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The map label for this gene is apt

Identifier: 38233954

GI number: 38233954

Start: 1387088

End: 1387642

Strand: Reverse

Name: apt

Synonym: DIP1369

Alternate gene names: 38233954

Gene position: 1387642-1387088 (Counterclockwise)

Preceding gene: 38233955

Following gene: 38233953

Centisome position: 55.76

GC content: 50.45

Gene sequence:

>555_bases
ATGACTGTCCCCCTGTATGCAGATGCCCGAGAAGCAATTGCGTGTAAAACTCGTTTCGTTCCCGATTTCCCTGTACCAGG
AGTAATTTTCGAGGACCTCACCCCAGTATTGGCTGATGCCGCCGCTTTTTCTCTCATCGTTGATGAATTGGCAAAAAATG
CAATGCGATTGGGAGCTGATTTCATCGGTGGGTTAGACGCACGTGGATTTCTTCTAGGTTCTGCAGTCGCGTACAAAGCC
GGAACCGGCATTCTTGCCATTAGGAAAAAGGGCAAATTGCCTCCGCCAGTACACTCTGAGGAATATTCTTTAGAGTATGG
CACTGCAGCACTCGAGCTACCTGCTGAAGGTCTAGAGTTGGAAGACAAAAAGGTCGTGCTGGTCGACGACGTTTTGGCTA
CTGGCGGCACATTGGATGCGGCTCGCAAATTGATTGAAGCTTGTGGTGCCACTGTAAGCGGATACGCAGTCGTGCTCGAA
GTCGACGGGCTGGGTGGCCGTGAGCGATTGAATGATGCACCTTTGGTAGTAATTAATGAAAGCGCTACGGCGTAA

Upstream 100 bases:

>100_bases
GGATGGAACATGGATAGGTGGTTCTTTTCTAAGAATTCAAAGTAAGAGCAAATGTACGTTATTTTTGATCAGTATCGATT
TCTAGGAAAGAACTGCCTTT

Downstream 100 bases:

>100_bases
CTCAAGTTGTTCCGGTACTTTTGGCTAAAAATAGAGTTGGAAAGGCATATTCGCAACGATGACGCAGGATAAGAAAACAG
CGAAGCAGTCCAATTCGATG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 184; Mature: 183

Protein sequence:

>184_residues
MTVPLYADAREAIACKTRFVPDFPVPGVIFEDLTPVLADAAAFSLIVDELAKNAMRLGADFIGGLDARGFLLGSAVAYKA
GTGILAIRKKGKLPPPVHSEEYSLEYGTAALELPAEGLELEDKKVVLVDDVLATGGTLDAARKLIEACGATVSGYAVVLE
VDGLGGRERLNDAPLVVINESATA

Sequences:

>Translated_184_residues
MTVPLYADAREAIACKTRFVPDFPVPGVIFEDLTPVLADAAAFSLIVDELAKNAMRLGADFIGGLDARGFLLGSAVAYKA
GTGILAIRKKGKLPPPVHSEEYSLEYGTAALELPAEGLELEDKKVVLVDDVLATGGTLDAARKLIEACGATVSGYAVVLE
VDGLGGRERLNDAPLVVINESATA
>Mature_183_residues
TVPLYADAREAIACKTRFVPDFPVPGVIFEDLTPVLADAAAFSLIVDELAKNAMRLGADFIGGLDARGFLLGSAVAYKAG
TGILAIRKKGKLPPPVHSEEYSLEYGTAALELPAEGLELEDKKVVLVDDVLATGGTLDAARKLIEACGATVSGYAVVLEV
DGLGGRERLNDAPLVVINESATA

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=168, Percent_Identity=44.6428571428571, Blast_Score=131, Evalue=3e-31,
Organism=Homo sapiens, GI71773201, Length=128, Percent_Identity=47.65625, Blast_Score=111, Evalue=3e-25,
Organism=Escherichia coli, GI1786675, Length=165, Percent_Identity=40.6060606060606, Blast_Score=120, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17509087, Length=180, Percent_Identity=36.6666666666667, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6323619, Length=168, Percent_Identity=34.5238095238095, Blast_Score=94, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320649, Length=173, Percent_Identity=37.5722543352601, Blast_Score=83, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17136334, Length=168, Percent_Identity=42.2619047619048, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_CORDI (Q6NGY0)

Other databases:

- EMBL:   BX248358
- RefSeq:   NP_939721.1
- ProteinModelPortal:   Q6NGY0
- SMR:   Q6NGY0
- GeneID:   2649900
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1369
- NMPDR:   fig|257309.1.peg.1312
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   Q6NGY0
- ProtClustDB:   PRK02304
- BioCyc:   CDIP257309:DIP1369-MONOMER
- BRENDA:   2.4.2.7
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19198; Mature: 19067

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVPLYADAREAIACKTRFVPDFPVPGVIFEDLTPVLADAAAFSLIVDELAKNAMRLGAD
CCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
FIGGLDARGFLLGSAVAYKAGTGILAIRKKGKLPPPVHSEEYSLEYGTAALELPAEGLEL
HHCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEECCCEEEECCCCCCCC
EDKKVVLVDDVLATGGTLDAARKLIEACGATVSGYAVVLEVDGLGGRERLNDAPLVVINE
CCCEEEEEECHHHCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHCCCCCEEEECC
SATA
CCCC
>Mature Secondary Structure 
TVPLYADAREAIACKTRFVPDFPVPGVIFEDLTPVLADAAAFSLIVDELAKNAMRLGAD
CCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
FIGGLDARGFLLGSAVAYKAGTGILAIRKKGKLPPPVHSEEYSLEYGTAALELPAEGLEL
HHCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEECCCEEEECCCCCCCC
EDKKVVLVDDVLATGGTLDAARKLIEACGATVSGYAVVLEVDGLGGRERLNDAPLVVINE
CCCEEEEEECHHHCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHCCCCCEEEECC
SATA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910