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The map label for this gene is galK [H]

Identifier: 38233610

GI number: 38233610

Start: 988473

End: 989702

Strand: Direct

Name: galK [H]

Synonym: DIP1015

Alternate gene names: 38233610

Gene position: 988473-989702 (Clockwise)

Preceding gene: 38233609

Following gene: 38233613

Centisome position: 39.72

GC content: 57.4

Gene sequence:

>1230_bases
ATGCCACGCTGGATTAACACCCGAAGCCCCGAACAATTAGACACCGACGCCCGAGCACTGTTTACCCAAGCCTTCGGCAA
CGAACCCGAAGGCGTATGGGCAGCACCAGGACGCGTCAACGTCATCGGTGACCACGTCGATTACGCCGGCGGAATGTCCA
TCCCCTTCGCACTGCAACAAAACACAGCCGTAGCAGTACGTCAGCGTGACGACGCCCTCCTCAACGTCGTATCGCTCATT
CCAGGTGCCAAAGAACCAGCACGCCTGAGCATCCCCCTAGCTGAAGTCGGCCCGCTCAACCCCGACTCATGGGCAGGCTA
TGTTGTAGGAACAGTGTGGGCAGGCGTGCAATCAGGAGTGATTCCACGTTGCAGCGGCCTCGACATCGCAGTTGTCTCCG
ACGTACCGGTAGGCTCCGGACTATCCTCCTCAGCCGCACTGGAATGCTCTATAGGAGTAGCAGCATACGAGCTCGCAGTC
GGACACGCACCAGACGCAGCCGCACGCGCCGAGCTAGTCGAGGCAGCAATTCGTGCGGAAAATGAGGTCGTGGGGGCGTC
GACAGGCGGACTCGACCAGCGGGCTTCAATTTTTGGTGAAGAAGGCAAAGCCCTTGTCATCGACTTTCACACTAATCAAT
TTCGGCTGGTACCCTTCGACCTTGAGTCGCGGGGTTTGGTTCTGCTCATTGCAGACACCAATGCTCCGCACGCGCTTAAC
GACGGCCAATATGCTTCTCGACGTGGCGTGACCGATGAAGTCGCTCATGCTCTAGGAGGGGAGAATGCCACCATTCGCAG
CGTGAATTCCACAGGAGACATCCTTGATCGCACCCGCGAATGGGCCGCTGCTAACAACAAAGATATTGATGTAGTAGTTC
GCCGCGTGAAGCACATCGTGGAAGAAACTGAACGCACCGCTGAAGCTGCAACTGCGCTTGATGCGGGGAACTTTGATCGC
TTCCGCGAGCTCATGAAGGACTCCCATATCTCGTTACGGGACCAATATAAGGTTTCTACACCCGAGCTTGATTCAGCATT
CGATGCGGCTGGGCAATATGGTGCACGAATGACAGGTGGTGGCTTCGGTGGCTCGGTGATTACCCTCGTCGCCGCTGACC
GAGTAGAAGAAGTAGCAACAGCGATTGCAGACGCTGCGCAACGCCAAGGCTATCCAGAACCCACATTTGTGGTGGCCTCG
CCGGGTCGAGGCGCGCGACGCCTGAGCTAA

Upstream 100 bases:

>100_bases
CGAATGAAGTTCCTCGCCGGTTCAGAATCAAGCCAAGGGGTCTGGATCAACGACACAACCCCAGAACGCATTGCACAACG
ATTCAAGGAGGTATGGCCAC

Downstream 100 bases:

>100_bases
GGCATAGGGGAGAGCCCTTCGCAATCATGTGTGTGACTGCGAAGGGCTTTTAGTTACACCACTGCACGGCCTTGGATGAA
GAGGTGCTGTGGCATGCTTC

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MPRWINTRSPEQLDTDARALFTQAFGNEPEGVWAAPGRVNVIGDHVDYAGGMSIPFALQQNTAVAVRQRDDALLNVVSLI
PGAKEPARLSIPLAEVGPLNPDSWAGYVVGTVWAGVQSGVIPRCSGLDIAVVSDVPVGSGLSSSAALECSIGVAAYELAV
GHAPDAAARAELVEAAIRAENEVVGASTGGLDQRASIFGEEGKALVIDFHTNQFRLVPFDLESRGLVLLIADTNAPHALN
DGQYASRRGVTDEVAHALGGENATIRSVNSTGDILDRTREWAAANNKDIDVVVRRVKHIVEETERTAEAATALDAGNFDR
FRELMKDSHISLRDQYKVSTPELDSAFDAAGQYGARMTGGGFGGSVITLVAADRVEEVATAIADAAQRQGYPEPTFVVAS
PGRGARRLS

Sequences:

>Translated_409_residues
MPRWINTRSPEQLDTDARALFTQAFGNEPEGVWAAPGRVNVIGDHVDYAGGMSIPFALQQNTAVAVRQRDDALLNVVSLI
PGAKEPARLSIPLAEVGPLNPDSWAGYVVGTVWAGVQSGVIPRCSGLDIAVVSDVPVGSGLSSSAALECSIGVAAYELAV
GHAPDAAARAELVEAAIRAENEVVGASTGGLDQRASIFGEEGKALVIDFHTNQFRLVPFDLESRGLVLLIADTNAPHALN
DGQYASRRGVTDEVAHALGGENATIRSVNSTGDILDRTREWAAANNKDIDVVVRRVKHIVEETERTAEAATALDAGNFDR
FRELMKDSHISLRDQYKVSTPELDSAFDAAGQYGARMTGGGFGGSVITLVAADRVEEVATAIADAAQRQGYPEPTFVVAS
PGRGARRLS
>Mature_408_residues
PRWINTRSPEQLDTDARALFTQAFGNEPEGVWAAPGRVNVIGDHVDYAGGMSIPFALQQNTAVAVRQRDDALLNVVSLIP
GAKEPARLSIPLAEVGPLNPDSWAGYVVGTVWAGVQSGVIPRCSGLDIAVVSDVPVGSGLSSSAALECSIGVAAYELAVG
HAPDAAARAELVEAAIRAENEVVGASTGGLDQRASIFGEEGKALVIDFHTNQFRLVPFDLESRGLVLLIADTNAPHALND
GQYASRRGVTDEVAHALGGENATIRSVNSTGDILDRTREWAAANNKDIDVVVRRVKHIVEETERTAEAATALDAGNFDRF
RELMKDSHISLRDQYKVSTPELDSAFDAAGQYGARMTGGGFGGSVITLVAADRVEEVATAIADAAQRQGYPEPTFVVASP
GRGARRLS

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=375, Percent_Identity=40.2666666666667, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI48527957, Length=444, Percent_Identity=27.027027027027, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4503897, Length=441, Percent_Identity=26.984126984127, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1786972, Length=400, Percent_Identity=31.75, Blast_Score=180, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71989053, Length=428, Percent_Identity=28.0373831775701, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319494, Length=249, Percent_Identity=28.9156626506024, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24661292, Length=485, Percent_Identity=25.360824742268, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21355577, Length=485, Percent_Identity=25.360824742268, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24661285, Length=485, Percent_Identity=25.360824742268, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 43191; Mature: 43059

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRWINTRSPEQLDTDARALFTQAFGNEPEGVWAAPGRVNVIGDHVDYAGGMSIPFALQQ
CCCCCCCCCCHHHCHHHHHHHHHHHCCCCCCEEECCCEEEEEECCCCCCCCCCCCEEECC
NTAVAVRQRDDALLNVVSLIPGAKEPARLSIPLAEVGPLNPDSWAGYVVGTVWAGVQSGV
CCEEEEECCCHHHHHHHHHCCCCCCCCEEECCHHHCCCCCCCCCCHHHHHHHHHHHHCCC
IPRCSGLDIAVVSDVPVGSGLSSSAALECSIGVAAYELAVGHAPDAAARAELVEAAIRAE
CCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHCC
NEVVGASTGGLDQRASIFGEEGKALVIDFHTNQFRLVPFDLESRGLVLLIADTNAPHALN
CCEEECCCCCCCHHHHHHCCCCCEEEEEEECCEEEEEEECCCCCCEEEEEECCCCCCCCC
DGQYASRRGVTDEVAHALGGENATIRSVNSTGDILDRTREWAAANNKDIDVVVRRVKHIV
CCCHHHHCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
EETERTAEAATALDAGNFDRFRELMKDSHISLRDQYKVSTPELDSAFDAAGQYGARMTGG
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHCCCEECCC
GFGGSVITLVAADRVEEVATAIADAAQRQGYPEPTFVVASPGRGARRLS
CCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure 
PRWINTRSPEQLDTDARALFTQAFGNEPEGVWAAPGRVNVIGDHVDYAGGMSIPFALQQ
CCCCCCCCCHHHCHHHHHHHHHHHCCCCCCEEECCCEEEEEECCCCCCCCCCCCEEECC
NTAVAVRQRDDALLNVVSLIPGAKEPARLSIPLAEVGPLNPDSWAGYVVGTVWAGVQSGV
CCEEEEECCCHHHHHHHHHCCCCCCCCEEECCHHHCCCCCCCCCCHHHHHHHHHHHHCCC
IPRCSGLDIAVVSDVPVGSGLSSSAALECSIGVAAYELAVGHAPDAAARAELVEAAIRAE
CCCCCCCCEEEEECCCCCCCCCCCCEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHCC
NEVVGASTGGLDQRASIFGEEGKALVIDFHTNQFRLVPFDLESRGLVLLIADTNAPHALN
CCEEECCCCCCCHHHHHHCCCCCEEEEEEECCEEEEEEECCCCCCEEEEEECCCCCCCCC
DGQYASRRGVTDEVAHALGGENATIRSVNSTGDILDRTREWAAANNKDIDVVVRRVKHIV
CCCHHHHCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
EETERTAEAATALDAGNFDRFRELMKDSHISLRDQYKVSTPELDSAFDAAGQYGARMTGG
HHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHCCCEECCC
GFGGSVITLVAADRVEEVATAIADAAQRQGYPEPTFVVASPGRGARRLS
CCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]