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The map label for this gene is nlpI [C]

Identifier: 21674885

GI number: 21674885

Start: 1967486

End: 1968379

Strand: Reverse

Name: nlpI [C]

Synonym: CT2075

Alternate gene names: 21674885

Gene position: 1968379-1967486 (Counterclockwise)

Preceding gene: 21674886

Following gene: 21674883

Centisome position: 91.34

GC content: 56.49

Gene sequence:

>894_bases
ATGCCGTTTGTGTCCGCCGCCGGACCTGCTGAAGAATTGATCGATCAGGGTATCCGGAGGGGGCTTGAAGGCAATTATCA
GGACGCGATCGATCATTTCAGCCGCGCGATACGTCTTACTCCCCGCAATGCAGATGCTTTTTACAACCGGGGTCTTGCCC
GTGTTTCAATTGGCGACCTGACAGGCGCGATTGCCGATTATAGCATGAGCATAAGCCTTGATCCCCGTTCATCCGGAGCA
TACAATAACCGCGGATTTGCCCTGGCGGCTCTTGGCAGATATGCGGAAGCCCTCGCGGACATGTCACGAGCGATAGCTCT
CCGGCCGGACATGGCTCAATTGTATAACAATCGAGGCACGATCAGGATGTCCATAAAGGCATATGCGCTTGCGATCGCCG
ATTTCACCAGAGCCATAGCGCTTGATCCGTTGCTTGCCGGTGCGTACAACAATCGCGGGCTTGCCAGAAATCTCTCTGGC
CAGCTTCAAGGTGCGGTCGCTGATTACCGCGAAGCGGTTCGGATCGATCCTCGTTACAAGGTCGCCTGGTACAATTTGGG
CAATGCGCACATCTCCCTCGGAGATGCAAAAGAGGCCGTTGAGGATTACTCGAAGGTTCTTGTGCTCGATCCTGGTATGC
TTGTCGCCCGGAATAACCGGGCTTTCGCTCGGCTTTCACTGGGAGACTATAAAGGGGCTCTGGAAGACTTGAACCTCGTC
ATATCGAAGTCTCCGCAAGATGCTGCGGGCTGGTACAACCGGGGCGTCGTCCGGAAGCTCGCTGGTGACCGGCAGGGTGC
CATTGAAGATCTCCGGCGGGCTGCGGCGTTTGGCGATTCTTTGGCTGTCGAGGCGCTCAGGGAGATAACGAGCCGGGATA
GCATGCCGCCCTGA

Upstream 100 bases:

>100_bases
ACATATCCAGTAGAGTCAGCACGTGGGACACAAACGAACCTGGCTTGCCGTCACACGGGTGACTGGCGCCATTCTGATGG
CGTTGTATCTGCTGTTGACC

Downstream 100 bases:

>100_bases
ACCGCGTCGGGTGGTGCTTGTTTGCAATTGGAAGCGAATGTGTATATTCTTTCGTTCGCATTATCCAGAAGCTTATGAGA
TCGTCTGTTATCACCCAAAG

Product: TPR domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MPFVSAAGPAEELIDQGIRRGLEGNYQDAIDHFSRAIRLTPRNADAFYNRGLARVSIGDLTGAIADYSMSISLDPRSSGA
YNNRGFALAALGRYAEALADMSRAIALRPDMAQLYNNRGTIRMSIKAYALAIADFTRAIALDPLLAGAYNNRGLARNLSG
QLQGAVADYREAVRIDPRYKVAWYNLGNAHISLGDAKEAVEDYSKVLVLDPGMLVARNNRAFARLSLGDYKGALEDLNLV
ISKSPQDAAGWYNRGVVRKLAGDRQGAIEDLRRAAAFGDSLAVEALREITSRDSMPP

Sequences:

>Translated_297_residues
MPFVSAAGPAEELIDQGIRRGLEGNYQDAIDHFSRAIRLTPRNADAFYNRGLARVSIGDLTGAIADYSMSISLDPRSSGA
YNNRGFALAALGRYAEALADMSRAIALRPDMAQLYNNRGTIRMSIKAYALAIADFTRAIALDPLLAGAYNNRGLARNLSG
QLQGAVADYREAVRIDPRYKVAWYNLGNAHISLGDAKEAVEDYSKVLVLDPGMLVARNNRAFARLSLGDYKGALEDLNLV
ISKSPQDAAGWYNRGVVRKLAGDRQGAIEDLRRAAAFGDSLAVEALREITSRDSMPP
>Mature_296_residues
PFVSAAGPAEELIDQGIRRGLEGNYQDAIDHFSRAIRLTPRNADAFYNRGLARVSIGDLTGAIADYSMSISLDPRSSGAY
NNRGFALAALGRYAEALADMSRAIALRPDMAQLYNNRGTIRMSIKAYALAIADFTRAIALDPLLAGAYNNRGLARNLSGQ
LQGAVADYREAVRIDPRYKVAWYNLGNAHISLGDAKEAVEDYSKVLVLDPGMLVARNNRAFARLSLGDYKGALEDLNLVI
SKSPQDAAGWYNRGVVRKLAGDRQGAIEDLRRAAAFGDSLAVEALREITSRDSMPP

Specific function: May Be Involved In Cell Division. Overexpression Of Nlpi Results In The Loss Of The Rod Morphology And The Formation Of Single Prolate Ellipsoids And Pairs Of Prolate Ellipsoids Joined By Partial Constrictions. [C]

COG id: COG0457

COG function: function code R; FOG: TPR repeat

Gene ontology:

Cell location: Attached To The Membrane By A Lipid Anchor [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 TPR repeats [H]

Homologues:

Organism=Homo sapiens, GI170784867, Length=238, Percent_Identity=28.9915966386555, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI310131789, Length=253, Percent_Identity=26.8774703557312, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI310110582, Length=253, Percent_Identity=26.8774703557312, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI310123097, Length=253, Percent_Identity=26.8774703557312, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI32307148, Length=251, Percent_Identity=29.4820717131474, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI32307150, Length=251, Percent_Identity=29.4820717131474, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI296531396, Length=186, Percent_Identity=29.0322580645161, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI24308141, Length=103, Percent_Identity=37.8640776699029, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI301336134, Length=186, Percent_Identity=29.0322580645161, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI83415184, Length=186, Percent_Identity=29.0322580645161, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4506921, Length=109, Percent_Identity=36.697247706422, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI224809432, Length=244, Percent_Identity=26.2295081967213, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI115532692, Length=302, Percent_Identity=29.1390728476821, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI115532690, Length=302, Percent_Identity=29.1390728476821, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI25147174, Length=163, Percent_Identity=28.8343558282209, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17647755, Length=250, Percent_Identity=29.2, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24585827, Length=250, Percent_Identity=29.2, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24585829, Length=250, Percent_Identity=29.2, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24647123, Length=214, Percent_Identity=26.6355140186916, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF00515 TPR_1 [H]

EC number: NA

Molecular weight: Translated: 32242; Mature: 32111

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS50005 TPR ; PS50293 TPR_REGION

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFVSAAGPAEELIDQGIRRGLEGNYQDAIDHFSRAIRLTPRNADAFYNRGLARVSIGDL
CCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHEEECCCCCHHHHHCCEEEEEHHHH
TGAIADYSMSISLDPRSSGAYNNRGFALAALGRYAEALADMSRAIALRPDMAQLYNNRGT
HHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCE
IRMSIKAYALAIADFTRAIALDPLLAGAYNNRGLARNLSGQLQGAVADYREAVRIDPRYK
EEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCHHHHHHHHHHHHHHCCCCCEE
VAWYNLGNAHISLGDAKEAVEDYSKVLVLDPGMLVARNNRAFARLSLGDYKGALEDLNLV
EEEEECCCCEEECCCHHHHHHHHHEEEEECCCEEEEECCCEEEEEECHHHHHHHHHHHEE
ISKSPQDAAGWYNRGVVRKLAGDRQGAIEDLRRAAAFGDSLAVEALREITSRDSMPP
EECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PFVSAAGPAEELIDQGIRRGLEGNYQDAIDHFSRAIRLTPRNADAFYNRGLARVSIGDL
CCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHEEECCCCCHHHHHCCEEEEEHHHH
TGAIADYSMSISLDPRSSGAYNNRGFALAALGRYAEALADMSRAIALRPDMAQLYNNRGT
HHHHHCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCE
IRMSIKAYALAIADFTRAIALDPLLAGAYNNRGLARNLSGQLQGAVADYREAVRIDPRYK
EEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCHHHHHHHHHHHHHHCCCCCEE
VAWYNLGNAHISLGDAKEAVEDYSKVLVLDPGMLVARNNRAFARLSLGDYKGALEDLNLV
EEEEECCCCEEECCCHHHHHHHHHEEEEECCCEEEEECCCEEEEEECHHHHHHHHHHHEE
ISKSPQDAAGWYNRGVVRKLAGDRQGAIEDLRRAAAFGDSLAVEALREITSRDSMPP
EECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1368342; 8905231 [H]