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The map label for this gene is hemN [H]

Identifier: 21674821

GI number: 21674821

Start: 1906037

End: 1907164

Strand: Reverse

Name: hemN [H]

Synonym: CT2010

Alternate gene names: 21674821

Gene position: 1907164-1906037 (Counterclockwise)

Preceding gene: 21674822

Following gene: 21674820

Centisome position: 88.5

GC content: 60.02

Gene sequence:

>1128_bases
ATGATTTGCCTGTATTTGCACATTCCTTTCTGCCGGGAGCGTTGCCCTTACTGCGACTTTTTTCTGGTCACGCGGCCCGG
CTTCGTCGAGCGCTTTTTCGAGGCGCTTGCCGTTGAGACGGCGGCGAAGGCGGCGCTCTTCGCGGGACAGTCGATCAAGG
CGATTCACTTCGGCGGCGGCACGCCTTCTCTGGTTCCGCCCTCCTTCATCGACGGCTGGCTGTCGCAAATCTCCGGTATT
GCCCGAATCTCCGCTGAAACCGAAATCACGCTCGAAGCCAATCCCGAGGATCTCTTGCCAGCCTCGCTCGATGCGCTGCA
ATCGGTCGGCGTCAACCGGCTCTCTATTGGTGTGCAGTCTTTTGCTGACCGCAAGCTCCGGGCGCTCGGACGGGCGCATT
CGGCTGCCGACGCCCGCCGTGTTGTTTTGGAAGCGCTCGAACGCTTTCCGTCGGTCAGCATCGATCTGATGTGCGGCGCG
GAGGGGGAGATGCTCGCCGAGTGGGAGGGCGACCTTCGTGCGGCGCTCGATCTTTGTCCGCAGCACATCTCGATCTATAT
GCTCACGCTCGAAGAGAAGACCCGGCTGTGGCGCGATGTGCGGAAAGGTCTCCGTGACCTGCCTGGCGAAGAGGCGCAGG
CGGCGATGTACCGGATGGCGGCGGAGTTGCTTGGCAATGCGGGGTACGGCCACTACGAAATTTCCAACTTCGCGCTCGAA
GGGCATCACTCGCGCTACAACCTCGCGAGCTGGATGCGCGAGCCGTACCTCGGTTTCGGCCCGGCGGCACACAGCTTTCT
TGTCGATGGCGACGCCGAGACGCGCTTCTCGAACGTGAGCAGCCTGACGCGCTACCTCACTGATCCTGTCGGCGCGGTCG
ATTTTCGCGAGGTGTTGACCGAAGCGCAGCGCTTCGACGAAGAGGTTTTTCTCTCCCTGAGAATCCGCAAACCGCTGTCT
GTTGGGTTTTTGCGAAAAGGGCATAAATTAGGGCATCAGCATCTCGATGACATCCTTGTTACGCTACAGGAAAAAGGGTG
GATCGGTGTCAAAAAGGGCACGGTGACGCTGACCGAAGAAGGCTTTCTTTTTGCCGATCATGTGGCCGCCGAACTGCTTT
CGGAGTGA

Upstream 100 bases:

>100_bases
GCCAACATCAAGGGACTGAAAGGACGAAAAGGACTTCAGGGACAGCAGGGTTTGGAGAATCGGTTTCGGGGTGTTGGAAA
AATAATGAGAAAGGCGCCCG

Downstream 100 bases:

>100_bases
ATGCCCGGCTGATACGAATTGTCTAACAACCAGTCCCGAATGACTCACAGAAACGCGAACCGGATCATCGCCGCCGGAAT
ATTTCTGGTTGCCGAAGCGG

Product: oxygen-independent coproporphyrinogen III oxidase, putative

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MICLYLHIPFCRERCPYCDFFLVTRPGFVERFFEALAVETAAKAALFAGQSIKAIHFGGGTPSLVPPSFIDGWLSQISGI
ARISAETEITLEANPEDLLPASLDALQSVGVNRLSIGVQSFADRKLRALGRAHSAADARRVVLEALERFPSVSIDLMCGA
EGEMLAEWEGDLRAALDLCPQHISIYMLTLEEKTRLWRDVRKGLRDLPGEEAQAAMYRMAAELLGNAGYGHYEISNFALE
GHHSRYNLASWMREPYLGFGPAAHSFLVDGDAETRFSNVSSLTRYLTDPVGAVDFREVLTEAQRFDEEVFLSLRIRKPLS
VGFLRKGHKLGHQHLDDILVTLQEKGWIGVKKGTVTLTEEGFLFADHVAAELLSE

