Click here to switch to the map view.

The map label for this gene is gppA [H]

Identifier: 21674530

GI number: 21674530

Start: 1624755

End: 1626311

Strand: Reverse

Name: gppA [H]

Synonym: CT1713

Alternate gene names: 21674530

Gene position: 1626311-1624755 (Counterclockwise)

Preceding gene: 21674533

Following gene: 21674529

Centisome position: 75.47

GC content: 60.5

Gene sequence:

>1557_bases
ATGTCATCAGAGAAACTCAGGGTGGCCGCCATCGATCTTGGCACCAACTCCTTTCACATGGTCATCGTCGAGGAGAGCGA
AGAGAAGGGCATTGTGGAAATCGATCGTGTCAAGGACATGATCTGTATCGGGCGTGGCAGCATTTCCACCAAACGGCTCG
ATGACGGGGCGATGGAGGCTGGCGTGGCTACGCTCCGGAACTTCATTGTACTGGCCACCCAGCGGGGTGTCGCGCTGCAC
AACATTCTCGCCTTTGCCACCAGCGCCATTCGCGAGGCCGATAACCGCGACGAGTTTATCGACATGGTGCGGCGCGAAAC
CGGCCTGAAGATTCGGGTGATTACCGGCAAGGAGGAGGCGCAGTTCATCTACTACGGTGTGCGCAATGCCGTGACGCTGC
GTGACAAACCGGATCTTTTGTTTGACATCGGCGGCGGGTCGGTGGAGTTCATCATCGCCGACAAGTCGAAGGTGCACCTG
CTCGAAAGCCGCAAGATCGGCGTGGCCAGAATGCTGGAGCGTTTCGTGACTACCGATCCGGTTTCGGCACACGAGCTGCA
TTTGTTGCAGCAGTTTTTCGCCGCCGAGATGTATGGCGGCGCGGCGGAGATGGCGCACGAACTTGGCGTGAGCCGAGCCA
TCGCCTCGTCAGGTACGGCGCAGAACATCGCCCGCATGATTCGCTTGGGCAAGCATGCCGATGGGGCGGACGTGCTGAAC
CAGAGCAGCTTTACCCGTCAGGAGTTCGAGAGCTTCTACCGGCAGGTGATCGCGATGGACGCTTCGGCGCGGCGCAAGCT
GACCGGCCTCGACGAGAAGCGCGTCGATCTGATTGTGCCGGGGCTGATCCTCTTTGACACGATCTTCCGGGTGTTTGGCA
TCAAGGATGTGGTGATCTCCGATTCAGCGCTGCGCGAAGGAATGGTGCTGCACCAGATCGCCTTGATCCGGGGGCGTGAC
GGCAGTAGCCAGCTCGACATCCGGCGGCAGAGCGTGATGGAACTCGGCTACCGCTGCAACTGGCACAAGCCGCACTCGGA
GCAGGTTGCCCGTCTTGCGCTGATGCTCTTCGACGAACTCCATCCGCTGCACGGGCTCAAGGAGCGCTACCGCGAGCTGC
TCGAATACGCGGCGATGCTGCACAATATCGGGGAGTTCATCTCGATTTCGGCGCACCACAAGCACAGCCAGTACATTATC
ATGAACGCCGATCTGCGCGGCTTTTCACCGACCGAAATCGACATCATCGGCAACGTCGCCCGCTATCACCGCAAGCAGCC
GCCCACCGAAAGGCATCCACTCTACAGCCAGCTCAAGCCCTCGCACCGCCGTGTGGTCGATGTGCTCTCCGGCATCCTGC
GCATCGCCAATGGTCTCGAACGGGGCCACCGCCAGAATGTGCAGTCGATCACGGCCCGCATCGACCAGGAGCGCATCGTG
CTCGAAGCGCTCACGCAGTTCGAGCCTGACATCGAACTCTGGGCGGCTTGCGGGCTAAAGGAGTGGCTCGAAGAGGTGCT
CGGGAAACCCATTCTGATCGAAGCCCGCGTCCGGTAA

Upstream 100 bases:

