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The map label for this gene is uvrC

Identifier: 38233900

GI number: 38233900

Start: 1325463

End: 1327526

Strand: Reverse

Name: uvrC

Synonym: DIP1314

Alternate gene names: 38233900

Gene position: 1327526-1325463 (Counterclockwise)

Preceding gene: 38233901

Following gene: 38233899

Centisome position: 53.34

GC content: 46.66

Gene sequence:

>2064_bases
GTGTCTGACCCATCTACATATCGCCCAGCCCCCGGCACCATTCCAACGGAACCGGGGGTCTATAAGTTTCGTGATCCCGA
AGGCAGGGTCATTTATGTAGGTAAAGCAATCAACCTACGATCGCGGTTGTCCAATTATTTCCAAGATCTCAGTGTTTTGC
ATCCGCGCACGCGGCAGATGGTAACCACAGCTACCTCAGTAGAATGGACAGTCGTTGCCTCTGAAGTAGAAGCGCTTCAG
CTGGAATATACTTGGATTAAAAAATTCGATCCTCATTTCAACGTTAAATATCGCGATGATAAAACGTACCCAGTACTCGC
AGTTTCAGTAGGTGAGAGGTTTCCCCGTGCTTATTTTTATCGCGGTCCGCAGCGAAAAGGAGTGCGATATTACGGCCCAT
ATTCCCATGCATGGGCTGTTCGAGAAACTTTGGATTTGCTGACACGAGTTTTCCCCATTCGAACTTGTACCAAAGCCGTA
TTTAATAGGCATGAGTCATTAGGAAGGCCATGTTTGCTGGGGTATATCGACAAGTGTTCAGCTCCGTGTATTGGTCGAGT
GAGCGAATCTGAACATCGAATAATAGTAGATGGATTCTGCTCATTCATGGCGGGTAACACCGATTCGGTCGTGCGGCGCT
TAACTAACGAGATGATCTCGGCCTCAGAGGCTCTAGACTTTGAAAAAGCAGCTCGTAAACGTGACGATCTGAATGCTGTT
CGTAAAATTACGGAACAACAAGCAGTAGTCCTTGGGGATGGTACCGACGCAGATGTTATTGCAGTTGCTGCTGATGATCT
TGAAGCTTCAATTCAATTATTCCACGTGAGAAGTGGCAAGATTCGAGGTCAACGCGGGTGGATTGTTGAGCGTACCGACA
ATTCTGAAAGTGAATTGGAAGAGCTATTACAATCGTTCCTTATTCGGTTCTATTCCGATGAAGTGGCACATGAGGATCAA
GTATCCGATAAAGAACTAACAGTTGCTCGGCGAGGCGTCGATAAGCAGTCCCATGAAAGTGATCTTGCCAATCGTCGTAT
TAATACCTCGGTGGTTCCTAAAGAGGTGTTAGTACATAAAGCTCCTGCAAATGTTGAGCAAACTACCGCAGTTTTGCGTA
GTTTGCGTCATTCGAATGTGGATGTGCGCGTACCTCAGCGTGGCGATAAACGAGCGTTAGCAGATACAGTTTTTGCCAAT
GCTCAAGAAGCTTTGCGACAGCATAAAATTAAGCGAGTATCGGATTTAACTACACGATCCGCTGCCCTACAAGAGATTCA
TGAGGCTCTTGGCCTAGACGAACCGCCTCTGCGCATTGAGTGTACAGATATTTCTCATATTCAAGGCACAGACGTAGTGG
CCTCACTTGTGGTTTTTGAAGATGGACTGCCGAAAAAATCGGACTACCGTCGTTACAAAATCAAAGAGGCGGCAGGCGAG
GGTAAGTCCAACGATGTTGGGTCTATTGCAGAAGTCGTACGTCGAAGGTTCGCACGATACAAAAACGATTGCCGCATGGT
TCCTCAAGAGGATGAGTTTGACGGCTCGCGATTTGAAGATGAATCGTTGGCGGGAGAAAACACTGTGGCAGCGAAACAGA
GGTTTGCTTATTCACCTCAATTGTTCATAGTAGACGGTGGAGCGCCCCAAGTAGCTGCAGCACAAGATGTGCTCGATGAA
TTGGGGATTACGGATGTAGCGCTAATCGGAATTGCTAAACGCTTAGAGGAAATATGGTTACCTGGCGAAGAAGACCCATT
GATTCTTCCACGAAATTCTCAAGGGTTGTACCTTATTCAGCAGCTGCGTGATGAAGCACATCGATTCGCTATTACATTTC
ACCGACAACAGCGATCGCAACGGATGCGACGGTCTATTCTTGACGATATCAAAGGCCTAGGCCCTGCACGTCGAAAAGTT
TTAGTAGCGCATTTTGGTTCGGTCAAAGAACTAAAAAAGGCATCGGAATCAGAGATTATGATGGTAAACGGAATTGGTCC
TGCTCTTGCACATAGTATTTATGTCGCATTGCACCCAGACTCAGATGACTCCTCAGTACAATAG

Upstream 100 bases:

>100_bases
GTGGGCCATTCAAGCTGGTGATGGTGCACGATCAATCTCAGCCATTGAAGATTTTCGTATTCTTGAGTCTCAATTTATGC
CAGAGGATTAAGCCACAGCA

Downstream 100 bases:

>100_bases
GCGGTATGAACCTCAACATGAGAACTGATGTCGAGCCTAGAACTGAAATCCCACCAGTAGTAATTACAGGTCTGTCTGGC
GCAGGATTGAGTTCTGCAGC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 687; Mature: 686

Protein sequence:

>687_residues
MSDPSTYRPAPGTIPTEPGVYKFRDPEGRVIYVGKAINLRSRLSNYFQDLSVLHPRTRQMVTTATSVEWTVVASEVEALQ
LEYTWIKKFDPHFNVKYRDDKTYPVLAVSVGERFPRAYFYRGPQRKGVRYYGPYSHAWAVRETLDLLTRVFPIRTCTKAV
FNRHESLGRPCLLGYIDKCSAPCIGRVSESEHRIIVDGFCSFMAGNTDSVVRRLTNEMISASEALDFEKAARKRDDLNAV
RKITEQQAVVLGDGTDADVIAVAADDLEASIQLFHVRSGKIRGQRGWIVERTDNSESELEELLQSFLIRFYSDEVAHEDQ
VSDKELTVARRGVDKQSHESDLANRRINTSVVPKEVLVHKAPANVEQTTAVLRSLRHSNVDVRVPQRGDKRALADTVFAN
AQEALRQHKIKRVSDLTTRSAALQEIHEALGLDEPPLRIECTDISHIQGTDVVASLVVFEDGLPKKSDYRRYKIKEAAGE
GKSNDVGSIAEVVRRRFARYKNDCRMVPQEDEFDGSRFEDESLAGENTVAAKQRFAYSPQLFIVDGGAPQVAAAQDVLDE
LGITDVALIGIAKRLEEIWLPGEEDPLILPRNSQGLYLIQQLRDEAHRFAITFHRQQRSQRMRRSILDDIKGLGPARRKV
LVAHFGSVKELKKASESEIMMVNGIGPALAHSIYVALHPDSDDSSVQ

Sequences:

>Translated_687_residues
MSDPSTYRPAPGTIPTEPGVYKFRDPEGRVIYVGKAINLRSRLSNYFQDLSVLHPRTRQMVTTATSVEWTVVASEVEALQ
LEYTWIKKFDPHFNVKYRDDKTYPVLAVSVGERFPRAYFYRGPQRKGVRYYGPYSHAWAVRETLDLLTRVFPIRTCTKAV
FNRHESLGRPCLLGYIDKCSAPCIGRVSESEHRIIVDGFCSFMAGNTDSVVRRLTNEMISASEALDFEKAARKRDDLNAV
RKITEQQAVVLGDGTDADVIAVAADDLEASIQLFHVRSGKIRGQRGWIVERTDNSESELEELLQSFLIRFYSDEVAHEDQ
VSDKELTVARRGVDKQSHESDLANRRINTSVVPKEVLVHKAPANVEQTTAVLRSLRHSNVDVRVPQRGDKRALADTVFAN
AQEALRQHKIKRVSDLTTRSAALQEIHEALGLDEPPLRIECTDISHIQGTDVVASLVVFEDGLPKKSDYRRYKIKEAAGE
GKSNDVGSIAEVVRRRFARYKNDCRMVPQEDEFDGSRFEDESLAGENTVAAKQRFAYSPQLFIVDGGAPQVAAAQDVLDE
LGITDVALIGIAKRLEEIWLPGEEDPLILPRNSQGLYLIQQLRDEAHRFAITFHRQQRSQRMRRSILDDIKGLGPARRKV
LVAHFGSVKELKKASESEIMMVNGIGPALAHSIYVALHPDSDDSSVQ
>Mature_686_residues
SDPSTYRPAPGTIPTEPGVYKFRDPEGRVIYVGKAINLRSRLSNYFQDLSVLHPRTRQMVTTATSVEWTVVASEVEALQL
EYTWIKKFDPHFNVKYRDDKTYPVLAVSVGERFPRAYFYRGPQRKGVRYYGPYSHAWAVRETLDLLTRVFPIRTCTKAVF
NRHESLGRPCLLGYIDKCSAPCIGRVSESEHRIIVDGFCSFMAGNTDSVVRRLTNEMISASEALDFEKAARKRDDLNAVR
KITEQQAVVLGDGTDADVIAVAADDLEASIQLFHVRSGKIRGQRGWIVERTDNSESELEELLQSFLIRFYSDEVAHEDQV
SDKELTVARRGVDKQSHESDLANRRINTSVVPKEVLVHKAPANVEQTTAVLRSLRHSNVDVRVPQRGDKRALADTVFANA
QEALRQHKIKRVSDLTTRSAALQEIHEALGLDEPPLRIECTDISHIQGTDVVASLVVFEDGLPKKSDYRRYKIKEAAGEG
KSNDVGSIAEVVRRRFARYKNDCRMVPQEDEFDGSRFEDESLAGENTVAAKQRFAYSPQLFIVDGGAPQVAAAQDVLDEL
GITDVALIGIAKRLEEIWLPGEEDPLILPRNSQGLYLIQQLRDEAHRFAITFHRQQRSQRMRRSILDDIKGLGPARRKVL
VAHFGSVKELKKASESEIMMVNGIGPALAHSIYVALHPDSDDSSVQ

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=697, Percent_Identity=33.5724533715925, Blast_Score=342, Evalue=4e-95,
Organism=Escherichia coli, GI1788037, Length=197, Percent_Identity=26.3959390862944, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_CORDI (Q6NH31)

Other databases:

- EMBL:   BX248357
- RefSeq:   NP_939667.1
- ProteinModelPortal:   Q6NH31
- GeneID:   2649868
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1314
- NMPDR:   fig|257309.1.peg.1258
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q6NH31
- ProtClustDB:   PRK00558
- BioCyc:   CDIP257309:DIP1314-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 77281; Mature: 77150

