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The map label for this gene is lysA [H]

Identifier: 38233630

GI number: 38233630

Start: 1015432

End: 1016760

Strand: Direct

Name: lysA [H]

Synonym: DIP1035

Alternate gene names: 38233630

Gene position: 1015432-1016760 (Clockwise)

Preceding gene: 38233629

Following gene: 38233631

Centisome position: 40.8

GC content: 52.52

Gene sequence:

>1329_bases
ATGGATTTCAACGCGCTGCCTTCCCACGTGTGGCCACGACATGCTGCACGTGAGGCTGGGGGAGATGTCAGTGTCGCCGG
TGTATCTTTGGTGTCCATTGCTCAGGAATATGGAACTCCCGTATTTGTAGTTGATGAGGCAGATTTCCGAAGCCGTTGTC
GTGACATGGCAGCAGCTTTTGGCGGCGCGGATAAGGTCCACTACGCATCCAAAGCGTTTCTTACTCGCCGAATTGCTCGG
TGGGTTGAAGAAGAAGGCTTAAGCCTCGATATCGCATCTCATGGGGAACTACAGGTCGCACTGCGGGCAGGTTTTCCGTC
GCAACGCATAACGGCACATGGCAACAATAAAGATCGTGCCTTTTTGCAAGCGCTTGTCGACGCCCGTGTGGGACATGTCG
TCATCGACTCCATGGTGGAACTCGAACGCCTTGAGGAAATTGCTGGTGCGGCAGGTATTCAACAGCCTGTGATGGTGCGT
GTAAAACCTGGTATCGAAGCCCACACTCACGAGTTCATCGCTACTAGCCACGAAGACCAAAAATTCGGTTTCTCGTTGGC
CTCTGGTTCTGCATATGCGGCGGCGGCGCGCGCTATCTCGTCTGAGTCTTTGTACCTCATTGGTCTGCATTGTCACGTGG
GATCGCAGGTATTTGACGCTCAGGGATTTAGCTTGGCAGCTCAGCGTGTTCTCGATTTGTACTCCAGAATTCACCGGGAA
CTTGGTGTGGATTTAGAGCAGCTTGACCTCGGTGGCGGATACGGAATTGCGTATACCGAAGATGAAACACCATTGGATGT
TGCTGCTGTGGCTCAAGATTTGCTCAAAGCAGTACAGTCTGCGGCTGATGAAATCGGTATCAGTGCACCGGAAATCCTCG
TTGAGCCTGGGCGAGCCATTGCTGGTCCCTCAACCGTTACGGTTTATGAGGTAGGAACGGTAAAAGACGTCCACGTGACT
GACCGGCAGACGCGTCGTTATCTAGCAGTAGATGGTGGCATGAGCGACAACATTCGTCCTGCTCTTTATGAGGCTGAGTA
TGATGCGCGGGTGATTAACCGAAACATCACCGGAACACCAATTTCGAGTCGAGTAGTGGGCTCGCATTGTGAATCCGGAG
ACATTTTGATCAACGATGCGATGCTGCCTGATGATATTCGCGAGGGCGACTTGTTGGCATTGGCCGCTACCGGTGCCTAT
TGCTTTGCTATGAGCAGTCGCTACAACATGATGGGGCGTCCTGCGGTTGTGAGTGTGCTCGATGGGCAAGCAAGCGTGAT
GGTGAAACGGGAAAATATCGACGATTTATTGCAGTTAGACGTTCCGTAA

Upstream 100 bases:

>100_bases
CTATTCACACTGCACGTTTGGCGCTGGCTAACGCGACGCGTCAGGTATTGGCTAATGCGCTGAGGCTTGTCGGAGTATCT
GCACCGGAGCGTATGTAGTC

Downstream 100 bases:

>100_bases
CATGAGACGAACGTCCAAATACCCCCATTTTATGCATATATTGAGCGTGAAATGGGGGTAAAGAGAAGTATCGTGCCCCC
ATGGCACCGAAGTGGGAAGC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MDFNALPSHVWPRHAAREAGGDVSVAGVSLVSIAQEYGTPVFVVDEADFRSRCRDMAAAFGGADKVHYASKAFLTRRIAR
WVEEEGLSLDIASHGELQVALRAGFPSQRITAHGNNKDRAFLQALVDARVGHVVIDSMVELERLEEIAGAAGIQQPVMVR
VKPGIEAHTHEFIATSHEDQKFGFSLASGSAYAAAARAISSESLYLIGLHCHVGSQVFDAQGFSLAAQRVLDLYSRIHRE
LGVDLEQLDLGGGYGIAYTEDETPLDVAAVAQDLLKAVQSAADEIGISAPEILVEPGRAIAGPSTVTVYEVGTVKDVHVT
DRQTRRYLAVDGGMSDNIRPALYEAEYDARVINRNITGTPISSRVVGSHCESGDILINDAMLPDDIREGDLLALAATGAY
CFAMSSRYNMMGRPAVVSVLDGQASVMVKRENIDDLLQLDVP

Sequences:

