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The map label for this gene is gloB [H]

Identifier: 21674855

GI number: 21674855

Start: 1942679

End: 1943326

Strand: Reverse

Name: gloB [H]

Synonym: CT2045

Alternate gene names: 21674855

Gene position: 1943326-1942679 (Counterclockwise)

Preceding gene: 21674856

Following gene: 21674854

Centisome position: 90.18

GC content: 58.33

Gene sequence:

>648_bases
ATGAGCGTGCAGGTTGAGCAGATCAGAACGGGCGGGGATCGCAATTTCGGCTATCTCTGCGCCGACAAGGCGACAGGTGA
GGCGTTTGCGGTCGATCCCTCCAATTCACCAAAAGTGCTTGTCGATGCCGCCGCCCGCAAGGGTTGGCAGCTCGTGCGGG
CCTTCTGCACCCATGGCCATGCCGACCACACCAACGGCAACGAGGAGTTCGAGCGGTTGACCGGCATCCGGGTGCTGCTC
TTCGGCGACCGCGACGCCCGTTTGGGAATCGAGGTGATGCACGGCGCGAGTTTTCCGCTTGGCGAGGGCGTTGTCGAAAT
CATCCACACCCCCGGCCACACGCTGGACTCGATCTGCCTGCTTGCCGGAGACGCGCTTTTTACCGGCGATACGCTCTTTG
TAGGCAAGGTTGGCGGCACGTGGAGCGAGGCGGATGCCCGGTTGGAGTACCGTTCACTGCACGAGCGACTGATGGTGCTA
CCGGCTGGTACGAATGTATTTCCCGGTCATGATTATGGCACGGCGCCAGTTTCAACCATTGGTCATGAAAAAACTACCAA
TCCGTTTCTGCTTCAGCCCGATGCAGAATCGTTTATTGACCTGAAAAACAACTGGTCTGCCTACAAAAAAGCACACGGAA
TCAGCTGA

Upstream 100 bases:

>100_bases
TCATGAAAGACATTGAGGCGAACCCTCTTGCCGCCGACCCGGCGTTTCCGGCAAAGGCGTTCATGATGAATGTCGAAAAG
ATGATCTGAGGAGCGTGGCC

Downstream 100 bases:

>100_bases
ATTTTTCCCTGTTTGCTTGATTTTTCTCTCTTCTTTGCTTTTATTCTTTAATTATGCTTCTTGGGGTTTTTGCCTCGTAG
CGCGCCTTCCTTACAGTTAA

Product: hydroxyacylglutathione hydrolase, putative

Products: NA

Alternate protein names: Glyoxalase II; Glx II [H]

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MSVQVEQIRTGGDRNFGYLCADKATGEAFAVDPSNSPKVLVDAAARKGWQLVRAFCTHGHADHTNGNEEFERLTGIRVLL
FGDRDARLGIEVMHGASFPLGEGVVEIIHTPGHTLDSICLLAGDALFTGDTLFVGKVGGTWSEADARLEYRSLHERLMVL
PAGTNVFPGHDYGTAPVSTIGHEKTTNPFLLQPDAESFIDLKNNWSAYKKAHGIS

Sequences:

>Translated_215_residues
MSVQVEQIRTGGDRNFGYLCADKATGEAFAVDPSNSPKVLVDAAARKGWQLVRAFCTHGHADHTNGNEEFERLTGIRVLL
FGDRDARLGIEVMHGASFPLGEGVVEIIHTPGHTLDSICLLAGDALFTGDTLFVGKVGGTWSEADARLEYRSLHERLMVL
PAGTNVFPGHDYGTAPVSTIGHEKTTNPFLLQPDAESFIDLKNNWSAYKKAHGIS
>Mature_214_residues
SVQVEQIRTGGDRNFGYLCADKATGEAFAVDPSNSPKVLVDAAARKGWQLVRAFCTHGHADHTNGNEEFERLTGIRVLLF
GDRDARLGIEVMHGASFPLGEGVVEIIHTPGHTLDSICLLAGDALFTGDTLFVGKVGGTWSEADARLEYRSLHERLMVLP
AGTNVFPGHDYGTAPVSTIGHEKTTNPFLLQPDAESFIDLKNNWSAYKKAHGIS

Specific function: Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid [H]

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family [H]

Homologues:

Organism=Homo sapiens, GI94538320, Length=166, Percent_Identity=37.3493975903614, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI94538322, Length=166, Percent_Identity=37.3493975903614, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI41327741, Length=203, Percent_Identity=31.5270935960591, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI14150041, Length=217, Percent_Identity=33.1797235023041, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI46361987, Length=166, Percent_Identity=36.7469879518072, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI116642887, Length=227, Percent_Identity=29.5154185022026, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI21703352, Length=227, Percent_Identity=29.5154185022026, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1786406, Length=184, Percent_Identity=33.695652173913, Blast_Score=62, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17536925, Length=231, Percent_Identity=28.1385281385281, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17538952, Length=200, Percent_Identity=25, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320478, Length=198, Percent_Identity=28.7878787878788, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221330176, Length=203, Percent_Identity=31.5270935960591, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21356335, Length=206, Percent_Identity=32.0388349514563, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24667711, Length=206, Percent_Identity=32.0388349514563, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24667703, Length=220, Percent_Identity=30.4545454545455, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR017782 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.2.6 [H]

Molecular weight: Translated: 23289; Mature: 23158

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVQVEQIRTGGDRNFGYLCADKATGEAFAVDPSNSPKVLVDAAARKGWQLVRAFCTHGH
CCEEHHHHHCCCCCCCEEEEECCCCCCEEEECCCCCCEEEEEHHHHHHHHHHHHHHHCCC
ADHTNGNEEFERLTGIRVLLFGDRDARLGIEVMHGASFPLGEGVVEIIHTPGHTLDSICL
CCCCCCHHHHHHHCCEEEEEECCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCHHHHHH
LAGDALFTGDTLFVGKVGGTWSEADARLEYRSLHERLMVLPAGTNVFPGHDYGTAPVSTI
HHCCEEEECCEEEEECCCCCCCCHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCHHHC
GHEKTTNPFLLQPDAESFIDLKNNWSAYKKAHGIS
CCCCCCCCEEECCCHHHHHCCCCCHHHHHHHCCCC
>Mature Secondary Structure 
SVQVEQIRTGGDRNFGYLCADKATGEAFAVDPSNSPKVLVDAAARKGWQLVRAFCTHGH
CEEHHHHHCCCCCCCEEEEECCCCCCEEEECCCCCCEEEEEHHHHHHHHHHHHHHHCCC
ADHTNGNEEFERLTGIRVLLFGDRDARLGIEVMHGASFPLGEGVVEIIHTPGHTLDSICL
CCCCCCHHHHHHHCCEEEEEECCCCCCCCEEEECCCCCCCCCCCEEEEECCCCCHHHHHH
LAGDALFTGDTLFVGKVGGTWSEADARLEYRSLHERLMVLPAGTNVFPGHDYGTAPVSTI
HHCCEEEECCEEEEECCCCCCCCHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCHHHC
GHEKTTNPFLLQPDAESFIDLKNNWSAYKKAHGIS
CCCCCCCCEEECCCHHHHHCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA