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The map label for this gene is xseA

Identifier: 38233538

GI number: 38233538

Start: 912814

End: 914055

Strand: Reverse

Name: xseA

Synonym: DIP0942

Alternate gene names: 38233538

Gene position: 914055-912814 (Counterclockwise)

Preceding gene: 38233540

Following gene: 38233537

Centisome position: 36.73

GC content: 55.96

Gene sequence:

>1242_bases
TTGGCTGCACAACCAAATGCACCGGAAAGTGCGTGGCCTGTTCGTGAGCTTAATTCCAAAGTAAAAAGTTGGATCGAGCG
ATTGGGCCATCTGTGGGTTGAAGGACAAATAACCCAGCTAAATATGAAACCTAGCTGGAAGTTTTCCTATATCACTCTGC
GTGATCCTGAAGCTGAAGCCAGCGTGCAGCTCACATGCGCTACTTCGTTACTGCACTCGTTGCCTAGTCGGCTTCAAGAC
GGTGACCGCGTAGTGGTTTACGGTAAGCCAGCGTTTTATGAGGGCCGTGGCTCTTTTTCGTTGTGGGTTACCGATATCCG
CCCTGTGGGCGTTGGTGAGCTACTGGCTCGTATCGAAAGATTACGGCAACAACTCGCAAGCGAAGGACTTTTCGATCCCG
CATTAAAAAAGCCGCTGCCGTTTTTACCTCACACCATCGGTTTGATTACAGGGCGTGGCTCCGCCGCCGAGCGCGATGTG
CTGGCCGTTGCCCACAGTAGATGGCCTGAAGTGAAGTTCAACGTGATCAATACTGCGGTGCAAGGTGCACGCGCCGTGCC
AGAGATCATCGAAGCCCTACAGCGTCTCGACGCCGACCCTAGCGTGGACGTGATCATCATTGCCCGTGGCGGTGGCTCTG
TCGAAGACCTACTCCCCTTTTCCGAAGAAGCACTCCAACGTGCCGTTGTTGCAGCGCACACACCAGTTGTCTCTGCCATC
GGCCACGAACCAGACAATCCTGTTTTAGATAACGTTGCCGATCTTCGCGCAGCAACACCAACTGACGCTGCCAAAAAGGT
TGTTCCAGATGTTGCTGCTGAACGTCAGCTCATCGCCGAACTTCGCTCCCGTAGCGCCGCAGCGTTACGCGGCTGGGTCC
ACAAAGAGCGCCAACAACTTGCCGCCGTACGCAGTAGACCAGCCCTTGCAGATCCCGTCCGCGCTATCACGCTGCATCGC
GAGGAGATTGCTCGGTCAATTTCTTCTATCCGACGCGATATGCGTTACATGCTCAGTACTGAACGCGCCACAGTGGCGTC
GCTACGCCAACAAGTCGCAGCCCTTGGACCTTCGGCCACATTGGCACGAGGCTACGCAGTCGTCCAAGTCGTGCCACGAG
ATGGCAGCGCTCCCGAGGTAGTGACCACCATTGGAATGTCACCACCTGGCAGCCAGTTACGCATCCGCGTTGCCGACGGC
TCCATCACCGCCGCCGCAATGCAAACAACCCCAGCAGACTAA

Upstream 100 bases:

>100_bases
AAACTACTGTCCCACTGAGTGCTCCCTCCTGCCGTATGCTTGTGTGTTGGTTCCTGTTGAATACAGTTTGTTGCTCGCCG
TGAAGAAGGGGGTTTAAGGT

Downstream 100 bases:

>100_bases
GACATACAACAGAAAGACGCATCTCCTCATGCCACATGACATCATCGGTCAAGGAACTGGAACCAACGCCTTTGCACCAG
TAGAAGAACTCTCCTACGAA

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MAAQPNAPESAWPVRELNSKVKSWIERLGHLWVEGQITQLNMKPSWKFSYITLRDPEAEASVQLTCATSLLHSLPSRLQD
GDRVVVYGKPAFYEGRGSFSLWVTDIRPVGVGELLARIERLRQQLASEGLFDPALKKPLPFLPHTIGLITGRGSAAERDV
LAVAHSRWPEVKFNVINTAVQGARAVPEIIEALQRLDADPSVDVIIIARGGGSVEDLLPFSEEALQRAVVAAHTPVVSAI
GHEPDNPVLDNVADLRAATPTDAAKKVVPDVAAERQLIAELRSRSAAALRGWVHKERQQLAAVRSRPALADPVRAITLHR
EEIARSISSIRRDMRYMLSTERATVASLRQQVAALGPSATLARGYAVVQVVPRDGSAPEVVTTIGMSPPGSQLRIRVADG
SITAAAMQTTPAD

Sequences:

>Translated_413_residues
MAAQPNAPESAWPVRELNSKVKSWIERLGHLWVEGQITQLNMKPSWKFSYITLRDPEAEASVQLTCATSLLHSLPSRLQD
GDRVVVYGKPAFYEGRGSFSLWVTDIRPVGVGELLARIERLRQQLASEGLFDPALKKPLPFLPHTIGLITGRGSAAERDV
LAVAHSRWPEVKFNVINTAVQGARAVPEIIEALQRLDADPSVDVIIIARGGGSVEDLLPFSEEALQRAVVAAHTPVVSAI
GHEPDNPVLDNVADLRAATPTDAAKKVVPDVAAERQLIAELRSRSAAALRGWVHKERQQLAAVRSRPALADPVRAITLHR
EEIARSISSIRRDMRYMLSTERATVASLRQQVAALGPSATLARGYAVVQVVPRDGSAPEVVTTIGMSPPGSQLRIRVADG
SITAAAMQTTPAD
>Mature_412_residues
AAQPNAPESAWPVRELNSKVKSWIERLGHLWVEGQITQLNMKPSWKFSYITLRDPEAEASVQLTCATSLLHSLPSRLQDG
DRVVVYGKPAFYEGRGSFSLWVTDIRPVGVGELLARIERLRQQLASEGLFDPALKKPLPFLPHTIGLITGRGSAAERDVL
AVAHSRWPEVKFNVINTAVQGARAVPEIIEALQRLDADPSVDVIIIARGGGSVEDLLPFSEEALQRAVVAAHTPVVSAIG
HEPDNPVLDNVADLRAATPTDAAKKVVPDVAAERQLIAELRSRSAAALRGWVHKERQQLAAVRSRPALADPVRAITLHRE
EIARSISSIRRDMRYMLSTERATVASLRQQVAALGPSATLARGYAVVQVVPRDGSAPEVVTTIGMSPPGSQLRIRVADGS
ITAAAMQTTPAD

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=455, Percent_Identity=29.6703296703297, Blast_Score=176, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_CORDI (Q6NI37)

Other databases:

- EMBL:   BX248356
- RefSeq:   NP_939305.1
- GeneID:   2649982
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP0942
- NMPDR:   fig|257309.1.peg.896
- HOGENOM:   HBG634411
- OMA:   PWPVRTV
- ProtClustDB:   PRK00286
- BioCyc:   CDIP257309:DIP0942-MONOMER
- BRENDA:   3.1.11.6
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 44735; Mature: 44603

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAQPNAPESAWPVRELNSKVKSWIERLGHLWVEGQITQLNMKPSWKFSYITLRDPEAEA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCEEECCEEEEEECCCCCEEEEEEEECCCCCC
SVQLTCATSLLHSLPSRLQDGDRVVVYGKPAFYEGRGSFSLWVTDIRPVGVGELLARIER
CEEEHHHHHHHHHHHHHHCCCCEEEEEECCCEECCCCCEEEEEECCCCCCHHHHHHHHHH
LRQQLASEGLFDPALKKPLPFLPHTIGLITGRGSAAERDVLAVAHSRWPEVKFNVINTAV
HHHHHHHCCCCCHHHHCCCCCCCHHHEEEECCCCCCHHHHHHHHHCCCCCEEEHHHHHHH
QGARAVPEIIEALQRLDADPSVDVIIIARGGGSVEDLLPFSEEALQRAVVAAHTPVVSAI
HHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHCCCCHHHHHHHHHHHHCHHHHHH
GHEPDNPVLDNVADLRAATPTDAAKKVVPDVAAERQLIAELRSRSAAALRGWVHKERQQL
CCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
AAVRSRPALADPVRAITLHREEIARSISSIRRDMRYMLSTERATVASLRQQVAALGPSAT
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LARGYAVVQVVPRDGSAPEVVTTIGMSPPGSQLRIRVADGSITAAAMQTTPAD
HHCCEEEEEEECCCCCCCCEEEEECCCCCCCCEEEEEECCCEEEEEECCCCCC
>Mature Secondary Structure 
AAQPNAPESAWPVRELNSKVKSWIERLGHLWVEGQITQLNMKPSWKFSYITLRDPEAEA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCEEECCEEEEEECCCCCEEEEEEEECCCCCC
SVQLTCATSLLHSLPSRLQDGDRVVVYGKPAFYEGRGSFSLWVTDIRPVGVGELLARIER
CEEEHHHHHHHHHHHHHHCCCCEEEEEECCCEECCCCCEEEEEECCCCCCHHHHHHHHHH
LRQQLASEGLFDPALKKPLPFLPHTIGLITGRGSAAERDVLAVAHSRWPEVKFNVINTAV
HHHHHHHCCCCCHHHHCCCCCCCHHHEEEECCCCCCHHHHHHHHHCCCCCEEEHHHHHHH
QGARAVPEIIEALQRLDADPSVDVIIIARGGGSVEDLLPFSEEALQRAVVAAHTPVVSAI
HHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHCCCCHHHHHHHHHHHHCHHHHHH
GHEPDNPVLDNVADLRAATPTDAAKKVVPDVAAERQLIAELRSRSAAALRGWVHKERQQL
CCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
AAVRSRPALADPVRAITLHREEIARSISSIRRDMRYMLSTERATVASLRQQVAALGPSAT
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LARGYAVVQVVPRDGSAPEVVTTIGMSPPGSQLRIRVADGSITAAAMQTTPAD
HHCCEEEEEEECCCCCCCCEEEEECCCCCCCCEEEEEECCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910