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The map label for this gene is ribH

Identifier: 38233902

GI number: 38233902

Start: 1328235

End: 1328702

Strand: Reverse

Name: ribH

Synonym: DIP1316

Alternate gene names: 38233902

Gene position: 1328702-1328235 (Counterclockwise)

Preceding gene: 38233903

Following gene: 38233901

Centisome position: 53.39

GC content: 49.15

Gene sequence:

>468_bases
GTGAGCAAAGAGGGACTGCCCAATGTATCTTCGGTAGCAGGAGCAGGTCTTGTTGTCGGAATAGTCTCCGCAACGTGGAA
TGAAAAGATCTGTAATCAGCTCCATGCTGAAGCGATTCGCACGGCAAAGGACTGCGGTGCAAAAGTCATCGAAACACGAG
TGATCGGTGCGCTGGAGCTACCGATTGTAGTGCAAAAACTCGCTCAGACCTGTGATGCGGTGGTTGCTAATGGTTGTGTG
ATTAAAGGTGGCACTCCTCATTTTGACTACGTTTGCGACTCGGTAACTGAAGGGCTTACCCGAATTGCTTTAGATAGTGG
AGTACCAGTCGGTAACGGAGTGCTTACTACTTTGAATGAAGAACAGGCGATTGACCGCGCTGGTTTTGATGGTTCCACTG
AGAATAAAGGAGCAGAGGCAACCATTGCGGCTATGCATACTGCGCTTGTTCTAAGGGATTTGCCGTAA

Upstream 100 bases:

>100_bases
GGAAGTGCACGAAGATAATATTCGTTATTTGACCACAAAACGGGATCGAATGAACCATGATCTGCCATGGATTGCCGAAT
ACAAAAAGGAGCAAAGCTAA

Downstream 100 bases:

>100_bases
AGTACAACGTCGCAGTCACGTAAGCTGAGATCGTTACGATTGAAGCTGTGGCGCCTTAAGTACTAGAGTCGTGTGAAGGC
AAACGCATGATAAGTGCTTC

Product: 6,7-dimethyl-8-ribityllumazine synthase

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain

Number of amino acids: Translated: 155; Mature: 154

Protein sequence:

>155_residues
MSKEGLPNVSSVAGAGLVVGIVSATWNEKICNQLHAEAIRTAKDCGAKVIETRVIGALELPIVVQKLAQTCDAVVANGCV
IKGGTPHFDYVCDSVTEGLTRIALDSGVPVGNGVLTTLNEEQAIDRAGFDGSTENKGAEATIAAMHTALVLRDLP

Sequences:

>Translated_155_residues
MSKEGLPNVSSVAGAGLVVGIVSATWNEKICNQLHAEAIRTAKDCGAKVIETRVIGALELPIVVQKLAQTCDAVVANGCV
IKGGTPHFDYVCDSVTEGLTRIALDSGVPVGNGVLTTLNEEQAIDRAGFDGSTENKGAEATIAAMHTALVLRDLP
>Mature_154_residues
SKEGLPNVSSVAGAGLVVGIVSATWNEKICNQLHAEAIRTAKDCGAKVIETRVIGALELPIVVQKLAQTCDAVVANGCVI
KGGTPHFDYVCDSVTEGLTRIALDSGVPVGNGVLTTLNEEQAIDRAGFDGSTENKGAEATIAAMHTALVLRDLP

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family

Homologues:

Organism=Escherichia coli, GI1786617, Length=140, Percent_Identity=43.5714285714286, Blast_Score=89, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324429, Length=163, Percent_Identity=36.1963190184049, Blast_Score=79, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISB_CORDI (P61721)

Other databases:

- EMBL:   BX248357
- RefSeq:   NP_939669.1
- ProteinModelPortal:   P61721
- SMR:   P61721
- GeneID:   2649870
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1316
- NMPDR:   fig|257309.1.peg.1260
- HOGENOM:   HBG311126
- OMA:   ARWHGEL
- PhylomeDB:   P61721
- ProtClustDB:   PRK00061
- BioCyc:   CDIP257309:DIP1316-MONOMER
- BRENDA:   2.5.1.9
- HAMAP:   MF_00178
- InterPro:   IPR002180
- Gene3D:   G3DSA:3.40.50.960
- PANTHER:   PTHR21058
- TIGRFAMs:   TIGR00114

Pfam domain/function: PF00885 DMRL_synthase; SSF52121 DMRL_synthase

EC number: =2.5.1.9

Molecular weight: Translated: 16011; Mature: 15880

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKEGLPNVSSVAGAGLVVGIVSATWNEKICNQLHAEAIRTAKDCGAKVIETRVIGALEL
CCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PIVVQKLAQTCDAVVANGCVIKGGTPHFDYVCDSVTEGLTRIALDSGVPVGNGVLTTLNE
HHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCH
EQAIDRAGFDGSTENKGAEATIAAMHTALVLRDLP
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKEGLPNVSSVAGAGLVVGIVSATWNEKICNQLHAEAIRTAKDCGAKVIETRVIGALEL
CCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PIVVQKLAQTCDAVVANGCVIKGGTPHFDYVCDSVTEGLTRIALDSGVPVGNGVLTTLNE
HHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCH
EQAIDRAGFDGSTENKGAEATIAAMHTALVLRDLP
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910