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPSTYRPAPGTIPTEPGVYKFRDPEGRVIYVGKAINLRSRLSNYFQDLSVLHPRTRQM
CCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCHHHH
VTTATSVEWTVVASEVEALQLEYTWIKKFDPHFNVKYRDDKTYPVLAVSVGERFPRAYFY
EEEECCEEEEEEECCHHHEEEEEEEHECCCCCCCEEECCCCCCEEEEEECCCCCCHHHHC
RGPQRKGVRYYGPYSHAWAVRETLDLLTRVFPIRTCTKAVFNRHESLGRPCLLGYIDKCS
CCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHCC
APCIGRVSESEHRIIVDGFCSFMAGNTDSVVRRLTNEMISASEALDFEKAARKRDDLNAV
CCCCCCCCCCCCEEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKITEQQAVVLGDGTDADVIAVAADDLEASIQLFHVRSGKIRGQRGWIVERTDNSESELE
HHHHHCCEEEEECCCCCCEEEEEECCCCCEEEEEEEECCCEECCCCEEEEECCCCHHHHH
ELLQSFLIRFYSDEVAHEDQVSDKELTVARRGVDKQSHESDLANRRINTSVVPKEVLVHK
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHCC
APANVEQTTAVLRSLRHSNVDVRVPQRGDKRALADTVFANAQEALRQHKIKRVSDLTTRS
CCCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AALQEIHEALGLDEPPLRIECTDISHIQGTDVVASLVVFEDGLPKKSDYRRYKIKEAAGE
HHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCHHEEEHHHCCC
GKSNDVGSIAEVVRRRFARYKNDCRMVPQEDEFDGSRFEDESLAGENTVAAKQRFAYSPQ
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHCCCCE
LFIVDGGAPQVAAAQDVLDELGITDVALIGIAKRLEEIWLPGEEDPLILPRNSQGLYLIQ
EEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHH
QLRDEAHRFAITFHRQQRSQRMRRSILDDIKGLGPARRKVLVAHFGSVKELKKASESEIM
HHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHEHHHHCCCHHHHHCCCCCCEE
MVNGIGPALAHSIYVALHPDSDDSSVQ
EEECCCHHHHCEEEEEECCCCCCCCCC
>Mature Secondary Structure 
SDPSTYRPAPGTIPTEPGVYKFRDPEGRVIYVGKAINLRSRLSNYFQDLSVLHPRTRQM
CCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCHHHH
VTTATSVEWTVVASEVEALQLEYTWIKKFDPHFNVKYRDDKTYPVLAVSVGERFPRAYFY
EEEECCEEEEEEECCHHHEEEEEEEHECCCCCCCEEECCCCCCEEEEEECCCCCCHHHHC
RGPQRKGVRYYGPYSHAWAVRETLDLLTRVFPIRTCTKAVFNRHESLGRPCLLGYIDKCS
CCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHCC
APCIGRVSESEHRIIVDGFCSFMAGNTDSVVRRLTNEMISASEALDFEKAARKRDDLNAV
CCCCCCCCCCCCEEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKITEQQAVVLGDGTDADVIAVAADDLEASIQLFHVRSGKIRGQRGWIVERTDNSESELE
HHHHHCCEEEEECCCCCCEEEEEECCCCCEEEEEEEECCCEECCCCEEEEECCCCHHHHH
ELLQSFLIRFYSDEVAHEDQVSDKELTVARRGVDKQSHESDLANRRINTSVVPKEVLVHK
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHCC
APANVEQTTAVLRSLRHSNVDVRVPQRGDKRALADTVFANAQEALRQHKIKRVSDLTTRS
CCCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AALQEIHEALGLDEPPLRIECTDISHIQGTDVVASLVVFEDGLPKKSDYRRYKIKEAAGE
HHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCHHEEEHHHCCC
GKSNDVGSIAEVVRRRFARYKNDCRMVPQEDEFDGSRFEDESLAGENTVAAKQRFAYSPQ
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHCCCCE
LFIVDGGAPQVAAAQDVLDELGITDVALIGIAKRLEEIWLPGEEDPLILPRNSQGLYLIQ
EEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHH
QLRDEAHRFAITFHRQQRSQRMRRSILDDIKGLGPARRKVLVAHFGSVKELKKASESEIM
HHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHEHHHHCCCHHHHHCCCCCCEE
MVNGIGPALAHSIYVALHPDSDDSSVQ
EEECCCHHHHCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910