>Translated_442_residues
MDFNALPSHVWPRHAAREAGGDVSVAGVSLVSIAQEYGTPVFVVDEADFRSRCRDMAAAFGGADKVHYASKAFLTRRIAR
WVEEEGLSLDIASHGELQVALRAGFPSQRITAHGNNKDRAFLQALVDARVGHVVIDSMVELERLEEIAGAAGIQQPVMVR
VKPGIEAHTHEFIATSHEDQKFGFSLASGSAYAAAARAISSESLYLIGLHCHVGSQVFDAQGFSLAAQRVLDLYSRIHRE
LGVDLEQLDLGGGYGIAYTEDETPLDVAAVAQDLLKAVQSAADEIGISAPEILVEPGRAIAGPSTVTVYEVGTVKDVHVT
DRQTRRYLAVDGGMSDNIRPALYEAEYDARVINRNITGTPISSRVVGSHCESGDILINDAMLPDDIREGDLLALAATGAY
CFAMSSRYNMMGRPAVVSVLDGQASVMVKRENIDDLLQLDVP
>Mature_442_residues
MDFNALPSHVWPRHAAREAGGDVSVAGVSLVSIAQEYGTPVFVVDEADFRSRCRDMAAAFGGADKVHYASKAFLTRRIAR
WVEEEGLSLDIASHGELQVALRAGFPSQRITAHGNNKDRAFLQALVDARVGHVVIDSMVELERLEEIAGAAGIQQPVMVR
VKPGIEAHTHEFIATSHEDQKFGFSLASGSAYAAAARAISSESLYLIGLHCHVGSQVFDAQGFSLAAQRVLDLYSRIHRE
LGVDLEQLDLGGGYGIAYTEDETPLDVAAVAQDLLKAVQSAADEIGISAPEILVEPGRAIAGPSTVTVYEVGTVKDVHVT
DRQTRRYLAVDGGMSDNIRPALYEAEYDARVINRNITGTPISSRVVGSHCESGDILINDAMLPDDIREGDLLALAATGAY
CFAMSSRYNMMGRPAVVSVLDGQASVMVKRENIDDLLQLDVP

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=385, Percent_Identity=23.3766233766234, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1789203, Length=429, Percent_Identity=28.9044289044289, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1789307, Length=320, Percent_Identity=26.875, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562780, Length=365, Percent_Identity=23.013698630137, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 47543; Mature: 47543

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFNALPSHVWPRHAAREAGGDVSVAGVSLVSIAQEYGTPVFVVDEADFRSRCRDMAAAF
CCCCCCCCCCCCHHHHHHCCCCEEEHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHH
GGADKVHYASKAFLTRRIARWVEEEGLSLDIASHGELQVALRAGFPSQRITAHGNNKDRA
CCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEECCCCCCCEEECCCCCHHH
FLQALVDARVGHVVIDSMVELERLEEIAGAAGIQQPVMVRVKPGIEAHTHEFIATSHEDQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHCCCCCCC
KFGFSLASGSAYAAAARAISSESLYLIGLHCHVGSQVFDAQGFSLAAQRVLDLYSRIHRE
CCCEEECCCCHHHHHHHHHCCCCEEEEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHH
LGVDLEQLDLGGGYGIAYTEDETPLDVAAVAQDLLKAVQSAADEIGISAPEILVEPGRAI
HCCCHHHEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEE
AGPSTVTVYEVGTVKDVHVTDRQTRRYLAVDGGMSDNIRPALYEAEYDARVINRNITGTP
CCCCEEEEEEECCEEEEEECCCCCCEEEEECCCCCCCCCCEEEECCCCCEEECCCCCCCC
ISSRVVGSHCESGDILINDAMLPDDIREGDLLALAATGAYCFAMSSRYNMMGRPAVVSVL
CCHHHHCCCCCCCCEEEECCCCCCCCCCCCEEEEEECCEEEEEECCCCCCCCCCEEEEEE
DGQASVMVKRENIDDLLQLDVP
CCCEEEEEEECCCCHHHEECCC
>Mature Secondary Structure
MDFNALPSHVWPRHAAREAGGDVSVAGVSLVSIAQEYGTPVFVVDEADFRSRCRDMAAAF
CCCCCCCCCCCCHHHHHHCCCCEEEHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHH
GGADKVHYASKAFLTRRIARWVEEEGLSLDIASHGELQVALRAGFPSQRITAHGNNKDRA
CCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEECCCCCCCEEECCCCCHHH
FLQALVDARVGHVVIDSMVELERLEEIAGAAGIQQPVMVRVKPGIEAHTHEFIATSHEDQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHCCCCCCC
KFGFSLASGSAYAAAARAISSESLYLIGLHCHVGSQVFDAQGFSLAAQRVLDLYSRIHRE
CCCEEECCCCHHHHHHHHHCCCCEEEEEEEEECCCCEECCCCHHHHHHHHHHHHHHHHHH
LGVDLEQLDLGGGYGIAYTEDETPLDVAAVAQDLLKAVQSAADEIGISAPEILVEPGRAI
HCCCHHHEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEE
AGPSTVTVYEVGTVKDVHVTDRQTRRYLAVDGGMSDNIRPALYEAEYDARVINRNITGTP
CCCCEEEEEEECCEEEEEECCCCCCEEEEECCCCCCCCCCEEEECCCCCEEECCCCCCCC
ISSRVVGSHCESGDILINDAMLPDDIREGDLLALAATGAYCFAMSSRYNMMGRPAVVSVL
CCHHHHCCCCCCCCEEEECCCCCCCCCCCCEEEEEECCEEEEEECCCCCCCCCCEEEEEE
DGQASVMVKRENIDDLLQLDVP
CCCEEEEEEECCCCHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]