Click here to switch to the map view.

The map label for this gene is ndk [H]

Identifier: 21674813

GI number: 21674813

Start: 1898362

End: 1898784

Strand: Direct

Name: ndk [H]

Synonym: CT2002

Alternate gene names: 21674813

Gene position: 1898362-1898784 (Clockwise)

Preceding gene: 21674812

Following gene: 21674824

Centisome position: 88.09

GC content: 59.34

Gene sequence:

>423_bases
ATGGAACGTACCCTTACCATCCTGAAACCCGATTGCGTGCGCAAGCAGCTTATCGGCGCTGTCACCAATATGATCGAGCG
CGCCGGTTTCCGCATCGTAGCGATGAAGAAAACCCGCCTCACCAAAGAGACTGCCGGCGCATTTTATGCCGTGCACAAGG
AGCGCCCGTTCTACGGCGAGCTGGTCGAGTTCATGTCGTCCGGCCCGTGCGTGCCGATGATCCTCGAAAAAGAGAACGCT
GTAGCCGACTTCCGCACACTGATTGGCGCAACCGATCCGGCGCAGGCTGACGAGGGCACCATCCGCAAGCTCTACGCCGA
CAGCAAAGGAGAGAACATCATCCACGGTTCCGACTCCGCGGAGAACGCCGCCATCGAAAGCGCCTTCTTCTTCGCTGCCG
AAGAGGTGGTCCGGGTTGACTGA

Upstream 100 bases:

>100_bases
CCTCGTAACGATTGATGCGGCGCGCTGGGATTGCCTGAATCCGAATCTTTTTTTGTATCTTCGCGGGCAAACTTTTCAGA
ACAAAATGCAGACCCGAATA

Downstream 100 bases:

>100_bases
TTGGAATCAGGACTGACCGGACTTCATAAAAAAAGAGCGGCCTGAATTCATCATCGGGCCGCTCTTTTTCGTTTTATTCA
CACGCTCCCTTGTCACAATC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 140; Mature: 140

Protein sequence:

>140_residues
MERTLTILKPDCVRKQLIGAVTNMIERAGFRIVAMKKTRLTKETAGAFYAVHKERPFYGELVEFMSSGPCVPMILEKENA
VADFRTLIGATDPAQADEGTIRKLYADSKGENIIHGSDSAENAAIESAFFFAAEEVVRVD

Sequences:

>Translated_140_residues
MERTLTILKPDCVRKQLIGAVTNMIERAGFRIVAMKKTRLTKETAGAFYAVHKERPFYGELVEFMSSGPCVPMILEKENA
VADFRTLIGATDPAQADEGTIRKLYADSKGENIIHGSDSAENAAIESAFFFAAEEVVRVD
>Mature_140_residues
MERTLTILKPDCVRKQLIGAVTNMIERAGFRIVAMKKTRLTKETAGAFYAVHKERPFYGELVEFMSSGPCVPMILEKENA
VADFRTLIGATDPAQADEGTIRKLYADSKGENIIHGSDSAENAAIESAFFFAAEEVVRVD

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=45.5882352941176, Blast_Score=126, Evalue=7e-30,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=43.0656934306569, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=43.0656934306569, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=43.0656934306569, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=43.0656934306569, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=43.0656934306569, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI4557797, Length=136, Percent_Identity=41.1764705882353, Blast_Score=114, Evalue=3e-26,
Organism=Homo sapiens, GI38045913, Length=136, Percent_Identity=41.1764705882353, Blast_Score=114, Evalue=3e-26,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=41.1764705882353, Blast_Score=109, Evalue=7e-25,
Organism=Homo sapiens, GI7019465, Length=135, Percent_Identity=33.3333333333333, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI37574614, Length=135, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=3e-18,
Organism=Homo sapiens, GI5031951, Length=135, Percent_Identity=39.2592592592593, Blast_Score=80, Evalue=4e-16,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=34.8148148148148, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI148839372, Length=126, Percent_Identity=36.5079365079365, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1788866, Length=136, Percent_Identity=53.6764705882353, Blast_Score=138, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=37.7777777777778, Blast_Score=106, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=36.0294117647059, Blast_Score=102, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=44.1176470588235, Blast_Score=120, Evalue=4e-28,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=36.5671641791045, Blast_Score=85, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15446; Mature: 15446

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTLTILKPDCVRKQLIGAVTNMIERAGFRIVAMKKTRLTKETAGAFYAVHKERPFYGE
CCCEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCEEEEEECCCCCHHH
LVEFMSSGPCVPMILEKENAVADFRTLIGATDPAQADEGTIRKLYADSKGENIIHGSDSA
HHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCEEEECCCCC
ENAAIESAFFFAAEEVVRVD
CHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MERTLTILKPDCVRKQLIGAVTNMIERAGFRIVAMKKTRLTKETAGAFYAVHKERPFYGE
CCCEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCEEEEEECCCCCHHH
LVEFMSSGPCVPMILEKENAVADFRTLIGATDPAQADEGTIRKLYADSKGENIIHGSDSA
HHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCEEEECCCCC
ENAAIESAFFFAAEEVVRVD
CHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA