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The map label for this gene is iscS [H]

Identifier: 21674806

GI number: 21674806

Start: 1892106

End: 1893308

Strand: Reverse

Name: iscS [H]

Synonym: CT1995

Alternate gene names: 21674806

Gene position: 1893308-1892106 (Counterclockwise)

Preceding gene: 21674807

Following gene: 21674805

Centisome position: 87.86

GC content: 59.68

Gene sequence:

>1203_bases
ATGCCATCAAGACAGATTTACTTCGATAACAATGCTACCACGCCGCTTCATCCCGAGGTGAAGAAGGAGCTGGTGGCGGC
CATGGAGATGTACGGCAATCCTTCGAGTATGCATGCGTTTGGCCGCGAGGCCCGCGCCAACGTCGAGGATGCACGTCACC
GCGTGGCGGCCTTCATGGGGGCCGACGAGAGCGAGATCGTTTTCACCGGAAGCGGTTCGGAAGGCAACAATACCGTGCTG
TCGCTGTTCGCGTGCGGCACGAGCCAGTGCTTTCCGGGTATGAAGCCGAAGATCGTGACCACCAAAATCGAGCATCCCTG
CGTGCTGGAAACCTCGCAATGCCTGGTGCATCGCGGCGTTGATGTGAGCTATCTCGATGTGGATGCTTATGGCAAGATCG
ATCTCGGGCAGCTCGAAGAGTATCTGAAGTCGGACGGCGTGGGGCTGGTGTCGGTAATGATGGCCAACAACGAGATCGGC
ACGATTCAGGATATTCCGGCCATCAGCGCCCTCGCTCACCAGTACGGCGCGCTCATGCACACCGACGCCGTGCAGGCGTT
CGGCAAGATTCCGGTCGATGTGAATGAGCTCGGTGTCGATTTCCTGACCATTTCCGGCCACAAGATTTACGGCCCGAAAG
GGATTGGTGCGCTGTACGTCCGCAAGGGCACGCCGTACTGCCCCTTCATCCGCGGAGGCCACCAGGAGCGGGGCCGCCGT
GCGGGCACCGAAAACACGCTTGGTATCATGGGCTTGGCGATGGCGGTCGATATGCGCAAGATCGAGATGGCGGCTGAGGC
GGAACGGTTGCGCGGTTTCCGTGAGATGCTGCGTGAAGGCATCTCGGCCCGGATCGACGATGCGCTTTTCAATGGCCATC
CGACTGATTCGATACCGAACACGCTCAACGTGTCGTTTCCCGGCGCAGAGGGCGAATCGATTTTACTCTACCTTGACCTT
GCGGGAATCGCGGTTTCGACCGGCTCGGCCTGCGCGTCGGGGTCGCTCGATCCGTCGCACGTGCTGCTCGCCACGGGCGT
CGATGCCGAGCGCGCTCACGGCTCGATCCGCATCAGCATGGGCCGCTCGACCACCGTCGAGGATGTGGAGTACATGCTCG
ACGTTTTGCCGGGCATTATTGAAAGAATCAGAAACATGTCAACTGCATATATCAAAGGAGGCCCGCATGCTGCAATCAGG
TGA

Upstream 100 bases:

>100_bases
GATGCCGGGAACCTTATCTTTTGGCATGGGTGTTCATCGGTAATAACCTTATATTTGTCCTGCTTGCGGCAAAAATCACC
GAAATTCAGAAACCAGTTTT

Downstream 100 bases:

>100_bases
ATGGGCATATACGGAAAAACTCAAGGAGCATTTCGAGAGTCCGAAAAATGTTCTTCAGGGCAACGACACCAGCGCCTTCG
ACGGCGTCGGCATGGAGGGT

Product: IscS protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MPSRQIYFDNNATTPLHPEVKKELVAAMEMYGNPSSMHAFGREARANVEDARHRVAAFMGADESEIVFTGSGSEGNNTVL
SLFACGTSQCFPGMKPKIVTTKIEHPCVLETSQCLVHRGVDVSYLDVDAYGKIDLGQLEEYLKSDGVGLVSVMMANNEIG
TIQDIPAISALAHQYGALMHTDAVQAFGKIPVDVNELGVDFLTISGHKIYGPKGIGALYVRKGTPYCPFIRGGHQERGRR
AGTENTLGIMGLAMAVDMRKIEMAAEAERLRGFREMLREGISARIDDALFNGHPTDSIPNTLNVSFPGAEGESILLYLDL
AGIAVSTGSACASGSLDPSHVLLATGVDAERAHGSIRISMGRSTTVEDVEYMLDVLPGIIERIRNMSTAYIKGGPHAAIR

Sequences:

>Translated_400_residues
MPSRQIYFDNNATTPLHPEVKKELVAAMEMYGNPSSMHAFGREARANVEDARHRVAAFMGADESEIVFTGSGSEGNNTVL
SLFACGTSQCFPGMKPKIVTTKIEHPCVLETSQCLVHRGVDVSYLDVDAYGKIDLGQLEEYLKSDGVGLVSVMMANNEIG
TIQDIPAISALAHQYGALMHTDAVQAFGKIPVDVNELGVDFLTISGHKIYGPKGIGALYVRKGTPYCPFIRGGHQERGRR
AGTENTLGIMGLAMAVDMRKIEMAAEAERLRGFREMLREGISARIDDALFNGHPTDSIPNTLNVSFPGAEGESILLYLDL
AGIAVSTGSACASGSLDPSHVLLATGVDAERAHGSIRISMGRSTTVEDVEYMLDVLPGIIERIRNMSTAYIKGGPHAAIR
>Mature_399_residues
PSRQIYFDNNATTPLHPEVKKELVAAMEMYGNPSSMHAFGREARANVEDARHRVAAFMGADESEIVFTGSGSEGNNTVLS
LFACGTSQCFPGMKPKIVTTKIEHPCVLETSQCLVHRGVDVSYLDVDAYGKIDLGQLEEYLKSDGVGLVSVMMANNEIGT
IQDIPAISALAHQYGALMHTDAVQAFGKIPVDVNELGVDFLTISGHKIYGPKGIGALYVRKGTPYCPFIRGGHQERGRRA
GTENTLGIMGLAMAVDMRKIEMAAEAERLRGFREMLREGISARIDDALFNGHPTDSIPNTLNVSFPGAEGESILLYLDLA
GIAVSTGSACASGSLDPSHVLLATGVDAERAHGSIRISMGRSTTVEDVEYMLDVLPGIIERIRNMSTAYIKGGPHAAIR

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=395, Percent_Identity=42.0253164556962, Blast_Score=297, Evalue=1e-80,
Organism=Homo sapiens, GI156713448, Length=422, Percent_Identity=36.7298578199052, Blast_Score=216, Evalue=3e-56,
Organism=Escherichia coli, GI48994898, Length=395, Percent_Identity=43.5443037974684, Blast_Score=301, Evalue=7e-83,
Organism=Escherichia coli, GI1787970, Length=316, Percent_Identity=28.1645569620253, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1789175, Length=410, Percent_Identity=25.8536585365854, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI25143064, Length=393, Percent_Identity=40.7124681933842, Blast_Score=272, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17533177, Length=327, Percent_Identity=32.1100917431193, Blast_Score=144, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6319831, Length=393, Percent_Identity=41.9847328244275, Blast_Score=288, Evalue=1e-78,
Organism=Drosophila melanogaster, GI20129463, Length=392, Percent_Identity=42.6020408163265, Blast_Score=291, Evalue=8e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 43002; Mature: 42870

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSRQIYFDNNATTPLHPEVKKELVAAMEMYGNPSSMHAFGREARANVEDARHRVAAFMG
CCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHC
ADESEIVFTGSGSEGNNTVLSLFACGTSQCFPGMKPKIVTTKIEHPCVLETSQCLVHRGV
CCCCCEEEEECCCCCCCEEEEEEECCCHHCCCCCCCEEEEEECCCCEEECHHHHHHHCCC
DVSYLDVDAYGKIDLGQLEEYLKSDGVGLVSVMMANNEIGTIQDIPAISALAHQYGALMH
CEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
TDAVQAFGKIPVDVNELGVDFLTISGHKIYGPKGIGALYVRKGTPYCPFIRGGHQERGRR
HHHHHHHCCCCCCHHHCCEEEEEECCCEEECCCCCCEEEEECCCCCCCCCCCCCHHHHCC
AGTENTLGIMGLAMAVDMRKIEMAAEAERLRGFREMLREGISARIDDALFNGHPTDSIPN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
TLNVSFPGAEGESILLYLDLAGIAVSTGSACASGSLDPSHVLLATGVDAERAHGSIRISM
EEEEEECCCCCCEEEEEEEECCEEEECCCCCCCCCCCCCEEEEEECCCHHHCCCEEEEEE
GRSTTVEDVEYMLDVLPGIIERIRNMSTAYIKGGPHAAIR
CCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCC
>Mature Secondary Structure 
PSRQIYFDNNATTPLHPEVKKELVAAMEMYGNPSSMHAFGREARANVEDARHRVAAFMG
CCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHC
ADESEIVFTGSGSEGNNTVLSLFACGTSQCFPGMKPKIVTTKIEHPCVLETSQCLVHRGV
CCCCCEEEEECCCCCCCEEEEEEECCCHHCCCCCCCEEEEEECCCCEEECHHHHHHHCCC
DVSYLDVDAYGKIDLGQLEEYLKSDGVGLVSVMMANNEIGTIQDIPAISALAHQYGALMH
CEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHH
TDAVQAFGKIPVDVNELGVDFLTISGHKIYGPKGIGALYVRKGTPYCPFIRGGHQERGRR
HHHHHHHCCCCCCHHHCCEEEEEECCCEEECCCCCCEEEEECCCCCCCCCCCCCHHHHCC
AGTENTLGIMGLAMAVDMRKIEMAAEAERLRGFREMLREGISARIDDALFNGHPTDSIPN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
TLNVSFPGAEGESILLYLDLAGIAVSTGSACASGSLDPSHVLLATGVDAERAHGSIRISM
EEEEEECCCCCCEEEEEEEECCEEEECCCCCCCCCCCCCEEEEEECCCHHHCCCEEEEEE
GRSTTVEDVEYMLDVLPGIIERIRNMSTAYIKGGPHAAIR
CCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA