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The map label for this gene is hisG

Identifier: 21674799

GI number: 21674799

Start: 1886342

End: 1887223

Strand: Reverse

Name: hisG

Synonym: CT1988

Alternate gene names: 21674799

Gene position: 1887223-1886342 (Counterclockwise)

Preceding gene: 21674800

Following gene: 21674798

Centisome position: 87.58

GC content: 58.16

Gene sequence:

>882_bases
ATGAGCAACAACAAGGTTCTCAAGCTGGGTCTGCCGAAGGGCAGCCTTCAGGATTCGACTCTCGAACTTTTCGCCAACGC
CGGCTTCCACTTTTCCGTCCAGAGCCGCTCCTACTTTCCCTCCATCGACGATGACGAGCTGGAGGCGATCCTGATCCGCG
CGCAGGAGATGGGGCGTTATGTTTCTCTGGGTGCGTTCGACGCTGGTCTGACCGGCAAGGACTGGATCATCGAGACCGAC
GCCGATGTGGTGGAGGTGGCCGATCTGGTTTACTCGAAAGCCTCGATGAGGCCGGTGCGCTGGGTGCTCGCTGTGCCGGA
AAGCTCGCCGATCAAGACGGTCAAAGACCTTGAAGGCAAGCACATTGCGACCGAGGTGGTGAACATCACGAAAAAATATC
TGGCCGAAAATGGCGTGAACGCCTCGGTCGAGTTCAGTTGGGGCGCGACCGAGGTCAAACCACCGGAGCTGGCTGATGCC
ATTGTCGAAGTGACCGAAACCGGTTCCTCGTTGCGGGCTAACAAACTCCGCATCGTCGAAACGGTGCTTCAGTCCAATAC
CCAGTTGATCGCCAACAAGGCGGCGTGGGCAGACCCGTGGAAGCGCAAAAAGATCGAAAACATGGCCATGCTGCTGCAAG
GTGCGATCAACGCCCAGGGCAAGGTGGGGTTGAAGATGAACGCCCCGAAGGCTGCGCTCGACAAGATCATGAGCGGCATT
CCCGCCCTGCGCCAGCCGACCGTCTCCGACCTGGCCGACAAGGAGTGGGTTGCGCTCGAAGTGATCGTCTCCGAGAAGAT
CGTGCGCACGCTCATTCCCGAGCTGAAACGTGCGGGCGCAGAGGGGATTTTCGAGTACAACATCAACAAACTCATTGATT
AA

Upstream 100 bases:

>100_bases
CGGCTCGTGGATCGAAGGACGCTATCACTATGGCGTTTACGAACAGGGGCAGTTCCGGCTCGAAAAGCTTTAAGTCAACT
ATCAGATTCTATTTTATCAC

Downstream 100 bases:

>100_bases
GGACAACAGGGACTGAGAGGAGAAAACCTACTGATTCCTGATTAAACGCCAATCAGATGCATTGCAAGGCCGCCGGGGGC
GGCCTTTTTTTTACTATGAT

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MSNNKVLKLGLPKGSLQDSTLELFANAGFHFSVQSRSYFPSIDDDELEAILIRAQEMGRYVSLGAFDAGLTGKDWIIETD
ADVVEVADLVYSKASMRPVRWVLAVPESSPIKTVKDLEGKHIATEVVNITKKYLAENGVNASVEFSWGATEVKPPELADA
IVEVTETGSSLRANKLRIVETVLQSNTQLIANKAAWADPWKRKKIENMAMLLQGAINAQGKVGLKMNAPKAALDKIMSGI
PALRQPTVSDLADKEWVALEVIVSEKIVRTLIPELKRAGAEGIFEYNINKLID

Sequences:

>Translated_293_residues
MSNNKVLKLGLPKGSLQDSTLELFANAGFHFSVQSRSYFPSIDDDELEAILIRAQEMGRYVSLGAFDAGLTGKDWIIETD
ADVVEVADLVYSKASMRPVRWVLAVPESSPIKTVKDLEGKHIATEVVNITKKYLAENGVNASVEFSWGATEVKPPELADA
IVEVTETGSSLRANKLRIVETVLQSNTQLIANKAAWADPWKRKKIENMAMLLQGAINAQGKVGLKMNAPKAALDKIMSGI
PALRQPTVSDLADKEWVALEVIVSEKIVRTLIPELKRAGAEGIFEYNINKLID
>Mature_292_residues
SNNKVLKLGLPKGSLQDSTLELFANAGFHFSVQSRSYFPSIDDDELEAILIRAQEMGRYVSLGAFDAGLTGKDWIIETDA
DVVEVADLVYSKASMRPVRWVLAVPESSPIKTVKDLEGKHIATEVVNITKKYLAENGVNASVEFSWGATEVKPPELADAI
VEVTETGSSLRANKLRIVETVLQSNTQLIANKAAWADPWKRKKIENMAMLLQGAINAQGKVGLKMNAPKAALDKIMSGIP
ALRQPTVSDLADKEWVALEVIVSEKIVRTLIPELKRAGAEGIFEYNINKLID

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=300, Percent_Identity=27, Blast_Score=108, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6320896, Length=284, Percent_Identity=27.112676056338, Blast_Score=102, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_CHLTE (Q8KB10)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662864.1
- ProteinModelPortal:   Q8KB10
- SMR:   Q8KB10
- GeneID:   1007573
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1988
- NMPDR:   fig|194439.1.peg.1958
- TIGR:   CT1988
- HOGENOM:   HBG391868
- OMA:   YLRPRDI
- ProtClustDB:   PRK00489
- BioCyc:   CTEP194439:CT_1988-MONOMER
- BRENDA:   2.4.2.17
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 32103; Mature: 31972

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNNKVLKLGLPKGSLQDSTLELFANAGFHFSVQSRSYFPSIDDDELEAILIRAQEMGRY
CCCCCEEEEECCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCE
VSLGAFDAGLTGKDWIIETDADVVEVADLVYSKASMRPVRWVLAVPESSPIKTVKDLEGK
EEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHCCCC
HIATEVVNITKKYLAENGVNASVEFSWGATEVKPPELADAIVEVTETGSSLRANKLRIVE
HHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
TVLQSNTQLIANKAAWADPWKRKKIENMAMLLQGAINAQGKVGLKMNAPKAALDKIMSGI
HHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCC
PALRQPTVSDLADKEWVALEVIVSEKIVRTLIPELKRAGAEGIFEYNINKLID
CCCCCCCHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHCC
>Mature Secondary Structure 
SNNKVLKLGLPKGSLQDSTLELFANAGFHFSVQSRSYFPSIDDDELEAILIRAQEMGRY
CCCCEEEEECCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCE
VSLGAFDAGLTGKDWIIETDADVVEVADLVYSKASMRPVRWVLAVPESSPIKTVKDLEGK
EEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHCCCC
HIATEVVNITKKYLAENGVNASVEFSWGATEVKPPELADAIVEVTETGSSLRANKLRIVE
HHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
TVLQSNTQLIANKAAWADPWKRKKIENMAMLLQGAINAQGKVGLKMNAPKAALDKIMSGI
HHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCC
PALRQPTVSDLADKEWVALEVIVSEKIVRTLIPELKRAGAEGIFEYNINKLID
CCCCCCCHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901