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The map label for this gene is yhcW [H]

Identifier: 21674514

GI number: 21674514

Start: 1606600

End: 1607256

Strand: Reverse

Name: yhcW [H]

Synonym: CT1696

Alternate gene names: 21674514

Gene position: 1607256-1606600 (Counterclockwise)

Preceding gene: 21674515

Following gene: 21674510

Centisome position: 74.58

GC content: 57.84

Gene sequence:

>657_bases
ATGATCGAAGCCATTCTGTGGGATAATGATGGATTGCTCGTGGACAGTGAGTCGCTGTTTTTCGAGATGACCCGGACTTT
TTTTGCCGAAGCCGGCTTGCAGGTCGAGGCGGAGTACTGGGGGGTGGAGTACCTTGGGAACGCCAAACACAGCTATCAGA
TTGCCGCTGAACTTGGCCTTGCGCCAGAGCTGATTCCTTCGCTGCTTGACCGGCGCAATGAGGCGTTTGTCCAGCGTTTG
CGTCATTCCGTACCGCTCATGCCGAAGGTACGCGAAACCATCGAGGCGCTTGCCGGAACTGTGCGCCTTGCCATTGTGAC
CGGCAGTCCGCGCGACAAGGTGCTGCTGATGCACGGCAATAATGGACTGCTCGATCATTTCGAGGTGATTGTGACTGATG
ACGAAATCAGCAATCCGAAGCCCCATCCTGAGCCGTATCTCAAAGCGATGGAGATGCTTGGCGTCAAGCCGGAGCGCTGT
CTGGCGGTCGAAGATTCACAGCGTGGCCTCGATTCGGCGGTCGCCGCCGGCCTGCGGTGTATCGCGGTTCCCAATGCGCT
GACGAAGGTGCAGCGCTTTGACCGTGCTCATGCGGTGGAAGCGGATGTTTCAGGTGTGCTGAAGCATGTCAACGCCACCA
AGCGTCTGGCACGCTGA

Upstream 100 bases:

>100_bases
CGCGCTCTTCGCCGATCGTGATATCCGCCAAGTGGCGATGCGATTCTGGCGGCTGTATCGGGGGTGTTTCAAGTGACTAT
CAACGATGTAACGAATTTTT

Downstream 100 bases:

>100_bases
GTCCGGTTCTCCTCAAATTTTTTCGACCTCACTGTTCAGCACCTGGTCGATCGCACGGAGAAACTCGTCGATGCCGAACG
GCTTCTCGATAAAATCCACT

Product: HAD superfamily hydrolase

Products: Beta-D-Glucose 6- Phosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MIEAILWDNDGLLVDSESLFFEMTRTFFAEAGLQVEAEYWGVEYLGNAKHSYQIAAELGLAPELIPSLLDRRNEAFVQRL
RHSVPLMPKVRETIEALAGTVRLAIVTGSPRDKVLLMHGNNGLLDHFEVIVTDDEISNPKPHPEPYLKAMEMLGVKPERC
LAVEDSQRGLDSAVAAGLRCIAVPNALTKVQRFDRAHAVEADVSGVLKHVNATKRLAR

Sequences:

>Translated_218_residues
MIEAILWDNDGLLVDSESLFFEMTRTFFAEAGLQVEAEYWGVEYLGNAKHSYQIAAELGLAPELIPSLLDRRNEAFVQRL
RHSVPLMPKVRETIEALAGTVRLAIVTGSPRDKVLLMHGNNGLLDHFEVIVTDDEISNPKPHPEPYLKAMEMLGVKPERC
LAVEDSQRGLDSAVAAGLRCIAVPNALTKVQRFDRAHAVEADVSGVLKHVNATKRLAR
>Mature_218_residues
MIEAILWDNDGLLVDSESLFFEMTRTFFAEAGLQVEAEYWGVEYLGNAKHSYQIAAELGLAPELIPSLLDRRNEAFVQRL
RHSVPLMPKVRETIEALAGTVRLAIVTGSPRDKVLLMHGNNGLLDHFEVIVTDDEISNPKPHPEPYLKAMEMLGVKPERC
LAVEDSQRGLDSAVAAGLRCIAVPNALTKVQRFDRAHAVEADVSGVLKHVNATKRLAR

Specific function: Reversible Transformation Of Glucose 6-Phosphate And Beta-Glucose 1-Phosphate (By Similarity). [C]

COG id: COG0637

COG function: function code R; Predicted phosphatase/phosphohexomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family [H]

Homologues:

Organism=Escherichia coli, GI1787576, Length=198, Percent_Identity=25.2525252525253, Blast_Score=71, Evalue=4e-14,
Organism=Escherichia coli, GI1789046, Length=184, Percent_Identity=28.2608695652174, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1788021, Length=193, Percent_Identity=31.0880829015544, Blast_Score=66, Evalue=1e-12,
Organism=Drosophila melanogaster, GI116008157, Length=210, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006402
- InterPro:   IPR005833 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: 5.4.2.6 [C]

Molecular weight: Translated: 24163; Mature: 24163

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEAILWDNDGLLVDSESLFFEMTRTFFAEAGLQVEAEYWGVEYLGNAKHSYQIAAELGL
CCEEEEECCCCEEEECHHHHHHHHHHHHHHCCCEEEHHHCCCHHHCCCCHHEEHHHHHCC
APELIPSLLDRRNEAFVQRLRHSVPLMPKVRETIEALAGTVRLAIVTGSPRDKVLLMHGN
CHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHCEEEEEEEECCCCCCEEEEECC
NGLLDHFEVIVTDDEISNPKPHPEPYLKAMEMLGVKPERCLAVEDSQRGLDSAVAAGLRC
CCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCHHEEEECCCCCCHHHHHHHCEEE
IAVPNALTKVQRFDRAHAVEADVSGVLKHVNATKRLAR
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIEAILWDNDGLLVDSESLFFEMTRTFFAEAGLQVEAEYWGVEYLGNAKHSYQIAAELGL
CCEEEEECCCCEEEECHHHHHHHHHHHHHHCCCEEEHHHCCCHHHCCCCHHEEHHHHHCC
APELIPSLLDRRNEAFVQRLRHSVPLMPKVRETIEALAGTVRLAIVTGSPRDKVLLMHGN
CHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHCEEEEEEEECCCCCCEEEEECC
NGLLDHFEVIVTDDEISNPKPHPEPYLKAMEMLGVKPERCLAVEDSQRGLDSAVAAGLRC
CCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCHHEEEECCCCCCHHHHHHHCEEE
IAVPNALTKVQRFDRAHAVEADVSGVLKHVNATKRLAR
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Beta-D-Glucose 1-Phosphate [C]

Specific reaction: Beta-D-Glucose 1-Phosphate = Beta-D-Glucose 6- Phosphate. [C]

General reaction: Group transfer (intramolecular phosphate group isomerization [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969498; 9384377 [H]