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The map label for this gene is nadC [H]

Identifier: 21674748

GI number: 21674748

Start: 1830024

End: 1830926

Strand: Reverse

Name: nadC [H]

Synonym: CT1936

Alternate gene names: 21674748

Gene position: 1830926-1830024 (Counterclockwise)

Preceding gene: 21674751

Following gene: 21674747

Centisome position: 84.96

GC content: 53.71

Gene sequence:

>903_bases
TTGGCAGTTATGGCAGAAAAAAGAACCAATCATGCGTTCAGGGAGTTTTTTGAGACATGCAGGTTGAAGGCCATGCAACT
TGCACTCGAAGAGGACCGTTTCCAGGGGGATATCACTACCGAGGCGACTGTCGATCAGAATCAGCTTGGTCTTGGTTACA
TCGAGGTCAAATCTGAAGGGATCATTGCCGGAGTGGAGGTCGCCAGACAGGTGTTCCAGTCACTGGATGCCGCGCTTGAA
TTCACGGCGTACGTCAAGGATGGCAAGAGGGTTTATCCTGGAGAACGAGTGCTCGAGGTAAAGGGACGTATAGCCTCGAT
TCTGATTGGTGAACGTACGGCGCTCAATTTCATGCAGCGCATGTCCGGCATCGCCACCCGCACGAACATGTATGTCGAAC
GGGTCAGCCACACCAACGCATCTATTCTCGATACCCGGAAGACAGCGCCAGCTCTGCGTTATTACGACAAGGAAGCCGTC
CGGATCGGGGGCGGGACCAATCACCGCTTTGGGCTTTTCGATATGATCCTGATCAAGGACAATCACATTGATGCTGCCGG
AAGTGTGGAGGAGGCCATAAGACGGGCGAAGGCATATTGCCAGGAGCAGGGGGTTTCAGCGAAGATTGAAACTGAAGTCC
GCAGCATCTCCGAGCTGGTTCGCGCCTGTGCCAGCCGCCCGGACATGATTCTTCTCGACAACTTCATGGTTGATGACCTG
GCCGAAGCGGTGCGCTGGATCAAGGCGAACGGTTTTGGCAACATTCTGCTTGAAGCGTCGGGAAACATCGGTCTGCACAA
TGTTTCCGAAGTCGCCATGACCGGCGTCGATTTTATTTCAATCGGCGAGCTGACTCATAGCGTCAAGGCGCTCGATATGT
CCATGAAGATCGAACGTGCCTGA

Upstream 100 bases:

>100_bases
GTACCGTGAGACATTGCGAATACCAAAAAAGTATTACCTTGCATGAGAAGGATTTAACGTTCTCAGAGCGTTTTCCGGAT
TCCTCTAACCTCTTTCTGAT

Downstream 100 bases:

>100_bases
TCCCGTCGATGGAGATCGGGGTTGACATCGTCGAGATAGCTCGTATCCGTTCGAGTTATGACCGTTTCGGAGAGGCCTTC
ATGAAGAAAATTCTGACCTC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MAVMAEKRTNHAFREFFETCRLKAMQLALEEDRFQGDITTEATVDQNQLGLGYIEVKSEGIIAGVEVARQVFQSLDAALE
FTAYVKDGKRVYPGERVLEVKGRIASILIGERTALNFMQRMSGIATRTNMYVERVSHTNASILDTRKTAPALRYYDKEAV
RIGGGTNHRFGLFDMILIKDNHIDAAGSVEEAIRRAKAYCQEQGVSAKIETEVRSISELVRACASRPDMILLDNFMVDDL
AEAVRWIKANGFGNILLEASGNIGLHNVSEVAMTGVDFISIGELTHSVKALDMSMKIERA

Sequences:

>Translated_300_residues
MAVMAEKRTNHAFREFFETCRLKAMQLALEEDRFQGDITTEATVDQNQLGLGYIEVKSEGIIAGVEVARQVFQSLDAALE
FTAYVKDGKRVYPGERVLEVKGRIASILIGERTALNFMQRMSGIATRTNMYVERVSHTNASILDTRKTAPALRYYDKEAV
RIGGGTNHRFGLFDMILIKDNHIDAAGSVEEAIRRAKAYCQEQGVSAKIETEVRSISELVRACASRPDMILLDNFMVDDL
AEAVRWIKANGFGNILLEASGNIGLHNVSEVAMTGVDFISIGELTHSVKALDMSMKIERA
>Mature_299_residues
AVMAEKRTNHAFREFFETCRLKAMQLALEEDRFQGDITTEATVDQNQLGLGYIEVKSEGIIAGVEVARQVFQSLDAALEF
TAYVKDGKRVYPGERVLEVKGRIASILIGERTALNFMQRMSGIATRTNMYVERVSHTNASILDTRKTAPALRYYDKEAVR
IGGGTNHRFGLFDMILIKDNHIDAAGSVEEAIRRAKAYCQEQGVSAKIETEVRSISELVRACASRPDMILLDNFMVDDLA
EAVRWIKANGFGNILLEASGNIGLHNVSEVAMTGVDFISIGELTHSVKALDMSMKIERA

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=246, Percent_Identity=35.7723577235772, Blast_Score=154, Evalue=1e-37,
Organism=Escherichia coli, GI1786299, Length=304, Percent_Identity=37.828947368421, Blast_Score=167, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6321162, Length=252, Percent_Identity=34.5238095238095, Blast_Score=144, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 33316; Mature: 33184

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVMAEKRTNHAFREFFETCRLKAMQLALEEDRFQGDITTEATVDQNQLGLGYIEVKSEG
CCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCC
IIAGVEVARQVFQSLDAALEFTAYVKDGKRVYPGERVLEVKGRIASILIGERTALNFMQR
CCHHHHHHHHHHHHHHHHHHHHHEECCCCEECCCCCEEHHHHHHHHHHCCCHHHHHHHHH
MSGIATRTNMYVERVSHTNASILDTRKTAPALRYYDKEAVRIGGGTNHRFGLFDMILIKD
HHHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHCCCCEEEECCCCCCCCCEEEEEEEEC
NHIDAAGSVEEAIRRAKAYCQEQGVSAKIETEVRSISELVRACASRPDMILLDNFMVDDL
CCCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHH
AEAVRWIKANGFGNILLEASGNIGLHNVSEVAMTGVDFISIGELTHSVKALDMSMKIERA
HHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHCCCCEEHHHHHHHHHHHHHHEEEECC
>Mature Secondary Structure 
AVMAEKRTNHAFREFFETCRLKAMQLALEEDRFQGDITTEATVDQNQLGLGYIEVKSEG
CCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCC
IIAGVEVARQVFQSLDAALEFTAYVKDGKRVYPGERVLEVKGRIASILIGERTALNFMQR
CCHHHHHHHHHHHHHHHHHHHHHEECCCCEECCCCCEEHHHHHHHHHHCCCHHHHHHHHH
MSGIATRTNMYVERVSHTNASILDTRKTAPALRYYDKEAVRIGGGTNHRFGLFDMILIKD
HHHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHCCCCEEEECCCCCCCCCEEEEEEEEC
NHIDAAGSVEEAIRRAKAYCQEQGVSAKIETEVRSISELVRACASRPDMILLDNFMVDDL
CCCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHH
AEAVRWIKANGFGNILLEASGNIGLHNVSEVAMTGVDFISIGELTHSVKALDMSMKIERA
HHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHCCCCEEHHHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]