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The map label for this gene is pyrC [H]

Identifier: 38233919

GI number: 38233919

Start: 1347449

End: 1348795

Strand: Reverse

Name: pyrC [H]

Synonym: DIP1333

Alternate gene names: 38233919

Gene position: 1348795-1347449 (Counterclockwise)

Preceding gene: 38233920

Following gene: 38233918

Centisome position: 54.2

GC content: 50.71

Gene sequence:

>1347_bases
ATGAGTACTCAAAATTATCCAGCAACTGGCCGACTCGCCGAGCCGGAATATGGCACTCTGCTAGTCAAAAACGTGAAGAT
CTACGGAGAGGGTGAGCCTGTCAACGTCTTGATCACTGATGGGGTGATCACTGACACTCACGCTGGTGATGTAAAAGCAG
ATCGTGAAGTAGACGGCCAAGGCGGAGTTTTGCTTCCTGGCCTTGTAGATATTCACGTTCATCTTCGAGAACCAGGCCGC
GAGGATACTGAAACAATTGCGACTGGTTCAGCTGCCGCTGCGAAGGGCGGTTTCACGGCTGTATTCACAATGGCAAACAC
AATGCCTGTAATGGATCAACCGATTATCGCAGAGTCAGTGTGGCATAAAGGCCAAGATATTGGACTTTGCGACGTTCACC
CTGTCGGATCGATAACAAAGGGTCTTGAGGGCAAAGAAATCACCGAATTTGGCATGATGGCACATTCTCAGGCCAAGGTT
CGTATGTTCTCCGATGACGGAAAGTGCGTCGATAATCCACTGATCATGCGTCGAGCAGTTGAGTATGCACGGGGTACGGA
TGTGCTACTAGCACAACATTGCGAGGATCCTCGATTGACTGACGGGGCAGTCGCTCACGAAGGCGCAATGGCAGCCAAAC
TCGGTTTGGGCGGTTGGCCACGCGTTGCAGAAGAGTCGATCGTGGCGCGAGATGCAATCTTAGCCCGCGATTATGGCGGG
CGTATGCACATCTGTCATGCTTCAACACAAGGAACTGTTGAACTTGTTAAATGGGCGAAAGAACATGAAATTCCACTGAC
AGCCGAAGTTACTCCGCACCATTTATTGCTAACTGATGAACGACTCGCCACATATGACGGTGTAAATCGTGTTAATCCGC
CACTTCGTGAAAACTCCGATATTCTCGCATTACGTGACGCATTGCTCAACGGAACTATTGACTGCGTAGCAACTGACCAT
GCACCGCACGGGTCCGAAGATAAATGTTGCGAATTTGAACATGCGAAACCAGGTATGTTGGGCTTGGAGACTTCCTTAGC
AGTGGTTGCAGCAGTCTTCGTGGAAACTGGACTCGCAGATTGGCGTTTTGTAGCCAAAGTCATGAGTGAGCGTCCTGCAG
AAATCGTCAAACTTCCTGGCCATGGCCGGCCAATCGCAGTCGGTGAGCCAGCGAATTTAACGATCGTAGATCCAGGTGCC
AAGTGGACTGCTTCGGGTGAAAAGATGGCGTCCAAAGCAACAAATACGCCATATGAGGGCATGGAATTTAATGCGCGGGT
AACGACCACGATTTTGCGCGGTCGTCTGACCTGTGTCGATGGTGAACCAACTCAAGCACGAGCGTAA

Upstream 100 bases:

>100_bases
GGTTAGTAATGGGGTGCACACCCGAATGGCCGTTTTGTTCACTCTTATCGCTGGCCAAGACGCAGCGGCATTTTAAAAAA
CTCAAGGAAGAGCAGCAACT

Downstream 100 bases:

>100_bases
CGAACAAACGGGTGTAAAAAGCGCTAAGTCTGAGAAAATTGGGTAACTTATCCACCAGCTGGCTTTATCGCCTGAGCACC
TCAAAACGCACAAAGTGAAA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSTQNYPATGRLAEPEYGTLLVKNVKIYGEGEPVNVLITDGVITDTHAGDVKADREVDGQGGVLLPGLVDIHVHLREPGR
EDTETIATGSAAAAKGGFTAVFTMANTMPVMDQPIIAESVWHKGQDIGLCDVHPVGSITKGLEGKEITEFGMMAHSQAKV
RMFSDDGKCVDNPLIMRRAVEYARGTDVLLAQHCEDPRLTDGAVAHEGAMAAKLGLGGWPRVAEESIVARDAILARDYGG
RMHICHASTQGTVELVKWAKEHEIPLTAEVTPHHLLLTDERLATYDGVNRVNPPLRENSDILALRDALLNGTIDCVATDH
APHGSEDKCCEFEHAKPGMLGLETSLAVVAAVFVETGLADWRFVAKVMSERPAEIVKLPGHGRPIAVGEPANLTIVDPGA
KWTASGEKMASKATNTPYEGMEFNARVTTTILRGRLTCVDGEPTQARA

Sequences:

>Translated_448_residues
MSTQNYPATGRLAEPEYGTLLVKNVKIYGEGEPVNVLITDGVITDTHAGDVKADREVDGQGGVLLPGLVDIHVHLREPGR
EDTETIATGSAAAAKGGFTAVFTMANTMPVMDQPIIAESVWHKGQDIGLCDVHPVGSITKGLEGKEITEFGMMAHSQAKV
RMFSDDGKCVDNPLIMRRAVEYARGTDVLLAQHCEDPRLTDGAVAHEGAMAAKLGLGGWPRVAEESIVARDAILARDYGG
RMHICHASTQGTVELVKWAKEHEIPLTAEVTPHHLLLTDERLATYDGVNRVNPPLRENSDILALRDALLNGTIDCVATDH
APHGSEDKCCEFEHAKPGMLGLETSLAVVAAVFVETGLADWRFVAKVMSERPAEIVKLPGHGRPIAVGEPANLTIVDPGA
KWTASGEKMASKATNTPYEGMEFNARVTTTILRGRLTCVDGEPTQARA
>Mature_447_residues
STQNYPATGRLAEPEYGTLLVKNVKIYGEGEPVNVLITDGVITDTHAGDVKADREVDGQGGVLLPGLVDIHVHLREPGRE
DTETIATGSAAAAKGGFTAVFTMANTMPVMDQPIIAESVWHKGQDIGLCDVHPVGSITKGLEGKEITEFGMMAHSQAKVR
MFSDDGKCVDNPLIMRRAVEYARGTDVLLAQHCEDPRLTDGAVAHEGAMAAKLGLGGWPRVAEESIVARDAILARDYGGR
MHICHASTQGTVELVKWAKEHEIPLTAEVTPHHLLLTDERLATYDGVNRVNPPLRENSDILALRDALLNGTIDCVATDHA
PHGSEDKCCEFEHAKPGMLGLETSLAVVAAVFVETGLADWRFVAKVMSERPAEIVKLPGHGRPIAVGEPANLTIVDPGAK
WTASGEKMASKATNTPYEGMEFNARVTTTILRGRLTCVDGEPTQARA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=386, Percent_Identity=31.0880829015544, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1786722, Length=429, Percent_Identity=27.972027972028, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI87082175, Length=420, Percent_Identity=24.5238095238095, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193204318, Length=383, Percent_Identity=29.7650130548303, Blast_Score=122, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6322218, Length=442, Percent_Identity=26.9230769230769, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24642586, Length=389, Percent_Identity=29.8200514138817, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI18859883, Length=467, Percent_Identity=26.5524625267666, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 48051; Mature: 47920

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQNYPATGRLAEPEYGTLLVKNVKIYGEGEPVNVLITDGVITDTHAGDVKADREVDGQ
CCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCEEEEEECCEEECCCCCCCCCCCCCCCC
GGVLLPGLVDIHVHLREPGREDTETIATGSAAAAKGGFTAVFTMANTMPVMDQPIIAESV
CCEECCCEEEEEEEECCCCCCCHHHEECCCCHHCCCCCEEEEEECCCCCCCCCCHHHHHH
WHKGQDIGLCDVHPVGSITKGLEGKEITEFGMMAHSQAKVRMFSDDGKCVDNPLIMRRAV
HCCCCCCCEECCCCCCHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHH
EYARGTDVLLAQHCEDPRLTDGAVAHEGAMAAKLGLGGWPRVAEESIVARDAILARDYGG
HHHCCCCEEEECCCCCCCCCCCCHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCC
RMHICHASTQGTVELVKWAKEHEIPLTAEVTPHHLLLTDERLATYDGVNRVNPPLRENSD
EEEEEECCCCCHHHHHHHHHHCCCCEEEECCCCEEEEECCHHHHHCCCCCCCCCCCCCCC
ILALRDALLNGTIDCVATDHAPHGSEDKCCEFEHAKPGMLGLETSLAVVAAVFVETGLAD
CHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCHH
WRFVAKVMSERPAEIVKLPGHGRPIAVGEPANLTIVDPGAKWTASGEKMASKATNTPYEG
HHHHHHHHHCCCCEEEECCCCCCEEEECCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCC
MEFNARVTTTILRGRLTCVDGEPTQARA
EEECCEEEEEEECCEEEEECCCCCCCCC
>Mature Secondary Structure 
STQNYPATGRLAEPEYGTLLVKNVKIYGEGEPVNVLITDGVITDTHAGDVKADREVDGQ
CCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCEEEEEECCEEECCCCCCCCCCCCCCCC
GGVLLPGLVDIHVHLREPGREDTETIATGSAAAAKGGFTAVFTMANTMPVMDQPIIAESV
CCEECCCEEEEEEEECCCCCCCHHHEECCCCHHCCCCCEEEEEECCCCCCCCCCHHHHHH
WHKGQDIGLCDVHPVGSITKGLEGKEITEFGMMAHSQAKVRMFSDDGKCVDNPLIMRRAV
HCCCCCCCEECCCCCCHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHH
EYARGTDVLLAQHCEDPRLTDGAVAHEGAMAAKLGLGGWPRVAEESIVARDAILARDYGG
HHHCCCCEEEECCCCCCCCCCCCHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCC
RMHICHASTQGTVELVKWAKEHEIPLTAEVTPHHLLLTDERLATYDGVNRVNPPLRENSD
EEEEEECCCCCHHHHHHHHHHCCCCEEEECCCCEEEEECCHHHHHCCCCCCCCCCCCCCC
ILALRDALLNGTIDCVATDHAPHGSEDKCCEFEHAKPGMLGLETSLAVVAAVFVETGLAD
CHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCHH
WRFVAKVMSERPAEIVKLPGHGRPIAVGEPANLTIVDPGAKWTASGEKMASKATNTPYEG
HHHHHHHHHCCCCEEEECCCCCCEEEECCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCC
MEFNARVTTTILRGRLTCVDGEPTQARA
EEECCEEEEEEECCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]