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The map label for this gene is galE

Identifier: 38234000

GI number: 38234000

Start: 1432038

End: 1433024

Strand: Direct

Name: galE

Synonym: DIP1415

Alternate gene names: 38234000

Gene position: 1432038-1433024 (Clockwise)

Preceding gene: 38233999

Following gene: 38234002

Centisome position: 57.54

GC content: 49.75

Gene sequence:

>987_bases
ATGAAACTCCTCGTTACCGGTGGTGCCGGATACGTAGGAAGTGTCTGTTCCACTGTTCTGCTCGAACAGGGACACGAAGT
AACAATTGTCGATAATCTTACAACCGGCAATCGCGATGCTGTTCCACTAGGAGCTACTTTTGTCGAGGGTGATATCAAAG
ACGTTGCCGATAACGTTTTATCATCTGATTCTTTTGACGCGGTTCTTCACTTCGCGGCTCGTTCGCTTGTCGGCGAATCA
GTTGAAAAGCCAGATGAATATTGGCAGCACAACATGGTGACCACACTCGCGCTTCTTGATGCCATGAAGCGTAATAACGT
GCGAAACATCGTCTTTTCTTCGACAGCTGCTACATACGGCGAACCCGAAACAGTCCCGATTACTGAAGACGCTCCTACCC
ACCCAACGAATCCATACGGCGCAACCAAGCTGTCTATCGACTACGCGATCACGTCATATGCACATGCATATGGGTTTGCG
GCGACGAGTCTGCGGTACTTCAACGTAGCTGGCGCATATGGTTTGGTGGGTGAAAATCGAGAAATAGAAACCCATCTCAT
TCCGCTCGTTTTACAAGTAGCACTGGGACACCGTGACAAGATTTTCATGTTTGGTGACGACTGGCCAACTGAAGATGGAA
CCCCCATCCGCGATTACATTCATATTCGTGATCTTGCAGATGCCCATATTTTGGCACTTCAAAGTAACGTCGAAGGTAGC
CACCGGATCTTTAATCTCGGATCCGGTGAAGGATATTCGGTCAAACAGGTCATTGATACCTGCAGAGAAGTTACCGGTCA
TCTCATCCCCGCTGAGGTAGCTCCTCGACGGGCTGGTGATCCTGCAGTGCTCATTGCATCATCGGCTAAGGCACAATCCG
AACTGGGTTGGAAACCACAACGGACTGATCTGCACACGATTGTCTCTGATGCCTGGGCTTTTACCTCTCAGCTCGGAGAC
AAAGCCCATAGCGCTTCTCGCGGATAA

Upstream 100 bases:

>100_bases
ATCACGTTGAGCCACAATGGAAAAGATGTCGAACTTATCGATGATCTGGCCCACACTATTCGTATCGAAGAACTCTAAAT
ATTAAAGGCGGCGAAATTAG

Downstream 100 bases:

>100_bases
CAGCGAGTAGATTCATCTTTCACACTCCGCGGTGTGACTTCCAAGAAGTCACACCGCGGATTTTACATTTGTTGCTTCAC
CAAAGTGTTTCTGCGCTTCT

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MKLLVTGGAGYVGSVCSTVLLEQGHEVTIVDNLTTGNRDAVPLGATFVEGDIKDVADNVLSSDSFDAVLHFAARSLVGES
VEKPDEYWQHNMVTTLALLDAMKRNNVRNIVFSSTAATYGEPETVPITEDAPTHPTNPYGATKLSIDYAITSYAHAYGFA
ATSLRYFNVAGAYGLVGENREIETHLIPLVLQVALGHRDKIFMFGDDWPTEDGTPIRDYIHIRDLADAHILALQSNVEGS
HRIFNLGSGEGYSVKQVIDTCREVTGHLIPAEVAPRRAGDPAVLIASSAKAQSELGWKPQRTDLHTIVSDAWAFTSQLGD
KAHSASRG

Sequences:

>Translated_328_residues
MKLLVTGGAGYVGSVCSTVLLEQGHEVTIVDNLTTGNRDAVPLGATFVEGDIKDVADNVLSSDSFDAVLHFAARSLVGES
VEKPDEYWQHNMVTTLALLDAMKRNNVRNIVFSSTAATYGEPETVPITEDAPTHPTNPYGATKLSIDYAITSYAHAYGFA
ATSLRYFNVAGAYGLVGENREIETHLIPLVLQVALGHRDKIFMFGDDWPTEDGTPIRDYIHIRDLADAHILALQSNVEGS
HRIFNLGSGEGYSVKQVIDTCREVTGHLIPAEVAPRRAGDPAVLIASSAKAQSELGWKPQRTDLHTIVSDAWAFTSQLGD
KAHSASRG
>Mature_328_residues
MKLLVTGGAGYVGSVCSTVLLEQGHEVTIVDNLTTGNRDAVPLGATFVEGDIKDVADNVLSSDSFDAVLHFAARSLVGES
VEKPDEYWQHNMVTTLALLDAMKRNNVRNIVFSSTAATYGEPETVPITEDAPTHPTNPYGATKLSIDYAITSYAHAYGFA
ATSLRYFNVAGAYGLVGENREIETHLIPLVLQVALGHRDKIFMFGDDWPTEDGTPIRDYIHIRDLADAHILALQSNVEGS
HRIFNLGSGEGYSVKQVIDTCREVTGHLIPAEVAPRRAGDPAVLIASSAKAQSELGWKPQRTDLHTIVSDAWAFTSQLGD
KAHSASRG

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family

Homologues:

Organism=Homo sapiens, GI56237023, Length=337, Percent_Identity=41.5430267062315, Blast_Score=231, Evalue=5e-61,
Organism=Homo sapiens, GI56118217, Length=337, Percent_Identity=41.5430267062315, Blast_Score=231, Evalue=5e-61,
Organism=Homo sapiens, GI189083684, Length=337, Percent_Identity=41.5430267062315, Blast_Score=231, Evalue=5e-61,
Organism=Homo sapiens, GI42516563, Length=305, Percent_Identity=26.2295081967213, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI7657641, Length=270, Percent_Identity=27.037037037037, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI4504031, Length=336, Percent_Identity=24.702380952381, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786974, Length=333, Percent_Identity=42.9429429429429, Blast_Score=251, Evalue=4e-68,
Organism=Escherichia coli, GI1788353, Length=343, Percent_Identity=29.7376093294461, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI48994969, Length=334, Percent_Identity=28.1437125748503, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788366, Length=358, Percent_Identity=24.8603351955307, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790049, Length=266, Percent_Identity=27.8195488721804, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71982035, Length=341, Percent_Identity=37.2434017595308, Blast_Score=211, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI71982038, Length=343, Percent_Identity=37.0262390670554, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17568069, Length=271, Percent_Identity=28.0442804428044, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI133901786, Length=338, Percent_Identity=23.6686390532544, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI133901788, Length=338, Percent_Identity=23.6686390532544, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI133901790, Length=338, Percent_Identity=23.6686390532544, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539424, Length=338, Percent_Identity=23.6686390532544, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539422, Length=338, Percent_Identity=23.6686390532544, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17507723, Length=338, Percent_Identity=23.3727810650888, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115532424, Length=325, Percent_Identity=23.0769230769231, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6319493, Length=340, Percent_Identity=39.7058823529412, Blast_Score=224, Evalue=1e-59,
Organism=Drosophila melanogaster, GI19923002, Length=338, Percent_Identity=38.1656804733728, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI21356223, Length=311, Percent_Identity=26.0450160771704, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GALE_CORDI (P33119)

Other databases:

- EMBL:   M80338
- EMBL:   M34239
- EMBL:   BX248358
- RefSeq:   NP_939767.1
- ProteinModelPortal:   P33119
- SMR:   P33119
- GeneID:   2649689
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1415
- NMPDR:   fig|257309.1.peg.1358
- HOGENOM:   HBG755066
- OMA:   TQKHPNG
- PhylomeDB:   P33119
- ProtClustDB:   CLSK900066
- BioCyc:   CDIP257309:DIP1415-MONOMER
- BRENDA:   5.1.3.2
- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10366:SF39
- TIGRFAMs:   TIGR01179

Pfam domain/function: PF01370 Epimerase

EC number: =5.1.3.2

Molecular weight: Translated: 35433; Mature: 35433

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: ACT_SITE 139-139 BINDING 115-115

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLVTGGAGYVGSVCSTVLLEQGHEVTIVDNLTTGNRDAVPLGATFVEGDIKDVADNVL
CEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEECCHHHHHHHHHH
SSDSFDAVLHFAARSLVGESVEKPDEYWQHNMVTTLALLDAMKRNNVRNIVFSSTAATYG
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
EPETVPITEDAPTHPTNPYGATKLSIDYAITSYAHAYGFAATSLRYFNVAGAYGLVGENR
CCCEEECCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHEEEEECCCCEEECCCCC
EIETHLIPLVLQVALGHRDKIFMFGDDWPTEDGTPIRDYIHIRDLADAHILALQSNVEGS
CHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHEEEHHHCCCCEEEEEECCCCCC
HRIFNLGSGEGYSVKQVIDTCREVTGHLIPAEVAPRRAGDPAVLIASSAKAQSELGWKPQ
CEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHHCCCCCC
RTDLHTIVSDAWAFTSQLGDKAHSASRG
CCHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKLLVTGGAGYVGSVCSTVLLEQGHEVTIVDNLTTGNRDAVPLGATFVEGDIKDVADNVL
CEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCEEECCHHHHHHHHHH
SSDSFDAVLHFAARSLVGESVEKPDEYWQHNMVTTLALLDAMKRNNVRNIVFSSTAATYG
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
EPETVPITEDAPTHPTNPYGATKLSIDYAITSYAHAYGFAATSLRYFNVAGAYGLVGENR
CCCEEECCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHEEEEECCCCEEECCCCC
EIETHLIPLVLQVALGHRDKIFMFGDDWPTEDGTPIRDYIHIRDLADAHILALQSNVEGS
CHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHEEEHHHCCCCEEEEEECCCCCC
HRIFNLGSGEGYSVKQVIDTCREVTGHLIPAEVAPRRAGDPAVLIASSAKAQSELGWKPQ
CEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHHCCCCCC
RTDLHTIVSDAWAFTSQLGDKAHSASRG
CCHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2116013; 14602910