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The map label for this gene is thrB

Identifier: 38233632

GI number: 38233632

Start: 1018282

End: 1019208

Strand: Direct

Name: thrB

Synonym: DIP1037

Alternate gene names: 38233632

Gene position: 1018282-1019208 (Clockwise)

Preceding gene: 38233631

Following gene: 38233634

Centisome position: 40.92

GC content: 53.61

Gene sequence:

>927_bases
ATGGCTATAGAGCTGCCGGTAGGTAAAAAAGTAACGGTCACGGTGCCAGCATCGTCGGCAAACTTGGGCCCAGGCTTTGA
CACTTTGGGTTTGGCATTGTCTTTGTATGACACCGTGGAAGTGGAGGTGACTGACCACGGTCTTGAAGTCGAGGTTTTTG
GTGAAGGCCAAGGAGAGCTTCCCCTTGATGGTTCCCACCTTGTTGTCAAAGCAATCCGTGCGGGATTGAAGGCTGCTGAT
GTACAGGTACCTGGGCTAAGAGTTGTCTGCCATAACAACATTCCGCAGTCACGTGGTTTAGGCTCGTCTGCGGCTGCTGC
TGTTGCCGGTGTTGCGGCGGCAAATGGTCTAGCTGGATTCCCGCTTGACGACGCCCGTGTGGTTCAGCTTTCCTCAGCAT
TCGAAGGGCATCCAGACAATGCCGCTGCTTCAGTACTAGGAAATGCGGTTGTTTCATGGACTGAAATTCCAGTCGACGGA
CGTACTGAACCGCAATTCAAGGCGGTGACGATTAACGTCGATAGCCGAATTAAAGCGACAGCGTTGGTTCCTGATTTCCA
TGCGTCAACGGAAGCTGTTCGTCGAGTTTTGCCTAGCGACGTTACTCACCTAGATGCGCGATTTAATGTTTCGCGTTGTG
CCGTCATGACAGTAGCTTTGCAGCACCATCCAGAGCTGTTGTGGGAAGGTACCCGCGATAGACTGCATCAGCCGTACCGT
GCAGATGTCTTGCCTGTGACGGCGGAATGGGTCAACCGACTCCGCAATCGTGGCTATGCTGCCTACTTGTCTGGGGCTGG
GCCGACCATCATGGTGCTTCATACTGAGCCAGTTGACGAGGCTGTTCTCAATGACGCGCGTGAAGCTGGGTTGCGTGTGC
TGTCCTTGGATGTAGCAGATGCTGTATCGGTGAAAGTCGATGCCTAG

Upstream 100 bases:

>100_bases
GCCAAGGAATCGGAACTTGAAGCAACCGTTGAACAGATTAAGAATTCTGACTCGGTGAAAAAGATCAACAGCGTTATTCG
TCTAGCAGGGGAGTAAACCC

Downstream 100 bases:

>100_bases
ATAACCGCATGCCAATTTAACTACCGCCCTCCTAGTCAAGTCTCTAGGAGGGCGGTAGTCGTCATTCGGCGGAATCGCTA
TGGGAGGATCTACCTGGGCC

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MAIELPVGKKVTVTVPASSANLGPGFDTLGLALSLYDTVEVEVTDHGLEVEVFGEGQGELPLDGSHLVVKAIRAGLKAAD
VQVPGLRVVCHNNIPQSRGLGSSAAAAVAGVAAANGLAGFPLDDARVVQLSSAFEGHPDNAAASVLGNAVVSWTEIPVDG
RTEPQFKAVTINVDSRIKATALVPDFHASTEAVRRVLPSDVTHLDARFNVSRCAVMTVALQHHPELLWEGTRDRLHQPYR
ADVLPVTAEWVNRLRNRGYAAYLSGAGPTIMVLHTEPVDEAVLNDAREAGLRVLSLDVADAVSVKVDA

Sequences:

>Translated_308_residues
MAIELPVGKKVTVTVPASSANLGPGFDTLGLALSLYDTVEVEVTDHGLEVEVFGEGQGELPLDGSHLVVKAIRAGLKAAD
VQVPGLRVVCHNNIPQSRGLGSSAAAAVAGVAAANGLAGFPLDDARVVQLSSAFEGHPDNAAASVLGNAVVSWTEIPVDG
RTEPQFKAVTINVDSRIKATALVPDFHASTEAVRRVLPSDVTHLDARFNVSRCAVMTVALQHHPELLWEGTRDRLHQPYR
ADVLPVTAEWVNRLRNRGYAAYLSGAGPTIMVLHTEPVDEAVLNDAREAGLRVLSLDVADAVSVKVDA
>Mature_307_residues
AIELPVGKKVTVTVPASSANLGPGFDTLGLALSLYDTVEVEVTDHGLEVEVFGEGQGELPLDGSHLVVKAIRAGLKAADV
QVPGLRVVCHNNIPQSRGLGSSAAAAVAGVAAANGLAGFPLDDARVVQLSSAFEGHPDNAAASVLGNAVVSWTEIPVDGR
TEPQFKAVTINVDSRIKATALVPDFHASTEAVRRVLPSDVTHLDARFNVSRCAVMTVALQHHPELLWEGTRDRLHQPYRA
DVLPVTAEWVNRLRNRGYAAYLSGAGPTIMVLHTEPVDEAVLNDAREAGLRVLSLDVADAVSVKVDA

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=282, Percent_Identity=29.0780141843972, Blast_Score=85, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6321814, Length=338, Percent_Identity=31.0650887573964, Blast_Score=134, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_CORDI (Q6NHU3)

Other databases:

- EMBL:   BX248356
- RefSeq:   NP_939399.1
- ProteinModelPortal:   Q6NHU3
- SMR:   Q6NHU3
- GeneID:   2648622
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1037
- NMPDR:   fig|257309.1.peg.990
- HOGENOM:   HBG646290
- OMA:   FDCLGAA
- PhylomeDB:   Q6NHU3
- ProtClustDB:   PRK01212
- BioCyc:   CDIP257309:DIP1037-MONOMER
- BRENDA:   2.7.1.39
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 32455; Mature: 32324

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIELPVGKKVTVTVPASSANLGPGFDTLGLALSLYDTVEVEVTDHGLEVEVFGEGQGEL
CEEECCCCCEEEEEEECCCCCCCCCCHHHHHEEEEEEEEEEEEECCCEEEEEEECCCCCC
PLDGSHLVVKAIRAGLKAADVQVPGLRVVCHNNIPQSRGLGSSAAAAVAGVAAANGLAGF
CCCCCHHHHHHHHCCCCCCCEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCC
PLDDARVVQLSSAFEGHPDNAAASVLGNAVVSWTEIPVDGRTEPQFKAVTINVDSRIKAT
CCCCCEEEEEEHHCCCCCCHHHHHHHHHHHEEEEECCCCCCCCCCEEEEEEEECCCEEEE
ALVPDFHASTEAVRRVLPSDVTHLDARFNVSRCAVMTVALQHHPELLWEGTRDRLHQPYR
EECCCCCCCHHHHHHHCCCCCCEECCCCCHHHHHEEEHHHHHCCHHEECCCHHHCCCCCC
ADVLPVTAEWVNRLRNRGYAAYLSGAGPTIMVLHTEPVDEAVLNDAREAGLRVLSLDVAD
CCEEEECHHHHHHHHHCCEEEEECCCCCEEEEEECCCCHHHHHHHHHHCCEEEEEEECCC
AVSVKVDA
EEEEEECC
>Mature Secondary Structure 
AIELPVGKKVTVTVPASSANLGPGFDTLGLALSLYDTVEVEVTDHGLEVEVFGEGQGEL
EEECCCCCEEEEEEECCCCCCCCCCHHHHHEEEEEEEEEEEEECCCEEEEEEECCCCCC
PLDGSHLVVKAIRAGLKAADVQVPGLRVVCHNNIPQSRGLGSSAAAAVAGVAAANGLAGF
CCCCCHHHHHHHHCCCCCCCEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCC
PLDDARVVQLSSAFEGHPDNAAASVLGNAVVSWTEIPVDGRTEPQFKAVTINVDSRIKAT
CCCCCEEEEEEHHCCCCCCHHHHHHHHHHHEEEEECCCCCCCCCCEEEEEEEECCCEEEE
ALVPDFHASTEAVRRVLPSDVTHLDARFNVSRCAVMTVALQHHPELLWEGTRDRLHQPYR
EECCCCCCCHHHHHHHCCCCCCEECCCCCHHHHHEEEHHHHHCCHHEECCCHHHCCCCCC
ADVLPVTAEWVNRLRNRGYAAYLSGAGPTIMVLHTEPVDEAVLNDAREAGLRVLSLDVAD
CCEEEECHHHHHHHHHCCEEEEECCCCCEEEEEECCCCHHHHHHHHHHCCEEEEEEECCC
AVSVKVDA
EEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910