>100_bases
CGCGAGAAATTCGTCCATGAACACCTGGCTGAAGGGGGTTCGTTTTTTGGTGAAATCGCTTATTTTATTCACAGAAGTTT
CCGTTATCAGGTTCAAGCGC

Downstream 100 bases:

>100_bases
TGGCTTTGTACGAAAAGCTTGCTAGTCCGGGATCGCTCTGGTTTGAATCGACCTTGCCCGGCGCGCTCTACGGCGATTCC
CTCTTTTTCTCCGATCCGCT

Product: exopolyphosphatase, putative

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 518; Mature: 517

Protein sequence:

>518_residues
MSSEKLRVAAIDLGTNSFHMVIVEESEEKGIVEIDRVKDMICIGRGSISTKRLDDGAMEAGVATLRNFIVLATQRGVALH
NILAFATSAIREADNRDEFIDMVRRETGLKIRVITGKEEAQFIYYGVRNAVTLRDKPDLLFDIGGGSVEFIIADKSKVHL
LESRKIGVARMLERFVTTDPVSAHELHLLQQFFAAEMYGGAAEMAHELGVSRAIASSGTAQNIARMIRLGKHADGADVLN
QSSFTRQEFESFYRQVIAMDASARRKLTGLDEKRVDLIVPGLILFDTIFRVFGIKDVVISDSALREGMVLHQIALIRGRD
GSSQLDIRRQSVMELGYRCNWHKPHSEQVARLALMLFDELHPLHGLKERYRELLEYAAMLHNIGEFISISAHHKHSQYII
MNADLRGFSPTEIDIIGNVARYHRKQPPTERHPLYSQLKPSHRRVVDVLSGILRIANGLERGHRQNVQSITARIDQERIV
LEALTQFEPDIELWAACGLKEWLEEVLGKPILIEARVR

Sequences:

>Translated_518_residues
MSSEKLRVAAIDLGTNSFHMVIVEESEEKGIVEIDRVKDMICIGRGSISTKRLDDGAMEAGVATLRNFIVLATQRGVALH
NILAFATSAIREADNRDEFIDMVRRETGLKIRVITGKEEAQFIYYGVRNAVTLRDKPDLLFDIGGGSVEFIIADKSKVHL
LESRKIGVARMLERFVTTDPVSAHELHLLQQFFAAEMYGGAAEMAHELGVSRAIASSGTAQNIARMIRLGKHADGADVLN
QSSFTRQEFESFYRQVIAMDASARRKLTGLDEKRVDLIVPGLILFDTIFRVFGIKDVVISDSALREGMVLHQIALIRGRD
GSSQLDIRRQSVMELGYRCNWHKPHSEQVARLALMLFDELHPLHGLKERYRELLEYAAMLHNIGEFISISAHHKHSQYII
MNADLRGFSPTEIDIIGNVARYHRKQPPTERHPLYSQLKPSHRRVVDVLSGILRIANGLERGHRQNVQSITARIDQERIV
LEALTQFEPDIELWAACGLKEWLEEVLGKPILIEARVR
>Mature_517_residues
SSEKLRVAAIDLGTNSFHMVIVEESEEKGIVEIDRVKDMICIGRGSISTKRLDDGAMEAGVATLRNFIVLATQRGVALHN
ILAFATSAIREADNRDEFIDMVRRETGLKIRVITGKEEAQFIYYGVRNAVTLRDKPDLLFDIGGGSVEFIIADKSKVHLL
ESRKIGVARMLERFVTTDPVSAHELHLLQQFFAAEMYGGAAEMAHELGVSRAIASSGTAQNIARMIRLGKHADGADVLNQ
SSFTRQEFESFYRQVIAMDASARRKLTGLDEKRVDLIVPGLILFDTIFRVFGIKDVVISDSALREGMVLHQIALIRGRDG
SSQLDIRRQSVMELGYRCNWHKPHSEQVARLALMLFDELHPLHGLKERYRELLEYAAMLHNIGEFISISAHHKHSQYIIM
NADLRGFSPTEIDIIGNVARYHRKQPPTERHPLYSQLKPSHRRVVDVLSGILRIANGLERGHRQNVQSITARIDQERIVL
EALTQFEPDIELWAACGLKEWLEEVLGKPILIEARVR

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=447, Percent_Identity=27.0693512304251, Blast_Score=148, Evalue=9e-37,
Organism=Escherichia coli, GI48994966, Length=456, Percent_Identity=27.1929824561404, Blast_Score=139, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 58437; Mature: 58306

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSEKLRVAAIDLGTNSFHMVIVEESEEKGIVEIDRVKDMICIGRGSISTKRLDDGAMEA
CCCCCEEEEEEEECCCCEEEEEEECCCCCCCEEHHHHHHHHEECCCCCCCCCCCCHHHHH
GVATLRNFIVLATQRGVALHNILAFATSAIREADNRDEFIDMVRRETGLKIRVITGKEEA
HHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEECCCCC
QFIYYGVRNAVTLRDKPDLLFDIGGGSVEFIIADKSKVHLLESRKIGVARMLERFVTTDP
EEEEEECCCEEEECCCCCEEEEECCCEEEEEEECCCCEEEHHHCCCCHHHHHHHHHCCCC
VSAHELHLLQQFFAAEMYGGAAEMAHELGVSRAIASSGTAQNIARMIRLGKHADGADVLN
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHC
QSSFTRQEFESFYRQVIAMDASARRKLTGLDEKRVDLIVPGLILFDTIFRVFGIKDVVIS
CCCCCHHHHHHHHHHHHHHCHHHHHHHCCCCCCCHHEEECHHHHHHHHHHHHCCHHHEEC
DSALREGMVLHQIALIRGRDGSSQLDIRRQSVMELGYRCNWHKPHSEQVARLALMLFDEL
CHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
HPLHGLKERYRELLEYAAMLHNIGEFISISAHHKHSQYIIMNADLRGFSPTEIDIIGNVA
CHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
RYHRKQPPTERHPLYSQLKPSHRRVVDVLSGILRIANGLERGHRQNVQSITARIDQERIV
HHHCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEALTQFEPDIELWAACGLKEWLEEVLGKPILIEARVR
HHHHHHCCCCHHHHHHCCHHHHHHHHCCCCEEEEECCC
>Mature Secondary Structure 
SSEKLRVAAIDLGTNSFHMVIVEESEEKGIVEIDRVKDMICIGRGSISTKRLDDGAMEA
CCCCEEEEEEEECCCCEEEEEEECCCCCCCEEHHHHHHHHEECCCCCCCCCCCCHHHHH
GVATLRNFIVLATQRGVALHNILAFATSAIREADNRDEFIDMVRRETGLKIRVITGKEEA
HHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEECCCCC
QFIYYGVRNAVTLRDKPDLLFDIGGGSVEFIIADKSKVHLLESRKIGVARMLERFVTTDP
EEEEEECCCEEEECCCCCEEEEECCCEEEEEEECCCCEEEHHHCCCCHHHHHHHHHCCCC
VSAHELHLLQQFFAAEMYGGAAEMAHELGVSRAIASSGTAQNIARMIRLGKHADGADVLN
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHC
QSSFTRQEFESFYRQVIAMDASARRKLTGLDEKRVDLIVPGLILFDTIFRVFGIKDVVIS
CCCCCHHHHHHHHHHHHHHCHHHHHHHCCCCCCCHHEEECHHHHHHHHHHHHCCHHHEEC
DSALREGMVLHQIALIRGRDGSSQLDIRRQSVMELGYRCNWHKPHSEQVARLALMLFDEL
CHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
HPLHGLKERYRELLEYAAMLHNIGEFISISAHHKHSQYIIMNADLRGFSPTEIDIIGNVA
CHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
RYHRKQPPTERHPLYSQLKPSHRRVVDVLSGILRIANGLERGHRQNVQSITARIDQERIV
HHHCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEALTQFEPDIELWAACGLKEWLEEVLGKPILIEARVR
HHHHHHCCCCHHHHHHCCHHHHHHHHCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA