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The map label for this gene is 38233546

Identifier: 38233546

GI number: 38233546

Start: 921923

End: 922816

Strand: Direct

Name: 38233546

Synonym: DIP0950

Alternate gene names: NA

Gene position: 921923-922816 (Clockwise)

Preceding gene: 38233544

Following gene: 38233547

Centisome position: 37.05

GC content: 55.48

Gene sequence:

>894_bases
ATGCATATTGTGATCGTTGGTGCCGGCGCAGTCGGCGGGTTTTTCGGTGGTTTGTTGCACGAGTCGGGCACGAAGGTCAC
TTTTGTTGCCCGTGGGAAATCTCTGGACGCGCTGCAGCGCCGCGGCATGAGGCTTCACGACGCCTCCGGTGTGCGTGACA
TCCGTGTTCCGGTGGTAGAAGACCTAAGCCACGTTCCCGACGCCGATGTGGTGATTTTGGCGACCAAGACCTTAGGCAGC
GTGGATGTGCCCAAAAATCTTCCCAAGAGTGCCGTGTTGGTTACCACTCAGAATTCAGTGGAAATGCCCCACATCGCCGT
AGAAGCGCTTGGTGTCGACCGAGTAATACCGGGCGTGGTACGCAGCTTTTTAACCAAGCGTGGACCAGCCGAAGCGGAGT
TCTCCGGCGGAATTTTCACGTTTACCTTCGGGTGCATGAGTGAGGCGACACGTGGGATCGTCGATAAGCTGGCGCACGTC
TTAGATCGAGCCGGAATCGAACCGGTGGTGCACCCAGCGATCATGACCGATATTTGGTTCAAAGCGATGTTTGTCACTTG
CTTTGGTGCCCTAGGTGCGCTCGTCAACCAACCGTTGGGTGTTGTGCGAACAACGTACCGTGACGATTTTAAAGCTCTGA
TCAACGAGGTTGTCACAGCCGGCCAAGCACATGGTGTGGACTTTCCAGAAGATGTGGTCGATCGCGTATTAGCTTTTGCT
GACGCGCAGCCTAAAGGGGCAACTAGCTCTATGCAGCGAGATCTAGCCAATGGTCTTCCTAGTGAGCTCGATGCTCAAGC
TGGTGCGGTCGTGCGAATGGCACAGCGTGTAGGCGTTGATGCTCGCCTCCATCACCTAGTAGGCAACGTACTTTCCCATA
AGCACAGCGACTGA

Upstream 100 bases:

>100_bases
GCTGCTAAGCCACCGGCCATGGGAAACCTCAATTTCGCTTTGTGACATGGTCAACTTTTACTCCTAGTCTACGTCGCAGG
ACTGCTCTATTGTCGGTGGC

Downstream 100 bases:

>100_bases
GTATGCTTTAAGCGCACAATTTTTATAAATCACGGGTGCTGGACGGCATACGTTTGCCACAAAGCTGAGACAGGGCGAGA
AGACGTGCACGTCCCTGAAC

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MHIVIVGAGAVGGFFGGLLHESGTKVTFVARGKSLDALQRRGMRLHDASGVRDIRVPVVEDLSHVPDADVVILATKTLGS
VDVPKNLPKSAVLVTTQNSVEMPHIAVEALGVDRVIPGVVRSFLTKRGPAEAEFSGGIFTFTFGCMSEATRGIVDKLAHV
LDRAGIEPVVHPAIMTDIWFKAMFVTCFGALGALVNQPLGVVRTTYRDDFKALINEVVTAGQAHGVDFPEDVVDRVLAFA
DAQPKGATSSMQRDLANGLPSELDAQAGAVVRMAQRVGVDARLHHLVGNVLSHKHSD

Sequences:

>Translated_297_residues
MHIVIVGAGAVGGFFGGLLHESGTKVTFVARGKSLDALQRRGMRLHDASGVRDIRVPVVEDLSHVPDADVVILATKTLGS
VDVPKNLPKSAVLVTTQNSVEMPHIAVEALGVDRVIPGVVRSFLTKRGPAEAEFSGGIFTFTFGCMSEATRGIVDKLAHV
LDRAGIEPVVHPAIMTDIWFKAMFVTCFGALGALVNQPLGVVRTTYRDDFKALINEVVTAGQAHGVDFPEDVVDRVLAFA
DAQPKGATSSMQRDLANGLPSELDAQAGAVVRMAQRVGVDARLHHLVGNVLSHKHSD
>Mature_297_residues
MHIVIVGAGAVGGFFGGLLHESGTKVTFVARGKSLDALQRRGMRLHDASGVRDIRVPVVEDLSHVPDADVVILATKTLGS
VDVPKNLPKSAVLVTTQNSVEMPHIAVEALGVDRVIPGVVRSFLTKRGPAEAEFSGGIFTFTFGCMSEATRGIVDKLAHV
LDRAGIEPVVHPAIMTDIWFKAMFVTCFGALGALVNQPLGVVRTTYRDDFKALINEVVTAGQAHGVDFPEDVVDRVLAFA
DAQPKGATSSMQRDLANGLPSELDAQAGAVVRMAQRVGVDARLHHLVGNVLSHKHSD

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 31564; Mature: 31564

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIVIVGAGAVGGFFGGLLHESGTKVTFVARGKSLDALQRRGMRLHDASGVRDIRVPVVE
CEEEEEECCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHCCCEEECCCCCCEEECHHHH
DLSHVPDADVVILATKTLGSVDVPKNLPKSAVLVTTQNSVEMPHIAVEALGVDRVIPGVV
HHHHCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHCHHHHHHHHH
RSFLTKRGPAEAEFSGGIFTFTFGCMSEATRGIVDKLAHVLDRAGIEPVVHPAIMTDIWF
HHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
KAMFVTCFGALGALVNQPLGVVRTTYRDDFKALINEVVTAGQAHGVDFPEDVVDRVLAFA
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
DAQPKGATSSMQRDLANGLPSELDAQAGAVVRMAQRVGVDARLHHLVGNVLSHKHSD
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MHIVIVGAGAVGGFFGGLLHESGTKVTFVARGKSLDALQRRGMRLHDASGVRDIRVPVVE
CEEEEEECCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHCCCEEECCCCCCEEECHHHH
DLSHVPDADVVILATKTLGSVDVPKNLPKSAVLVTTQNSVEMPHIAVEALGVDRVIPGVV
HHHHCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHCHHHHHHHHH
RSFLTKRGPAEAEFSGGIFTFTFGCMSEATRGIVDKLAHVLDRAGIEPVVHPAIMTDIWF
HHHHHCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
KAMFVTCFGALGALVNQPLGVVRTTYRDDFKALINEVVTAGQAHGVDFPEDVVDRVLAFA
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
DAQPKGATSSMQRDLANGLPSELDAQAGAVVRMAQRVGVDARLHHLVGNVLSHKHSD
CCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]