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The map label for this gene is aroK

Identifier: 38233930

GI number: 38233930

Start: 1356838

End: 1357359

Strand: Reverse

Name: aroK

Synonym: DIP1344

Alternate gene names: 38233930

Gene position: 1357359-1356838 (Counterclockwise)

Preceding gene: 38233931

Following gene: 38233929

Centisome position: 54.54

GC content: 48.66

Gene sequence:

>522_bases
GTGAGTGGTCGGGTTCGCCCAATCGTTGTTTTAGTAGGTCCACCGGGGTCAGGTAAAACGACTATTGGCCGTCGTCTTGC
GAATGCCCTGAATACTTCGGTGGTGGATAGCGATGTGTTGATTGAACAACTCCAAGGCAAACCCTGTGGTGTTGTATTTG
CTGAACTCGGTGAGCCAAACTTTCGAGATTTAGAAGCAGAAGTAATAGACTTTGCCCTCACAACAGCAGGGGTAGTGAGC
CTCGGTGGCGGTGCCGTGACAACGGAATCAGTGCGACAAAAGCTTCGAGCGCAAATAGTGGTATGGGTAGATGTATCCGC
AGCGGAAGGCGTGCGTCGAACTGCAGTTGAAAATTCGAGGCCATTACTGGATACAACGAATCCACTTGAACGCTACAGCG
AATTATTAGCTCAGCGTCGTGATTTTTATAAAGAAGTAGCAGATTATCGCGCGCACACAGATGGTCGGAGTCCACAGCAA
ATTGTTGCTGATATTTTGGGCTTTCTTGAAACCTTACGTTGA

Upstream 100 bases:

>100_bases
ACGAAGCGAAATATCGCTGCTTATAACGAATACGTTAAAACCCGGATTGCATTCGATGGTGAGTAGGAAAATGATGAACG
ATCAGTTACTCGAATCAGAC

Downstream 100 bases:

>100_bases
ATCGTGTGACTAGTTTTATCGCCGTATGCCGAAAAGGAATTAAATAGTGCCAACTATAGAAGTGAAAAGCAGTAATCCGT
ACCAAGTACGGATTGATAAA

Product: shikimate kinase

Products: NA

Alternate protein names: SK

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MSGRVRPIVVLVGPPGSGKTTIGRRLANALNTSVVDSDVLIEQLQGKPCGVVFAELGEPNFRDLEAEVIDFALTTAGVVS
LGGGAVTTESVRQKLRAQIVVWVDVSAAEGVRRTAVENSRPLLDTTNPLERYSELLAQRRDFYKEVADYRAHTDGRSPQQ
IVADILGFLETLR

Sequences:

>Translated_173_residues
MSGRVRPIVVLVGPPGSGKTTIGRRLANALNTSVVDSDVLIEQLQGKPCGVVFAELGEPNFRDLEAEVIDFALTTAGVVS
LGGGAVTTESVRQKLRAQIVVWVDVSAAEGVRRTAVENSRPLLDTTNPLERYSELLAQRRDFYKEVADYRAHTDGRSPQQ
IVADILGFLETLR
>Mature_172_residues
SGRVRPIVVLVGPPGSGKTTIGRRLANALNTSVVDSDVLIEQLQGKPCGVVFAELGEPNFRDLEAEVIDFALTTAGVVSL
GGGAVTTESVRQKLRAQIVVWVDVSAAEGVRRTAVENSRPLLDTTNPLERYSELLAQRRDFYKEVADYRAHTDGRSPQQI
VADILGFLETLR

Specific function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate

COG id: COG0703

COG function: function code E; Shikimate kinase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate kinase family

Homologues:

Organism=Escherichia coli, GI87082255, Length=166, Percent_Identity=38.5542168674699, Blast_Score=104, Evalue=3e-24,
Organism=Escherichia coli, GI1786587, Length=166, Percent_Identity=32.5301204819277, Blast_Score=60, Evalue=6e-11,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): AROK_CORDI (Q6NH03)

Other databases:

- EMBL:   BX248357
- RefSeq:   NP_939697.1
- ProteinModelPortal:   Q6NH03
- SMR:   Q6NH03
- GeneID:   2648787
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1344
- NMPDR:   fig|257309.1.peg.1288
- HOGENOM:   HBG335815
- OMA:   VIYLRAN
- PhylomeDB:   Q6NH03
- ProtClustDB:   PRK00131
- BioCyc:   CDIP257309:DIP1344-MONOMER
- BRENDA:   2.7.1.71
- GO:   GO:0005737
- HAMAP:   MF_00109
- InterPro:   IPR003593
- InterPro:   IPR000623
- InterPro:   IPR023000
- PRINTS:   PR01100
- SMART:   SM00382

Pfam domain/function: PF01202 SKI

EC number: =2.7.1.71

Molecular weight: Translated: 18774; Mature: 18642

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS01128 SHIKIMATE_KINASE

Important sites: BINDING 38-38 BINDING 62-62 BINDING 83-83 BINDING 120-120 BINDING 139-139 BINDING 156-156

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGRVRPIVVLVGPPGSGKTTIGRRLANALNTSVVDSDVLIEQLQGKPCGVVFAELGEPN
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
FRDLEAEVIDFALTTAGVVSLGGGAVTTESVRQKLRAQIVVWVDVSAAEGVRRTAVENSR
CHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEEEEEEECCHHHHHHHHHHCCCC
PLLDTTNPLERYSELLAQRRDFYKEVADYRAHTDGRSPQQIVADILGFLETLR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SGRVRPIVVLVGPPGSGKTTIGRRLANALNTSVVDSDVLIEQLQGKPCGVVFAELGEPN
CCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
FRDLEAEVIDFALTTAGVVSLGGGAVTTESVRQKLRAQIVVWVDVSAAEGVRRTAVENSR
CHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHEEEEEEECCHHHHHHHHHHCCCC
PLLDTTNPLERYSELLAQRRDFYKEVADYRAHTDGRSPQQIVADILGFLETLR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910