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The map label for this gene is lpxA

Identifier: 21674819

GI number: 21674819

Start: 1902550

End: 1903344

Strand: Reverse

Name: lpxA

Synonym: CT2008

Alternate gene names: 21674819

Gene position: 1903344-1902550 (Counterclockwise)

Preceding gene: 21674820

Following gene: 21674818

Centisome position: 88.32

GC content: 59.57

Gene sequence:

>795_bases
ATGCGCAATATTCACGCAACAGCGGTCATCGGCTCCGGAGCCGTGCTTGGCGAAGGGGTCGAAATCGGGCCTTACACCGT
GATCGAAGATGATGTCGTCATCGGCGACAGGACGGTCATCGGGCCTCATGTTCACATCGCCGACGGGGCGCGCATCGGCA
ATGAGTGCCGGATTTCGACCGGCGCGGTGCTTGCGACCGCACCACAGGATCTCAAGTACGCCGGGGAGAAGACCTATCTT
CACATCGGCGACCGTACAGTCATCCGCGAGTGTGTGACCCTGAACCGCGGCACCAAGGCCAGTGGCAAGACCGTGGTTGG
TTCCGACAATCTCATCATGGCTTACGTCCACGCGGGGCATGACTGCGTGATCGGCAACCATGTGGTGATCGCCAACTCGG
TGCAGTTTGGCGGCCACTGCCATGTGGGCGATTACGTGGTGGTGGGCGGTCTGGCCGGAGTGCACCAGYTCGTCAGGATT
GGGCGGTACGCGATGGTTGGCGGCATCTCCCGCGCGGCGCTTGATGTCCCACCCTTTGTCATGGCTGGTGGGCATGCCTC
GTTCCGGTACGAAGGACTCAATGTCATTGGCCTGAAACGGCGTGGTTTTACCTCCGAACAACTCGGCAACATCCGGGACG
CCTACCGCATTATTTTCCAGTCGGGCCTGTTGCTCTCCAAAGCGCTCGAAGCGGTGCGCAACGATCTTCCGCAAACGCCG
GAGGTGGTTGAAATCCTCGACTTCTTCGCCTCGGGAGTGTACAATCGGAAGTTTCTCAAGCCCTTCAATTCATAA

Upstream 100 bases:

>100_bases
AGGGTTCACGAGGCGGATCGGATCATGAAAGAACTGGAAACGGCGCTCCCTGAACTGCGGAAGCGCCTGGATTCACTCAA
GCAATAGTCTCTATTTTTCA

Downstream 100 bases:

>100_bases
GCAGTGACGGATATGCCATCATGGGGGCTAGGCATCGATCTCGGCGGGACGAACATCAAGATAGCGGTCGTCGATGAGTT
GAAAGGGATTCTCTTCGAGG

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MRNIHATAVIGSGAVLGEGVEIGPYTVIEDDVVIGDRTVIGPHVHIADGARIGNECRISTGAVLATAPQDLKYAGEKTYL
HIGDRTVIRECVTLNRGTKASGKTVVGSDNLIMAYVHAGHDCVIGNHVVIANSVQFGGHCHVGDYVVVGGLAGVHQXVRI
GRYAMVGGISRAALDVPPFVMAGGHASFRYEGLNVIGLKRRGFTSEQLGNIRDAYRIIFQSGLLLSKALEAVRNDLPQTP
EVVEILDFFASGVYNRKFLKPFNS

Sequences:

