

EC number: NA

Molecular weight: Translated: 41192; Mature: 41192

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS01136 UPF0034

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVTLTIGSLALDSVVALAPMAGVTNIAFRTLCREQELERTGTVSGLYICEMITARALVE
CEEEEEECHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
RNEKTLHMTTFGPQEDIRSLQLYTVDPEYTYKAAKMIAENNMADHIDMNFGCPVPKVTKR
CCCCEEEEEECCCHHHHCCEEEEEECCCHHHHHHHHHHHCCCCCEECCCCCCCCCHHHCC
GGGSALPYKRRLFGNIVAAAVKGVEGTDIPITVKFRMGIDDDHLTYLDAGRIAAEEGAAA
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCEEEEECCCEECCCCCEE
VTLHARTAAERYSGDAHWDAIGTLKEHMRDSGIPVLGNGDIFKAEDAKAMLDASGCDGVV
EEEEHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEECCCCEEECCCCHHHHCCCCCCEEE
VGRGCLGRPWLFAGISAALRGEELPPEPTLGEVTRIIYRHAELLAEHDGEKKASRDMRKH
ECCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
MGWYMRGFPVGGEFRGALARINSLAELREVLAPFADSNALAADSDSARGRQGSPAKVALP
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCEEECC
DGWLADPDDATVPEGAEIMHSGG
CCCCCCCCCCCCCCCHHHHCCCC
>Mature Secondary Structure
MQVTLTIGSLALDSVVALAPMAGVTNIAFRTLCREQELERTGTVSGLYICEMITARALVE
CEEEEEECHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
RNEKTLHMTTFGPQEDIRSLQLYTVDPEYTYKAAKMIAENNMADHIDMNFGCPVPKVTKR
CCCCEEEEEECCCHHHHCCEEEEEECCCHHHHHHHHHHHCCCCCEECCCCCCCCCHHHCC
GGGSALPYKRRLFGNIVAAAVKGVEGTDIPITVKFRMGIDDDHLTYLDAGRIAAEEGAAA
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCEEEEECCCEECCCCCEE
VTLHARTAAERYSGDAHWDAIGTLKEHMRDSGIPVLGNGDIFKAEDAKAMLDASGCDGVV
EEEEHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEECCCCEEECCCCHHHHCCCCCCEEE
VGRGCLGRPWLFAGISAALRGEELPPEPTLGEVTRIIYRHAELLAEHDGEKKASRDMRKH
ECCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
MGWYMRGFPVGGEFRGALARINSLAELREVLAPFADSNALAADSDSARGRQGSPAKVALP
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCEEECC
DGWLADPDDATVPEGAEIMHSGG
CCCCCCCCCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]