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The map label for this gene is arsB [H]

Identifier: 21674540

GI number: 21674540

Start: 1634389

End: 1635444

Strand: Reverse

Name: arsB [H]

Synonym: CT1724

Alternate gene names: 21674540

Gene position: 1635444-1634389 (Counterclockwise)

Preceding gene: 21674541

Following gene: 21674539

Centisome position: 75.89

GC content: 56.63

Gene sequence:

>1056_bases
ATGAGTATCTCGACAAAACAGCTCTCTTTCCTTGACCGTTATTTGACGCTCTGGATTTTTCTCGCGATGGGCATCGGCGT
GCTCTCCGGCTTTCTCTACCCGCAGATCGCCGGATTCTGGAACCAGTTCCAGTCCGGCACGACCAACATTCCCATCGCCA
TCGGCCTGATCGTCATGATGTATCCGCCGCTCGCCAAAGTGAAGTACGAGGAGCTGGGCGATGTGTTCCGCAACACGAAG
TTGCTGGGCCTGTCGCTCCTGCAGAACTGGGTGATCGGGCCGGTGTTGATGTTTGCGCTCGCTGTGACGTTTCTCTCCGA
CATGCCGCACTACATGGCCGGTCTCATCATGATCGGGCTGGCGCGGTGCATCGCAATGGTGATCGTCTGGAACGAACTGG
CCAAGGGCGACACGGAGTACGCCGCCGGTCTCGTGGCGTTCAACTCGGTGTTCCAGGTGCTCTTCTTTTCGGTCTATGCG
TGGCTCTTTCTGACCGTGCTGCCGGAGAAACTCGGCATGACATCCTTCCACGTCAAGATCACCATCGGCGAGATCGCCCG
TTCGGTCTTCATCTACCTCGGCATTCCATTCATCGCCGGATTTCTGACGCGCTTCGTGATGCTCCGGGTCAAAAGCCGTG
AGTGGTACGAGCGGGAGTTTATTCCAAAAATCAGCCCGCTGACGCTGGTGGCGCTGCTCTTCACGATTGTGGTGATGTTC
TCGCTCAAGGGCGAATACATCGTCAAAATTCCGATGGATGTGCTGCGCATCGCCATTCCGTTGCTGCTCTATTTTGTCAT
TATGTTCTTGGTGTCGTTCTGGCTGGGCAAAAAGATCGGCGCGGACTACTCGAAATCGGCCACGCTTTCCTTCACAGCGG
CGAGCAACAACTTCGAGCTGGCCATCGCCGTGGCAGTCGCCGTCTTCAGAATCGACTCCGGCGAGGCCTTCGCCGCCGTC
ATCGGCCCGCTTGTCGAAGTGCCCGCGCTCATCACACTGGTGAACGTCTCACTCTGGTTCAGGGAAAAATGGTTCCGCGT
TATTGACAACGCATAA

Upstream 100 bases:

>100_bases
GCAGCAGCGAAGAGGTGCTCGCCGAGTTCCGCCGGGTACGCGACGAGATCGAGCAGGAGTTTGGGAAATTTTATCGTGAA
ACCATCCGGGGAGAAAAACC

Downstream 100 bases:

>100_bases
CTGCTTTTTTCGGCTTTAAACAAAACTGACAAAAATGGAAAAACAAGCTGTCCGAGAGTCTGGCCCGGCCTGCTCGGCAG
CCGCCGTTATTTCTGGCCAT

Product: arsenite efflux transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MSISTKQLSFLDRYLTLWIFLAMGIGVLSGFLYPQIAGFWNQFQSGTTNIPIAIGLIVMMYPPLAKVKYEELGDVFRNTK
LLGLSLLQNWVIGPVLMFALAVTFLSDMPHYMAGLIMIGLARCIAMVIVWNELAKGDTEYAAGLVAFNSVFQVLFFSVYA
WLFLTVLPEKLGMTSFHVKITIGEIARSVFIYLGIPFIAGFLTRFVMLRVKSREWYEREFIPKISPLTLVALLFTIVVMF
SLKGEYIVKIPMDVLRIAIPLLLYFVIMFLVSFWLGKKIGADYSKSATLSFTAASNNFELAIAVAVAVFRIDSGEAFAAV
IGPLVEVPALITLVNVSLWFREKWFRVIDNA

Sequences:

>Translated_351_residues
MSISTKQLSFLDRYLTLWIFLAMGIGVLSGFLYPQIAGFWNQFQSGTTNIPIAIGLIVMMYPPLAKVKYEELGDVFRNTK
LLGLSLLQNWVIGPVLMFALAVTFLSDMPHYMAGLIMIGLARCIAMVIVWNELAKGDTEYAAGLVAFNSVFQVLFFSVYA
WLFLTVLPEKLGMTSFHVKITIGEIARSVFIYLGIPFIAGFLTRFVMLRVKSREWYEREFIPKISPLTLVALLFTIVVMF
SLKGEYIVKIPMDVLRIAIPLLLYFVIMFLVSFWLGKKIGADYSKSATLSFTAASNNFELAIAVAVAVFRIDSGEAFAAV
IGPLVEVPALITLVNVSLWFREKWFRVIDNA
>Mature_350_residues
SISTKQLSFLDRYLTLWIFLAMGIGVLSGFLYPQIAGFWNQFQSGTTNIPIAIGLIVMMYPPLAKVKYEELGDVFRNTKL
LGLSLLQNWVIGPVLMFALAVTFLSDMPHYMAGLIMIGLARCIAMVIVWNELAKGDTEYAAGLVAFNSVFQVLFFSVYAW
LFLTVLPEKLGMTSFHVKITIGEIARSVFIYLGIPFIAGFLTRFVMLRVKSREWYEREFIPKISPLTLVALLFTIVVMFS
LKGEYIVKIPMDVLRIAIPLLLYFVIMFLVSFWLGKKIGADYSKSATLSFTAASNNFELAIAVAVAVFRIDSGEAFAAVI
GPLVEVPALITLVNVSLWFREKWFRVIDNA

Specific function: Seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump [H]

COG id: COG0798

COG function: function code P; Arsenite efflux pump ACR3 and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ACR3 family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6325459, Length=317, Percent_Identity=36.2776025236593, Blast_Score=172, Evalue=6e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004706
- InterPro:   IPR002657 [H]

Pfam domain/function: PF01758 SBF [H]

EC number: NA

Molecular weight: Translated: 39405; Mature: 39274

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SISTKQLSFLDRYLTLWIFLAMGIGVLSGFLYPQIAGFWNQFQSGTTNIPIAIGLIVMM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
YPPLAKVKYEELGDVFRNTKLLGLSLLQNWVIGPVLMFALAVTFLSDMPHYMAGLIMIGL
CCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
ARCIAMVIVWNELAKGDTEYAAGLVAFNSVFQVLFFSVYAWLFLTVLPEKLGMTSFHVKI
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
TIGEIARSVFIYLGIPFIAGFLTRFVMLRVKSREWYEREFIPKISPLTLVALLFTIVVMF
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
SLKGEYIVKIPMDVLRIAIPLLLYFVIMFLVSFWLGKKIGADYSKSATLSFTAASNNFEL
HCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHH
AIAVAVAVFRIDSGEAFAAVIGPLVEVPALITLVNVSLWFREKWFRVIDNA
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7704261; 8969508; 9384377; 7489895; 9537360 [H]