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The map label for this gene is mazG [H]

Identifier: 21674896

GI number: 21674896

Start: 1976813

End: 1977631

Strand: Direct

Name: mazG [H]

Synonym: CT2086

Alternate gene names: 21674896

Gene position: 1976813-1977631 (Clockwise)

Preceding gene: 21674892

Following gene: 21674901

Centisome position: 91.73

GC content: 58.49

Gene sequence:

>819_bases
ATGAAGCACGAAGCGAACCCATCCATTGAAACACTGAAGGAGTCCGTTCTCAAACACAACGCGGTCACGCCCGCCGAGCA
TTTCGAACGGGTGGTGAACCTGGTGCGGGTGCTGCGCTCGGAGTGTCCGTGGGATCGCAAACAGACACCGGAATCGCTGG
CGCACCTCTTGCTCGAAGAGAGCTACGAGCTGGTGCATGCCATCGACACGGGGGACGATCCTGAGCTGAAAAAGGAGCTG
GGCGACCTCTTTTTGCACGTCTGCTTTCAGGTGCTGCTGGCCGATGAGGCAAAGAAGTTCTCCTTCATCGATGTCTTCGA
GGCGCTCTGCCACAAGCTCATCAGCCGCCATCCGCATGTGTTTGGCGACGTGAAAGCTGAAACCGAGCAGGATGTACTCG
GCAACTGGGAAAACCTCAAGATGAAGGAGGGGCGCACAAGCCTGCTCGACGGTGTGCCGAAGGCGATGTCGGAGCTGCTT
CGCGCCTACCGGGTGCAGAAAAAGGTGGCGGGCATCGGTTTCGACTGGCCAAGCGACGAAGGAGTGCTCGACAAACTCAC
CGAGGAGATCGGCGAGCTGCGCAACGCGGCCAGCAAGCAGGAGCGCGAGGAGGAGTTCGGCGACCTGCTCTTCACGATCG
TCAACTACAGCCGCTTCATCGACACCAACCCCGAAGACGCCCTGCGCAAGGCGACCAACAAATTCATGGATCGCTTCAGG
AAGGTCGAAGCCTCTGTTCTGGCTTCAGGAAAAAGCTGGAAGGAGTTCTCGGCTGAGGAGCTGAACGGCTTGTGGAACGA
GGCGAAGAAGGCGAAGTAA

Upstream 100 bases:

>100_bases
AGCCCGGCGCTCCCCGGGTAAAACGCTTCGTCATTTTAATAGTAAGAATTCTGCACGCGAAAGAGTAACTTCCGGCACAT
CACAACAAGCCCCCGACATC

Downstream 100 bases:

>100_bases
GCGAAGTCATACGTCGGGCGAAGAATGACCGCAGGGGCAACCCAGGTGCCGTTAATTCACCCTCTCCCTATCTTGTTTAG
AAACCTTCCCGCAGCATCAA

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MKHEANPSIETLKESVLKHNAVTPAEHFERVVNLVRVLRSECPWDRKQTPESLAHLLLEESYELVHAIDTGDDPELKKEL
GDLFLHVCFQVLLADEAKKFSFIDVFEALCHKLISRHPHVFGDVKAETEQDVLGNWENLKMKEGRTSLLDGVPKAMSELL
RAYRVQKKVAGIGFDWPSDEGVLDKLTEEIGELRNAASKQEREEEFGDLLFTIVNYSRFIDTNPEDALRKATNKFMDRFR
KVEASVLASGKSWKEFSAEELNGLWNEAKKAK

Sequences:

>Translated_272_residues
MKHEANPSIETLKESVLKHNAVTPAEHFERVVNLVRVLRSECPWDRKQTPESLAHLLLEESYELVHAIDTGDDPELKKEL
GDLFLHVCFQVLLADEAKKFSFIDVFEALCHKLISRHPHVFGDVKAETEQDVLGNWENLKMKEGRTSLLDGVPKAMSELL
RAYRVQKKVAGIGFDWPSDEGVLDKLTEEIGELRNAASKQEREEEFGDLLFTIVNYSRFIDTNPEDALRKATNKFMDRFR
KVEASVLASGKSWKEFSAEELNGLWNEAKKAK
>Mature_272_residues
MKHEANPSIETLKESVLKHNAVTPAEHFERVVNLVRVLRSECPWDRKQTPESLAHLLLEESYELVHAIDTGDDPELKKEL
GDLFLHVCFQVLLADEAKKFSFIDVFEALCHKLISRHPHVFGDVKAETEQDVLGNWENLKMKEGRTSLLDGVPKAMSELL
RAYRVQKKVAGIGFDWPSDEGVLDKLTEEIGELRNAASKQEREEEFGDLLFTIVNYSRFIDTNPEDALRKATNKFMDRFR
KVEASVLASGKSWKEFSAEELNGLWNEAKKAK

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=256, Percent_Identity=40.234375, Blast_Score=184, Evalue=4e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 31094; Mature: 31094

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHEANPSIETLKESVLKHNAVTPAEHFERVVNLVRVLRSECPWDRKQTPESLAHLLLEE
CCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
SYELVHAIDTGDDPELKKELGDLFLHVCFQVLLADEAKKFSFIDVFEALCHKLISRHPHV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FGDVKAETEQDVLGNWENLKMKEGRTSLLDGVPKAMSELLRAYRVQKKVAGIGFDWPSDE
CCCCCCCHHHHHHCCHHHCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GVLDKLTEEIGELRNAASKQEREEEFGDLLFTIVNYSRFIDTNPEDALRKATNKFMDRFR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
KVEASVLASGKSWKEFSAEELNGLWNEAKKAK
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKHEANPSIETLKESVLKHNAVTPAEHFERVVNLVRVLRSECPWDRKQTPESLAHLLLEE
CCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
SYELVHAIDTGDDPELKKELGDLFLHVCFQVLLADEAKKFSFIDVFEALCHKLISRHPHV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FGDVKAETEQDVLGNWENLKMKEGRTSLLDGVPKAMSELLRAYRVQKKVAGIGFDWPSDE
CCCCCCCHHHHHHCCHHHCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GVLDKLTEEIGELRNAASKQEREEEFGDLLFTIVNYSRFIDTNPEDALRKATNKFMDRFR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
KVEASVLASGKSWKEFSAEELNGLWNEAKKAK
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]