Click here to switch to the map view.

The map label for this gene is iscU [H]

Identifier: 21674805

GI number: 21674805

Start: 1891511

End: 1892122

Strand: Reverse

Name: iscU [H]

Synonym: CT1994

Alternate gene names: 21674805

Gene position: 1892122-1891511 (Counterclockwise)

Preceding gene: 21674806

Following gene: 21674804

Centisome position: 87.8

GC content: 57.19

Gene sequence:

>612_bases
ATGCTGCAATCAGGTGAATGGGCATATACGGAAAAACTCAAGGAGCATTTCGAGAGTCCGAAAAATGTTCTTCAGGGCAA
CGACACCAGCGCCTTCGACGGCGTCGGCATGGAGGGTAACCTCCAGTGCGGCGACCAGATGATGGTGGCCATCAAGGTTG
ATAAGGAGTCGGAAAAAATAACCGATTGCCAGTGGAAGACTTACGGCTGCGCCAGCGCGATCGCCAGCACCTCGATACTC
TCCGAGATGGTGAAAGGCATGACGCTCGACCAGGCGTTCAACATTTCGCCCAAAGAGGTGGCCAAGGAGCTTGGCGGCTT
GCCGGAGAACAAGATTCATTGCTCGGTGCTTGGCGACAAGGCACTGCGGGCGGCGATCAACGACTACTTCATCCGCAACG
GCATGAGCGACCGCGTCCAGAAGGTGCAGGCGCGCACGGTTTGCCAGTGCATGAACGTAACCGATCACGACATCGAGGAG
GCGGTGCTCGAAGGCGCGCGCACCTTCTATGAGCTTCAGGAGCACACCAAGATCAGCACGGTGTGCGGCCAGTGCAGGGA
GGATGCCGAAAACGAACTCCAGAAGTACATCCACCTCCACTTCGGCTCCTGA

Upstream 100 bases:

>100_bases
TCGACCACCGTCGAGGATGTGGAGTACATGCTCGACGTTTTGCCGGGCATTATTGAAAGAATCAGAAACATGTCAACTGC
ATATATCAAAGGAGGCCCGC

Downstream 100 bases:

>100_bases
CGGATTCCGTCGGTGAGCATTCAGTTTCAAGGGAAGGAGGCGGCAGGGCGCGCCTTGTGACGACTCCGGTTCGCCGGACA
AATCACGAGATCGCGCCTCG

Product: IscU protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MLQSGEWAYTEKLKEHFESPKNVLQGNDTSAFDGVGMEGNLQCGDQMMVAIKVDKESEKITDCQWKTYGCASAIASTSIL
SEMVKGMTLDQAFNISPKEVAKELGGLPENKIHCSVLGDKALRAAINDYFIRNGMSDRVQKVQARTVCQCMNVTDHDIEE
AVLEGARTFYELQEHTKISTVCGQCREDAENELQKYIHLHFGS

Sequences:

>Translated_203_residues
MLQSGEWAYTEKLKEHFESPKNVLQGNDTSAFDGVGMEGNLQCGDQMMVAIKVDKESEKITDCQWKTYGCASAIASTSIL
SEMVKGMTLDQAFNISPKEVAKELGGLPENKIHCSVLGDKALRAAINDYFIRNGMSDRVQKVQARTVCQCMNVTDHDIEE
AVLEGARTFYELQEHTKISTVCGQCREDAENELQKYIHLHFGS
>Mature_203_residues
MLQSGEWAYTEKLKEHFESPKNVLQGNDTSAFDGVGMEGNLQCGDQMMVAIKVDKESEKITDCQWKTYGCASAIASTSIL
SEMVKGMTLDQAFNISPKEVAKELGGLPENKIHCSVLGDKALRAAINDYFIRNGMSDRVQKVQARTVCQCMNVTDHDIEE
AVLEGARTFYELQEHTKISTVCGQCREDAENELQKYIHLHFGS

Specific function: May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins (Potential) [H]

COG id: COG0822

COG function: function code C; NifU homolog involved in Fe-S cluster formation

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nifU family [H]

Homologues:

Organism=Homo sapiens, GI56699456, Length=124, Percent_Identity=45.1612903225806, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI24307953, Length=118, Percent_Identity=45.7627118644068, Blast_Score=104, Evalue=4e-23,
Organism=Escherichia coli, GI1788878, Length=122, Percent_Identity=48.3606557377049, Blast_Score=109, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17543474, Length=123, Percent_Identity=46.3414634146341, Blast_Score=103, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6325122, Length=121, Percent_Identity=46.2809917355372, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6324800, Length=129, Percent_Identity=41.0852713178295, Blast_Score=108, Evalue=5e-25,
Organism=Drosophila melanogaster, GI21355597, Length=124, Percent_Identity=44.3548387096774, Blast_Score=107, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007419
- InterPro:   IPR016217
- InterPro:   IPR010238
- InterPro:   IPR001075
- InterPro:   IPR002871
- ProDom:   PD002830 [H]

Pfam domain/function: PF04324 Fer2_BFD; PF01106 NifU; PF01592 NifU_N [H]

EC number: NA

Molecular weight: Translated: 22621; Mature: 22621

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
3.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQSGEWAYTEKLKEHFESPKNVLQGNDTSAFDGVGMEGNLQCGDQMMVAIKVDKESEKI
CCCCCCHHHHHHHHHHHHCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHH
TDCQWKTYGCASAIASTSILSEMVKGMTLDQAFNISPKEVAKELGGLPENKIHCSVLGDK
CCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHCCCCCCCEEEEEHHHH
ALRAAINDYFIRNGMSDRVQKVQARTVCQCMNVTDHDIEEAVLEGARTFYELQEHTKIST
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VCGQCREDAENELQKYIHLHFGS
HHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLQSGEWAYTEKLKEHFESPKNVLQGNDTSAFDGVGMEGNLQCGDQMMVAIKVDKESEKI
CCCCCCHHHHHHHHHHHHCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHH
TDCQWKTYGCASAIASTSILSEMVKGMTLDQAFNISPKEVAKELGGLPENKIHCSVLGDK
CCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHCCCCCCCEEEEEHHHH
ALRAAINDYFIRNGMSDRVQKVQARTVCQCMNVTDHDIEEAVLEGARTFYELQEHTKIST
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VCGQCREDAENELQKYIHLHFGS
HHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7496536 [H]