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The map label for this gene is cat1 [H]

Identifier: 38234472

GI number: 38234472

Start: 1956426

End: 1957979

Strand: Reverse

Name: cat1 [H]

Synonym: DIP1902

Alternate gene names: 38234472

Gene position: 1957979-1956426 (Counterclockwise)

Preceding gene: 38234475

Following gene: 38234465

Centisome position: 78.68

GC content: 56.5

Gene sequence:

>1554_bases
TTGGCATGCACTGCGGCAGACGTTGTTGAGGAGGATTTAATGTCTGATCGTATTGCGAATGCTCAGCTTCGTGGCAAGGT
TATGTCGGCTGAAGAGGCTGCGCAGTTTGTCAATCACGGTGACAAAGTAGGCGTGTCCGGCTTCACCGGCGCTGGTTACC
CGAAGGCTTTGCCTACCGCTATCGCAGAGCGTGCTAAGGAAGCACACGCGCGTGGCGACGAATACATGATCGACCTGTTT
ACCGGTGCATCCACTGCACCTGACTGTGACGGTGTGCTCGCAGAGGCTGATGCCCTGCGCTTCCGTACCCCATACCAGTC
CGATCCAATCTTGCGCTCCAAGATTAACGACGGCACCACCTTGTACGCCGACTACCACCTGTCCGAGTCCGGTATCTACG
TTGAGCAGGGCTTCTTTGGGCAGATGAATGTGGCTATCGTTGAGGCAGTTCGCATCACCGAAGAAGGCCACATCGTGCCA
TCCTCCTCAGTGGGTAACAACGTGGAATACCTCGACAACGCCGAGAAGATCATCATCGAGGTCAACTCTTGGCAGTCCGA
GGAACTCGAAGGCATGGCGGATATTTACCGCATGAACAAGCTGCCTAACCGCCAGCCAATTCCGATTACCGAGGCTGGCC
AGCGTATCGGTACCACCTACATCGACATCGACCTGTCCAAGGTTGTTGCCGTCGTAGAAACCGATGCCCCTGACCGCAAC
GCACCGTTTAAGCCACTGGATGAAACCTCCAAGCAGATCGCTGGACACTTCCTTGACTTCCTCGAAGGCGAGGTCGCAGC
TGGCCGCCTGACTTACGACGGCTACGTCATGCAGTCCGGTGTGGGCAACGTGCCAAACGCTGTGATGGCAGGCCTGCTGG
ATTCCAAGTTCGAAAACATCAAGGCCTACACCGAGGTGATCCAGGACGGCATGGTCGACCTGATCGACGCCGGTAAGATG
ACTGTCGCCTCCGCAACCTCCTTCTCGCTGTCTCCTGAGTACGCAGAGCGCATGAACGCAGAGGCAAAGAACTACGCCCA
GAAGATCATCCTGCGCCCACAGCAGATCTCCAACCACCCAGAGGTTGTCCGCCGCCTCGGTCTGATCTGCACCAACGGTC
TTATCGAAGCCGACATCTACGGCAACGTTAACTCCACCAACGTCACCGGCTCCCGCATGATGAACGGTGTCGGCGGTTCC
GCAGACTTCACCCGCAACGGCTTCATCAGCTCCTTTATCACCCCATCGGTTGCCAAGGGCGGCGACATCTCCGCATTCGT
GCCATTCGTCTCCCACGTAGACCACACCGAGCAAGATGTGAAGGTTCTCATCTCCGAGTACGGTTACGCCGACCTCCGTG
GTCTAGCCCCACGTCAGCGTGTAGAAAAGATCATCGCTATCGCACACCCTGACTATCGACCACTTCTGCAGGACTACTAC
GATCGCGCCCTGGCTTTTGCCAAGGAAAAGAAGATCATGCAGACCCCGCACCTGTTGGGTGAAGCGCTGAGCTTCCACCA
GCGTTTCCAAGAGACTGGTTCCATGAAGAAGTAA

Upstream 100 bases:

>100_bases
TGTCCGTAACTATATGCCGGTATCTCGGACGTTTTCACATTGAGGCGTTTAAAGTGCTGGTTATTAACCAAAAATCTGCC
ACATACTGCCTGCCTCTCCT

Downstream 100 bases:

>100_bases
CCACCTCAACAACAAAAGGGTTGGCACTGACACAGATAATGTGAAAGGTGCCGACCCATTCGTTGTTATTTCATGCCCTT
ACTGCATATGCGTGACTACG

Product: succinyl-CoA:coenzyme A transferase

Products: propionate; succinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MACTAADVVEEDLMSDRIANAQLRGKVMSAEEAAQFVNHGDKVGVSGFTGAGYPKALPTAIAERAKEAHARGDEYMIDLF
TGASTAPDCDGVLAEADALRFRTPYQSDPILRSKINDGTTLYADYHLSESGIYVEQGFFGQMNVAIVEAVRITEEGHIVP
SSSVGNNVEYLDNAEKIIIEVNSWQSEELEGMADIYRMNKLPNRQPIPITEAGQRIGTTYIDIDLSKVVAVVETDAPDRN
APFKPLDETSKQIAGHFLDFLEGEVAAGRLTYDGYVMQSGVGNVPNAVMAGLLDSKFENIKAYTEVIQDGMVDLIDAGKM
TVASATSFSLSPEYAERMNAEAKNYAQKIILRPQQISNHPEVVRRLGLICTNGLIEADIYGNVNSTNVTGSRMMNGVGGS
ADFTRNGFISSFITPSVAKGGDISAFVPFVSHVDHTEQDVKVLISEYGYADLRGLAPRQRVEKIIAIAHPDYRPLLQDYY
DRALAFAKEKKIMQTPHLLGEALSFHQRFQETGSMKK

Sequences:

>Translated_517_residues
MACTAADVVEEDLMSDRIANAQLRGKVMSAEEAAQFVNHGDKVGVSGFTGAGYPKALPTAIAERAKEAHARGDEYMIDLF
TGASTAPDCDGVLAEADALRFRTPYQSDPILRSKINDGTTLYADYHLSESGIYVEQGFFGQMNVAIVEAVRITEEGHIVP
SSSVGNNVEYLDNAEKIIIEVNSWQSEELEGMADIYRMNKLPNRQPIPITEAGQRIGTTYIDIDLSKVVAVVETDAPDRN
APFKPLDETSKQIAGHFLDFLEGEVAAGRLTYDGYVMQSGVGNVPNAVMAGLLDSKFENIKAYTEVIQDGMVDLIDAGKM
TVASATSFSLSPEYAERMNAEAKNYAQKIILRPQQISNHPEVVRRLGLICTNGLIEADIYGNVNSTNVTGSRMMNGVGGS
ADFTRNGFISSFITPSVAKGGDISAFVPFVSHVDHTEQDVKVLISEYGYADLRGLAPRQRVEKIIAIAHPDYRPLLQDYY
DRALAFAKEKKIMQTPHLLGEALSFHQRFQETGSMKK
>Mature_516_residues
ACTAADVVEEDLMSDRIANAQLRGKVMSAEEAAQFVNHGDKVGVSGFTGAGYPKALPTAIAERAKEAHARGDEYMIDLFT
GASTAPDCDGVLAEADALRFRTPYQSDPILRSKINDGTTLYADYHLSESGIYVEQGFFGQMNVAIVEAVRITEEGHIVPS
SSVGNNVEYLDNAEKIIIEVNSWQSEELEGMADIYRMNKLPNRQPIPITEAGQRIGTTYIDIDLSKVVAVVETDAPDRNA
PFKPLDETSKQIAGHFLDFLEGEVAAGRLTYDGYVMQSGVGNVPNAVMAGLLDSKFENIKAYTEVIQDGMVDLIDAGKMT
VASATSFSLSPEYAERMNAEAKNYAQKIILRPQQISNHPEVVRRLGLICTNGLIEADIYGNVNSTNVTGSRMMNGVGGSA
DFTRNGFISSFITPSVAKGGDISAFVPFVSHVDHTEQDVKVLISEYGYADLRGLAPRQRVEKIIAIAHPDYRPLLQDYYD
RALAFAKEKKIMQTPHLLGEALSFHQRFQETGSMKK

Specific function: Forms succinyl-CoA from succinate and acetyl-CoA [H]

COG id: COG0427

COG function: function code C; Acetyl-CoA hydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetyl-CoA hydrolase/transferase family [H]

Homologues:

Organism=Escherichia coli, GI1789287, Length=490, Percent_Identity=44.8979591836735, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17538151, Length=488, Percent_Identity=24.5901639344262, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI32563853, Length=476, Percent_Identity=25.8403361344538, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319456, Length=517, Percent_Identity=39.8452611218569, Blast_Score=376, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003702
- InterPro:   IPR006472
- InterPro:   IPR017821 [H]

Pfam domain/function: PF02550 AcetylCoA_hydro; PF04223 CitF [H]

EC number: NA

Molecular weight: Translated: 56515; Mature: 56384

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACTAADVVEEDLMSDRIANAQLRGKVMSAEEAAQFVNHGDKVGVSGFTGAGYPKALPTA
CCCCHHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
IAERAKEAHARGDEYMIDLFTGASTAPDCDGVLAEADALRFRTPYQSDPILRSKINDGTT
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHEECCCCCCCCHHHHCCCCCEE
LYADYHLSESGIYVEQGFFGQMNVAIVEAVRITEEGHIVPSSSVGNNVEYLDNAEKIIIE
EEEEEEECCCCEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCEEEEEE
VNSWQSEELEGMADIYRMNKLPNRQPIPITEAGQRIGTTYIDIDLSKVVAVVETDAPDRN
ECCCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHCCEEEEEEHHHEEEEEECCCCCCC
APFKPLDETSKQIAGHFLDFLEGEVAAGRLTYDGYVMQSGVGNVPNAVMAGLLDSKFENI
CCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCEEEECCCCCCHHHHHHHHHHHHHHHH
KAYTEVIQDGMVDLIDAGKMTVASATSFSLSPEYAERMNAEAKNYAQKIILRPQQISNHP
HHHHHHHHCCHHHHHCCCCEEEEECCCCCCCHHHHHHHCCHHHHHHHHHHCCCHHHCCCH
EVVRRLGLICTNGLIEADIYGNVNSTNVTGSRMMNGVGGSADFTRNGFISSFITPSVAKG
HHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCC
GDISAFVPFVSHVDHTEQDVKVLISEYGYADLRGLAPRQRVEKIIAIAHPDYRPLLQDYY
CCCHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHH
DRALAFAKEKKIMQTPHLLGEALSFHQRFQETGSMKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ACTAADVVEEDLMSDRIANAQLRGKVMSAEEAAQFVNHGDKVGVSGFTGAGYPKALPTA
CCCHHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHH
IAERAKEAHARGDEYMIDLFTGASTAPDCDGVLAEADALRFRTPYQSDPILRSKINDGTT
HHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHEECCCCCCCCHHHHCCCCCEE
LYADYHLSESGIYVEQGFFGQMNVAIVEAVRITEEGHIVPSSSVGNNVEYLDNAEKIIIE
EEEEEEECCCCEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCEEEEEE
VNSWQSEELEGMADIYRMNKLPNRQPIPITEAGQRIGTTYIDIDLSKVVAVVETDAPDRN
ECCCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHCCEEEEEEHHHEEEEEECCCCCCC
APFKPLDETSKQIAGHFLDFLEGEVAAGRLTYDGYVMQSGVGNVPNAVMAGLLDSKFENI
CCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCEEEECCCCCCHHHHHHHHHHHHHHHH
KAYTEVIQDGMVDLIDAGKMTVASATSFSLSPEYAERMNAEAKNYAQKIILRPQQISNHP
HHHHHHHHCCHHHHHCCCCEEEEECCCCCCCHHHHHHHCCHHHHHHHHHHCCCHHHCCCH
EVVRRLGLICTNGLIEADIYGNVNSTNVTGSRMMNGVGGSADFTRNGFISSFITPSVAKG
HHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCC
GDISAFVPFVSHVDHTEQDVKVLISEYGYADLRGLAPRQRVEKIIAIAHPDYRPLLQDYY
CCCHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHH
DRALAFAKEKKIMQTPHLLGEALSFHQRFQETGSMKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: propionyl-CoA; succinate [C]

Specific reaction: propionyl-CoA + succinate = propionate + succinyl-CoA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550525 [H]