Sequences:

>Translated_375_residues
MICLYLHIPFCRERCPYCDFFLVTRPGFVERFFEALAVETAAKAALFAGQSIKAIHFGGGTPSLVPPSFIDGWLSQISGI
ARISAETEITLEANPEDLLPASLDALQSVGVNRLSIGVQSFADRKLRALGRAHSAADARRVVLEALERFPSVSIDLMCGA
EGEMLAEWEGDLRAALDLCPQHISIYMLTLEEKTRLWRDVRKGLRDLPGEEAQAAMYRMAAELLGNAGYGHYEISNFALE
GHHSRYNLASWMREPYLGFGPAAHSFLVDGDAETRFSNVSSLTRYLTDPVGAVDFREVLTEAQRFDEEVFLSLRIRKPLS
VGFLRKGHKLGHQHLDDILVTLQEKGWIGVKKGTVTLTEEGFLFADHVAAELLSE
>Mature_375_residues
MICLYLHIPFCRERCPYCDFFLVTRPGFVERFFEALAVETAAKAALFAGQSIKAIHFGGGTPSLVPPSFIDGWLSQISGI
ARISAETEITLEANPEDLLPASLDALQSVGVNRLSIGVQSFADRKLRALGRAHSAADARRVVLEALERFPSVSIDLMCGA
EGEMLAEWEGDLRAALDLCPQHISIYMLTLEEKTRLWRDVRKGLRDLPGEEAQAAMYRMAAELLGNAGYGHYEISNFALE
GHHSRYNLASWMREPYLGFGPAAHSFLVDGDAETRFSNVSSLTRYLTDPVGAVDFREVLTEAQRFDEEVFLSLRIRKPLS
VGFLRKGHKLGHQHLDDILVTLQEKGWIGVKKGTVTLTEEGFLFADHVAAELLSE

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=283, Percent_Identity=39.5759717314488, Blast_Score=192, Evalue=3e-49,
Organism=Escherichia coli, GI1789325, Length=268, Percent_Identity=37.3134328358209, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI87082341, Length=244, Percent_Identity=28.2786885245902, Blast_Score=100, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 41629; Mature: 41629

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MICLYLHIPFCRERCPYCDFFLVTRPGFVERFFEALAVETAAKAALFAGQSIKAIHFGGG
CEEEEEECCHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
TPSLVPPSFIDGWLSQISGIARISAETEITLEANPEDLLPASLDALQSVGVNRLSIGVQS
CCCCCCHHHHHHHHHHHHHHHEECCCEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHH
FADRKLRALGRAHSAADARRVVLEALERFPSVSIDLMCGAEGEMLAEWEGDLRAALDLCP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEHHCHHHHHHHHHCC
QHISIYMLTLEEKTRLWRDVRKGLRDLPGEEAQAAMYRMAAELLGNAGYGHYEISNFALE
CCEEEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEECCEEEE
GHHSRYNLASWMREPYLGFGPAAHSFLVDGDAETRFSNVSSLTRYLTDPVGAVDFREVLT
CCCCCHHHHHHHHCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
EAQRFDEEVFLSLRIRKPLSVGFLRKGHKLGHQHLDDILVTLQEKGWIGVKKGTVTLTEE
HHHHCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECC
GFLFADHVAAELLSE
CCEEHHHHHHHHHCC
>Mature Secondary Structure
MICLYLHIPFCRERCPYCDFFLVTRPGFVERFFEALAVETAAKAALFAGQSIKAIHFGGG
CEEEEEECCHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
TPSLVPPSFIDGWLSQISGIARISAETEITLEANPEDLLPASLDALQSVGVNRLSIGVQS
CCCCCCHHHHHHHHHHHHHHHEECCCEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHH
FADRKLRALGRAHSAADARRVVLEALERFPSVSIDLMCGAEGEMLAEWEGDLRAALDLCP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEHHCHHHHHHHHHCC
QHISIYMLTLEEKTRLWRDVRKGLRDLPGEEAQAAMYRMAAELLGNAGYGHYEISNFALE
CCEEEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEECCEEEE
GHHSRYNLASWMREPYLGFGPAAHSFLVDGDAETRFSNVSSLTRYLTDPVGAVDFREVLT
CCCCCHHHHHHHHCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
EAQRFDEEVFLSLRIRKPLSVGFLRKGHKLGHQHLDDILVTLQEKGWIGVKKGTVTLTEE
HHHHCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECC
GFLFADHVAAELLSE
CCEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]