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The map label for this gene is pgl [H]

Identifier: 38233892

GI number: 38233892

Start: 1317678

End: 1318394

Strand: Direct

Name: pgl [H]

Synonym: DIP1306

Alternate gene names: 38233892

Gene position: 1317678-1318394 (Clockwise)

Preceding gene: 38233891

Following gene: 38233922

Centisome position: 52.95

GC content: 48.81

Gene sequence:

>717_bases
ATGGTTGAAGTTATTCGAGTATCAGACCTCGACGCAGTTATTCAGGAAGCCCATCGCAGATTCCTCCAGGTTATCGATGA
TGTTGTTTCAAACGGCGGAGTACATGGCGATGGTGTCGCTCGTATAGTCCTCACCGGCGGCGGTGCAGGAATTGGCTTAC
TTAAGGAGCTATCCCATAGTTCAATTGATTGGTCAAAAATACATGTGTTCTTCGGTGATGAACGAAACGTACCAGTGACA
CATCCAGATTCGAATGAGGGGCAAGCACGCGAAGTACTACTCAATCGAATTGCCATTCCATCATCAAACATCCATGGTTT
CCATCTCAATGGTGGCGAGATGTCTACTCCCGCCTCAGCATATAGCGAATGCATCAATAAATATGCACCGCGAGGGTTTG
ACCTTCATTTATTAGGAATGGGCGGCGAAGGACACATCAATTCGTTGTTCCCCGATTCATCGGCTATTAAAGAAGATGTA
CACCTAGTCTCTGTGGTTACCGACTCTCCAAAGCCACCAGCACAGCGTGTGTCGCTCACGCTTCCTGCTGTAAATTCTTC
TGCACGTGTGTGGCTACTCGTTGCCGGTGCAGAAAAAGCTGAAGCAGCACAGCACGTCGTTGCTGCTTCACCAGCCGACC
AATGGCCAGCTGCAGGCGTTCACGGCACCAAAGAAACGTTACTTATACTCGATAATTCGGCAGCACAGCTTCTTTAG

Upstream 100 bases:

>100_bases
CGCCATCTCGACCCAGATATCGCTTATGCTCGAGCACTTCGCGGTCTGAGTAGAGTGTCCTATCCTACTCAATAAAATTT
TCGAAAGATGAAGCACTTTT

Downstream 100 bases:

>100_bases
TCGTATAAAACCAAAACGTGTGGGGCGGAAAGCTGAATTTTAGCTTTCCGCCCCACACGTTTTGGTTTTACTTGTATGCC
TGAATGAGGTTCAACGCAAC

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MVEVIRVSDLDAVIQEAHRRFLQVIDDVVSNGGVHGDGVARIVLTGGGAGIGLLKELSHSSIDWSKIHVFFGDERNVPVT
HPDSNEGQAREVLLNRIAIPSSNIHGFHLNGGEMSTPASAYSECINKYAPRGFDLHLLGMGGEGHINSLFPDSSAIKEDV
HLVSVVTDSPKPPAQRVSLTLPAVNSSARVWLLVAGAEKAEAAQHVVAASPADQWPAAGVHGTKETLLILDNSAAQLL

Sequences:

>Translated_238_residues
MVEVIRVSDLDAVIQEAHRRFLQVIDDVVSNGGVHGDGVARIVLTGGGAGIGLLKELSHSSIDWSKIHVFFGDERNVPVT
HPDSNEGQAREVLLNRIAIPSSNIHGFHLNGGEMSTPASAYSECINKYAPRGFDLHLLGMGGEGHINSLFPDSSAIKEDV
HLVSVVTDSPKPPAQRVSLTLPAVNSSARVWLLVAGAEKAEAAQHVVAASPADQWPAAGVHGTKETLLILDNSAAQLL
>Mature_238_residues
MVEVIRVSDLDAVIQEAHRRFLQVIDDVVSNGGVHGDGVARIVLTGGGAGIGLLKELSHSSIDWSKIHVFFGDERNVPVT
HPDSNEGQAREVLLNRIAIPSSNIHGFHLNGGEMSTPASAYSECINKYAPRGFDLHLLGMGGEGHINSLFPDSSAIKEDV
HLVSVVTDSPKPPAQRVSLTLPAVNSSARVWLLVAGAEKAEAAQHVVAASPADQWPAAGVHGTKETLLILDNSAAQLL

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=223, Percent_Identity=34.9775784753363, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI6912586, Length=180, Percent_Identity=35.5555555555556, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI115533060, Length=187, Percent_Identity=31.0160427807487, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI115533058, Length=187, Percent_Identity=31.0160427807487, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6321687, Length=253, Percent_Identity=29.2490118577075, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321957, Length=168, Percent_Identity=30.952380952381, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324362, Length=181, Percent_Identity=32.5966850828729, Blast_Score=83, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319918, Length=178, Percent_Identity=33.1460674157303, Blast_Score=83, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24641119, Length=199, Percent_Identity=35.1758793969849, Blast_Score=94, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 25202; Mature: 25202

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEVIRVSDLDAVIQEAHRRFLQVIDDVVSNGGVHGDGVARIVLTGGGAGIGLLKELSHS
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHCCC
SIDWSKIHVFFGDERNVPVTHPDSNEGQAREVLLNRIAIPSSNIHGFHLNGGEMSTPASA
CCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHH
YSECINKYAPRGFDLHLLGMGGEGHINSLFPDSSAIKEDVHLVSVVTDSPKPPAQRVSLT
HHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHCEEEEEEEECCCCCCHHEEEEE
LPAVNSSARVWLLVAGAEKAEAAQHVVAASPADQWPAAGVHGTKETLLILDNSAAQLL
EECCCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCHHHCC
>Mature Secondary Structure
MVEVIRVSDLDAVIQEAHRRFLQVIDDVVSNGGVHGDGVARIVLTGGGAGIGLLKELSHS
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHCCC
SIDWSKIHVFFGDERNVPVTHPDSNEGQAREVLLNRIAIPSSNIHGFHLNGGEMSTPASA
CCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHH
YSECINKYAPRGFDLHLLGMGGEGHINSLFPDSSAIKEDVHLVSVVTDSPKPPAQRVSLT
HHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHCEEEEEEEECCCCCCHHEEEEE
LPAVNSSARVWLLVAGAEKAEAAQHVVAASPADQWPAAGVHGTKETLLILDNSAAQLL
EECCCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]