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The map label for this gene is thrA [H]

Identifier: 38233631

GI number: 38233631

Start: 1016931

End: 1018277

Strand: Direct

Name: thrA [H]

Synonym: DIP1036

Alternate gene names: 38233631

Gene position: 1016931-1018277 (Clockwise)

Preceding gene: 38233630

Following gene: 38233632

Centisome position: 40.86

GC content: 52.64

Gene sequence:

>1347_bases
ATGAACCCTGACTCACAGCATCATGCAACGTTTAACCCTGGCAAAGGTGAAGGATCACCTGTGGGAATCGCGATTTTGGG
CTATGGCACAGTGGGTAGCCAAGTTCTTCGTCTCCTCACCGAGAATCATAATGATTTCCAACATCGCGCCGGTGGACCGC
TTGAGATCAAGGGTGTTGCTGCCTCCAGTGTGGAAAAGCACCGTGGATCTCTTGCCGATCAACTAGGACTACTTACAGAC
GATGCGCGCTCGCTTATTGCTCGTGATGACGTAGATATCGTTGTGGAAGTCATCGGTGGAATCGACTATCCGCGTGAGCT
CATTCTTGAGGCTCTACACAGCGGAAAGTCTGTGGTGACAGCAAACAAGGCGCTGGTCGCGGCTCATTCAGAGGAGCTTG
CTGCTGCAGCTGACGAGGCCGGAGTTGACCTCTACTTCGAGGCCGCAGTTGCCGCTGCAATCCCAGTGCTTGGCCCACTA
CGTCGTTCCTTGGCTGGTGACCAAATCCAGTCGGTTGCCGGCATTGTTAACGGAACGACCAACTTCATCTTGGACGCCAT
GGATTCTACGGGTGCAAGCTATGATGACATGCTCGCAGAAGCCACCCGATTGGGCTATGCAGAAGCAGACCCAACAGCAG
ATGTTGAAGGCCATGACGCAGCATCGAAAGCAGCTATTCTTGCATCCTTGGCATTCCATACACGCGTAACTTATGCGGAT
GTGTACTGTGAGGGAATCTCGAAGATCACGGCAGACGACATCAACGCAGCCAAGGAAGCAGGCTTTACCATCAAACTGCT
TGCTATCTGCGAGCGGCTCAATGTTGATGGCGTAGAAAAGGTTTCTGCGCGCGTTCATCCCACCTTGGTCCCACGCAATC
ACCCCCTGGCCAGCGTAGATAAGTCCTTCAACGCAATTTTCGTTGAAGCTGAAGCTGCAGGCCGACTTATGTTCTATGGC
AATGGTGCTGGTGGTAACCCAACGGCATCGGCGGTGCTCGGCGATATTGTCGGCGCTGCTCGCAACAAGGTTTTTGGTGG
GCGTGCCCCAGGCGAATCCACCTATGCGGATCTTCCCATTGCACCATTCGGTGAGGTCCCTACACGCTTCCATATCGATA
TGGAAGTAGAAGACCGCGTTGGCGTATTGGCGGATCTTGCTAAGACTTTCTCTAACCATGGTATTTCGTTGCGCACTGTG
CGTCAGGCTGAAAAAGATGGTCATGCCCGCTTGATTGTGGTTACGCATACGGCCAAGGAATCGGAACTTGAAGCAACCGT
TGAACAGATTAAGAATTCTGACTCGGTGAAAAAGATCAACAGCGTTATTCGTCTAGCAGGGGAGTAA

Upstream 100 bases:

>100_bases
TCGTGCCCCCATGGCACCGAAGTGGGAAGCGGAACGCTGCTACAATTTGGGAAACCTAATGCCCACCTGTTCCGCTATAG
GAACCTCTACGAGGAGTGCT

Downstream 100 bases:

>100_bases
ACCCATGGCTATAGAGCTGCCGGTAGGTAAAAAAGTAACGGTCACGGTGCCAGCATCGTCGGCAAACTTGGGCCCAGGCT
TTGACACTTTGGGTTTGGCA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MNPDSQHHATFNPGKGEGSPVGIAILGYGTVGSQVLRLLTENHNDFQHRAGGPLEIKGVAASSVEKHRGSLADQLGLLTD
DARSLIARDDVDIVVEVIGGIDYPRELILEALHSGKSVVTANKALVAAHSEELAAAADEAGVDLYFEAAVAAAIPVLGPL
RRSLAGDQIQSVAGIVNGTTNFILDAMDSTGASYDDMLAEATRLGYAEADPTADVEGHDAASKAAILASLAFHTRVTYAD
VYCEGISKITADDINAAKEAGFTIKLLAICERLNVDGVEKVSARVHPTLVPRNHPLASVDKSFNAIFVEAEAAGRLMFYG
NGAGGNPTASAVLGDIVGAARNKVFGGRAPGESTYADLPIAPFGEVPTRFHIDMEVEDRVGVLADLAKTFSNHGISLRTV
RQAEKDGHARLIVVTHTAKESELEATVEQIKNSDSVKKINSVIRLAGE

Sequences:

>Translated_448_residues
MNPDSQHHATFNPGKGEGSPVGIAILGYGTVGSQVLRLLTENHNDFQHRAGGPLEIKGVAASSVEKHRGSLADQLGLLTD
DARSLIARDDVDIVVEVIGGIDYPRELILEALHSGKSVVTANKALVAAHSEELAAAADEAGVDLYFEAAVAAAIPVLGPL
RRSLAGDQIQSVAGIVNGTTNFILDAMDSTGASYDDMLAEATRLGYAEADPTADVEGHDAASKAAILASLAFHTRVTYAD
VYCEGISKITADDINAAKEAGFTIKLLAICERLNVDGVEKVSARVHPTLVPRNHPLASVDKSFNAIFVEAEAAGRLMFYG
NGAGGNPTASAVLGDIVGAARNKVFGGRAPGESTYADLPIAPFGEVPTRFHIDMEVEDRVGVLADLAKTFSNHGISLRTV
RQAEKDGHARLIVVTHTAKESELEATVEQIKNSDSVKKINSVIRLAGE
>Mature_448_residues
MNPDSQHHATFNPGKGEGSPVGIAILGYGTVGSQVLRLLTENHNDFQHRAGGPLEIKGVAASSVEKHRGSLADQLGLLTD
DARSLIARDDVDIVVEVIGGIDYPRELILEALHSGKSVVTANKALVAAHSEELAAAADEAGVDLYFEAAVAAAIPVLGPL
RRSLAGDQIQSVAGIVNGTTNFILDAMDSTGASYDDMLAEATRLGYAEADPTADVEGHDAASKAAILASLAFHTRVTYAD
VYCEGISKITADDINAAKEAGFTIKLLAICERLNVDGVEKVSARVHPTLVPRNHPLASVDKSFNAIFVEAEAAGRLMFYG
NGAGGNPTASAVLGDIVGAARNKVFGGRAPGESTYADLPIAPFGEVPTRFHIDMEVEDRVGVLADLAKTFSNHGISLRTV
RQAEKDGHARLIVVTHTAKESELEATVEQIKNSDSVKKINSVIRLAGE

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=369, Percent_Identity=26.5582655826558, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786183, Length=250, Percent_Identity=28.8, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322599, Length=333, Percent_Identity=24.3243243243243, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47066; Mature: 47066

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPDSQHHATFNPGKGEGSPVGIAILGYGTVGSQVLRLLTENHNDFQHRAGGPLEIKGVA
CCCCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCHHHCCCCCEEEECCH
ASSVEKHRGSLADQLGLLTDDARSLIARDDVDIVVEVIGGIDYPRELILEALHSGKSVVT
HHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHCCCEEEE
ANKALVAAHSEELAAAADEAGVDLYFEAAVAAAIPVLGPLRRSLAGDQIQSVAGIVNGTT
ECCEEEEECHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCH
NFILDAMDSTGASYDDMLAEATRLGYAEADPTADVEGHDAASKAAILASLAFHTRVTYAD
HHEEECHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEHHH
VYCEGISKITADDINAAKEAGFTIKLLAICERLNVDGVEKVSARVHPTLVPRNHPLASVD
HHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHCCCCCHHHHHHCCCCEECCCCCCCHHHC
KSFNAIFVEAEAAGRLMFYGNGAGGNPTASAVLGDIVGAARNKVFGGRAPGESTYADLPI
CCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
APFGEVPTRFHIDMEVEDRVGVLADLAKTFSNHGISLRTVRQAEKDGHARLIVVTHTAKE
CCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCEEEEEEEECCCH
SELEATVEQIKNSDSVKKINSVIRLAGE
HHHHHHHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNPDSQHHATFNPGKGEGSPVGIAILGYGTVGSQVLRLLTENHNDFQHRAGGPLEIKGVA
CCCCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCHHHCCCCCEEEECCH
ASSVEKHRGSLADQLGLLTDDARSLIARDDVDIVVEVIGGIDYPRELILEALHSGKSVVT
HHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHCCCEEEE
ANKALVAAHSEELAAAADEAGVDLYFEAAVAAAIPVLGPLRRSLAGDQIQSVAGIVNGTT
ECCEEEEECHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCH
NFILDAMDSTGASYDDMLAEATRLGYAEADPTADVEGHDAASKAAILASLAFHTRVTYAD
HHEEECHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEHHH
VYCEGISKITADDINAAKEAGFTIKLLAICERLNVDGVEKVSARVHPTLVPRNHPLASVD
HHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHCCCCCHHHHHHCCCCEECCCCCCCHHHC
KSFNAIFVEAEAAGRLMFYGNGAGGNPTASAVLGDIVGAARNKVFGGRAPGESTYADLPI
CCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
APFGEVPTRFHIDMEVEDRVGVLADLAKTFSNHGISLRTVRQAEKDGHARLIVVTHTAKE
CCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCEEEEEEEECCCH
SELEATVEQIKNSDSVKKINSVIRLAGE
HHHHHHHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2835591; 3320973; 9362124; 12948626; 1902466 [H]