>Translated_264_residues
MRNIHATAVIGSGAVLGEGVEIGPYTVIEDDVVIGDRTVIGPHVHIADGARIGNECRISTGAVLATAPQDLKYAGEKTYL
HIGDRTVIRECVTLNRGTKASGKTVVGSDNLIMAYVHAGHDCVIGNHVVIANSVQFGGHCHVGDYVVVGGLAGVHQXVRI
GRYAMVGGISRAALDVPPFVMAGGHASFRYEGLNVIGLKRRGFTSEQLGNIRDAYRIIFQSGLLLSKALEAVRNDLPQTP
EVVEILDFFASGVYNRKFLKPFNS
>Mature_264_residues
MRNIHATAVIGSGAVLGEGVEIGPYTVIEDDVVIGDRTVIGPHVHIADGARIGNECRISTGAVLATAPQDLKYAGEKTYL
HIGDRTVIRECVTLNRGTKASGKTVVGSDNLIMAYVHAGHDCVIGNHVVIANSVQFGGHCHVGDYVVVGGLAGVHQXVRI
GRYAMVGGISRAALDVPPFVMAGGHASFRYEGLNVIGLKRRGFTSEQLGNIRDAYRIIFQSGLLLSKALEAVRNDLPQTP
EVVEILDFFASGVYNRKFLKPFNS

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=248, Percent_Identity=43.1451612903226, Blast_Score=200, Evalue=7e-53,
Organism=Escherichia coli, GI1786376, Length=196, Percent_Identity=30.6122448979592, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_CHLTE (Q8KAZ0)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662884.1
- ProteinModelPortal:   Q8KAZ0
- GeneID:   1007553
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT2008
- NMPDR:   fig|194439.1.peg.1978
- TIGR:   CT2008
- HOGENOM:   HBG659295
- OMA:   DLKYQGE
- ProtClustDB:   PRK05289
- BioCyc:   CTEP194439:CT_2008-MONOMER
- BRENDA:   2.3.1.129
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR001451
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: PF00132 Hexapep; SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 28131; Mature: 28131

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNIHATAVIGSGAVLGEGVEIGPYTVIEDDVVIGDRTVIGPHVHIADGARIGNECRIST
CCCEEEEEEEECCCEECCCEEECCEEEEECCEEECCCEEECCEEEEECCCCCCCEEEEEC
GAVLATAPQDLKYAGEKTYLHIGDRTVIRECVTLNRGTKASGKTVVGSDNLIMAYVHAGH
CEEEEECCHHHHHCCCEEEEEECCHHHHHHHHHCCCCCCCCCCEEECCCCEEEEEEECCC
DCVIGNHVVIANSVQFGGHCHVGDYVVVGGLAGVHQXVRIGRYAMVGGISRAALDVPPFV
EEEECCEEEEEECEECCCEEECCCEEEECCHHHHHHHHHHCCHHHHCCCCHHHCCCCCEE
MAGGHASFRYEGLNVIGLKRRGFTSEQLGNIRDAYRIIFQSGLLLSKALEAVRNDLPQTP
EECCCCEEEECCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCH
EVVEILDFFASGVYNRKFLKPFNS
HHHHHHHHHHCCCCCCHHCCCCCC
>Mature Secondary Structure
MRNIHATAVIGSGAVLGEGVEIGPYTVIEDDVVIGDRTVIGPHVHIADGARIGNECRIST
CCCEEEEEEEECCCEECCCEEECCEEEEECCEEECCCEEECCEEEEECCCCCCCEEEEEC
GAVLATAPQDLKYAGEKTYLHIGDRTVIRECVTLNRGTKASGKTVVGSDNLIMAYVHAGH
CEEEEECCHHHHHCCCEEEEEECCHHHHHHHHHCCCCCCCCCCEEECCCCEEEEEEECCC
DCVIGNHVVIANSVQFGGHCHVGDYVVVGGLAGVHQXVRIGRYAMVGGISRAALDVPPFV
EEEECCEEEEEECEECCCEEECCCEEEECCHHHHHHHHHHCCHHHHCCCCHHHCCCCCEE
MAGGHASFRYEGLNVIGLKRRGFTSEQLGNIRDAYRIIFQSGLLLSKALEAVRNDLPQTP
EECCCCEEEECCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCH
EVVEILDFFASGVYNRKFLKPFNS
HHHHHHHHHHCCCCCCHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901